STRINGSTRING
reck reck glula glula bmper bmper fgf2 fgf2 gpib gpib tbxa2r tbxa2r fgfbp1a fgfbp1a aamp aamp nf1a nf1a vash2 vash2 adam17b adam17b jcada jcada RIN2 RIN2 zc3h12a zc3h12a met met mst1ra mst1ra bcas3 bcas3 tgfb1b tgfb1b gata2b gata2b vegfab vegfab nf1b nf1b mmrn2a mmrn2a rgcc rgcc cd40 cd40 pik3cg pik3cg VASH1 VASH1 rin2 rin2 sp1 sp1 mecp2 mecp2 bmpr2b bmpr2b fgf18a fgf18a nfe2l2b nfe2l2b hspb15 hspb15 fgf9 fgf9 mmrn2b mmrn2b vegfc vegfc tsta3l2 tsta3l2 sirt1 sirt1 meox2b meox2b bmp10 bmp10 plpp3 plpp3 gata2a gata2a jupb jupb sash1b sash1b adam17a adam17a nfe2l2a nfe2l2a fgf1b fgf1b fgf16 fgf16 mt2 mt2 tgfb1a tgfb1a atp5f1b atp5f1b hspb1 hspb1 meox2a meox2a TSTA3 TSTA3 tsta3 tsta3 bmpr2a bmpr2a tek tek fgf24 fgf24 F1RCE2_DANRE F1RCE2_DANRE map2k5 map2k5 efna1a efna1a sash1a sash1a angpt1 angpt1 atp5fa1 atp5fa1 jupa jupa itgb1bp1 itgb1bp1 bsg bsg agt agt efna1b efna1b tnfb tnfb gpia gpia fgf1a fgf1a mst1rb mst1rb si:dkey-1k23.3 si:dkey-1k23.3 Zmp:0000000896 Zmp:0000000896 lgmn lgmn bmp10l bmp10l angpt4 angpt4 pdgfbb pdgfbb pdgfba pdgfba nrp1a nrp1a angpt2a angpt2a cib1 cib1 gadd45ab gadd45ab glulb glulb B8JJU9_DANRE B8JJU9_DANRE fgf4 fgf4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
reckReversion-inducing cysteine-rich protein with Kazal motifs; Functions together with adgra2 to enable brain endothelial cells to selectively respond to Wnt7 signals (wnt7a or wnt7b). Plays a key role in Wnt7-specific responses: required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation. Acts as a Wnt7-specific coactivator of canonical Wnt signaling by decoding Wnt ligands: acts by interacting specifically with the disordered linker region of Wnt7, thereby conferring ligand selectivity for Wnt7. Adgra2 is then required to deliver reck-bound Wnt7 to frizzled [...] (755 aa)
glulaGlutamine synthetase. (371 aa)
bmperBMP-binding endothelial regulator. (667 aa)
fgf2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (154 aa)
gpibGlucose-6-phosphate isomerase; Belongs to the GPI family. (553 aa)
tbxa2rThromboxane A2 receptor. (202 aa)
fgfbp1aFibroblast growth factor-binding protein 1b. (197 aa)
aampAngio-associated, migratory cell protein. (416 aa)
nf1aNeurofibromin 1a. (2759 aa)
vash2Vasohibin 2. (348 aa)
adam17bADAM metallopeptidase domain 17b. (843 aa)
jcadaJunctional cadherin 5-associated a. (1465 aa)
RIN2Si:ch211-85n16.4. (824 aa)
zc3h12aZinc finger CCCH-type-containing 12A. (367 aa)
metMET proto-oncogene, receptor tyrosine kinase. (1382 aa)
mst1raMacrophage-stimulating 1 receptor a. (1350 aa)
bcas3BCAS3 microtubule-associated cell migration factor. (910 aa)
tgfb1bTransforming growth factor beta; Belongs to the TGF-beta family. (379 aa)
gata2bGATA-binding protein 2b. (428 aa)
vegfabVascular endothelial growth factor Ab; Belongs to the PDGF/VEGF growth factor family. (251 aa)
nf1bNeurofibromin 1b. (2759 aa)
mmrn2aMultimerin 2a. (1087 aa)
rgccRegulator of cell cycle. (128 aa)
cd40CD40 molecule, TNF receptor superfamily member 5. (286 aa)
pik3cgPhosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1098 aa)
VASH1Vasohibin 1. (370 aa)
rin2Ras and Rab interactor 2. (938 aa)
sp1Sp1 transcription factor. (594 aa)
mecp2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (524 aa)
bmpr2bReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1071 aa)
fgf18aFibroblast growth factor 18a; Belongs to the heparin-binding growth factors family. (208 aa)
nfe2l2bNuclear factor, erythroid 2-like 2b. (507 aa)
hspb15Heat shock protein, alpha-crystallin-related, b15; Belongs to the small heat shock protein (HSP20) family. (154 aa)
fgf9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (142 aa)
mmrn2bMultimerin 2b. (641 aa)
vegfcVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (396 aa)
tsta3l2Tissue-specific transplantation antigen P35B,-like 2. (354 aa)
sirt1Sirtuin 1. (710 aa)
meox2bMesenchyme homeobox 2b. (289 aa)
bmp10Bone morphogenetic protein 10. (485 aa)
plpp3Phospholipid phosphatase 3. (312 aa)
gata2aGATA-binding protein 2a. (456 aa)
jupbJunction plakoglobin b. (726 aa)
sash1bSAM and SH3 domain-containing 1b. (1032 aa)
adam17aADAM metallopeptidase domain 17a. (842 aa)
nfe2l2aNuclear factor (Erythroid-derived 2)-like 2. (586 aa)
fgf1bMultifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (102 aa)
fgf16Fibroblast growth factor 16; Plays a crucial role in pectoral fin bud outgrowth. Belongs to the heparin-binding growth factors family. (203 aa)
mt2Metallothionein-2; Metallothioneins have a high content of cysteine residues that bind various heavy metals; Belongs to the metallothionein superfamily. Type 1 family. (60 aa)
tgfb1aTransforming growth factor beta; Belongs to the TGF-beta family. (377 aa)
atp5f1bATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (517 aa)
hspb1Heat shock protein, alpha-crystallin-related, 1; Belongs to the small heat shock protein (HSP20) family. (199 aa)
meox2aMesenchyme homeobox 2a. (302 aa)
TSTA3Zgc:100864. (328 aa)
tsta3Tissue-specific transplantation antigen P35B. (318 aa)
bmpr2aReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1003 aa)
tekTyrosine-protein kinase receptor Tie-2; Tyrosine-protein kinase that acts as cell-surface receptor for angiopoietins and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Can activate or inhibit angiogenesis, depending on the context. Angiopoietin signaling triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors (By similarity). (1116 aa)
fgf24Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
F1RCE2_DANRESi:rp71-17i16.5; Belongs to the PI3/PI4-kinase family. (1072 aa)
map2k5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (450 aa)
efna1aEphrin-A1a; Belongs to the ephrin family. (222 aa)
sash1aSAM and SH3 domain-containing 1a. (1192 aa)
angpt1Angiopoietin 1. (513 aa)
atp5fa1ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (551 aa)
jupaJunction plakoglobin a. (729 aa)
itgb1bp1Integrin beta-1-binding protein 1. (198 aa)
bsgBasigin. (404 aa)
agtAngiotensinogen; Belongs to the serpin family. (454 aa)
efna1bEphrin A-L1; Belongs to the ephrin family. (229 aa)
tnfbTumor necrosis factor b (TNF superfamily, member 2). (242 aa)
gpiaGlucose-6-phosphate isomerase; Belongs to the GPI family. (553 aa)
fgf1aPutative fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with i [...] (147 aa)
mst1rbMacrophage-stimulating 1 receptor b. (1380 aa)
si:dkey-1k23.3Si:dkey-1k23.3; Belongs to the small heat shock protein (HSP20) family. (365 aa)
Zmp:0000000896Guanylate kinase-like domain-containing protein. (259 aa)
lgmnLegumain. (438 aa)
bmp10lBone morphogenetic protein 10,-like. (406 aa)
angpt4Angiopoietin 4. (499 aa)
pdgfbbPlatelet-derived growth factor beta polypeptide b; Belongs to the PDGF/VEGF growth factor family. (483 aa)
pdgfbaPlatelet-derived growth factor beta polypeptide a; Belongs to the PDGF/VEGF growth factor family. (463 aa)
nrp1aNeuropilin-1a; Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. Regulates angiogenesis through a VEGF-dependent pathway. (923 aa)
angpt2aAngiopoietin 2a. (488 aa)
cib1Calcium and integrin-binding 1 (calmyrin). (188 aa)
gadd45abGrowth arrest and DNA-damage-inducible, alpha, b. (156 aa)
glulbGlutamine synthetase. (372 aa)
B8JJU9_DANRESi:dkey-206d17.12. (626 aa)
fgf4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (191 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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