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dgkab dgkab nr1h3 nr1h3 dkk3a dkk3a pdk3b pdk3b lpgat1 lpgat1 ppardb ppardb pparaa pparaa nr1h5 nr1h5 nr1d1 nr1d1 etfbkmt etfbkmt wdtc1 wdtc1 fh fh dkk3b dkk3b nr1d4a nr1d4a sirt1 sirt1 atcaya atcaya LOC100537809 LOC100537809 pdk4 pdk4 pptc7b pptc7b nr1h4 nr1h4 F1QSV1_DANRE F1QSV1_DANRE cln3 cln3 ncor2 ncor2 tle3a tle3a stard4 stard4 fgf19 fgf19 atcayb atcayb mlycd mlycd pparab pparab pparda pparda h6pd h6pd tysnd1 tysnd1 scap scap ncor1 ncor1 pdk3a pdk3a apoa1b apoa1b pdk2b pdk2b sirt5 sirt5 trib3 trib3 coq3 coq3 dab2 dab2 sirt4 sirt4 ptgs2a ptgs2a pdk1 pdk1 pptc7a pptc7a pibf1 pibf1 pdk2a pdk2a prmt3 prmt3 ptgs2b ptgs2b LOC100535417 LOC100535417 ENSDARP00000146183 ENSDARP00000146183 fgfr4 fgfr4 pparg pparg slc7a11 slc7a11 adipoqb adipoqb il1b il1b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
dgkabDiacylglycerol kinase. (727 aa)
nr1h3Nuclear receptor subfamily 1, group H, member 3. (441 aa)
dkk3aDickkopf WNT-signaling pathway inhibitor 3a. (293 aa)
pdk3bProtein-serine/threonine kinase. (176 aa)
lpgat1Lysophosphatidylglycerol acyltransferase 1. (426 aa)
ppardbPeroxisome proliferator-activated receptor delta b. (517 aa)
pparaaPeroxisome proliferator-activated receptor alpha a. (470 aa)
nr1h5Nuclear receptor subfamily 1, group H, member 5. (486 aa)
nr1d1Nuclear receptor subfamily 1, group d, member 1. (637 aa)
etfbkmtElectron transfer flavoprotein beta subunit lysine methyltransferase; Protein-lysine methyltransferase that selectively trimethylates the flavoprotein ETFB in mitochondria. Thereby, may negatively regulate the function of ETFB in electron transfer from Acyl-CoA dehydrogenases to the main respiratory chain. Belongs to the methyltransferase superfamily. ETFBKMT family. (258 aa)
wdtc1WD and tetratricopeptide repeats 1. (674 aa)
fhFumarate hydratase, mitochondrial; Catalyzes the reversible stereospecific interconversion of fumarate to L-malate (By similarity). Experiments in other species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable). [Isoform Cytoplasmic]: Catalyzes the dehydration of L-malate to fumarate. Fumarate metabolism in the cytosol plays a role during urea cycle and arginine metabolism; fumarate being a by-product of the urea cycle and amino-acid catabolism (By similarity). Also plays a role in DNA repair by promoting [...] (509 aa)
dkk3bDickkopf WNT-signaling pathway inhibitor 3b. (283 aa)
nr1d4aNuclear receptor subfamily 1, group D, member 4a. (570 aa)
sirt1Sirtuin 1. (710 aa)
atcayaATCAY kinesin light chain-interacting caytaxin a. (367 aa)
LOC100537809ATP-binding cassette, sub-family D (ALD), member 2. (509 aa)
pdk4Protein-serine/threonine kinase. (409 aa)
pptc7bProtein phosphatase; Belongs to the PP2C family. (297 aa)
nr1h4Nuclear receptor subfamily 1, group H, member 4. (483 aa)
F1QSV1_DANRESi:ch73-352p4.8. (492 aa)
cln3Battenin. (446 aa)
ncor2Nuclear receptor corepressor 2. (2315 aa)
tle3aTransducin-like enhancer protein 3-A; Transcriptional corepressor that binds to a number of transcription factors. Enhances the transcriptional repression activity of pnx; Belongs to the WD repeat Groucho/TLE family. (776 aa)
stard4StAR-related lipid transfer (START) domain-containing 4. (198 aa)
fgf19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
atcaybATCAY kinesin light chain-interacting caytaxin b. (339 aa)
mlycdMalonyl-CoA decarboxylase. (504 aa)
pparabPeroxisome proliferator-activated receptor alpha b. (459 aa)
ppardaPeroxisome proliferator-activated receptor delta a. (496 aa)
h6pdHexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase). (791 aa)
tysnd1Trypsin domain-containing 1. (521 aa)
scapSREBF chaperone. (1245 aa)
ncor1Nuclear receptor corepressor 1. (2398 aa)
pdk3aProtein-serine/threonine kinase. (405 aa)
apoa1bApolipoprotein A-Ib. (257 aa)
pdk2bProtein-serine/threonine kinase. (409 aa)
sirt5NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. (305 aa)
trib3Tribbles pseudokinase 3. (348 aa)
coq3Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. (319 aa)
dab2DAB adaptor protein 2. (589 aa)
sirt4NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily. (310 aa)
ptgs2aProstaglandin-endoperoxide synthase 2a. (601 aa)
pdk1Protein-serine/threonine kinase. (405 aa)
pptc7aProtein phosphatase PTC7 homolog; Protein phosphatase which positively regulates biosynthesis of the ubiquinone, coenzyme Q (By similarity). Dephosphorylates the ubiquinone biosynthesis protein coq7 which is likely to lead to its activation (By similarity). (297 aa)
pibf1Progesterone immunomodulatory-binding factor 1. (752 aa)
pdk2aProtein-serine/threonine kinase. (409 aa)
prmt3Protein arginine methyltransferase 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (512 aa)
ptgs2bProstaglandin-endoperoxide synthase 2b. (606 aa)
LOC100535417Lyase_1 domain-containing protein. (334 aa)
ENSDARP00000146183Si:ch211-204c21.1. (697 aa)
fgfr4Fibroblast growth factor receptor 4; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down- regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation o [...] (923 aa)
ppargPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (116 aa)
slc7a11Solute carrier family 7 member 11. (498 aa)
adipoqbAdiponectin, C1Q and collagen domain-containing, b. (299 aa)
il1bInterleukin-1. (284 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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