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| | prkci | Protein kinase C iota type; Calcium- and diacylglycerol-independent serine/ threonine- protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway (By similarity). Is required for the formation and maintenance of the zonula adherens during early epithelial development and plays a critical role in organ morphogenesis and in regulating the orientation of cell division. (588 aa) |
| | spint1b | Serine peptidase inhibitor, Kunitz type 1 b. (499 aa) |
| | phactr1 | Phosphatase and actin regulator. (542 aa) |
| | efhc2 | EF-hand domain-containing family member C2. (748 aa) |
| | wnt11f2 | Protein Wnt-11; Ligand for members of the frizzled family of seven transmembrane receptors. May play a role in the formation of dermal structure, both limb and feather buds. Is likely to signal over only few cell diameters (By similarity); Belongs to the Wnt family. (353 aa) |
| | pdx1 | Pancreatic and duodenal homeobox 1. (246 aa) |
| | fgf8a | Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration (By similarity). Required for Kupffer's vesicle ciliogenesis. (210 aa) |
| | mab21l2 | Protein mab-21-like 2; Required for eye morphogenesis. May promote the survival of proliferating retinal progenitor cells; Belongs to the mab-21 family. (359 aa) |
| | mthfd1b | Methylenetetrahydrofolate dehydrogenase (NADP+-dependent) 1b. (934 aa) |
| | dvl2 | Dishevelled segment polarity protein 2. (747 aa) |
| | mpp5b | Membrane protein, palmitoylated 5b (MAGUK p55 subfamily member 5); Belongs to the MAGUK family. (639 aa) |
| | hand2 | Heart- and neural crest derivatives-expressed protein 2; Essential for myocardial and pectoral fin differentiation, patterning and morphogenesis. (205 aa) |
| | prkacba | Protein kinase, cAMP-dependent, catalytic, beta a; Belongs to the protein kinase superfamily. (395 aa) |
| | vangl2 | Vang-like protein 2; Plays a role in non-canonical Wnt/planar cell polarity (PCP) signaling to regulate convergent extension cell movements during gastrulation. Acts together with scrib and prickle1 and localizes prickle1 and dvl2/dsh to the plasma membrane. Has an overlapping role with kny during both convergent extension and eye development. In the eye, involved in establishing proper alignment of the anterior neural plate and midline cells expressing shha and shhb/twhh. Has indirect effects on a number of other developmental processes including notochord shape formation, neural prog [...] (526 aa) |
| | tsc1a | TSC complex subunit 1a. (1128 aa) |
| | vax1 | Ventral anterior homeobox 1; Transcription factor that is required for closure of the choroid fissure and together with Vax2 is required for optic nerve differentiation and to limit retinal development to the optic cup. Belongs to the EMX homeobox family. (317 aa) |
| | abl2 | Tyrosine-protein kinase. (1135 aa) |
| | grem1a | Gremlin. (177 aa) |
| | phactr4b | Phosphatase and actin regulator 4B; Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to repression of the integrin signaling through the rho/rock pathway (By similarity). (754 aa) |
| | pitx2 | Pituitary homeobox 2; Isoform a and isoform c differentially regulate mesendoderm formation and asymmetric organ development. Both isoforms regulate left-right development, but isoform a has a stronger effect on heart laterality; Belongs to the paired homeobox family. Bicoid subfamily. (314 aa) |
| | tgfb1a | Transforming growth factor beta; Belongs to the TGF-beta family. (377 aa) |
| | mthfd1l | Methylenetetrahydrofolate dehydrogenase (NADP+-dependent) 1-like. (978 aa) |
| | ccdc88c | Protein Daple; Positive regulator of Wnt signaling, acting synergistically with dvl2 (By similarity). Functions upstream of ctnnb1/beta-catenin in the canonical Wnt pathway, and also activates jnk in the Wnt/planar cell polarity (PCP) pathway (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein G(i) alpha (Gi-alpha) subunits. This promotes apical cell constriction and subsequent bending of the neural plate during neurulation via arhgef18 (By similarity). (1997 aa) |
