(68 nodes) Cortical cytoskeleton organization network (Danio rerio)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	R4GED8_DANRE	Si:ch211-1f22.2. (190 aa)
	arf6a	ADP-ribosylation factor 6a. (175 aa)
	plek	Pleckstrin. (352 aa)
	rock2a	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1375 aa)
	pdcd6ip	Programmed cell death 6-interacting protein. (866 aa)
	fhod3b	Formin homology 2 domain-containing 3b. (847 aa)
	arf6b	ADP-ribosylation factor 6a; Belongs to the small GTPase superfamily. Arf family. (175 aa)
	fhod3a	Formin homology 2 domain-containing 3a. (1401 aa)
	rock1	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1359 aa)
	fhod1	Formin homology 2 domain-containing 1. (1387 aa)
	epb41a	Erythrocyte membrane protein band 4.1a. (914 aa)
	anln	Anillin, actin-binding protein. (1171 aa)
	LOC100331257	Uncharacterized protein. (172 aa)
	rhobtb2b	Rho-related BTB domain-containing 2b. (764 aa)
	fmnl2b	Formin-like 2b. (1129 aa)
	ENSDARP00000150236	Si:ch1073-416j23.1. (671 aa)
	rhoac	Rho-related GTP-binding protein RhoA-C; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. (193 aa)
	ENSDARP00000153262	Uncharacterized protein. (69 aa)
	rac1l-2	Rac family small GTPase 1,-like. (229 aa)
	epb41b	Erythrocyte membrane protein band 4.1 (Elliptocytosis 1, RH-linked). (1534 aa)
	nckap1	Nck-associated protein 1; Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1 (By similarity). (1134 aa)
	rnd2	Rho family GTPase 2. (234 aa)
	rac3a	Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3). (192 aa)
	epb41l3a	Erythrocyte membrane protein band 4.1-like 3a. (826 aa)
	rac3b	Rac family small GTPase 3b. (192 aa)
	si:dkey-6b12.5	Si:dkey-6b12.5. (619 aa)
	rac2	Rac family small GTPase 2. (219 aa)
	rhobtb1	Rho-related BTB domain-containing 1. (687 aa)
	rac1b	Ras-related C3 botulinum toxin substrate 1-like protein. (192 aa)
	rhogc	Ras homolog gene family, member Gc. (191 aa)
	rhobtb4	Rho-related BTB domain-containing 4. (716 aa)
	strip1	Striatin-interacting protein 1 homolog; May play a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape (By similarity). (876 aa)
	rnd3a	Rho family GTPase 3a. (243 aa)
	fmnl3	Formin-like protein 3; Required for developmental angiogenesis, but not for vasculogenesis; Belongs to the formin homology family. (1047 aa)
	E7FEE9_DANRE	Si:dkey-178k16.1. (881 aa)
	rac1a	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1). (192 aa)
	rhoca	Ras homolog gene family, member Ae. (193 aa)
	amotl2a	Angiomotin-like 2a; Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments and for cell movements during embryogenesis. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC. Belongs to the angiomotin family. (721 aa)
	NCKAP1L	Zgc:172352. (1123 aa)
	cdk5	Cyclin-dependent protein kinase 5; Belongs to the protein kinase superfamily. (292 aa)
	rhof	Ras homolog gene family, member F. (209 aa)
	ppp2r3c	Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma; Possible role in the regulation of cell death. (457 aa)
	rac1l	Rac family small GTPase 1,-like. (188 aa)
	ENSDARP00000052802	Si:dkey-30c15.10. (966 aa)
	rab13	Ras-related protein Rab-13; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may be involved in endocytic recycling and may regulate the transport to the plasma membrane of transmembrane proteins. May regulate the assembly and the activity of tight jun [...] (200 aa)
	rnd1a	Ras-like protein Rnd1b. (232 aa)
	rhoaa	Rho-related GTP-binding protein RhoA-A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. (193 aa)
	dlg1	Disks large homolog 1; Essential multidomain scaffolding protein required for normal development. Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherens junction assembly, signal transduction and cell proliferation (By similarity). May play a role in synapse assembly and function. Belongs to the MAGUK family. (909 aa)
	llgl2	LLGL scribble cell polarity complex component 2; Essential for hemidesmosome formation and maintenance of the cytoskeleton elements as well as cellular morphology in the basal epidermis during development. Also involved in regulating growth of the basal epidermis; Belongs to the WD repeat L(2)GL family. (1020 aa)
	rhogb	Ras homolog gene family, member Gb. (191 aa)
	rnd1b	Rho family GTPase 1 like. (232 aa)
	epb41l3b	Erythrocyte membrane protein band 4.1-like 3b. (838 aa)
	racgap1	Rac GTPase-activating protein 1. (654 aa)
	rhoab	Rho-related GTP-binding protein RhoA-B; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. (193 aa)
	rnd3b	Ras-like protein Rnd3b. (224 aa)
	tnfb	Tumor necrosis factor b (TNF superfamily, member 2). (242 aa)
	rhocb	Rho-related GTP-binding protein RhoA-D; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. (193 aa)
	fmnl2a	Formin-like 2a. (1077 aa)
	rhogd	Ras homolog gene family, member Ga. (191 aa)
	amotl2b	Angiomotin-like 2b. (681 aa)
	ENSDARP00000132302	Uncharacterized protein. (439 aa)
	EPB41L2	Si:ch73-18b11.1. (930 aa)
	dlg1l	Discs large homolog 1-like protein; May play a role in synapse assembly and function. (827 aa)
	rhoga	Ras homolog family member Ga. (191 aa)
	Rac1l	Si:ch211-1f22.1. (192 aa)
	fmnl1a	Formin-like 1a. (1085 aa)
	akap11	A kinase (PRKA) anchor protein 11. (1798 aa)
	rhobtb2a	Rho-related BTB domain-containing 2a. (470 aa)

