(38 nodes) Sterol transporter activity network (Danio rerio)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	osbpl2b	Oxysterol-binding protein; Belongs to the OSBP family. (472 aa)
	stard3	StAR-related lipid transfer protein 3; Sterol-binding protein that mediates cholesterol transport from the endoplasmic reticulum to endosomes. Creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum. Acts as a lipid transfer protein that redirects sterol to the endosome at the expense of the cell membrane and favors membrane formation inside endosomes. (448 aa)
	scp2a	Sterol carrier protein 2a; Belongs to the thiolase-like superfamily. Thiolase family. (538 aa)
	osbpl7	Oxysterol-binding protein; Belongs to the OSBP family. (888 aa)
	star	Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone (By similarity). (285 aa)
	A2BEG1_DANRE	Oxysterol-binding protein; Belongs to the OSBP family. (808 aa)
	osbpl10b	Oxysterol-binding protein; Belongs to the OSBP family. (752 aa)
	cetp	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. (493 aa)
	LOC100331467	START domain-containing protein. (277 aa)
	OSBPL8	Oxysterol-binding protein; Belongs to the OSBP family. (681 aa)
	apoba	Apolipoprotein Ba. (4418 aa)
	LOC100331149	Oxysterol-binding protein; Belongs to the OSBP family. (452 aa)
	abcg5	ATP-binding cassette, sub-family G (WHITE), member 5. (652 aa)
	abcg1	ATP-binding cassette, sub-family G (WHITE), member 1. (673 aa)
	osbpl9	Oxysterol-binding protein; Belongs to the OSBP family. (733 aa)
	abcg4b	ATP-binding cassette, sub-family G (WHITE), member 4b. (644 aa)
	abcg8	ATP-binding cassette, sub-family G (WHITE), member 8. (332 aa)
	arv1	ARV1 homolog, fatty acid homeostasis modulator. (239 aa)
	stard5	StAR-related lipid transfer (START) domain-containing 5. (210 aa)
	osbpl6	Oxysterol-binding protein; Belongs to the OSBP family. (910 aa)
	osbp2	Oxysterol-binding protein; Belongs to the OSBP family. (748 aa)
	osbpl11	Oxysterol-binding protein; Belongs to the OSBP family. (693 aa)
	abcg4a	ATP-binding cassette, sub-family G (WHITE), member 4a. (641 aa)
	osbpl3b	Oxysterol-binding protein; Belongs to the OSBP family. (882 aa)
	podn	Podocan. (530 aa)
	osbpl3a	Oxysterol-binding protein; Belongs to the OSBP family. (813 aa)
	gramd1a	GRAM domain-containing 1A. (771 aa)
	osbp	Oxysterol-binding protein; Belongs to the OSBP family. (760 aa)
	osbpl5	Oxysterol-binding protein; Belongs to the OSBP family. (865 aa)
	pltp	Phospholipid transfer protein. (486 aa)
	LOC100334085	Oxysterol-binding protein; Belongs to the OSBP family. (520 aa)
	stard4	StAR-related lipid transfer (START) domain-containing 4. (198 aa)
	osbpl1a	Oxysterol-binding protein; Belongs to the OSBP family. (972 aa)
	gramd1ba	GRAM domain-containing 1Ba. (872 aa)
	gramd1c	GRAM domain-containing 1c. (692 aa)
	osbpl2a	Oxysterol-binding protein; Belongs to the OSBP family. (475 aa)
	gramd1bb	GRAM domain-containing 1Bb. (896 aa)
	apoa1b	Apolipoprotein A-Ib. (257 aa)

Your Current Organism:

