STRINGSTRING
dnajb9a dnajb9a edem1 edem1 os9 os9 zgc:100832 zgc:100832 zgc:114081 zgc:114081 march6 march6 tmem67 tmem67 syvn1 syvn1 F1R5J5_DANRE F1R5J5_DANRE rhbdd2 rhbdd2 rnf175 rnf175 amfra amfra erlec1 erlec1 dnajc10 dnajc10 bag6 bag6 edem3 edem3 RNF5 RNF5 man1b1a man1b1a man1b1b man1b1b zgc:153722 zgc:153722 zgc:173570 zgc:173570 stt3b stt3b clgn clgn calr calr dnajc18 dnajc18 zgc:136908 zgc:136908 wfs1a wfs1a canx canx ecpas ecpas ube2j2 ube2j2 rnf121 rnf121 selenos selenos ubxn10 ubxn10 derl2 derl2 zgc:114174 zgc:114174 ube4a ube4a sec61b sec61b fam8a1b fam8a1b E7F7X8_DANRE E7F7X8_DANRE yod1 yod1 dnajb9b dnajb9b fam8a1a fam8a1a vcp vcp sgtb sgtb hsp90b1 hsp90b1 sgta sgta ube2g2 ube2g2 jkamp jkamp faf2 faf2 ufd1l ufd1l derl1 derl1 faf1 faf1 ube2j1 ube2j1 derl3 derl3 nccrp1 nccrp1 ttc33 ttc33 ube4b ube4b psmc6 psmc6 dnajb12a dnajb12a tmub1 tmub1 aup1 aup1 foxred2 foxred2 bag6l bag6l ankzf1 ankzf1 amfrb amfrb rnf103 rnf103 ubxn8 ubxn8 calr3b calr3b zgc:175088 zgc:175088 ubxn4 ubxn4 dnajb14 dnajb14 ENSDARP00000130853 ENSDARP00000130853 calr3a calr3a edem2 edem2 dnajb12b dnajb12b wfs1b wfs1b A3QJV7_DANRE A3QJV7_DANRE E9QJ85_DANRE E9QJ85_DANRE si:rp71-1k13.6 si:rp71-1k13.6 fbxo44 fbxo44
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
dnajb9aDnaJ heat shock protein family (Hsp40) member B9a. (218 aa)
edem1alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (628 aa)
os9OS9 endoplasmic reticulum lectin. (703 aa)
zgc:100832Zgc:100832. (247 aa)
zgc:114081Zgc:114081. (211 aa)
march6Membrane-associated ring finger (C3HC4) 6. (911 aa)
tmem67Transmembrane protein 67. (982 aa)
syvn1E3 ubiquitin-protein ligase synoviolin; Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin- dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins. Protects cells from ER stress-induced apoptosis. Sequesters p53 in the cytoplasm a [...] (618 aa)
F1R5J5_DANRESi:dkey-147f3.8. (405 aa)
rhbdd2Rhomboid domain-containing 2. (380 aa)
rnf175Ring finger protein 175. (313 aa)
amfraAutocrine motility factor receptor a. (620 aa)
erlec1Endoplasmic reticulum lectin 1. (425 aa)
dnajc10DnaJ (Hsp40) homolog, subfamily C, member 10. (791 aa)
bag6BCL2-associated athanogene 6. (1209 aa)
edem3alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (870 aa)
RNF5Ring finger protein 5. (192 aa)
man1b1aalpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (682 aa)
man1b1balpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (632 aa)
zgc:153722Zgc:153722. (281 aa)
zgc:173570Zgc:173570. (282 aa)
stt3bSTT3 oligosaccharyltransferase complex catalytic subunit B. (805 aa)
clgnCalmegin. (630 aa)
calrCalreticulin. (417 aa)
dnajc18DnaJ (Hsp40) homolog, subfamily C, member 18. (407 aa)
zgc:136908Zgc:136908; Belongs to the AAA ATPase family. (805 aa)
wfs1aWolfram syndrome 1a (wolframin). (814 aa)
canxCalnexin. (600 aa)
ecpasEcm29 proteasome adaptor and scaffold. (1867 aa)
ube2j2Ubiquitin-conjugating enzyme E2, J2 (UBC6 homolog, yeast). (259 aa)
rnf121Ring finger protein 121. (331 aa)
selenosSelenoprotein S; Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner (By similarity). (190 aa)
ubxn10UBX domain-containing protein 10; Required for ciliogenesis. Acts as a tethering factor that facilitates recruitment of vcp/p97 to the intraflagellar transport complex B (IFT-B) in cilia (By similarity). (214 aa)
derl2Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (239 aa)
zgc:114174Zgc:114174. (282 aa)
ube4aUbiquitination factor E4A (UFD2 homolog, yeast). (1076 aa)
sec61bProtein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum. (97 aa)
fam8a1bFamily with sequence similarity 8 member A1b. (346 aa)
