(41 nodes) Cholesterol transport network (Danio rerio)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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Predicted Interactions

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Your Input:
	NPC1L1	NPC1 like intracellular cholesterol transporter 1. (1085 aa)
	vps4a	Vacuolar protein sorting 4 homolog A; Belongs to the AAA ATPase family. (440 aa)
	cel.2	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (551 aa)
	apoa1a	Proapolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). (262 aa)
	star	Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone (By similarity). (285 aa)
	zgc:193725	Zgc:193725. (149 aa)
	ldlrap1a	Low density lipoprotein receptor adaptor protein 1a. (287 aa)
	scp2a	Sterol carrier protein 2a; Belongs to the thiolase-like superfamily. Thiolase family. (538 aa)
	stard3	StAR-related lipid transfer protein 3; Sterol-binding protein that mediates cholesterol transport from the endoplasmic reticulum to endosomes. Creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum. Acts as a lipid transfer protein that redirects sterol to the endosome at the expense of the cell membrane and favors membrane formation inside endosomes. (448 aa)
	cetp	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. (493 aa)
	npc2	NPC intracellular cholesterol transporter 2; Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. May bind and mobilize cholesterol that is associated with membranes. NPC2 binds cholesterol with a 1:1 stoichiometry. Can bind a variety of sterols, including lathosterol, desmosterol and the pl [...] (149 aa)
	ldlrap1b	Low density lipoprotein receptor adaptor protein 1b. (304 aa)
	apoeb	Apolipoprotein Eb; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. Belongs to the apolipoprotein A1/A4/E family. (281 aa)
	apoba	Apolipoprotein Ba. (4418 aa)
	stard3nl	STARD3 N-terminal-like. (227 aa)
	spg11	SPG11 vesicle-trafficking-associated, spatacsin. (1612 aa)
	lipca	Lipase, hepatic a. (514 aa)
	abcg5	ATP-binding cassette, sub-family G (WHITE), member 5. (652 aa)
	abcg1	ATP-binding cassette, sub-family G (WHITE), member 1. (673 aa)
	abcd1	ATP-binding cassette sub-family D member 1; Plays a role in the transport of free very-long-chain fatty acids (VLCFAs) as well as their CoA-esters across the peroxisomal membrane by acting as an ATP-specific binding subunit releasing ADP after ATP hydrolysis (By similarity). Involved in oligodendrocyte patterning and myelination. (766 aa)
	abcg4b	ATP-binding cassette, sub-family G (WHITE), member 4b. (644 aa)
	abcg8	ATP-binding cassette, sub-family G (WHITE), member 8. (332 aa)
	arv1	ARV1 homolog, fatty acid homeostasis modulator. (239 aa)
	stard5	StAR-related lipid transfer (START) domain-containing 5. (210 aa)
	vps4b	Vacuolar protein sorting 4 homolog B; Belongs to the AAA ATPase family. (437 aa)
	cel.1	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (552 aa)
	abcg4a	ATP-binding cassette, sub-family G (WHITE), member 4a. (641 aa)
	podn	Podocan. (530 aa)
	apom	Apolipoprotein M. (215 aa)
	syt7a	Synaptotagmin VIIa. (607 aa)
	X1WG66_DANRE	Si:dkey-185p13.1. (93 aa)
	lcat	Lecithin-cholesterol acyltransferase. (425 aa)
	lima1a	LIM domain and actin-binding 1a. (589 aa)
	apoea	Apolipoprotein Ea. (269 aa)
	relch	RAB11-binding protein RELCH homolog; May regulate intracellular cholesterol transport. (1197 aa)
	syt7b	Synaptotagmin VIIb. (488 aa)
	stard4	StAR-related lipid transfer (START) domain-containing 4. (198 aa)
	scarb1	Scavenger receptor class B, member 1; Belongs to the CD36 family. (496 aa)
	npc1	Niemann-Pick disease, type C1. (1277 aa)
	apoa1b	Apolipoprotein A-Ib. (257 aa)
	ENSDARP00000152122	LIM zinc-binding domain-containing protein. (110 aa)

Your Current Organism:

