STRINGSTRING
gpc4 gpc4 fgfr3 fgfr3 fgfr1a fgfr1a fibpa fibpa fgfr1b fgfr1b fgfrl1a fgfrl1a glg1a glg1a cep57 cep57 gpc1a gpc1a gpc6a gpc6a LOC569566 LOC569566 fibpb-2 fibpb-2 s100a11 s100a11 fgfr2 fgfr2 api5 api5 fgfbp3 fgfbp3 fgfbp1a fgfbp1a glg1b glg1b gpc2 gpc2 gpc6b gpc6b fgfrl1b fgfrl1b fgfr4 fgfr4 gpc1b gpc1b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
gpc4Glypican 4; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (557 aa)
fgfr3Fibroblast growth factor receptor 3; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Phosphorylates PLCG1, CBL and FRS2. Ligand binding l [...] (819 aa)
fgfr1aFibroblast growth factor receptor 1-A; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2 triggers [...] (809 aa)
fibpaFibroblast growth factor (acidic) intracellular-binding protein a. (357 aa)
fgfr1bFibroblast growth factor receptor. (766 aa)
fgfrl1aFibroblast growth factor receptor-like 1a. (483 aa)
glg1aGolgi glycoprotein 1a. (1151 aa)
cep57Centrosomal protein 57. (328 aa)
gpc1aSecreted glypican-1; Cell surface proteoglycan that bears heparan sulfate; Belongs to the glypican family. (563 aa)
gpc6aGlypican 6a; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (562 aa)
LOC569566Fibroblast growth factor receptor 1b,-like. (509 aa)
fibpb-2Acidic fibroblast growth factor intracellular-binding protein B; Mediates with IER2 FGF-signaling in Kupffer's vesicle ciliogenesis and in the establishment of laterality in the embryo. May be involved in mitogenic function of FGF1 (By similarity). (355 aa)
s100a11S100 calcium-binding protein A11. (85 aa)
fgfr2Fibroblast growth factor receptor 2; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in kerati [...] (838 aa)
api5Apoptosis inhibitor 5. (529 aa)
fgfbp3Fibroblast growth factor-binding protein 3. (239 aa)
fgfbp1aFibroblast growth factor-binding protein 1b. (197 aa)
glg1bGolgi glycoprotein 1b. (525 aa)
gpc2Glypican 2; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (371 aa)
gpc6bGlypican 6b; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (543 aa)
fgfrl1bFibroblast growth factor receptor-like 1b. (481 aa)
fgfr4Fibroblast growth factor receptor 4; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down- regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation o [...] (923 aa)
gpc1bGlypican 1b; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (559 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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