STRINGSTRING
gga3a gga3a snx8b snx8b rab6a rab6a arf6a arf6a tbc1d10b tbc1d10b arfrp1 arfrp1 clec16a clec16a X1WG66_DANRE X1WG66_DANRE X1WFU5_DANRE X1WFU5_DANRE ap5b1 ap5b1 stx16 stx16 ap5z1 ap5z1 vps25 vps25 rab8a rab8a pikfyve pikfyve clcf1 clcf1 als2b als2b snx6 snx6 E7F0T8_DANRE E7F0T8_DANRE tbc1d5 tbc1d5 bloc1s2 bloc1s2 rab41 rab41 snx1a snx1a zgc:153733 zgc:153733 chmp2a chmp2a ehd4 ehd4 vps26bl vps26bl vps26a vps26a F1QQY3_DANRE F1QQY3_DANRE vps36 vps36 snf8 snf8 golt1bb golt1bb vps16 vps16 itsn2b itsn2b washc4 washc4 vps51 vps51 dennd10 dennd10 grip2a grip2a wash1 wash1 F1R8V5_DANRE F1R8V5_DANRE snx18a snx18a eps15 eps15 rab8b rab8b lyst lyst zgc:136908 zgc:136908 vps29 vps29 dctn1b dctn1b snx9a snx9a cln5 cln5 rilp rilp als2a als2a alms1 alms1 stx10 stx10 reps2 reps2 micall1a micall1a zgc:162698 zgc:162698 vps39 vps39 vps50 vps50 rbsn rbsn Zgc:172215 Zgc:172215 gripap1 gripap1 lamtor1 lamtor1 zgc:100918 zgc:100918 ap5s1 ap5s1 snx8a snx8a rab14 rab14 heatr5a heatr5a rab11fip4a rab11fip4a washc2c washc2c si:dkey-6b12.5 si:dkey-6b12.5 cltcl1 cltcl1 atp6ap1b atp6ap1b ankrd27 ankrd27 vps53 vps53 golt1a golt1a trarg1a trarg1a rab11bb rab11bb vps4b vps4b micall1b.2 micall1b.2 grip2b grip2b caly caly vamp3 vamp3 zfyve16 zfyve16 stx5al stx5al snx27a snx27a chmp5a chmp5a golt1ba golt1ba ptpn23a ptpn23a itsn1 itsn1 ap5m1 ap5m1 reps1 reps1 A5WVV4_DANRE A5WVV4_DANRE micall2b micall2b cltcb cltcb dennd1a dennd1a arf6b arf6b A3KQM5_DANRE A3KQM5_DANRE tmem50a tmem50a F6NKU7_DANRE F6NKU7_DANRE tbc1d10ab tbc1d10ab stam stam hgs hgs vps35l vps35l tbc1d10c tbc1d10c chmp3 chmp3 chmp2ba chmp2ba vti1b vti1b ehd2b ehd2b chmp7 chmp7 atp6ap1a atp6ap1a rab11a rab11a snx9b snx9b rab11ba rab11ba stx6 stx6 itsn2a itsn2a eipr1 eipr1 cltca cltca snx18b snx18b tbc1d23 tbc1d23 rab9a rab9a vti1a vti1a vta1 vta1 ANKRD50 ANKRD50 rab10 rab10 scrib scrib ehd1b ehd1b ehd3 ehd3 snx5 snx5 chmp4ba chmp4ba dpy30 dpy30 rab11al rab11al chmp4c chmp4c bloc1s1 bloc1s1 snx3 snx3 vcp vcp snx27b snx27b prepl prepl ubxn6 ubxn6 chmp2bb chmp2bb snx12 snx12 snx33 snx33 grip1 grip1 vps35 vps35 snx4 snx4 plekhj1 plekhj1 coro1ca coro1ca rab7b rab7b chmp4bb chmp4bb rab7a rab7a vps50-2 vps50-2 vps26b vps26b vps26c vps26c arhgap1 arhgap1 stx5a stx5a rab35b rab35b rab6bb rab6bb vps4a vps4a rab13 rab13 rgp1 rgp1 rab15 rab15 snx30 snx30 ehd2a ehd2a rab14l rab14l laptm4b laptm4b RIC1 RIC1 wu:fb80c09 wu:fb80c09 SLC66A2 SLC66A2 srl srl ENSDARP00000153555 ENSDARP00000153555 eps15l1a eps15l1a ENSDARP00000152934 ENSDARP00000152934 TMEM87B TMEM87B vps28 vps28 LOC100538044 LOC100538044 LOC110440104 LOC110440104 chmp6b chmp6b arl1 arl1 dctn1a dctn1a rab11fip3 rab11fip3 ENSDARP00000147233 ENSDARP00000147233 ENSDARP00000145626 ENSDARP00000145626 coro1cb coro1cb gbf1 gbf1 ehd1a ehd1a ankrd50l ankrd50l chmp1a chmp1a snx2 snx2 cmtm6 cmtm6 trappc10 trappc10 rab9b rab9b rnf126 rnf126 dennd1b dennd1b nsg2 nsg2 vps52 vps52 LEPROTL1 LEPROTL1 heatr5b heatr5b ptpn23b ptpn23b zfyve9b zfyve9b chmp6a chmp6a rab35a rab35a chmp5b chmp5b vps54 vps54 gga3b gga3b eps15l1b eps15l1b lrrc1 lrrc1 rab6ba rab6ba E7F661_DANRE E7F661_DANRE megf8-2 megf8-2 mvb12a mvb12a E7EY00_DANRE E7EY00_DANRE snx1b snx1b ankfy1 ankfy1 micall2a micall2a ap3d1 ap3d1 chmp1b chmp1b K1109_DANRE K1109_DANRE snx7 snx7 rab11fip4b rab11fip4b UBE2O UBE2O zfyve9a zfyve9a tbc1d10aa tbc1d10aa
