STRINGSTRING
cldn12 cldn12 bsg bsg cse1l cse1l pkd2 pkd2 slc26a5 slc26a5 pkd1a pkd1a rab13 rab13 cx27.5 cx27.5 cldn1 cldn1 epcam epcam cldn5a cldn5a arl2 arl2 c1qtnf5 c1qtnf5 lepr lepr bves bves kcnq1.1 kcnq1.1 cldn5b cldn5b akap7 akap7 cx31.7 cx31.7 pkd1b pkd1b tbcd tbcd kcnq1.2 kcnq1.2 mtcl1 mtcl1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cldn12Claudin 12 isoform fc43a12. (341 aa)
bsgBasigin. (404 aa)
cse1lExportin-2; Export receptor for importin alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates have been released into the nucleoplasm (By similarity). Negatively regulates fluid secretion and plays a role in fluid homeostasis by downregulating cftr activity. (971 aa)
pkd2Polycystin-2; Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B. Can also form a functional, homotetrameric ion channel (By similarity). Functions as non-selective, voltage-gated cation channel (By similarity). Required for normal oscillation of Ca(2+) levels within cilia; these oscillations of the intraciliary Ca(2+) levels can trigger cytoplasmic Ca(2+) signaling cascades. May contribute to the release of Ca(2+) stores from the endoplasmic reticulum (By simila [...] (904 aa)
slc26a5Solute carrier family 26, member 5. (739 aa)
pkd1aPolycystic kidney disease 1a. (4346 aa)
rab13Ras-related protein Rab-13; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may be involved in endocytic recycling and may regulate the transport to the plasma membrane of transmembrane proteins. May regulate the assembly and the activity of tight jun [...] (200 aa)
cx27.5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (254 aa)
cldn1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (210 aa)
epcamEpithelial cell adhesion molecule. (303 aa)
cldn5aClaudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (215 aa)
arl2ADP-ribosylation factor-like 2; Belongs to the small GTPase superfamily. Arf family. (184 aa)
c1qtnf5C1q and tumor necrosis factor related protein 5. (248 aa)
leprLeptin receptor. (1065 aa)
bvesBlood vessel epicardial substance; Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in skeletal muscle and heart development as well as in the maintenance of heart function. May play a role in vamp3-mediated vesicular transport and recycling of receptor molecules. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells. May induce primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)- independent manner. May be involved in epithelial movement during [...] (352 aa)
kcnq1.1Potassium voltage-gated channel, KQT-like subfamily, member 1.1; Belongs to the potassium channel family. (655 aa)
cldn5bClaudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa)
akap7A kinase (PRKA) anchor protein 7. (115 aa)
cx31.7Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (275 aa)
pkd1bPolycystic kidney disease 1b. (3827 aa)
tbcdTubulin folding cofactor D. (1191 aa)
kcnq1.2Potassium voltage-gated channel, KQT-like subfamily, member 1.2; Belongs to the potassium channel family. (531 aa)
mtcl1Microtubule crosslinking factor 1. (520 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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