Danio rerio

NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC100331467	stard3	ENSDARP00000055742	ENSDARP00000007948	START domain-containing protein.	StAR-related lipid transfer protein 3; Sterol-binding protein that mediates cholesterol transport from the endoplasmic reticulum to endosomes. Creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum. Acts as a lipid transfer protein that redirects sterol to the endosome at the expense of the cell membrane and favors membrane formation inside endosomes.	0.463
LOC100331467	stard5	ENSDARP00000055742	ENSDARP00000103526	START domain-containing protein.	StAR-related lipid transfer (START) domain-containing 5.	0.467
LOC100334085	osbpl9	ENSDARP00000135449	ENSDARP00000091500	Oxysterol-binding protein; Belongs to the OSBP family.	Oxysterol-binding protein; Belongs to the OSBP family.	0.637
abcg1	abcg5	ENSDARP00000087241	ENSDARP00000086278	ATP-binding cassette, sub-family G (WHITE), member 1.	ATP-binding cassette, sub-family G (WHITE), member 5.	0.690
abcg1	apoba	ENSDARP00000087241	ENSDARP00000062792	ATP-binding cassette, sub-family G (WHITE), member 1.	Apolipoprotein Ba.	0.452
abcg1	cetp	ENSDARP00000087241	ENSDARP00000046890	ATP-binding cassette, sub-family G (WHITE), member 1.	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.	0.685
abcg1	gramd1a	ENSDARP00000087241	ENSDARP00000120012	ATP-binding cassette, sub-family G (WHITE), member 1.	GRAM domain-containing 1A.	0.446
abcg1	pltp	ENSDARP00000087241	ENSDARP00000131164	ATP-binding cassette, sub-family G (WHITE), member 1.	Phospholipid transfer protein.	0.438
abcg4a	abcg4b	ENSDARP00000116517	ENSDARP00000102351	ATP-binding cassette, sub-family G (WHITE), member 4a.	ATP-binding cassette, sub-family G (WHITE), member 4b.	0.902
abcg4a	abcg5	ENSDARP00000116517	ENSDARP00000086278	ATP-binding cassette, sub-family G (WHITE), member 4a.	ATP-binding cassette, sub-family G (WHITE), member 5.	0.683
abcg4a	pltp	ENSDARP00000116517	ENSDARP00000131164	ATP-binding cassette, sub-family G (WHITE), member 4a.	Phospholipid transfer protein.	0.504
abcg4b	abcg4a	ENSDARP00000102351	ENSDARP00000116517	ATP-binding cassette, sub-family G (WHITE), member 4b.	ATP-binding cassette, sub-family G (WHITE), member 4a.	0.902
abcg4b	abcg5	ENSDARP00000102351	ENSDARP00000086278	ATP-binding cassette, sub-family G (WHITE), member 4b.	ATP-binding cassette, sub-family G (WHITE), member 5.	0.602
abcg5	abcg1	ENSDARP00000086278	ENSDARP00000087241	ATP-binding cassette, sub-family G (WHITE), member 5.	ATP-binding cassette, sub-family G (WHITE), member 1.	0.690
abcg5	abcg4a	ENSDARP00000086278	ENSDARP00000116517	ATP-binding cassette, sub-family G (WHITE), member 5.	ATP-binding cassette, sub-family G (WHITE), member 4a.	0.683
abcg5	abcg4b	ENSDARP00000086278	ENSDARP00000102351	ATP-binding cassette, sub-family G (WHITE), member 5.	ATP-binding cassette, sub-family G (WHITE), member 4b.	0.602
abcg5	abcg8	ENSDARP00000086278	ENSDARP00000102567	ATP-binding cassette, sub-family G (WHITE), member 5.	ATP-binding cassette, sub-family G (WHITE), member 8.	0.999
abcg5	apoa1b	ENSDARP00000086278	ENSDARP00000151245	ATP-binding cassette, sub-family G (WHITE), member 5.	Apolipoprotein A-Ib.	0.427
abcg5	apoba	ENSDARP00000086278	ENSDARP00000062792	ATP-binding cassette, sub-family G (WHITE), member 5.	Apolipoprotein Ba.	0.615
abcg5	cetp	ENSDARP00000086278	ENSDARP00000046890	ATP-binding cassette, sub-family G (WHITE), member 5.	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.	0.486

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