Your Current Organism:

Danio rerio

NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
E7FEE9_DANRE	EPB41L2	ENSDARP00000099158	ENSDARP00000136665	Si:dkey-178k16.1.	Si:ch73-18b11.1.	0.596
E7FEE9_DANRE	epb41a	ENSDARP00000099158	ENSDARP00000143415	Si:dkey-178k16.1.	Erythrocyte membrane protein band 4.1a.	0.499
E7FEE9_DANRE	epb41l3a	ENSDARP00000099158	ENSDARP00000111490	Si:dkey-178k16.1.	Erythrocyte membrane protein band 4.1-like 3a.	0.511
ENSDARP00000052802	ENSDARP00000150236	ENSDARP00000052802	ENSDARP00000150236	Si:dkey-30c15.10.	Si:ch1073-416j23.1.	0.728
ENSDARP00000052802	ENSDARP00000153262	ENSDARP00000052802	ENSDARP00000153262	Si:dkey-30c15.10.	Uncharacterized protein.	0.457
ENSDARP00000052802	racgap1	ENSDARP00000052802	ENSDARP00000020703	Si:dkey-30c15.10.	Rac GTPase-activating protein 1.	0.728
ENSDARP00000052802	rhoaa	ENSDARP00000052802	ENSDARP00000040644	Si:dkey-30c15.10.	Rho-related GTP-binding protein RhoA-A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers.	0.477
ENSDARP00000052802	rhoab	ENSDARP00000052802	ENSDARP00000018377	Si:dkey-30c15.10.	Rho-related GTP-binding protein RhoA-B; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers.	0.477
ENSDARP00000052802	rhoac	ENSDARP00000052802	ENSDARP00000151463	Si:dkey-30c15.10.	Rho-related GTP-binding protein RhoA-C; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers.	0.477
ENSDARP00000052802	rhoca	ENSDARP00000052802	ENSDARP00000084961	Si:dkey-30c15.10.	Ras homolog gene family, member Ae.	0.477
ENSDARP00000052802	rhocb	ENSDARP00000052802	ENSDARP00000002761	Si:dkey-30c15.10.	Rho-related GTP-binding protein RhoA-D; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers.	0.477
ENSDARP00000052802	rhof	ENSDARP00000052802	ENSDARP00000071047	Si:dkey-30c15.10.	Ras homolog gene family, member F.	0.437
ENSDARP00000052802	rnd1a	ENSDARP00000052802	ENSDARP00000044985	Si:dkey-30c15.10.	Ras-like protein Rnd1b.	0.457
ENSDARP00000052802	rnd1b	ENSDARP00000052802	ENSDARP00000022232	Si:dkey-30c15.10.	Rho family GTPase 1 like.	0.457
ENSDARP00000052802	rnd3a	ENSDARP00000052802	ENSDARP00000102340	Si:dkey-30c15.10.	Rho family GTPase 3a.	0.457
ENSDARP00000052802	rnd3b	ENSDARP00000052802	ENSDARP00000018251	Si:dkey-30c15.10.	Ras-like protein Rnd3b.	0.457
ENSDARP00000150236	ENSDARP00000052802	ENSDARP00000150236	ENSDARP00000052802	Si:ch1073-416j23.1.	Si:dkey-30c15.10.	0.728
ENSDARP00000150236	anln	ENSDARP00000150236	ENSDARP00000143654	Si:ch1073-416j23.1.	Anillin, actin-binding protein.	0.728
ENSDARP00000150236	racgap1	ENSDARP00000150236	ENSDARP00000020703	Si:ch1073-416j23.1.	Rac GTPase-activating protein 1.	0.553
ENSDARP00000150236	rhoab	ENSDARP00000150236	ENSDARP00000018377	Si:ch1073-416j23.1.	Rho-related GTP-binding protein RhoA-B; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers.	0.441

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