node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
casp6a | casp6b.1 | ENSDARP00000050929 | ENSDARP00000113324 | Caspase 6, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family. | Caspase 6b.1, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. | 0.989 |
casp6a | pidd1 | ENSDARP00000050929 | ENSDARP00000122836 | Caspase 6, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family. | P53-induced death domain protein 1. | 0.564 |
casp6b.1 | casp6a | ENSDARP00000113324 | ENSDARP00000050929 | Caspase 6b.1, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. | Caspase 6, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family. | 0.989 |
casp6b.1 | pidd1 | ENSDARP00000113324 | ENSDARP00000122836 | Caspase 6b.1, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. | P53-induced death domain protein 1. | 0.434 |
ihha | shha | ENSDARP00000076101 | ENSDARP00000125090 | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. | Sonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). | 0.408 |
ihha | shhb | ENSDARP00000076101 | ENSDARP00000056746 | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. | Tiggy-winkle hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Involved in dorso-ventral patterning of the brain and in early patterning of the developing eyes. | 0.409 |
ihhb | shha | ENSDARP00000076199 | ENSDARP00000125090 | Indian hedgehog B protein C-product; Intercellular signal essential for a variety of patterning events during development. Signal produced by the notochord that induces somite patterning and muscle pioneer differentiation. | Sonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). | 0.436 |
ihhb | shhb | ENSDARP00000076199 | ENSDARP00000056746 | Indian hedgehog B protein C-product; Intercellular signal essential for a variety of patterning events during development. Signal produced by the notochord that induces somite patterning and muscle pioneer differentiation. | Tiggy-winkle hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Involved in dorso-ventral patterning of the brain and in early patterning of the developing eyes. | 0.437 |
pidd1 | casp6a | ENSDARP00000122836 | ENSDARP00000050929 | P53-induced death domain protein 1. | Caspase 6, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family. | 0.564 |
pidd1 | casp6b.1 | ENSDARP00000122836 | ENSDARP00000113324 | P53-induced death domain protein 1. | Caspase 6b.1, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. | 0.434 |
shha | ihha | ENSDARP00000125090 | ENSDARP00000076101 | Sonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. | 0.408 |
shha | ihhb | ENSDARP00000125090 | ENSDARP00000076199 | Sonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). | Indian hedgehog B protein C-product; Intercellular signal essential for a variety of patterning events during development. Signal produced by the notochord that induces somite patterning and muscle pioneer differentiation. | 0.436 |
shha | shhb | ENSDARP00000125090 | ENSDARP00000056746 | Sonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). | Tiggy-winkle hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Involved in dorso-ventral patterning of the brain and in early patterning of the developing eyes. | 0.452 |
shhb | ihha | ENSDARP00000056746 | ENSDARP00000076101 | Tiggy-winkle hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Involved in dorso-ventral patterning of the brain and in early patterning of the developing eyes. | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. | 0.409 |
shhb | ihhb | ENSDARP00000056746 | ENSDARP00000076199 | Tiggy-winkle hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Involved in dorso-ventral patterning of the brain and in early patterning of the developing eyes. | Indian hedgehog B protein C-product; Intercellular signal essential for a variety of patterning events during development. Signal produced by the notochord that induces somite patterning and muscle pioneer differentiation. | 0.437 |
shhb | shha | ENSDARP00000056746 | ENSDARP00000125090 | Tiggy-winkle hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Involved in dorso-ventral patterning of the brain and in early patterning of the developing eyes. | Sonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). | 0.452 |