E7F7X8_DANREalpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (837 aa)
yod1Ubiquitin thioesterase OTU1; Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. A [...] (301 aa)
dnajb9bDnaJ heat shock protein family (Hsp40) member B9b. (199 aa)
fam8a1aFamily with sequence similarity 8 member A1a. (277 aa)
vcpTransitional endoplasmic reticulum ATPase; Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. Also involved in DNA damage response: recruited to double-strand [...] (806 aa)
sgtbSmall glutamine-rich tetratricopeptide repeat (TPR)-containing, beta. (320 aa)
hsp90b1Heat shock protein 90, beta (Grp94), member 1. (793 aa)
sgtaSmall glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha. (320 aa)
ube2g2Ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast); Belongs to the ubiquitin-conjugating enzyme family. (165 aa)
jkampJnk1/mapk8-associated membrane protein. (309 aa)
faf2Fas-associated factor family member 2. (445 aa)
ufd1lUbiquitin recognition factor in ER-associated degradation 1. (308 aa)
derl1Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (261 aa)
faf1Fas (TNFRSF6)-associated factor 1. (675 aa)
ube2j1Ubiquitin-conjugating enzyme E2, J1. (314 aa)
derl3Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (247 aa)
nccrp1F-box only protein 50; May promote cell proliferation. (237 aa)
ttc33Tetratricopeptide repeat protein 33. (268 aa)
ube4bUbiquitination factor E4B, UFD2 homolog (S. cerevisiae). (1183 aa)
psmc6Proteasome (Prosome, macropain) 26S subunit, ATPase, 6; Belongs to the AAA ATPase family. (389 aa)
dnajb12aDnaJ heat shock protein family (Hsp40) member B12a. (371 aa)
tmub1Transmembrane and ubiquitin-like domain-containing protein 1; May contribute to the regulation of translation during cell- cycle progression. May contribute to the regulation of cell proliferation (By similarity). The membrane form is involved in sterol- regulated ubiquitination and degradation of HMG-CoA reductase HMGCR. May be involved in centrosome assembly. (292 aa)
aup1Ancient ubiquitous protein 1; May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome; Belongs to the AUP1 family. (423 aa)
foxred2FAD-dependent oxidoreductase domain-containing protein 2; Probable flavoprotein which may function in endoplasmic reticulum associated degradation (ERAD). May bind non-native proteins in the endoplasmic reticulum and target them to the ubiquitination machinery for subsequent degradation (By similarity); Belongs to the FOXRED2 family. (687 aa)
bag6lLarge proline-rich protein BAG6; ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins. Functions as part of a cytosolic protein quality control complex, the bag6/bat3 complex, which maintains these client proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The bag6/bat3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endo [...] (1216 aa)
ankzf1Ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1. (723 aa)
amfrbAutocrine motility factor receptor b. (459 aa)
rnf103Ring finger protein 103. (656 aa)
ubxn8UBX domain protein 8. (272 aa)
calr3bCalreticulin. (417 aa)
zgc:175088Zgc:175088 protein. (177 aa)
ubxn4UBX domain protein 4. (126 aa)
dnajb14DnaJ heat shock protein family (Hsp40) member B14. (391 aa)
ENSDARP00000130853Si:dkey-147f3.8. (323 aa)
calr3aCalreticulin. (418 aa)
edem2alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (560 aa)
dnajb12bDnaJ heat shock protein family (Hsp40) member B12b. (369 aa)
wfs1bWolfram syndrome 1b (wolframin). (895 aa)
A3QJV7_DANRESi:dkey-147f3.4. (182 aa)
E9QJ85_DANRESi:ch211-274f20.2. (452 aa)
si:rp71-1k13.6Si:rp71-1k13.6. (256 aa)
fbxo44F-box protein 44. (297 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: low (22%) [HD]