STRINGSTRING
ifrd2 ifrd2 her15.2 her15.2 her15.1 her15.1 epcam epcam id1 id1 sema3ab sema3ab wnt7aa wnt7aa dynlt1 dynlt1 neurog1 neurog1 cdk5 cdk5 ryk ryk LOC568110 LOC568110 tmem98 tmem98 sema6bb sema6bb sema4ab sema4ab ulk1a ulk1a sema4d sema4d wnt3a wnt3a sema6dl sema6dl ifrd1 ifrd1 spry4 spry4 skia skia sema3d sema3d nr1d4a nr1d4a ttpal ttpal M9MMA2_DANRE M9MMA2_DANRE rnf10 rnf10 sema4c sema4c brinp1 brinp1 sema4e sema4e sema4ga sema4ga sema4bb sema4bb nfatc4 nfatc4 nr1d1 nr1d1 wnt3 wnt3 dnajb11 dnajb11 ttc3 ttc3 sema7a sema7a ednrba ednrba sema4gb sema4gb sema3c sema3c DYNLT1 DYNLT1 F1Q5G8_DANRE F1Q5G8_DANRE ulk1b ulk1b med23 med23 sema4ba sema4ba ttpa ttpa dip2ca dip2ca nf1b nf1b nf2a nf2a sema6d sema6d epha4a epha4a ednrbb ednrbb F8W238_DANRE F8W238_DANRE rflnb rflnb nf1a nf1a ulk2 ulk2 wnt7bb wnt7bb sorl1 sorl1 sema6a sema6a ENSDARP00000134495 ENSDARP00000134495 pcm1 pcm1 rest rest sema6e sema6e sema5a sema5a notch1a notch1a sema5bb sema5bb ptn ptn nkx6.2 nkx6.2 cldn18 cldn18 SEMA4F SEMA4F si:ch73-40a2.1 si:ch73-40a2.1 sema6ba sema6ba sema3fb sema3fb LOC108179070 LOC108179070 ENSDARP00000151788 ENSDARP00000151788 rapgef2 rapgef2 ENSDARP00000153869 ENSDARP00000153869 sema5ba sema5ba dip2a dip2a gper1 gper1 rapgef6 rapgef6 sema3e sema3e f2 f2 sema3aa sema3aa notch1b notch1b sema3bl sema3bl sema3fa sema3fa dip2bb dip2bb ap1ar ap1ar rufy3 rufy3 rflna rflna rtn4r rtn4r nkx6.1 nkx6.1 nf2b nf2b itgb1bp1 itgb1bp1 rb1 rb1 dip2ba dip2ba igf2a igf2a sema3b sema3b wnt7ba wnt7ba tnr tnr kifap3a kifap3a kifap3b kifap3b dip2cb dip2cb sirt2 sirt2 epha4l epha4l
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ifrd2Interferon-related developmental regulator 2. (435 aa)
her15.2Zgc:136520 protein. (149 aa)
her15.1Hairy and enhancer of split-related 15, tandem duplicate 1. (149 aa)
epcamEpithelial cell adhesion molecule. (303 aa)
id1Inhibitor of DNA-binding 1, HLH protein. (128 aa)
sema3abSemaphorin-3ab; Might normally influence the midsegmental pathway choice of the ventrally extending motor axons by contributing to a repulsive domain in the posterior somite. (778 aa)
wnt7aaProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
dynlt1Dynein, light chain, Tctex-type 1. (113 aa)
neurog1Neurogenin-1; Transcriptional regulator. Activates transcription by binding to the E box-containing promoter (By similarity). Mediates neuronal differentiation. Required for the development of Rohon-Beard spinal sensory neurons and dorsal root ganglion neurons, but not for primary motoneurons or autonomic neurons. Required for development of all cranial ganglia but not associated glial cells. Regulates epiphysial neurogenesis, acting partially redundantly with ascl1a and downstream of flh. Required for the development of basal forebrain dopaminergic neurons; involved in the specificati [...] (208 aa)
cdk5Cyclin-dependent protein kinase 5; Belongs to the protein kinase superfamily. (292 aa)
rykReceptor-like tyrosine kinase. (604 aa)
LOC568110Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
tmem98Transmembrane protein 98. (220 aa)
sema6bbSema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6Bb. (639 aa)
sema4abSemaphorin-4A isoform X1; Belongs to the semaphorin family. (831 aa)
ulk1aUnc-51-like autophagy-activating kinase 1a. (927 aa)
sema4dUncharacterized protein; Belongs to the semaphorin family. (856 aa)
wnt3aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
