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smad4a smad4a gdf10b gdf10b gb:cr929477 gb:cr929477 bmpr2b bmpr2b spaw spaw gdf10a gdf10a gdf7 gdf7 bmp7b bmp7b Q1L8R8_DANRE Q1L8R8_DANRE tgfb1b tgfb1b tgfb2 tgfb2 E7FFZ5_DANRE E7FFZ5_DANRE gdf6b gdf6b LOC100332902 LOC100332902 bmp5 bmp5 LOC100329520 LOC100329520 rbpms rbpms ndr2 ndr2 bmp16 bmp16 ENSDARP00000146183 ENSDARP00000146183 bmp10l bmp10l ENSDARP00000148508 ENSDARP00000148508 inhbab inhbab bmp15 bmp15 acvrl1 acvrl1 tgfbr2b tgfbr2b dab2 dab2 tgfb3 tgfb3 bmp6 bmp6 bmp7a bmp7a inhbaa inhbaa lft1 lft1 acvr1l acvr1l gdf5 gdf5 gdf3 gdf3 bmpr2a bmpr2a inha inha inhbb inhbb tgfb1a tgfb1a mstna mstna lft2 lft2 gdf11 gdf11 bmp4 bmp4 gdf6a gdf6a F1QAH4_DANRE F1QAH4_DANRE ndr1 ndr1 gdf2 gdf2 tgfbr2a tgfbr2a bmp3 bmp3 bmp10 bmp10 mstnb mstnb bmp8a bmp8a tgfb5 tgfb5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
smad4aMothers against decapentaplegic homolog. (547 aa)
gdf10bGrowth differentiation factor 10b. (422 aa)
gb:cr929477SMAD family member 4. (332 aa)
bmpr2bReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1071 aa)
spawSouthpaw. (411 aa)
gdf10aGrowth differentiation factor 10a. (441 aa)
gdf7Growth differentiation factor 7. (396 aa)
bmp7bBone morphogenetic protein 7b. (427 aa)
Q1L8R8_DANREMothers against decapentaplegic homolog. (571 aa)
tgfb1bTransforming growth factor beta; Belongs to the TGF-beta family. (379 aa)
tgfb2Transforming growth factor, beta 2. (413 aa)
E7FFZ5_DANREMothers against decapentaplegic homolog. (568 aa)
gdf6bGrowth/differentiation factor 6-B; Belongs to the TGF-beta family. (412 aa)
LOC100332902TGF_BETA_2 domain-containing protein. (264 aa)
bmp5Bone morphogenetic protein 5. (446 aa)
LOC100329520Inhibin subunit beta C. (379 aa)
rbpmsRNA-binding protein, mRNA-processing factor. (160 aa)
ndr2Nodal-related 2. (505 aa)
bmp16Bone morphogenetic protein 16. (416 aa)
ENSDARP00000146183Si:ch211-204c21.1. (697 aa)
bmp10lBone morphogenetic protein 10,-like. (406 aa)
ENSDARP00000148508ecTbetaR2 domain-containing protein. (382 aa)
inhbabInhibin subunit beta Ab. (405 aa)
bmp15Bone morphogenetic protein 15. (384 aa)
acvrl1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (499 aa)
tgfbr2bTGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (556 aa)
dab2DAB adaptor protein 2. (589 aa)
tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
bmp6Bone morphogenetic protein 6. (417 aa)
bmp7aBone morphogenetic protein 7a. (432 aa)
inhbaaInhibin subunit beta Aa. (395 aa)
lft1Left-right determination factor; Belongs to the TGF-beta family. (358 aa)
acvr1lReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa)
gdf5Growth differentiation factor 5. (474 aa)
gdf3Protein DVR-1; Serves to facilitate the differentiation of either mesoderm or endoderm either as a cofactor in an instructive signal or by providing permissive environment. (355 aa)
bmpr2aReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1003 aa)
inhaInhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (347 aa)
inhbbInhibin subunit beta B. (393 aa)
tgfb1aTransforming growth factor beta; Belongs to the TGF-beta family. (377 aa)
mstnaGrowth differentiation factor 8, like. (366 aa)
lft2Left-right determination factor. (362 aa)
gdf11Growth differentiation factor 11. (390 aa)
bmp4Bone morphogenetic protein 4. (400 aa)
gdf6aGrowth/differentiation factor 6-A; Growth factor that controls proliferation and cellular differentiation in the retina. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map. Functions maternally in dorsal/ventral patterning to induce the expression of the zygotic bmp2b and bmp4 genes and ventralize embryos. Zygotic expression does not appear to regulate axis specification, but instead functions to establish the integrity of the axial vessels during embryon [...] (404 aa)
F1QAH4_DANRETGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (590 aa)
ndr1Nodal-related 1. (392 aa)
gdf2Growth/differentiation factor 2; Potent circulating inhibitor of angiogenesis. Signals through the type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/eng. (389 aa)
tgfbr2aSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (645 aa)
bmp3Bone morphogenetic protein 3; Belongs to the TGF-beta family. (452 aa)
bmp10Bone morphogenetic protein 10. (485 aa)
mstnbGrowth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth. May down-regulate muscle-specific transcription factors such as myod and myog. (374 aa)
bmp8aBone morphogenetic protein 8a. (433 aa)
tgfb5Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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