STRINGSTRING
tnfrsf9a tnfrsf9a il2rgb il2rgb il23r il23r sostdc1b sostdc1b cxcr3.2 cxcr3.2 zgc:153759-2 zgc:153759-2 csf1rb csf1rb cd4-1 cd4-1 zgc:153759 zgc:153759 ccr7 ccr7 Q5SNU5_DANRE Q5SNU5_DANRE ackr4a ackr4a cxcr3.1 cxcr3.1 E9QH26_DANRE E9QH26_DANRE cntfr cntfr F1RA20_DANRE F1RA20_DANRE il12rb2l il12rb2l nog2 nog2 tsku tsku crlf2 crlf2 LOC101887081 LOC101887081 zgc:195077 zgc:195077 zgc:66473 zgc:66473 tnfrsf11a tnfrsf11a LOC100332300 LOC100332300 bmpr2b bmpr2b ccr6a ccr6a E7FA55_DANRE E7FA55_DANRE cabz01093075.1 cabz01093075.1 tnfrsf1b tnfrsf1b il12ba il12ba chrdl2 chrdl2 ccr10 ccr10 il15ra il15ra kita kita crlf1a crlf1a ccr11.1 ccr11.1 zgc:136605 zgc:136605 sostdc1a sostdc1a il2rga il2rga crfb16 crfb16 ackr3a ackr3a tgfbr2a tgfbr2a wfikkn2b wfikkn2b nog1 nog1 cxcr4a cxcr4a lepr lepr F1QAH4_DANRE F1QAH4_DANRE cxcr2 cxcr2 xcr1a.1 xcr1a.1 zgc:172065 zgc:172065 zgc:66473-2 zgc:66473-2 ebi3 ebi3 nog3 nog3 prlrb prlrb il17a/f1 il17a/f1 F1QVS2_DANRE F1QVS2_DANRE zgc:172075 zgc:172075 csf3r csf3r ackr3b ackr3b cxcr4b cxcr4b lrrc32 lrrc32 ackr4b ackr4b F1R3F6_DANRE F1R3F6_DANRE lifrb lifrb il22ra2 il22ra2 il13ra2 il13ra2 bmpr2a bmpr2a klhl20 klhl20 hax1 hax1 plp2 plp2 chrd chrd kitb kitb il20ra il20ra acvrl1 acvrl1 grem1a grem1a tgfbr2b tgfbr2b E7FG49_DANRE E7FG49_DANRE il11ra il11ra ucmaa ucmaa tcap tcap wfikkn2a wfikkn2a tgfb3 tgfb3 bmpr1aa bmpr1aa crlf1b crlf1b tnfrsf1a tnfrsf1a cxcr5 cxcr5 il12rb2 il12rb2 acvr1l acvr1l il6r il6r ENSDARP00000150473 ENSDARP00000150473 cxcr1 cxcr1 ENSDARP00000148959 ENSDARP00000148959 ENSDARP00000148508 ENSDARP00000148508 csf1ra csf1ra LOC798191 LOC798191 ENSDARP00000142545 ENSDARP00000142545 ENSDARP00000142370 ENSDARP00000142370 ENSDARP00000142256 ENSDARP00000142256 ccr2 ccr2 ccr2-2 ccr2-2 twsg1b twsg1b bmpr1ab bmpr1ab il1rl1 il1rl1 bmpr1ba bmpr1ba fzd4 fzd4 nbl1 nbl1 wfikkn1 wfikkn1 LOC110438486 LOC110438486 tnfrsf9b tnfrsf9b ENSDARP00000136326 ENSDARP00000136326 ucmab ucmab il6st il6st bmper bmper LOC101882195 LOC101882195 grem2b grem2b lifra lifra bmpr1bb bmpr1bb twsg1a twsg1a il12bb il12bb ccr6b ccr6b il2rb il2rb grem2a grem2a ccr8.1 ccr8.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
tnfrsf9aTumor necrosis factor receptor superfamily, member 9a. (285 aa)
il2rgbInterleukin 2 receptor gamma common.b. (385 aa)
il23rInterleukin 23 receptor. (817 aa)
sostdc1bSclerostin domain-containing 1b. (204 aa)
cxcr3.2C-X-C chemokine receptor type 3-2; Receptor for the C-X-C chemokines cxcl11.1 and cxcl11.6. Promotes macrophage chemotaxis to sites of bacterial infection. (378 aa)
zgc:153759-2Zgc:153759. (285 aa)
csf1rbColony-stimulating factor 1 receptor, b; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (964 aa)
cd4-1CD4-1 molecule. (474 aa)
zgc:153759Zgc:153759. (266 aa)
ccr7Chemokine (C-C motif) receptor 7; Belongs to the G-protein coupled receptor 1 family. (385 aa)
Q5SNU5_DANRESi:ch211-285c6.4. (544 aa)
ackr4aAtypical chemokine receptor 4a; Belongs to the G-protein coupled receptor 1 family. (383 aa)
cxcr3.1Chemokine (C-X-C motif) receptor 3, tandem duplicate 1; Belongs to the G-protein coupled receptor 1 family. (367 aa)
E9QH26_DANRESi:ch73-29c22.1. (285 aa)
cntfrCiliary neurotrophic factor receptor. (357 aa)
F1RA20_DANRESi:ch211-285c6.1. (565 aa)
il12rb2lInterleukin 12 receptor, beta 2a,-like. (674 aa)
nog2Noggin-2; Inhibitor of bone morphogenetic proteins (BMP) signaling; Belongs to the noggin family. (212 aa)
tskuTsukushin; Dorsalizing factor. Functions as an inhibitor of bone morphogenetic proteins (BMP) during gastrulation. (347 aa)
crlf2Fibronectin type-III domain-containing protein. (259 aa)
LOC101887081G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (365 aa)
zgc:195077Zgc:195077. (522 aa)
zgc:66473Zgc:66473. (533 aa)
tnfrsf11aTumor necrosis factor receptor superfamily, member 11a, NFKB activator. (574 aa)
LOC100332300Gremlin 1a, DAN family BMP antagonist. (177 aa)
bmpr2bReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1071 aa)
ccr6aChemokine (C-C motif) receptor 6a; Belongs to the G-protein coupled receptor 1 family. (375 aa)
E7FA55_DANRESi:ch211-282j17.13. (523 aa)
cabz01093075.1Cabz01093075.1; Belongs to the G-protein coupled receptor 1 family. (411 aa)