sema6dlSema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D,-like. (1018 aa)
ifrd1Interferon-related developmental regulator 1. (427 aa)
spry4Sprouty homolog 4 (Drosophila). (310 aa)
skiaV-ski avian sarcoma viral oncogene homolog a. (727 aa)
sema3dSemaphorin-3D; May play a role in the guidance of several axon pathways. (764 aa)
nr1d4aNuclear receptor subfamily 1, group D, member 4a. (570 aa)
ttpalTocopherol (alpha) transfer protein-like. (341 aa)
M9MMA2_DANRESi:ch211-129c21.1; Belongs to the semaphorin family. (775 aa)
rnf10Ring finger protein 10. (778 aa)
sema4cSemaphorin-4C precursor; Belongs to the semaphorin family. (863 aa)
brinp1Bone morphogenetic protein/retinoic acid-inducible neural-specific 1. (759 aa)
sema4eSemaphorin-4E. (766 aa)
sema4gaSemaphorin-4G; Belongs to the semaphorin family. (883 aa)
sema4bbSemaphorin-4B; Belongs to the semaphorin family. (849 aa)
nfatc4Nuclear factor of-activated T cells 4. (865 aa)
nr1d1Nuclear receptor subfamily 1, group d, member 1. (637 aa)
wnt3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
dnajb11DnaJ heat shock protein family (Hsp40) member B11. (360 aa)
ttc3Tetratricopeptide repeat domain 3. (1694 aa)
sema7aSemaphorin 7A; Belongs to the semaphorin family. (640 aa)
ednrbaEndothelin receptor Ba; Belongs to the G-protein coupled receptor 1 family. (426 aa)
sema4gbSemaphorin-4G. (752 aa)
sema3cSema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C. (713 aa)
DYNLT1Si:dkey-148f10.4. (112 aa)
F1Q5G8_DANRESi:dkey-49n23.1; Belongs to the semaphorin family. (758 aa)
ulk1bUnc-51-like autophagy-activating kinase 1. (1011 aa)
med23Mediator of RNA polymerase II transcription subunit 23; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). (1387 aa)
sema4baSemaphorin 4; Belongs to the semaphorin family. (830 aa)
ttpaTocopherol (alpha) transfer protein. (285 aa)
dip2caDisco-interacting protein 2 homolog Ca. (1547 aa)
nf1bNeurofibromin 1b. (2759 aa)
nf2aSimilar to neurofibromin 2. (593 aa)
sema6dSema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D; Belongs to the semaphorin family. (898 aa)
epha4aEphrin type-A receptor 4a; Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI- anchored ephrin-A and transmembrane ephrin-B ligands including efna1 and efnb3. [...] (995 aa)
ednrbbEndothelin receptor type Bb; Belongs to the G-protein coupled receptor 1 family. (365 aa)
F8W238_DANRESi:ch211-113g11.6; Belongs to the semaphorin family. (474 aa)
rflnbRefilin B. (194 aa)
nf1aNeurofibromin 1a. (2759 aa)
ulk2Unc-51-like autophagy-activating kinase 2. (1034 aa)
wnt7bbProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
sorl1Sortilin-related receptor, L(DLR class) A repeats-containing. (2213 aa)
sema6aSema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A. (604 aa)
ENSDARP00000134495Uncharacterized protein; Belongs to the semaphorin family. (482 aa)
pcm1Pericentriolar material 1. (2018 aa)
restRE1-silencing transcription factor; Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. (854 aa)
sema6eSema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6E; Belongs to the semaphorin family. (1064 aa)
sema5aSemaphorin-5A. (1048 aa)
notch1aNeurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] (2438 aa)
sema5bbSemaphorin-5B. (1098 aa)
ptnPleiotrophin. (158 aa)
nkx6.2NK6 homeobox 2. (278 aa)
cldn18Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (258 aa)
SEMA4FSsemaphorin 4F; Belongs to the semaphorin family. (766 aa)