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
gga3aGolgi-associated, gamma adaptin ear-containing, ARF-binding protein 3a. (702 aa)
snx8bSorting nexin 8b. (418 aa)
rab6aRAB6A, member RAS oncogene family. (208 aa)
arf6aADP-ribosylation factor 6a. (175 aa)
tbc1d10bTBC1 domain family, member 10b. (849 aa)
arfrp1ADP-ribosylation factor-related protein 1. (188 aa)
clec16aC-type lectin domain-containing 16A. (926 aa)
X1WG66_DANRESi:dkey-185p13.1. (93 aa)
X1WFU5_DANRESi:dkey-28n18.9. (372 aa)
ap5b1Adaptor-related protein complex 5 subunit beta 1. (972 aa)
stx16Syntaxin 16; Belongs to the syntaxin family. (307 aa)
ap5z1Adaptor-related protein complex 5 subunit zeta 1. (812 aa)
vps25Vacuolar protein-sorting-associated protein 25; Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex (By similarity). (174 aa)
rab8aRAB8A, member RAS oncogene family. (207 aa)
pikfyvePhosphatidylinositol phosphate 5-kinase type III isoform d. (2075 aa)
clcf1Cardiotrophin-like cytokine factor 1. (380 aa)
als2bAlsin Rho guanine nucleotide exchange factor ALS2 b. (1681 aa)
snx6Sorting nexin; Involved in several stages of intracellular trafficking. (407 aa)
E7F0T8_DANRESi:ch211-11k18.4. (450 aa)
tbc1d5TBC1 domain family, member 5. (863 aa)
bloc1s2Biogenesis of lysosomal organelles complex-1, subunit 2. (177 aa)
rab41RAB41, member RAS oncogene family. (211 aa)
snx1aSorting nexin 1a. (659 aa)
zgc:153733Zgc:153733. (282 aa)
chmp2aCharged multivesicular body protein 2a; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids (By similarity). (220 aa)
ehd4EH-domain-containing 4; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (614 aa)
vps26blVacuolar protein sorting-associated protein 26B-like; Probable component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network; Belongs to the VPS26 family. (329 aa)
vps26aVacuolar protein sorting-associated protein 26A; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. Retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) (By similarity). (327 aa)
F1QQY3_DANRESortilin. (423 aa)
vps36Vacuolar protein-sorting-associated protein 36; Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. (382 aa)
snf8Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex (By similarity). (258 aa)
golt1bbGolgi transport 1Bb. (138 aa)
vps16Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family. (835 aa)
itsn2bIntersectin 2b. (1741 aa)
washc4WASH complex subunit 4. (1173 aa)
vps51Vacuolar protein sorting-associated protein 51 homolog; Involved in retrograde transport from early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. Acts as component of the EARP complex that is involved in endocytic recycling (By similarity). (827 aa)
dennd10DENN domain-containing protein 10; Guanine nucleotide exchange factor (GEF) which may be involved in the regulation of late endocytic pathway homeostasis, including endosomal positioning, maturation and secretion. Belongs to the DENND10 family. (349 aa)
grip2aGlutamate receptor-interacting protein 2a. (736 aa)
wash1WASH complex subunit 1; Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Its assembly in the WASH core complex seems to inhibit its NPF activity and is required for its membrane targeting; Belongs to the WASH1 family. (481 aa)
F1R8V5_DANRESi:ch211-193c2.2. (243 aa)
snx18aSorting nexin. (567 aa)
