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mical2b | Protein-methionine sulfoxide oxidase mical2b; Nuclear monooxygenase that promotes depolymerization of F- actin by mediating oxidation of specific methionine residues on actin and regulates the srf signaling. Acts by modifying nuclear actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization (By similarity). Acts as a key regulator of the srf signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase mkl1/mrt [...] (1679 aa) | ||||
nkx2.5 | NK2 homeobox 5. (314 aa) | ||||
srfa | Serum response factor a. (539 aa) | ||||
mical2a | Microtubule-associated monooxygenase, calponin and LIM domain-containing 2a. (834 aa) | ||||
srfb | Serum response factor b. (260 aa) |