si:ch73-40a2.1Si:ch73-40a2.1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (723 aa)
sema6baSema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6Ba; Belongs to the semaphorin family. (895 aa)
sema3fbSema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Fb; Belongs to the semaphorin family. (791 aa)
LOC108179070Protogenin A; May play a role in anteroposterior axis elongation. Belongs to the immunoglobulin superfamily. DCC family. (133 aa)
ENSDARP00000151788Sema domain-containing protein; Belongs to the semaphorin family. (305 aa)
rapgef2Rap guanine nucleotide exchange factor (GEF) 2. (1619 aa)
ENSDARP00000153869Uncharacterized protein. (84 aa)
sema5baannotation not available (1101 aa)
dip2aDisco-interacting protein 2 homolog A. (1610 aa)
gper1G-protein coupled estrogen receptor 1; Membrane G-protein coupled estrogen receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Plays a role in the embryonic development of sensory and motor neurons. Specifically induces apoptosis and reduces proliferation of brain cells. Involved in maintenance of meiotic arrest in oocytes. (353 aa)
rapgef6Rap guanine nucleotide exchange factor (GEF) 6. (1261 aa)
sema3eSema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E; Belongs to the semaphorin family. (768 aa)
f2Coagulation factor II (thrombin); Belongs to the peptidase S1 family. (635 aa)
sema3aaSemaphorin-3aa; May influence outgrowth by a variety of growth cones including those of the posterior lateral line ganglion. (860 aa)
notch1bNotch receptor 1b. (2465 aa)
sema3blSema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3bl; Belongs to the semaphorin family. (771 aa)
sema3faSema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Fa; Belongs to the semaphorin family. (801 aa)
dip2bbDisco-interacting protein 2 homolog B-A. (1603 aa)
ap1arAdaptor-related protein complex 1-associated regulatory protein. (293 aa)
rufy3RUN and FYVE domain-containing 3. (470 aa)
rflnaFamily with sequence similarity 101, member A. (222 aa)
rtn4rReticulon 4 receptor. (479 aa)
nkx6.1NK6 homeobox 1. (312 aa)
nf2bNeurofibromin 2b (merlin). (586 aa)
itgb1bp1Integrin beta-1-binding protein 1. (198 aa)
rb1Retinoblastoma 1. (903 aa)
dip2baDisco-interacting protein 2 homolog B-A; Belongs to the DIP2 family. (1577 aa)
igf2aInsulin-like growth factor 2a. (197 aa)
sema3bSema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B; Belongs to the semaphorin family. (775 aa)
wnt7baProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
tnrTenascin R (Restrictin, janusin). (1350 aa)
kifap3aKinesin-associated protein 3a. (789 aa)
kifap3bKinesin-associated protein 3b. (772 aa)
dip2cbDisco-interacting protein 2 homolog Cb. (1575 aa)
sirt2NAD-dependent protein deacetylase sirtuin-2; NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and alpha-tubulin as well as many other proteins such as key transcription factors (By similarity). Participates in the modulation of multiple and diverse biological processes such as cell cycle control, genomic integrity, microtubule dynamics, cell differentiation, metabolic networks, and autophagy. Plays a major role in the control of cell cycle progression and genomic stability. Deacetylates histone H4 at 'Lys-16' (H4K16ac) at the VEGFA promoter. Thereby con [...] (379 aa)
epha4lEph receptor A4,-like. (988 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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