tnfrsf1bTumor necrosis factor receptor superfamily, member 1B. (425 aa)
il12baInterleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (350 aa)
chrdl2Chordin-like protein. (454 aa)
ccr10Chemokine (C-C motif) receptor 10; Belongs to the G-protein coupled receptor 1 family. (412 aa)
il15raInterleukin 15 receptor subunit alpha. (308 aa)
kitaMast/stem cell growth factor receptor kita; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine kitlg/scf and plays a role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, and in mast cell development, migration and function. Required for the migration of cells in the melanocyte lineage and the survival of embryonic melanocytes. Required for the differentiation of some, but not all, melanocytes. Not essential for hematopoiesis or primordial germ cell development. (981 aa)
crlf1aCytokine receptor-like factor 1.a. (389 aa)
ccr11.1Chemokine (C-C motif) receptor 11.1; Belongs to the G-protein coupled receptor 1 family. (345 aa)
zgc:136605Zgc:136605. (140 aa)
sostdc1aSclerostin domain-containing 1a. (196 aa)
il2rgaInterleukin 2 receptor gamma common.a. (362 aa)
crfb16Cytokine receptor family member B16. (300 aa)
ackr3aAtypical chemokine receptor 3a; Belongs to the G-protein coupled receptor 1 family. (398 aa)
tgfbr2aSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (645 aa)
wfikkn2bWAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain-containing 2b. (563 aa)
nog1Noggin-1; Inhibitor of bone morphogenetic proteins (BMP) signaling. May play an important role in the dorsoventral patterning of the embryo; Belongs to the noggin family. (216 aa)
cxcr4aChemokine (C-X-C motif) receptor 4a; Belongs to the G-protein coupled receptor 1 family. (360 aa)
leprLeptin receptor. (1065 aa)
F1QAH4_DANRETGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (590 aa)
cxcr2Chemokine (C-X-C motif) receptor 2; Belongs to the G-protein coupled receptor 1 family. (340 aa)
xcr1a.1Chemokine (C motif) receptor 1a, duplicate 1; Belongs to the G-protein coupled receptor 1 family. (335 aa)
zgc:172065Zgc:172065. (532 aa)
zgc:66473-2Zgc:66473. (533 aa)
ebi3Epstein-Barr virus-induced 3. (302 aa)
nog3Noggin-3; May function as an inhibitor of bone morphogenetic proteins (BMP) signaling during later stages of development including late phases of dorsoventral patterning, to refine the early pattern set up by the interaction of chordino and BMP2/4. Not involved in organizer function or early phases of dorsoventral pattern formation; Belongs to the noggin family. (223 aa)
prlrbProlactin receptor; This is a receptor for the anterior pituitary hormone prolactin; Belongs to the type I cytokine receptor family. Type 1 subfamily. (450 aa)
il17a/f1Interleukin 17a/f1. (153 aa)
F1QVS2_DANRESi:dkey-187j14.4. (533 aa)
zgc:172075Zgc:172075. (543 aa)
csf3rColony-stimulating factor 3 receptor (granulocyte). (810 aa)
ackr3bAtypical chemokine receptor 3b; Belongs to the G-protein coupled receptor 1 family. (362 aa)
cxcr4bChemokine (C-X-C motif), receptor 4b; Belongs to the G-protein coupled receptor 1 family. (353 aa)
lrrc32Leucine-rich repeat-containing 32. (659 aa)
ackr4bAtypical chemokine receptor 4b; Belongs to the G-protein coupled receptor 1 family. (403 aa)
F1R3F6_DANREAAA domain-containing protein. (357 aa)
lifrbLIF receptor subunit alpha b. (960 aa)
il22ra2Interleukin 22 receptor, alpha 2. (238 aa)
il13ra2Interleukin 13 receptor, alpha 2. (407 aa)
bmpr2aReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1003 aa)
klhl20Kelch-like family member 20. (591 aa)
hax1HCLS1-associated protein X-1. (286 aa)
plp2Proteolipid protein 2. (153 aa)
chrdChordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes (By similarity); Belongs to the chordin family. (940 aa)
kitbMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (957 aa)
il20raInterleukin 20 receptor, alpha. (492 aa)
acvrl1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (499 aa)
grem1aGremlin. (177 aa)
tgfbr2bTGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (556 aa)
E7FG49_DANREAAA domain-containing protein. (517 aa)
il11raInterleukin 11 receptor alpha chain. (402 aa)
