STRINGSTRING
pcsk2 pcsk2 myrfl myrfl pcsk1 pcsk1 pisd pisd casp6a casp6a dhh dhh shhb shhb ihha ihha ihhb ihhb casp6b.2 casp6b.2 pcsk9 pcsk9 casp6b.1 casp6b.1 fxn fxn oma1 oma1 pidd1 pidd1 shha shha myrf myrf sprtn sprtn
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pcsk2Proprotein convertase subtilisin/kexin type 2; Belongs to the peptidase S8 family. (646 aa)
myrflMyelin regulatory factor-like. (850 aa)
pcsk1Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family. (755 aa)
pisdPhosphatidylserine decarboxylase proenzyme, mitochondrial; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. (426 aa)
casp6aCaspase 6, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family. (298 aa)
dhhDesert hedgehog protein; Intercellular signal essential for a variety of patterning events during development; Belongs to the hedgehog family. (447 aa)
shhbTiggy-winkle hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Involved in dorso-ventral patterning of the brain and in early patterning of the developing eyes. (416 aa)
ihhaHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (413 aa)
ihhbIndian hedgehog B protein C-product; Intercellular signal essential for a variety of patterning events during development. Signal produced by the notochord that induces somite patterning and muscle pioneer differentiation. (412 aa)
casp6b.2Caspase 6, apoptosis-related cysteine peptidase, like 2; Belongs to the peptidase C14A family. (245 aa)
pcsk9Proprotein convertase subtilisin/kexin type 9; Belongs to the peptidase S8 family. (667 aa)
casp6b.1Caspase 6b.1, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (249 aa)
fxnFrataxin. (200 aa)
oma1Metalloendopeptidase OMA1, mitochondrial; Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of opa1 at S1 position, leading to opa1 inactivation and negative regulation of mitochondrial fusion. (510 aa)
pidd1P53-induced death domain protein 1. (942 aa)
shhaSonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (418 aa)
myrfMyelin regulatory factor. (593 aa)
sprtnSprT-like N-terminal domain. (636 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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