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| | epha4l | Eph receptor A4,-like. (988 aa) |
| | sim1b | SIM bHLH transcription factor 1b. (586 aa) |
| | pcsk1 | Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family. (755 aa) |
| | nkx2.7 | NK2 transcription factor-related 7. (269 aa) |
| | gbx2 | Gastrulation brain homeo box 2. (342 aa) |
| | efhc1 | EF-hand domain (C-terminal)-containing 1. (554 aa) |
| | pex13 | Peroxisomal biogenesis factor 13. (416 aa) |
| | xab2 | Similar to Xab2 protein. (851 aa) |
| | tnr | Tenascin R (Restrictin, janusin). (1350 aa) |
| | gli2a | GLI family zinc finger 2a. (1439 aa) |
| | chd8 | Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/tp53-mediated apoptosis by recruiting histone H1 and preventing p53/tp53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (ctnnb1) activity. Negatively regulates ctnnb1-targeted gene expression by being recruited specifically to the promoter regions of several ctnnb1 responsive [...] (2555 aa) |
| | wnt7ba | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa) |
| | btbd3a | BTB (POZ) domain-containing 3a. (461 aa) |
| | dla | Delta-like protein A; Acts as a ligand for Notch receptors and is involved in primary neurogenesis. Can activate Notch receptors, thereby playing a key role in lateral inhibition, a process that prevents the immediate neighbors of each nascent neural cell from simultaneously embarking on neural differentiation. Required for boundary formation during segmentation of the hindbrain. Required for midline cell fate specification prior to germ layer formation; regulates specification of floorplate, notochord and hypochord. In inner ear, it prevents adjacent cells from adopting the same cell [...] (772 aa) |
| | smo | Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (822 aa) |
| | pax4 | Paired box 4. (344 aa) |
| | F1QTH1_DANRE | Uncharacterized protein. (470 aa) |
| | gli2b | GLI family zinc finger 2b. (1225 aa) |
| | dkk1a | Dickkopf WNT-signaling pathway inhibitor 1a. (256 aa) |
| | lhx6 | LIM homeobox 6. (375 aa) |
| | mdkb | Midkine-related growth factor Mdk2. (147 aa) |
| | emx3 | Empty spiracles homeobox 3. (233 aa) |
| | tbr1b | T-box brain transcription factor 1b. (676 aa) |
| | foxg1b | Forkhead box G1b. (341 aa) |
| | lhx1a | LIM/homeobox protein Lhx1; Seems to play a role in dorsal axis formation. (405 aa) |
| | dlb | Delta-like protein B; Acts as a ligand for Notch receptors and is involved in primary neurogenesis. Can activate Notch receptors, thereby playing a key role in lateral inhibition, a process that prevents the immediate neighbors of each nascent neural cell from simultaneously embarking on neural differentiation. (615 aa) |
| | mettl3 | N6-adenosine-methyltransferase subunit METTL3; The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some RNAs and regulates various processes such as the circadian clock, differentiation of embryonic and hematopoietic stem cells, cortical neurogenesis, response to DNA damage, differentiation of T-cells and primary miRNA processing. In the heterodimer formed with mettl14, mettl3 constitutes the catalytic core (By similarity). N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some [...] (584 aa) |
| | tacc3 | Transforming, acidic coiled-coil-containing protein 3. (942 aa) |
| | mpp5b | Membrane protein, palmitoylated 5b (MAGUK p55 subfamily member 5); Belongs to the MAGUK family. (639 aa) |
| | xrcc1 | X-ray repair-complementing defective repair in Chinese hamster cells 1. (617 aa) |
| | mkks | McKusick-Kaufman syndrome. (563 aa) |
| | lhx1b | LIM class homeodomain protein. (402 aa) |
| | hsd3b2 | Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2; Belongs to the 3-beta-HSD family. (374 aa) |
| | lhx8a | LIM homeobox 8a. (332 aa) |
