STRINGSTRING
Q5RHR2_DANRE Q5RHR2_DANRE ENSDARP00000155492 ENSDARP00000155492 slc18a3b slc18a3b ENSDARP00000146183 ENSDARP00000146183 ENSDARP00000144645 ENSDARP00000144645 LOC101884662 LOC101884662 cltb cltb AP3B2 AP3B2 ENSDARP00000140144 ENSDARP00000140144 ap1g1 ap1g1 epn1 epn1 sec23a sec23a sec22bb sec22bb ap2m1a ap2m1a sar1b sar1b sec16b sec16b sec24c sec24c ap1g2 ap1g2 ap2b1 ap2b1 klhl12 klhl12 sec24a sec24a ap3b1a ap3b1a E7FC63_DANRE E7FC63_DANRE atp6v1ab atp6v1ab epn2 epn2 ap2a1 ap2a1 epn3a epn3a sec31b sec31b ap2m1b ap2m1b ap1b1 ap1b1 tmed2 tmed2 scap scap F1R2Z4_DANRE F1R2Z4_DANRE prr15la prr15la aftphb aftphb copz2 copz2 prr15lb prr15lb dennd1a dennd1a cltcb cltcb dipk2ab dipk2ab atp6v0b atp6v0b vma21 vma21 aftpha aftpha stx17 stx17 clint1a clint1a vamp3 vamp3 atp6v1h atp6v1h clint1b clint1b dct dct si:dkey-9k7.3 si:dkey-9k7.3 atp6ap1b atp6ap1b cltcl1 cltcl1 atp6ap2 atp6ap2 reep6 reep6 sec31a sec31a synrg synrg uso1 uso1 zgc:194578 zgc:194578 sec24b sec24b tepsin tepsin mhc1zfa mhc1zfa srebf2 srebf2 srebf1 srebf1 adcy8 adcy8 copb1 copb1 tyrp1b tyrp1b sec13 sec13 gosr2 gosr2 necap2 necap2 clta clta atp6v1f atp6v1f vti1a vti1a cltca cltca epn3b epn3b atp6ap1a atp6ap1a kdelr3 kdelr3 nrgna nrgna vti1b vti1b kdelr2b kdelr2b atp6v0cb atp6v0cb tyrp1a tyrp1a atp6v1aa atp6v1aa copa copa arcn1b arcn1b copb2 copb2 copg2 copg2 sec22ba sec22ba sar1ab sar1ab sec24d sec24d pef1 pef1 ap2s1 ap2s1 dab2 dab2 zgc:101744 zgc:101744 atp6v1d atp6v1d sec23b sec23b dipk2aa dipk2aa copz1 copz1 atp6v0ca atp6v0ca necap1 necap1 slc18a3a slc18a3a kdelr2a kdelr2a arcn1a arcn1a pdcd6 pdcd6 cope cope
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Q5RHR2_DANREAdenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1187 aa)
ENSDARP00000155492Adaptin_N domain-containing protein. (179 aa)
slc18a3bProbable vesicular acetylcholine transporter-B; Involved in acetylcholine transport into synaptic vesicles. Belongs to the major facilitator superfamily. Vesicular transporter family. (431 aa)
ENSDARP00000146183Si:ch211-204c21.1. (697 aa)
ENSDARP00000144645Uncharacterized protein. (120 aa)
LOC101884662BTB domain-containing protein. (555 aa)
cltbClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (226 aa)
AP3B2AP-3 complex subunit beta. (991 aa)
ENSDARP00000140144ER lumen protein-retaining receptor. (203 aa)
ap1g1AP-1 complex subunit gamma. (819 aa)
epn1Epsin 1. (646 aa)
sec23aProtein transport protein Sec23A; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. Belongs to the SEC23/SEC24 family. SEC23 subfamily. (765 aa)
sec22bbVesicle-trafficking protein SEC22b-B; SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER. (215 aa)
ap2m1aAP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (441 aa)
sar1bSecretion-associated, Ras-related GTPase 1B; Belongs to the small GTPase superfamily. SAR1 family. (198 aa)
sec16bSEC16 homolog B, endoplasmic reticulum export factor. (935 aa)
sec24cSEC24 homolog C, COPII coat complex component. (1248 aa)
ap1g2AP-1 complex subunit gamma. (794 aa)
ap2b1AP complex subunit beta. (951 aa)
klhl12Kelch-like protein 12; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division (By similarity). Negatively regulates the Wnt signaling pathway, possibly via the targeted ubiquitination and subsequent proteolysis of dvl2 and dvl3. Regulates convergent-extension movements during early [...] (314 aa)
sec24aSEC24 homolog A, COPII coat complex component. (1096 aa)
ap3b1aAdaptor-related protein complex 3 subunit beta 1a. (676 aa)
E7FC63_DANREAdenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1183 aa)
atp6v1abATPase H+-transporting V1 subunit Ab. (617 aa)
epn2Epsin 2. (590 aa)
ap2a1AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (959 aa)
epn3aEpsin 3a. (645 aa)
sec31bSEC31 homolog B, COPII coat complex component. (1171 aa)
ap2m1bAP-2 complex subunit mu-B; Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. AP50 is a subunit of the plasma membrane adaptor. The complex binds polyphosphoinositide- containing lipids (By similarity). (436 aa)
ap1b1AP complex subunit beta. (947 aa)
tmed2Transmembrane p24-trafficking protein 2. (208 aa)
scapSREBF chaperone. (1245 aa)
F1R2Z4_DANRESi:dkey-13n15.2. (326 aa)
prr15laProline-rich protein 15-like protein A; Belongs to the PRR15 family. (110 aa)
aftphbAftiphilin b. (731 aa)
copz2Coatomer subunit zeta; The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex. (189 aa)
prr15lbProline-rich protein 15-like protein B; Belongs to the PRR15 family. (104 aa)
dennd1aDENN/MADD domain-containing 1A. (511 aa)
cltcbClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1677 aa)
dipk2abDivergent protein kinase domain 2Ab. (429 aa)
atp6v0bATPase H+-transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family. (206 aa)
vma21Vacuolar ATPase assembly integral membrane protein vma21; Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum; Belongs to the VMA21 family. (104 aa)
aftphaAftiphilin a. (793 aa)
stx17Syntaxin 17. (292 aa)
clint1aClathrin interactor 1a. (633 aa)
vamp3Vesicle-associated membrane protein 3 (Cellubrevin). (102 aa)
atp6v1hV-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (481 aa)
clint1bClathrin interactor 1b. (607 aa)