| | sall4 | Spalt-like transcription factor 4. (1091 aa) |
| | pou5f3 | POU domain, class 5, transcription factor 1; Involved in early development of embryos, especially in the process of gastrulation. May play an important role in establishing and specifying rhombomeric segments. Seems to be required to maintain the cells in a highly undifferentiated state. In contrast to POU2, T-POU2 lacks DNA-binding activity because of its incomplete pou domain structure. Overexpression of POU2 does not have any effect on development, whereas overexpression of t-POU2 causes developmental retardation or arrest before gastrulation; Belongs to the POU transcription factor [...] (472 aa) |
| | ift52 | Intraflagellar transport 52 homolog (Chlamydomonas). (435 aa) |
| | scrib | Protein scribble homolog; Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Regulates the caudal migration of the nVII motor neurons. Required for convergent extension movements during gastrulation. (1724 aa) |
| | hectd1 | Novel protein with HECT-domain (Ubiquitin-transferase). (2576 aa) |
| | ret | Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1106 aa) |
| | tmed2 | Transmembrane p24-trafficking protein 2. (208 aa) |
| | irx1b | Iroquois homeobox protein 1, b. (445 aa) |
| | glmna | Glomulin, FKBP-associated protein a. (592 aa) |
| | vax2 | Ventral anterior homeobox 2; Transcription factor that may function in dorsoventral specification of the forebrain. Required for closure of the choroid fissure and together with vax1 is required for optic nerve differentiation and to limit retinal development to the optic cup. Belongs to the EMX homeobox family. (307 aa) |
| | prkacbb | Protein kinase, cAMP-dependent, catalytic, beta b; Belongs to the protein kinase superfamily. (351 aa) |
| | mks1 | MKS transition zone complex subunit 1. (559 aa) |
| | kdm6al | Ubiquitously transcribed tetratricopeptide repeat, X chromosome like 1. (1311 aa) |
| | sdc4 | Syndecan 4. (207 aa) |
| | ccdc85b | Coiled-coil domain-containing protein 85B; Functions as a transcriptional repressor. May inhibit the activity of CTNNB1 in a TP53-dependent manner and thus regulate cell growth (By similarity). May function in adipocyte differentiation, negatively regulating mitotic clonal expansion (By similarity). Plays a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family (Probable). (200 aa) |
| | hs2st1b | Heparan sulfate 2-O-sulfotransferase 1b. (356 aa) |
| | dvl3a | Dishevelled segment polarity protein 3a. (676 aa) |
| | ptk7a | Protein tyrosine kinase 7a; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1061 aa) |
| | spint2 | Serine peptidase inhibitor, Kunitz type, 2. (431 aa) |
| | vegfc | Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (396 aa) |
| | sfrp2 | Secreted frizzled-related protein 2. (294 aa) |
| | dlx6a | Homeobox protein Dlx6a. (247 aa) |
| | dvl1b | Dishevelled segment polarity protein 1b. (716 aa) |
| | dlx5a | Homeobox protein Dlx5a; Belongs to the distal-less homeobox family. (282 aa) |
| | cecr2 | CECR2 histone acetyl-lysine reader. (1502 aa) |
| | fuz | Fuzzy planar cell polarity protein. (420 aa) |
| | prkacab | Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b; Belongs to the protein kinase superfamily. (351 aa) |
| | tctn1 | Tectonic family member 1. (534 aa) |
| | wnt6b | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa) |
| | bbs4 | Bardet-Biedl syndrome 4. (528 aa) |
