STRINGSTRING
dkk1a dkk1a smad7 smad7 rbpms2b rbpms2b grem1a grem1a chrd chrd dand5 dand5 smurf2 smurf2 skila skila dkk1b dkk1b nog3 nog3 bambia bambia nog1 nog1 ctdspl2b ctdspl2b ctdspl2a ctdspl2a tnfaip6 tnfaip6 sparta sparta sostdc1a sostdc1a skor1a skor1a smurf1 smurf1 lemd3 lemd3 smad6b smad6b skia skia sfrp2 sfrp2 skib skib chrdl2 chrdl2 skilb skilb LOC100332300 LOC100332300 skor2 skor2 nog2 nog2 smad6a smad6a vwc2 vwc2 vwc2l vwc2l skor1b skor1b sostdc1b sostdc1b grem2a grem2a sorl1 sorl1 grem2b grem2b bmper bmper nbl1 nbl1 bambib bambib spartb spartb rargb rargb sfrp2l sfrp2l ENSDARP00000151194 ENSDARP00000151194 fstl3 fstl3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
dkk1aDickkopf WNT-signaling pathway inhibitor 1a. (256 aa)
smad7Mothers against decapentaplegic homolog. (372 aa)
rbpms2bRNA-binding protein, mRNA-processing factor 2b. (200 aa)
grem1aGremlin. (177 aa)
chrdChordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes (By similarity); Belongs to the chordin family. (940 aa)
dand5DAN domain family, member 5. (243 aa)
smurf2E3 ubiquitin-protein ligase SMURF2; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (765 aa)
skilaSKI-like proto-oncogene a. (623 aa)
dkk1bDickkopf WNT-signaling pathway inhibitor 1b. (241 aa)
nog3Noggin-3; May function as an inhibitor of bone morphogenetic proteins (BMP) signaling during later stages of development including late phases of dorsoventral patterning, to refine the early pattern set up by the interaction of chordino and BMP2/4. Not involved in organizer function or early phases of dorsoventral pattern formation; Belongs to the noggin family. (223 aa)
bambiaBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (258 aa)
nog1Noggin-1; Inhibitor of bone morphogenetic proteins (BMP) signaling. May play an important role in the dorsoventral patterning of the embryo; Belongs to the noggin family. (216 aa)
ctdspl2bCTD small phosphatase-like protein 2-B; Probable phosphatase. (460 aa)
ctdspl2aCTD small phosphatase-like protein 2-A; Probable phosphatase. (469 aa)
tnfaip6Tumor necrosis factor, alpha-induced protein 6. (271 aa)
spartaZgc:172059 protein. (567 aa)
sostdc1aSclerostin domain-containing 1a. (196 aa)
skor1aSKI family transcriptional corepressor 1a. (751 aa)
smurf1E3 ubiquitin-protein ligase. (731 aa)
lemd3LEM domain-containing 3. (841 aa)
smad6bMothers against decapentaplegic homolog. (486 aa)
skiaV-ski avian sarcoma viral oncogene homolog a. (727 aa)
sfrp2Secreted frizzled-related protein 2. (294 aa)
skibV-ski avian sarcoma viral oncogene homolog b. (695 aa)
chrdl2Chordin-like protein. (454 aa)
skilbSKI-like proto-oncogene b. (624 aa)
LOC100332300Gremlin 1a, DAN family BMP antagonist. (177 aa)
skor2SKI family transcriptional corepressor 2. (255 aa)
nog2Noggin-2; Inhibitor of bone morphogenetic proteins (BMP) signaling; Belongs to the noggin family. (212 aa)
smad6aMothers against decapentaplegic homolog. (456 aa)
vwc2Von Willebrand factor C domain-containing 2. (309 aa)
vwc2lVon Willebrand factor C domain-containing protein 2-like; May play a role in bone differentiation and matrix mineralization (By similarity). May play a role in neural development. (223 aa)
skor1bSKI family transcriptional corepressor 1 homolog-B; May inhibit BMP signaling; Belongs to the SKI family. (751 aa)
sostdc1bSclerostin domain-containing 1b. (204 aa)
grem2aGremlin 2, DAN family BMP antagonist a. (195 aa)
sorl1Sortilin-related receptor, L(DLR class) A repeats-containing. (2213 aa)
grem2bGremlin. (166 aa)
bmperBMP-binding endothelial regulator. (667 aa)
nbl1Neuroblastoma suppressor of tumorigenicity 1; May act as a tumor suppressor; Belongs to the DAN family. (86 aa)
bambibBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (257 aa)
spartbSpartin b. (587 aa)
rargbRetinoic acid receptor gamma-B; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Required for hindbrain development; Belongs to the nuclear hormone receptor family. NR1 subfamily. (392 aa)
sfrp2lSecreted frizzled-related protein 2-like. (333 aa)
ENSDARP00000151194Uncharacterized protein. (516 aa)
fstl3Follistatin-like 3 (secreted glycoprotein). (246 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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