dctDopachrome tautomerase. (513 aa)
si:dkey-9k7.3Si:dkey-9k7.3. (648 aa)
atp6ap1bATPase H+-transporting accessory protein 1b. (459 aa)
cltcl1Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1638 aa)
atp6ap2ATPase H+-transporting accessory protein 2. (386 aa)
reep6Receptor expression-enhancing protein 6; Required correct function and survival of retinal photoreceptors. Required for retinal development (By similarity). In rod photoreceptors, facilitates stability and/or trafficking of guanylate cyclases and is required to maintain endoplasmic reticulum and mitochondrial homeostasis (By similarity). May play a role in clathrin-coated intracellular vesicle trafficking of proteins from the endoplasmic reticulum to the retinal rod plasma membrane (By similarity). (208 aa)
sec31aProtein transport protein Sec31A; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). (1250 aa)
synrgSynergin, gamma. (1409 aa)
uso1USO1 homolog, vesicle docking protein (Yeast). (956 aa)
zgc:194578Zgc:194578 protein. (504 aa)
sec24bSEC24 homolog B, COPII coat complex component. (1184 aa)
tepsinTEPSIN adaptor-related protein complex 4 accessory protein. (564 aa)
mhc1zfaMHC class I antigen ZFA transcript variant 1; Belongs to the MHC class I family. (371 aa)
srebf2Processed sterol regulatory element-binding protein 2; Transcriptional activator required for lipid homeostasis. May regulate transcription of the LDL receptor gene as well as the cholesterol and fatty acid synthesis pathways. Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes (By similarity). (1095 aa)
srebf1Sterol regulatory element-binding transcription factor 1. (879 aa)
adcy8Adenylate cyclase 8 (brain); Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (892 aa)
copb1Coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity). (953 aa)
tyrp1bTyrosinase-related protein 1b. (526 aa)
sec13SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family. (320 aa)
gosr2Golgi SNAP receptor complex member 2; Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network. (212 aa)
necap2NECAP endocytosis-associated 2. (260 aa)
cltaClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (235 aa)
atp6v1fV-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (119 aa)
vti1aVesicle transport through interaction with t-SNAREs 1A. (217 aa)
cltcaClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1680 aa)
epn3bEpsin 3b. (526 aa)
atp6ap1aATPase H+-transporting accessory protein 1a. (466 aa)
kdelr3ER lumen protein-retaining receptor 3; Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum. (215 aa)
nrgnaNeurogranin (protein kinase C substrate, RC3) a. (60 aa)
vti1bVesicle transport through interaction with t-SNAREs homolog 1B (Yeast). (225 aa)
kdelr2bKDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2, like. (212 aa)
atp6v0cbV-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (153 aa)
tyrp1aTyrosinase-related protein 1a. (524 aa)
atp6v1aaATPase H+-transporting V1 subunit Aa. (617 aa)
copaCoatomer subunit alpha; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. (1224 aa)
arcn1bCoatomer subunit delta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (512 aa)
copb2Coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (934 aa)
copg2Coatomer subunit gamma-2; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity); Belongs to the COPG family. (873 aa)
sec22baVesicle-trafficking protein SEC22b-A; SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER. (215 aa)
sar1abSecretion-associated, Ras-related GTPase 1Ab; Belongs to the small GTPase superfamily. SAR1 family. (198 aa)
sec24dSEC24 homolog D, COPII coat complex component. (1030 aa)
pef1Peflin; Calcium-binding protein that acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protein complexes in response to calcium. Acts as a negative regulator of ER-Golgi transport (By similarity). (270 aa)
ap2s1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (142 aa)
dab2DAB adaptor protein 2. (589 aa)
zgc:101744Receptor expression-enhancing protein. (184 aa)
atp6v1dATPase, H+ transporting, V1 subunit D. (248 aa)
sec23bProtein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (766 aa)
dipk2aaDivergent protein kinase domain 2Aa. (432 aa)
copz1Coatomer subunit zeta; The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex. (198 aa)
atp6v0caV-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (154 aa)
necap1NECAP endocytosis-associated 1. (261 aa)
slc18a3aProbable vesicular acetylcholine transporter-A; Involved in acetylcholine transport into synaptic vesicles. Belongs to the major facilitator superfamily. Vesicular transporter family. (513 aa)
kdelr2aER lumen protein-retaining receptor 2; Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum (By similarity). Binding is pH dependent, and is optimal at pH 5-5.4 (By similarity). (212 aa)
arcn1aCoatomer subunit delta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (509 aa)
pdcd6Programmed cell death 6. (185 aa)
copeCoatomer subunit epsilon; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Belongs to the COPE family. (300 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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