Danio rerio

NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
NPC1L1	abcg5	ENSDARP00000133903	ENSDARP00000086278	NPC1 like intracellular cholesterol transporter 1.	ATP-binding cassette, sub-family G (WHITE), member 5.	0.725
NPC1L1	abcg8	ENSDARP00000133903	ENSDARP00000102567	NPC1 like intracellular cholesterol transporter 1.	ATP-binding cassette, sub-family G (WHITE), member 8.	0.606
NPC1L1	apoba	ENSDARP00000133903	ENSDARP00000062792	NPC1 like intracellular cholesterol transporter 1.	Apolipoprotein Ba.	0.630
NPC1L1	apoeb	ENSDARP00000133903	ENSDARP00000058964	NPC1 like intracellular cholesterol transporter 1.	Apolipoprotein Eb; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. Belongs to the apolipoprotein A1/A4/E family.	0.434
NPC1L1	cetp	ENSDARP00000133903	ENSDARP00000046890	NPC1 like intracellular cholesterol transporter 1.	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.	0.587
NPC1L1	lcat	ENSDARP00000133903	ENSDARP00000132129	NPC1 like intracellular cholesterol transporter 1.	Lecithin-cholesterol acyltransferase.	0.418
NPC1L1	npc2	ENSDARP00000133903	ENSDARP00000050398	NPC1 like intracellular cholesterol transporter 1.	NPC intracellular cholesterol transporter 2; Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. May bind and mobilize cholesterol that is associated with membranes. NPC2 binds cholesterol with a 1:1 stoichiometry. Can bind a variety of sterols, including lathosterol, desmosterol and the pl [...]	0.843
NPC1L1	zgc:193725	ENSDARP00000133903	ENSDARP00000014574	NPC1 like intracellular cholesterol transporter 1.	Zgc:193725.	0.766
abcd1	npc1	ENSDARP00000101144	ENSDARP00000144951	ATP-binding cassette sub-family D member 1; Plays a role in the transport of free very-long-chain fatty acids (VLCFAs) as well as their CoA-esters across the peroxisomal membrane by acting as an ATP-specific binding subunit releasing ADP after ATP hydrolysis (By similarity). Involved in oligodendrocyte patterning and myelination.	Niemann-Pick disease, type C1.	0.468
abcd1	scp2a	ENSDARP00000101144	ENSDARP00000009052	ATP-binding cassette sub-family D member 1; Plays a role in the transport of free very-long-chain fatty acids (VLCFAs) as well as their CoA-esters across the peroxisomal membrane by acting as an ATP-specific binding subunit releasing ADP after ATP hydrolysis (By similarity). Involved in oligodendrocyte patterning and myelination.	Sterol carrier protein 2a; Belongs to the thiolase-like superfamily. Thiolase family.	0.598
abcg1	abcg5	ENSDARP00000087241	ENSDARP00000086278	ATP-binding cassette, sub-family G (WHITE), member 1.	ATP-binding cassette, sub-family G (WHITE), member 5.	0.690
abcg1	apoba	ENSDARP00000087241	ENSDARP00000062792	ATP-binding cassette, sub-family G (WHITE), member 1.	Apolipoprotein Ba.	0.452
abcg1	apoea	ENSDARP00000087241	ENSDARP00000133853	ATP-binding cassette, sub-family G (WHITE), member 1.	Apolipoprotein Ea.	0.655
abcg1	apoeb	ENSDARP00000087241	ENSDARP00000058964	ATP-binding cassette, sub-family G (WHITE), member 1.	Apolipoprotein Eb; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. Belongs to the apolipoprotein A1/A4/E family.	0.812
abcg1	cetp	ENSDARP00000087241	ENSDARP00000046890	ATP-binding cassette, sub-family G (WHITE), member 1.	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.	0.685
abcg1	npc1	ENSDARP00000087241	ENSDARP00000144951	ATP-binding cassette, sub-family G (WHITE), member 1.	Niemann-Pick disease, type C1.	0.635
abcg4a	abcg4b	ENSDARP00000116517	ENSDARP00000102351	ATP-binding cassette, sub-family G (WHITE), member 4a.	ATP-binding cassette, sub-family G (WHITE), member 4b.	0.902
abcg4a	abcg5	ENSDARP00000116517	ENSDARP00000086278	ATP-binding cassette, sub-family G (WHITE), member 4a.	ATP-binding cassette, sub-family G (WHITE), member 5.	0.683
abcg4b	abcg4a	ENSDARP00000102351	ENSDARP00000116517	ATP-binding cassette, sub-family G (WHITE), member 4b.	ATP-binding cassette, sub-family G (WHITE), member 4a.	0.902
abcg4b	abcg5	ENSDARP00000102351	ENSDARP00000086278	ATP-binding cassette, sub-family G (WHITE), member 4b.	ATP-binding cassette, sub-family G (WHITE), member 5.	0.602

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