| | foxc1a | Forkhead box C1-A; DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin development. Acts either as a transcriptional activator or repressor. Binds to the consensus binding site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes. Upon DNA-binding, promotes DNA bending. Required for cell viability and resistance to oxidative stress in the eye. Promotes cell growth inhibition by stopping the cell cycle in the G1 phase through TGFB1- mediated signals. Involved in epithelia [...] (476 aa) |
| | LOC100332300 | Gremlin 1a, DAN family BMP antagonist. (177 aa) |
| | deaf1 | DEAF1 transcription factor. (528 aa) |
| | setd2 | SET domain-containing 2, histone lysine methyltransferase. (2737 aa) |
| | cthrc1a | Collagen triple helix repeat-containing 1a. (232 aa) |
| | kdm6a | Lysine (K)-specific demethylase 6A. (1390 aa) |
| | cthrc1b | Collagen triple helix repeat-containing 1b. (233 aa) |
| | gdf7 | Growth differentiation factor 7. (396 aa) |
| | tsc1b | TSC complex subunit 1b. (1228 aa) |
| | dvl1a | Dishevelled segment polarity protein 1a. (569 aa) |
| | mthfr | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (656 aa) |
| | tgfb1b | Transforming growth factor beta; Belongs to the TGF-beta family. (379 aa) |
| | hoxb1b | Homeobox protein Hox-B1b; Sequence-specific transcription factor. Part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. Seems to act in the maintenance and/or generation of hindbrain segments; Belongs to the Antp homeobox family. Labial subfamily. (229 aa) |
| | mpp5a | MAGUK p55 subfamily member 5-A; Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells (By similarity). Also involved in adherens junction biogenesis (By similarity). Functions in cellular patterning of the retina. (703 aa) |
| | F8W5A4_DANRE | Si:ch73-236e11.2. (120 aa) |
| | grsf1 | G-rich RNA sequence-binding factor 1. (403 aa) |
| | abl1 | Tyrosine-protein kinase. (1081 aa) |
| | shha | Sonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (418 aa) |
| | grem2a | Gremlin 2, DAN family BMP antagonist a. (195 aa) |
| | tsc2 | TSC complex subunit 2. (1674 aa) |
| | mib1 | E3 ubiquitin-protein ligase mib1; E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. It thereby participates in many processes regulated by the Notch signaling pathway, such as midline cell fate specification prior to germ layer formation, patterning of sensory cell differentiation in the ear, neurogenesis of the hindbrain and commitment to a secretory fate in the intesti [...] (1041 aa) |
| | prkacaa | Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily. (352 aa) |
| | phactr4a | Phosphatase and actin regulator 4A. (1011 aa) |
| | irx1a | Iroquois homeobox protein 1, a. (426 aa) |
| | lrrc1 | Leucine-rich repeat-containing 1. (438 aa) |
| | mab21l1 | Putative nucleotidyltransferase MAB21L1; Putative nucleotidyltransferase required for several aspects of embryonic development including normal development of the eye (By similarity). It is unclear whether it displays nucleotidyltransferase activity in vivo. Binds single-stranded RNA (ssRNA) (By similarity). Belongs to the mab-21 family. (359 aa) |
| | irx3a | Iroquois 3 homeobox protein. (454 aa) |
| | hs2st1a | Heparan sulfate 2-O-sulfotransferase 1a. (354 aa) |
| | dvl3 | Dishevelled segment polarity protein 3b. (706 aa) |
| | nkd1 | Protein naked cuticle homolog 1; Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity (By similarity); Belongs to the NKD family. (440 aa) |
| | phactr4a-2 | Phosphatase and actin regulator 4A; Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to repression of the integrin signaling through the rho/rock pathway (By similarity). (118 aa) |
| | kdf1a | Keratinocyte differentiation factor 1a. (383 aa) |
| | sfrp2l | Secreted frizzled-related protein 2-like. (333 aa) |
| | spint1a | Serine peptidase inhibitor, Kunitz type 1 a. (523 aa) |
| | mthfd1a | C-1-tetrahydrofolate synthase, cytoplasmic isoform X2. (919 aa) |
| | ENSDARP00000153246 | Ig-like domain-containing protein. (160 aa) |
| | ENSDARP00000153406 | DUF3384 domain-containing protein. (162 aa) |