eps15Epidermal growth factor receptor pathway substrate 15. (1039 aa)
rab8bRAB8B, member RAS oncogene family. (209 aa)
lystLysosomal-trafficking regulator. (2666 aa)
zgc:136908Zgc:136908; Belongs to the AAA ATPase family. (805 aa)
vps29Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. Retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) (By similarity). Acts also as component of the retriever complex. The retriever complex is an heterotrimeric complex related to retromer cargo-selective com [...] (182 aa)
dctn1bDynactin 1b. (1258 aa)
snx9aSorting nexin. (562 aa)
cln5Uncharacterized protein. (329 aa)
rilpRab-interacting lysosomal protein. (441 aa)
als2aAlsin Rho guanine nucleotide exchange factor ALS2 a. (1662 aa)
alms1ALMS1 centrosome and basal body-associated protein. (2105 aa)
stx10Syntaxin 10. (247 aa)
reps2RALBP1-associated Eps domain-containing 2. (382 aa)
micall1aMICAL-like 1a. (867 aa)
zgc:162698Zgc:162698. (583 aa)
vps39VPS39 subunit of HOPS complex. (875 aa)
vps50VPS50 EARP/GARPII complex subunit. (965 aa)
rbsnRabenosyn, RAB effector. (715 aa)
Zgc:172215Zgc:172215. (196 aa)
gripap1GRIP1-associated protein 1. (867 aa)
lamtor1Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (160 aa)
zgc:100918Zgc:100918. (208 aa)
ap5s1Adaptor-related protein complex 5 subunit sigma 1. (196 aa)
snx8aSorting nexin 8a. (519 aa)
rab14RAB14, member RAS oncogene family. (215 aa)
heatr5aHEAT repeat-containing protein 5A. (2040 aa)
rab11fip4aRab11 family-interacting protein 4A; Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis (By similarity). May play a role in differentiation during retinal development. (621 aa)
washc2cWASH complex subunit 2C. (401 aa)
si:dkey-6b12.5Si:dkey-6b12.5. (619 aa)
cltcl1Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1638 aa)
atp6ap1bATPase H+-transporting accessory protein 1b. (459 aa)
ankrd27Ankyrin repeat domain 27 (VPS9 domain). (862 aa)
vps53VPS53 subunit of GARP complex. (832 aa)
golt1aGolgi transport 1A. (133 aa)
trarg1aTrafficking regulator of GLUT4 (SLC2A4) 1a. (177 aa)
rab11bbRAB11B, member RAS oncogene family, b. (218 aa)
vps4bVacuolar protein sorting 4 homolog B; Belongs to the AAA ATPase family. (437 aa)
micall1b.2MICAL-like 1b, duplicate 2. (686 aa)
grip2bGlutamate receptor-interacting protein 2b. (1119 aa)
calyCalcyon neuron-specific vesicular protein. (176 aa)
vamp3Vesicle-associated membrane protein 3 (Cellubrevin). (102 aa)
zfyve16Zinc finger FYVE domain-containing protein. (1384 aa)
stx5alSyntaxin 5A,-like. (347 aa)
snx27aSorting nexin 27a. (567 aa)
chmp5aCharged multivesicular body protein 5a. (251 aa)
golt1baGolgi transport 1Ba. (138 aa)
ptpn23aProtein tyrosine phosphatase, non-receptor type 23, a. (2003 aa)
itsn1Intersectin 1 (SH3 domain protein). (1722 aa)
ap5m1Adaptor-related protein complex 5 subunit mu 1; Belongs to the adaptor complexes medium subunit family. (488 aa)
reps1RALBP1-associated Eps domain-containing 1. (790 aa)
A5WVV4_DANRESi:dkey-98f17.5. (440 aa)
micall2bMical-like 2b. (783 aa)
cltcbClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1677 aa)
dennd1aDENN/MADD domain-containing 1A. (511 aa)
arf6bADP-ribosylation factor 6a; Belongs to the small GTPase superfamily. Arf family. (175 aa)
A3KQM5_DANRESi:dkey-246g23.2. (241 aa)
tmem50aTransmembrane protein 50A. (164 aa)
F6NKU7_DANRESi:dkey-76b14.2. (839 aa)
