STRINGSTRING
ccnt2a ccnt2a ENSDARP00000149043 ENSDARP00000149043 lsm10 lsm10 snrnp35 snrnp35 sf3b3 sf3b3 mepce mepce prpf8 prpf8 snrnp70 snrnp70 snrpb2 snrpb2 ro60 ro60 lsm11 lsm11 MEPCE MEPCE snrpa1 snrpa1 coil coil rbmx rbmx gemin5 gemin5 lrmda lrmda toe1 toe1 lrrc51 lrrc51 rbm41 rbm41 mettl16 mettl16 snu13a snu13a prpf4 prpf4 larp7 larp7 snrpd3l snrpd3l lsm3 lsm3 rbm22 rbm22 sart3 sart3 snrpc snrpc snrpd3 snrpd3 rnpc3 rnpc3 ncbp2 ncbp2 ccnt1 ccnt1 snrpa snrpa eftud2 eftud2 lsm4 lsm4 snu13b snu13b hexim1 hexim1 prpf31 prpf31 ccnt2b ccnt2b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ccnt2aCyclin T2a; Belongs to the cyclin family. (630 aa)
ENSDARP00000149043Sm domain-containing protein. (85 aa)
lsm10Organic solute carrier partner 1a. (132 aa)
snrnp35U11/U12 small nuclear ribonucleoprotein 35 kDa protein. (208 aa)
sf3b3Splicing factor 3B subunit 3; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12- dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mR [...] (1217 aa)
mepce7SK snRNA methylphosphate capping enzyme; S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA, leading to stabilize it. (701 aa)
prpf8Pre-mRNA-processing factor 8. (2342 aa)
snrnp70Small nuclear ribonucleoprotein 70 (U1). (495 aa)
snrpb2Small nuclear ribonucleoprotein polypeptide B2. (220 aa)
ro60Ro60, Y RNA-binding protein. (534 aa)
lsm11LSM11, U7 small nuclear RNA-associated. (328 aa)
MEPCESi:ch1073-157b13.1. (634 aa)
snrpa1Small nuclear ribonucleoprotein polypeptide A. (277 aa)
coilCoilin p80. (532 aa)
rbmxRNA-binding motif protein, X chromosome; RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue- specific regulation of gene transcription and alternative splicing of pre-mRNAs. Associates with chromatin. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Binds non-specifically to pre-mRNAs (By similarity). Required for embryonic development, in particular of the brain. (379 aa)
gemin5Gem (nuclear organelle)-associated protein 5. (1440 aa)
lrmdaLeucine-rich melanocyte differentiation-associated. (234 aa)
toe1Target of EGR1, exonuclease. (483 aa)
lrrc51Leucine-rich repeat-containing 51. (181 aa)
rbm41RNA-binding motif protein 41. (439 aa)
mettl16RNA N6-adenosine-methyltransferase mettl16; RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl- L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure. Plays a key role in S- adenosyl-L-methionine homeostasis by mediating N6-methylation of MAT2 [...] (471 aa)
snu13aRibonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (128 aa)
prpf4PRP4 pre-mRNA-processing factor 4 homolog (yeast). (507 aa)
larp7La-related protein 7; Negative transcriptional regulator of polymerase II genes, acting by means of the 7SK RNP system. Within the 7SK RNP complex, the positive transcription elongation factor b (P-TEFb) is sequestered in an inactive form, preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. (555 aa)
snrpd3lSmall nuclear ribonucleoprotein Sm D3. (128 aa)
lsm3U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (102 aa)
rbm22Pre-mRNA-splicing factor RBM22; Required for pre-mRNA splicing as component of the activated spliceosome. Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle (By similarity). Required for normal early embryogenesis. (425 aa)
sart3Squamous cell carcinoma antigen recognized by T-cells 3; U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery. Promotes the initial reassembly of U4 and U6 snRNPs following their ejection from the spliceosome during its maturation. May also function as a substrate targeting factor for deubiquitinases and mediate the deubiquitination of components of the spliceosome and histones (By similarity). (951 aa)
snrpcU1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. snrpc/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. Belongs to the U1 [...] (159 aa)
snrpd3Small nuclear ribonucleoprotein Sm D3. (127 aa)
rnpc3RNA-binding region-containing protein 3; Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprise less than 1% of all non-coding sequences. (505 aa)
ncbp2Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...] (155 aa)
ccnt1Cyclin T1; Belongs to the cyclin family. (674 aa)
snrpaSmall nuclear ribonucleoprotein polypeptide A. (281 aa)
eftud2Elongation factor Tu GTP-binding domain-containing 2. (973 aa)
lsm4U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (143 aa)
snu13bRibonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (128 aa)
hexim1Protein HEXIM; Probable transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor; Belongs to the HEXIM family. (319 aa)
prpf31U4/U6 small nuclear ribonucleoprotein Prp31; Involved in pre-mRNA splicing as component of the spliceosome. Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. (508 aa)
ccnt2bZgc:55690 protein; Belongs to the cyclin family. (569 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.