STRINGSTRING
scap scap ttc39a ttc39a podn podn ttc39b ttc39b fgf1a fgf1a asah1a asah1a apoa1b apoa1b LOC110438068 LOC110438068 dkk3a dkk3a stard4 stard4 tnfb tnfb fgf19 fgf19 sf1 sf1 ENSDARP00000146183 ENSDARP00000146183 fgfr4 fgfr4 dgkab dgkab cga cga armc5 armc5 h6pd h6pd abcg4a abcg4a rusc1 rusc1 cyp19a1a cyp19a1a lepa lepa nr0b1 nr0b1 nr1d1 nr1d1 lpcat3 lpcat3 lamtor1 lamtor1 arv1 arv1 abcg4b abcg4b dkk3b dkk3b nr1d4a nr1d4a sirt1 sirt1 abcg1 abcg1 srebf2 srebf2 srebf1 srebf1 zgc:158403 zgc:158403 fgf1b fgf1b apoba apoba ephx2 ephx2 snai2 snai2 LOC100331467 LOC100331467 asah1b asah1b dab2 dab2 apoa1a apoa1a star star
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
scapSREBF chaperone. (1245 aa)
ttc39aTetratricopeptide repeat protein 39A. (598 aa)
podnPodocan. (530 aa)
ttc39bTetratricopeptide repeat domain 39B. (316 aa)
fgf1aPutative fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with i [...] (147 aa)
asah1aN-acylsphingosine amidohydrolase (acid ceramidase) 1a; Belongs to the acid ceramidase family. (390 aa)
apoa1bApolipoprotein A-Ib. (257 aa)
LOC110438068Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (120 aa)
dkk3aDickkopf WNT-signaling pathway inhibitor 3a. (293 aa)
stard4StAR-related lipid transfer (START) domain-containing 4. (198 aa)
tnfbTumor necrosis factor b (TNF superfamily, member 2). (242 aa)
fgf19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
sf1Splicing factor 1. (663 aa)
ENSDARP00000146183Si:ch211-204c21.1. (697 aa)
fgfr4Fibroblast growth factor receptor 4; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down- regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation o [...] (923 aa)
dgkabDiacylglycerol kinase. (727 aa)
cgaGlycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (117 aa)
armc5Armadillo repeat-containing 5. (1218 aa)
h6pdHexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase). (791 aa)
abcg4aATP-binding cassette, sub-family G (WHITE), member 4a. (641 aa)
rusc1RUN and SH3 domain-containing 1. (610 aa)
cyp19a1aAromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. (517 aa)
lepaPutative leptin. (166 aa)
nr0b1Nuclear receptor subfamily 0, group B, member 1. (302 aa)
nr1d1Nuclear receptor subfamily 1, group d, member 1. (637 aa)
lpcat3Lysophosphatidylcholine acyltransferase 3; Belongs to the membrane-bound acyltransferase family. (465 aa)
lamtor1Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (160 aa)
arv1ARV1 homolog, fatty acid homeostasis modulator. (239 aa)
abcg4bATP-binding cassette, sub-family G (WHITE), member 4b. (644 aa)
dkk3bDickkopf WNT-signaling pathway inhibitor 3b. (283 aa)
nr1d4aNuclear receptor subfamily 1, group D, member 4a. (570 aa)
sirt1Sirtuin 1. (710 aa)
abcg1ATP-binding cassette, sub-family G (WHITE), member 1. (673 aa)
srebf2Processed sterol regulatory element-binding protein 2; Transcriptional activator required for lipid homeostasis. May regulate transcription of the LDL receptor gene as well as the cholesterol and fatty acid synthesis pathways. Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes (By similarity). (1095 aa)
srebf1Sterol regulatory element-binding transcription factor 1. (879 aa)
zgc:158403Tetratricopeptide repeat protein 39A; Belongs to the TTC39 family. (565 aa)
fgf1bMultifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (102 aa)
apobaApolipoprotein Ba. (4418 aa)
ephx2Epoxide hydrolase 2, cytoplasmic. (557 aa)
snai2Snail homolog 2 (Drosophila). (257 aa)
LOC100331467START domain-containing protein. (277 aa)
asah1bN-acylsphingosine amidohydrolase (acid ceramidase) 1b; Belongs to the acid ceramidase family. (395 aa)
dab2DAB adaptor protein 2. (589 aa)
apoa1aProapolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). (262 aa)
starSteroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone (By similarity). (285 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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