STRINGSTRING
npc1 npc1 podn podn apobb.1 apobb.1 osbpl3b osbpl3b abcg4a abcg4a cel.1 cel.1 osbpl11 osbpl11 osbp2 osbp2 vps4b vps4b osbpl6 osbpl6 stard5 stard5 arv1 arv1 abcg8 abcg8 abcg4b abcg4b abcd1 abcd1 osbpl9 osbpl9 abcg1 abcg1 abcg5 abcg5 LOC100331149 LOC100331149 lipca lipca spg11 spg11 stard3nl stard3nl apoba apoba apoeb apoeb ldlrap1b ldlrap1b OSBPL8 OSBPL8 LOC100331467 LOC100331467 npc2 npc2 cetp cetp osbpl10b osbpl10b vps4a vps4a cel.2 cel.2 A2BEG1_DANRE A2BEG1_DANRE apoa1a apoa1a star star zgc:193725 zgc:193725 osbpl7 osbpl7 ldlrap1a ldlrap1a scp2a scp2a stard3 stard3 osbpl2b osbpl2b ENSDARP00000152122 ENSDARP00000152122 apoa1b apoa1b gramd1bb gramd1bb osbpl2a osbpl2a gramd1c gramd1c gramd1ba gramd1ba osbpl1a osbpl1a scarb1 scarb1 stard4 stard4 syt7b syt7b LOC100334085 LOC100334085 relch relch NPC1L1 NPC1L1 apoea apoea lima1a lima1a lcat lcat pltp pltp X1WG66_DANRE X1WG66_DANRE syt7a syt7a osbpl5 osbpl5 apom apom osbp osbp apobb.2 apobb.2 gramd1a gramd1a osbpl3a osbpl3a
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
npc1Niemann-Pick disease, type C1. (1277 aa)
podnPodocan. (530 aa)
apobb.1Apolipoprotein Bb, tandem duplicate 1. (3730 aa)
osbpl3bOxysterol-binding protein; Belongs to the OSBP family. (882 aa)
abcg4aATP-binding cassette, sub-family G (WHITE), member 4a. (641 aa)
cel.1Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (552 aa)
osbpl11Oxysterol-binding protein; Belongs to the OSBP family. (693 aa)
osbp2Oxysterol-binding protein; Belongs to the OSBP family. (748 aa)
vps4bVacuolar protein sorting 4 homolog B; Belongs to the AAA ATPase family. (437 aa)
osbpl6Oxysterol-binding protein; Belongs to the OSBP family. (910 aa)
stard5StAR-related lipid transfer (START) domain-containing 5. (210 aa)
arv1ARV1 homolog, fatty acid homeostasis modulator. (239 aa)
abcg8ATP-binding cassette, sub-family G (WHITE), member 8. (332 aa)
abcg4bATP-binding cassette, sub-family G (WHITE), member 4b. (644 aa)
abcd1ATP-binding cassette sub-family D member 1; Plays a role in the transport of free very-long-chain fatty acids (VLCFAs) as well as their CoA-esters across the peroxisomal membrane by acting as an ATP-specific binding subunit releasing ADP after ATP hydrolysis (By similarity). Involved in oligodendrocyte patterning and myelination. (766 aa)
osbpl9Oxysterol-binding protein; Belongs to the OSBP family. (733 aa)
abcg1ATP-binding cassette, sub-family G (WHITE), member 1. (673 aa)
abcg5ATP-binding cassette, sub-family G (WHITE), member 5. (652 aa)
LOC100331149Oxysterol-binding protein; Belongs to the OSBP family. (452 aa)
lipcaLipase, hepatic a. (514 aa)
spg11SPG11 vesicle-trafficking-associated, spatacsin. (1612 aa)
stard3nlSTARD3 N-terminal-like. (227 aa)
apobaApolipoprotein Ba. (4418 aa)
apoebApolipoprotein Eb; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. Belongs to the apolipoprotein A1/A4/E family. (281 aa)
ldlrap1bLow density lipoprotein receptor adaptor protein 1b. (304 aa)
OSBPL8Oxysterol-binding protein; Belongs to the OSBP family. (681 aa)
LOC100331467START domain-containing protein. (277 aa)
npc2NPC intracellular cholesterol transporter 2; Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. May bind and mobilize cholesterol that is associated with membranes. NPC2 binds cholesterol with a 1:1 stoichiometry. Can bind a variety of sterols, including lathosterol, desmosterol and the pl [...] (149 aa)
cetpCholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. (493 aa)
osbpl10bOxysterol-binding protein; Belongs to the OSBP family. (752 aa)
vps4aVacuolar protein sorting 4 homolog A; Belongs to the AAA ATPase family. (440 aa)
cel.2Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (551 aa)
A2BEG1_DANREOxysterol-binding protein; Belongs to the OSBP family. (808 aa)
apoa1aProapolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). (262 aa)
starSteroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone (By similarity). (285 aa)
zgc:193725Zgc:193725. (149 aa)
osbpl7Oxysterol-binding protein; Belongs to the OSBP family. (888 aa)
ldlrap1aLow density lipoprotein receptor adaptor protein 1a. (287 aa)
scp2aSterol carrier protein 2a; Belongs to the thiolase-like superfamily. Thiolase family. (538 aa)
stard3StAR-related lipid transfer protein 3; Sterol-binding protein that mediates cholesterol transport from the endoplasmic reticulum to endosomes. Creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum. Acts as a lipid transfer protein that redirects sterol to the endosome at the expense of the cell membrane and favors membrane formation inside endosomes. (448 aa)
osbpl2bOxysterol-binding protein; Belongs to the OSBP family. (472 aa)
ENSDARP00000152122LIM zinc-binding domain-containing protein. (110 aa)
apoa1bApolipoprotein A-Ib. (257 aa)
gramd1bbGRAM domain-containing 1Bb. (896 aa)
osbpl2aOxysterol-binding protein; Belongs to the OSBP family. (475 aa)
gramd1cGRAM domain-containing 1c. (692 aa)
gramd1baGRAM domain-containing 1Ba. (872 aa)
osbpl1aOxysterol-binding protein; Belongs to the OSBP family. (972 aa)
scarb1Scavenger receptor class B, member 1; Belongs to the CD36 family. (496 aa)
stard4StAR-related lipid transfer (START) domain-containing 4. (198 aa)
syt7bSynaptotagmin VIIb. (488 aa)
LOC100334085Oxysterol-binding protein; Belongs to the OSBP family. (520 aa)
relchRAB11-binding protein RELCH homolog; May regulate intracellular cholesterol transport. (1197 aa)
NPC1L1NPC1 like intracellular cholesterol transporter 1. (1085 aa)
apoeaApolipoprotein Ea. (269 aa)
lima1aLIM domain and actin-binding 1a. (589 aa)
lcatLecithin-cholesterol acyltransferase. (425 aa)
pltpPhospholipid transfer protein. (486 aa)
X1WG66_DANRESi:dkey-185p13.1. (93 aa)
syt7aSynaptotagmin VIIa. (607 aa)
osbpl5Oxysterol-binding protein; Belongs to the OSBP family. (865 aa)
apomApolipoprotein M. (215 aa)
osbpOxysterol-binding protein; Belongs to the OSBP family. (760 aa)
apobb.2Apolipoprotein Bb, tandem duplicate 2. (2534 aa)
gramd1aGRAM domain-containing 1A. (771 aa)
osbpl3aOxysterol-binding protein; Belongs to the OSBP family. (813 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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