ucmaaUpper zone of growth plate and cartilage matrix-associated a. (135 aa)
tcapTitin-cap (telethonin). (179 aa)
wfikkn2aInfo WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain-containing 2a. (568 aa)
tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
bmpr1aaReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (527 aa)
crlf1bCytokine receptor-like factor 1b. (416 aa)
tnfrsf1aTumor necrosis factor receptor superfamily, member 1a. (389 aa)
cxcr5Chemokine (C-X-C motif) receptor 5; Belongs to the G-protein coupled receptor 1 family. (378 aa)
il12rb2Interleukin 12 receptor beta 2.a. (792 aa)
acvr1lReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa)
il6rInterleukin 6 receptor. (604 aa)
ENSDARP00000150473Si:ch211-261n11.7. (348 aa)
cxcr1Chemokine (C-X-C motif) receptor 1; Belongs to the G-protein coupled receptor 1 family. (364 aa)
ENSDARP00000148959Si:dkey-23c22.5. (239 aa)
ENSDARP00000148508ecTbetaR2 domain-containing protein. (382 aa)
csf1raMacrophage colony-stimulating factor 1 receptor; Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Promotes reorganization of the ac [...] (977 aa)
LOC798191Si:dkey-23c22.7. (234 aa)
ENSDARP00000142545Si:dkey-88n24.11. (532 aa)
ENSDARP00000142370Si:ch211-282j17.12. (523 aa)
ENSDARP00000142256Si:cabz01093077.1; Belongs to the G-protein coupled receptor 1 family. (352 aa)
ccr2Chemokine (C-C motif) receptor 2; Belongs to the G-protein coupled receptor 1 family. (354 aa)
ccr2-2Chemokine (C-C motif) receptor 2; Belongs to the G-protein coupled receptor 1 family. (360 aa)
twsg1bTwisted gastrulation protein homolog 1-B; Involved in dorsal-ventral patterning. Appears to function predominantly as a ventralizing factor, through its actions as a BMP signaling agonist, acting through both chd-dependent and chd- independent mechanisms. May also antagonize BMP signaling, probably via formation of ternary complexes with chd and BMPs, resulting in dorsalization; Belongs to the twisted gastrulation protein family. (155 aa)
bmpr1abReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (535 aa)
il1rl1Uncharacterized protein. (342 aa)
bmpr1baSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (530 aa)
fzd4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (523 aa)
nbl1Neuroblastoma suppressor of tumorigenicity 1; May act as a tumor suppressor; Belongs to the DAN family. (86 aa)
wfikkn1WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein; Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease- inhibitor activity (By similarity). (515 aa)
LOC110438486Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (208 aa)
tnfrsf9bTumor necrosis factor receptor superfamily, member 9b. (281 aa)
ENSDARP00000136326Si:zfos-1069f5.1. (415 aa)
ucmabUnique cartilage matrix-associated protein C-terminal fragment; May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface. Belongs to the UCMA family. (135 aa)
il6stInterleukin 6 signal transducer. (866 aa)
bmperBMP-binding endothelial regulator. (667 aa)
LOC101882195Uncharacterized protein. (430 aa)
grem2bGremlin. (166 aa)
lifraProlactin receptor; This is a receptor for the anterior pituitary hormone prolactin; Belongs to the type I cytokine receptor family. Type 1 subfamily. (939 aa)
bmpr1bbSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (535 aa)
twsg1aTwisted gastrulation protein homolog 1-A; Involved in dorsal-ventral patterning. Appears to function predominantly as a ventralizing factor, through its actions as a BMP signaling agonist, acting through both chd-dependent and chd- independent mechanisms. May also antagonize BMP signaling, probably via formation of ternary complexes with chd and BMPs, resulting in dorsalization (By similarity); Belongs to the twisted gastrulation protein family. (217 aa)
il12bbInterleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (314 aa)
ccr6bChemokine (C-C motif) receptor 6b. (354 aa)
il2rbInterleukin 2 receptor, beta. (503 aa)
grem2aGremlin 2, DAN family BMP antagonist a. (195 aa)
ccr8.1Chemokine (C-C motif) receptor 8.1; Belongs to the G-protein coupled receptor 1 family. (395 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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