tbc1d10abTBC1 domain family, member 10Ab. (478 aa)
stamSignal transducing adaptor molecule (SH3 domain and ITAM motif) 1. (516 aa)
hgsHepatocyte growth factor-regulated tyrosine kinase substrate. (757 aa)
vps35lVPS35 endosomal protein sorting factor-like; Acts as component of the retriever complex. The retriever complex is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrins. The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes. In the endosomes, drives the retrieval and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins ass [...] (963 aa)
tbc1d10cTBC1 domain family, member 10C. (1383 aa)
chmp3Charged multivesicular body protein 3; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Involved in late stages of cytokinesis. Plays a role in en [...] (221 aa)
chmp2baCharged multivesicular body protein 2Ba. (216 aa)
vti1bVesicle transport through interaction with t-SNAREs homolog 1B (Yeast). (225 aa)
ehd2bEH-domain-containing 2b; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (543 aa)
chmp7Charged multivesicular body protein 7; ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope during late anaphase. Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Plays a role in the endosomal sorting pathway; Belongs to the SNF7 family. (457 aa)
atp6ap1aATPase H+-transporting accessory protein 1a. (466 aa)
rab11aNovel protein similar to vertebrate Ras family. (215 aa)
snx9bSorting nexin. (581 aa)
rab11baRAB11B, member RAS oncogene family, a. (218 aa)
stx6Stx6 protein; Belongs to the syntaxin family. (256 aa)
itsn2aIntersectin 2a. (1665 aa)
eipr1EARP-interacting protein homolog; Belongs to the WD repeat EIPR1 family. (391 aa)
cltcaClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1680 aa)
snx18bSorting nexin. (563 aa)
tbc1d23TBC1 domain family member 23; Putative Rab GTPase-activating protein which plays a role in vesicular trafficking. Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles (By similarity). Plays a role in brain development. May act as a general inhibitor of innate immunity signaling (By similarity). (680 aa)
rab9aRAB9A, member RAS oncogene family. (201 aa)
vti1aVesicle transport through interaction with t-SNAREs 1A. (217 aa)
vta1Vesicle (multivesicular body)-trafficking 1. (302 aa)
ANKRD50Ankyrin repeat domain 50. (1133 aa)
rab10RAB10, member RAS oncogene family. (201 aa)
scribProtein scribble homolog; Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Regulates the caudal migration of the nVII motor neurons. Required for convergent extension movements during gastrulation. (1724 aa)
ehd1bEH-domain-containing 1b; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (532 aa)
ehd3EH-domain-containing 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (535 aa)
snx5Sorting nexin; Involved in several stages of intracellular trafficking. Belongs to the sorting nexin family. (399 aa)
chmp4baCharged multivesicular body protein 4b; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids (By similarity). (220 aa)
dpy30Dpy-30 histone methyltransferase complex regulatory subunit. (106 aa)
rab11alRAB11a, member RAS oncogene family,-like. (216 aa)
chmp4cCharged multivesicular body protein 4c. (239 aa)
bloc1s1Biogenesis of lysosomal organelles complex-1, subunit 1. (125 aa)
snx3Sorting nexin 3. (162 aa)
