STRINGSTRING
mdkb mdkb uts1 uts1 fabp2 fabp2 aqp1a.1 aqp1a.1 cel.2 cel.2 ugcg ugcg copa copa mdka mdka hrh2b hrh2b kcnq1.1 kcnq1.1 inavab inavab f11r.2 f11r.2 chrm5b chrm5b f11r.1 f11r.1 inavaa inavaa strap strap aqp1a.2 aqp1a.2 pbld2 pbld2 pbld pbld cel.1 cel.1 tp53 tp53 npr3 npr3 ghrl ghrl CRACD CRACD tert tert kcnn4 kcnn4 chrm3a chrm3a chrm5a chrm5a lima1a lima1a NPC1L1 NPC1L1 uhrf1 uhrf1 scarb1 scarb1 zgc:162592 zgc:162592 kcnq1.2 kcnq1.2 chrm1a chrm1a npc1 npc1 hrh2a hrh2a
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
mdkbMidkine-related growth factor Mdk2. (147 aa)
uts1Urotensin 1. (138 aa)
fabp2Fatty acid-binding protein 2, intestinal; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
aqp1a.1Aquaporin 1a (Colton blood group), tandem duplicate 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (260 aa)
cel.2Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (551 aa)
ugcgUDP-glucose ceramide glucosyltransferase. (438 aa)
copaCoatomer subunit alpha; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. (1224 aa)
mdkaMidkine-related growth factor Mdk1. (146 aa)
hrh2bHistamine receptor H2b; Belongs to the G-protein coupled receptor 1 family. (335 aa)
kcnq1.1Potassium voltage-gated channel, KQT-like subfamily, member 1.1; Belongs to the potassium channel family. (655 aa)
inavabInnate immunity activator b. (612 aa)
f11r.2F11 receptor, tandem duplicate 2. (294 aa)
chrm5bMuscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (457 aa)
f11r.1F11 receptor, tandem duplicate 1. (292 aa)
inavaaInnate immunity activator a. (596 aa)
strapSerine/threonine kinase receptor-associated protein. (329 aa)
aqp1a.2Aquaporin 1a (Colton blood group), tandem duplicate 2; Belongs to the MIP/aquaporin (TC 1.A.8) family. (269 aa)
pbld2Phenazine biosynthesis-like protein domain-containing 2. (286 aa)
pbldPhenazine biosynthesis-like protein domain-containing. (286 aa)
cel.1Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (552 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression. (369 aa)
npr3Natriuretic peptide receptor 3. (502 aa)
ghrlGhrelin/obestatin prepropeptide. (104 aa)
CRACDCapping protein inhibiting regulator of actin dynamics; Involved in epithelial cell integrity by acting on the maintenance of the actin cytoskeleton. Positively regulates the actin polymerization, by inhibiting the interaction of actin-capping proteins with actin. (1079 aa)
tertTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1098 aa)
kcnn4Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4. (481 aa)
chrm3aMuscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (595 aa)
chrm5aMuscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (490 aa)
lima1aLIM domain and actin-binding 1a. (589 aa)
NPC1L1NPC1 like intracellular cholesterol transporter 1. (1085 aa)
uhrf1E3 ubiquitin-protein ligase UHRF1; Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits dnmt1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylate [...] (775 aa)
scarb1Scavenger receptor class B, member 1; Belongs to the CD36 family. (496 aa)
zgc:162592Zgc:162592 protein; Belongs to the G-protein coupled receptor 1 family. (375 aa)
kcnq1.2Potassium voltage-gated channel, KQT-like subfamily, member 1.2; Belongs to the potassium channel family. (531 aa)
chrm1aMuscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (465 aa)
npc1Niemann-Pick disease, type C1. (1277 aa)
hrh2aHistamine receptor H2a; Belongs to the G-protein coupled receptor 1 family. (369 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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