vcpTransitional endoplasmic reticulum ATPase; Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. Also involved in DNA damage response: recruited to double-strand [...] (806 aa)
snx27bSorting nexin family member 27. (569 aa)
preplProlyl endopeptidase-like. (692 aa)
ubxn6UBX domain protein 6. (437 aa)
chmp2bbCharged multivesicular body protein 2b; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids (By similarity). (214 aa)
snx12Sorting nexin 12. (162 aa)
snx33Sorting nexin. (551 aa)
grip1Glutamate receptor-interacting protein 1. (1143 aa)
vps35Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (831 aa)
snx4Sorting nexin 4. (434 aa)
plekhj1Pleckstrin homology domain-containing family J member 1. (158 aa)
coro1caCoronin-1C-A; Plays a role in directed cell migration by regulating the activation and subcellular location of RAC1 (Probable). Increases the presence of activated RAC1 at the leading edge of migrating cells. Required for normal organization of the cytoskeleton, including the actin cytoskeleton, microtubules and the vimentin intermediate filaments. Plays a role in endoplasmic reticulum-associated endosome fission: endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane. [...] (474 aa)
rab7bRAB7b, member RAS oncogene family. (204 aa)
chmp4bbCharged multivesicular body protein 4c; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Key component of the cytokinesis checkpoint, a process re [...] (224 aa)
rab7aRAB7a, member RAS oncogene family. (207 aa)
vps50-2VPS50 EARP/GARPII complex subunit. (314 aa)
vps26bVacuolar protein sorting-associated protein 26B; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. Retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) (By similarity). (331 aa)
vps26cVPS26 endosomal protein sorting factor C. (297 aa)
arhgap1Rho GTPase-activating protein 1. (434 aa)
stx5aSyntaxin 5A; Belongs to the syntaxin family. (302 aa)
rab35bRAB35, member RAS oncogene family b. (201 aa)
rab6bbRAB6B, member RAS oncogene family b. (208 aa)
vps4aVacuolar protein sorting 4 homolog A; Belongs to the AAA ATPase family. (440 aa)
rab13Ras-related protein Rab-13; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may be involved in endocytic recycling and may regulate the transport to the plasma membrane of transmembrane proteins. May regulate the assembly and the activity of tight jun [...] (200 aa)
rgp1RGP1 retrograde golgi transport homolog (S. cerevisiae). (386 aa)
rab15RAB15, member RAS oncogene family. (212 aa)
snx30Sorting nexin-30; May be involved in several stages of intracellular trafficking. (430 aa)
ehd2aEH-domain-containing 2a; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (546 aa)
rab14lRAB14, member RAS oncogene family,-like. (215 aa)
laptm4bLysosomal associated protein transmembrane 4 beta. (225 aa)
RIC1RIC1 homolog, RAB6A GEF complex partner 1. (1321 aa)
wu:fb80c09Dynamin-type G domain-containing protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (384 aa)
SLC66A2Solute carrier family 66 member 2. (253 aa)
srlSarcalumenin; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (482 aa)
ENSDARP00000153555Uncharacterized protein. (70 aa)
eps15l1aEpidermal growth factor receptor pathway substrate 15-like 1a. (921 aa)
ENSDARP00000152934GRIP domain-containing protein. (383 aa)
TMEM87BTransmembrane protein 87B. (228 aa)
vps28Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process. (223 aa)
LOC100538044Leptin receptor gene-related protein; Involved in protein trafficking. May be involved in the down- regulation of membrane protein levels (By similarity); Belongs to the OB-RGRP/VPS55 family. (102 aa)
LOC110440104Syntaxin 10. (247 aa)
chmp6bCharged multivesicular body protein 6; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In the ESCRT-III complex, it probably serves as an accepto [...] (206 aa)
arl1ADP-ribosylation factor-like 1; Belongs to the small GTPase superfamily. Arf family. (181 aa)
dctn1aDynactin 1a. (1257 aa)
rab11fip3Rab11 family-interacting protein 3. (1875 aa)
ENSDARP00000147233Uncharacterized protein. (38 aa)
ENSDARP00000145626EH domain-containing protein. (105 aa)
coro1cbCoronin; Belongs to the WD repeat coronin family. (474 aa)
gbf1Golgi brefeldin A-resistant guanine nucleotide exchange factor 1. (1862 aa)
ehd1aEH-domain-containing 1a; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (533 aa)
ankrd50lAnkyrin repeat domain 50-like. (1441 aa)
chmp1aCharged multivesicular body protein 1a; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids (By similarity). Belongs to the SNF7 family. (198 aa)
snx2Sorting nexin 2. (506 aa)
cmtm6CKLF-like MARVEL transmembrane domain-containing 6. (189 aa)
trappc10Trafficking protein particle complex 10. (1228 aa)
rab9bRAB9B, member RAS oncogene family. (202 aa)
rnf126Ring finger protein 126. (309 aa)
dennd1bDENN/MADD domain-containing 1B. (468 aa)
nsg2Neuronal vesicle-trafficking-associated 2. (183 aa)
vps52VPS52 subunit of GARP complex. (724 aa)
LEPROTL1Leptin receptor overlapping transcript like 1. (131 aa)
heatr5bHEAT repeat-containing 5B. (2025 aa)
ptpn23bProtein tyrosine phosphatase, non-receptor type 23, b. (1215 aa)
zfyve9bZinc finger, FYVE domain-containing 9b. (788 aa)
chmp6aCharged multivesicular body protein 6a. (199 aa)
rab35aUncharacterized protein. (195 aa)
chmp5bCharged multivesicular body protein 5; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids (By similarity). (220 aa)
vps54VPS54 subunit of GARP complex. (1031 aa)
gga3bGolgi-associated, gamma adaptin ear-containing, ARF-binding protein 3b. (709 aa)
eps15l1bEpidermal growth factor receptor pathway substrate 15 like 1. (535 aa)
lrrc1Leucine-rich repeat-containing 1. (438 aa)
rab6baRAB6B, member RAS oncogene family a. (215 aa)
E7F661_DANRESi:ch73-389b16.2. (1573 aa)
megf8-2Multiple EGF-like-domains 8. (173 aa)
mvb12aMultivesicular body subunit 12A; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (By similarity). (89 aa)
E7EY00_DANRESi:dkey-16l2.16. (209 aa)
snx1bSorting nexin 1b. (493 aa)
ankfy1Ankyrin repeat and FYVE domain-containing 1. (1167 aa)
micall2aMical-like 2a. (799 aa)
ap3d1Adaptor-related protein complex 3 subunit delta 1. (1247 aa)
chmp1bCharged multivesicular body protein 1b; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. (199 aa)
K1109_DANRETransmembrane protein KIAA1109 homolog. (4923 aa)
snx7Sorting nexin 7. (435 aa)
rab11fip4bRab11 family-interacting protein 4B; Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis (By similarity). (502 aa)
UBE2OUbiquitin conjugating enzyme E2 O. (935 aa)
zfyve9aZinc finger, FYVE domain-containing 9a. (1216 aa)
tbc1d10aaTBC1 domain family, member 10Aa. (830 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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