| | six1b | Homeobox protein six1b; Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Depending on context, functions as transcriptional repressor or activator. Transcriptional activation is enhanced by eya1 (in vitro). Plays an important role in the development of the inner ear, where it promotes hair cell proliferation and inhibits proliferation of neural progenitor cells. Required for normal myogenesis. Plays a role in the development of fast muscle fibers throughout the body, as well as the development of craniofacial muscles. R [...] (284 aa) |
| | mycbp2 | E3 ubiquitin-protein ligase MYCBP2; Atypical E3 ubiquitin-protein ligase which specifically mediates ubiquitination of threonine and serine residues on target proteins, instead of ubiquitinating lysine residues (By similarity). Shows esterification activity towards both threonine and serine, with a preference for threonine, and acts via two essential catalytic cysteine residues that relay ubiquitin to its substrate via thioester intermediates (By similarity). Interacts with the E2 enzymes UBE2D1, UBE2D3, UBE2E1 and UBE2L3 (By similarity). Plays a key role in neural development, probabl [...] (4574 aa) |
| | six6a | Sine oculis-related homeobox 6a. (245 aa) |
| | sim1a | Single-minded homolog 1-A; Transcriptional factor that may have pleiotropic effects during embryogenesis and in the adult. (745 aa) |
| | sec61a1 | Protein transport protein Sec61 subunit alpha-like 1; Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adapter proteins (By similarity). Plays a role in the pronephric kidney tubule development. (476 aa) |
| | nf2b | Neurofibromin 2b (merlin). (586 aa) |
| | tsc1a | TSC complex subunit 1a. (1128 aa) |
| | rtn4r | Reticulon 4 receptor. (479 aa) |
| | aqp1a.1 | Aquaporin 1a (Colton blood group), tandem duplicate 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (260 aa) |
| | crkl | V-crk sarcoma virus CT10 oncogene homolog (Avian)-like. (305 aa) |
| | uqcrq | Ubiquinol-cytochrome c reductase, complex III subunit VII. (82 aa) |
| | SCYL2 | Si:ch211-244b2.1. (929 aa) |
| | tbr1a | T-box brain transcription factor 1a. (585 aa) |
| | cyp26a1 | Cytochrome P450 26A1; A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomer [...] (492 aa) |
| | ttc21b | Tetratricopeptide repeat domain 21B. (1321 aa) |
| | wnt8b | Protein Wnt-8b; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. May play a role in the establishment of polarity in the nervous system. (358 aa) |
| | C10H21orf91 | Protein EURL homolog; Plays a role in cortical progenitor cell proliferation and differentiation. May promote dendritic spine development of post- migratory cortical projection neurons by modulating the beta-catenin signaling pathway. (277 aa) |
| | notch1b | Notch receptor 1b. (2465 aa) |
| | mdka | Midkine-related growth factor Mdk1. (146 aa) |
| | Q1LWT0_DANRE | Cyclin-dependent kinase 5 activator. (317 aa) |
| | pitx2 | Pituitary homeobox 2; Isoform a and isoform c differentially regulate mesendoderm formation and asymmetric organ development. Both isoforms regulate left-right development, but isoform a has a stronger effect on heart laterality; Belongs to the paired homeobox family. Bicoid subfamily. (314 aa) |
| | hsd3b7 | Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase; Belongs to the 3-beta-HSD family. (368 aa) |
| | lhx9 | LIM/homeobox protein Lhx9; May be involved in gonadal development. (396 aa) |
| | cdk5r1a | Cyclin-dependent kinase 5 activator. (306 aa) |
| | ascl1a | Achaete-scute homolog 1a; Transcriptional regulator. May mediate transcription activation by binding to the E box-containing promoter (By similarity). Involved in neurogenesis. Required for the development of neurons in the epiphysis, acting partially redundantly with neurog1 and downstream of flh. Involved in maintaining rhombomere boundaries in the hindbrain, probably via up-regulation of delta expression. Also involved in pituitary development; required cell-autonomously in adenohypophyseal cells for endocrine differentiation and for survival of a subset of cells. (196 aa) |
| | nrp2b | Neuropilin; Belongs to the neuropilin family. (920 aa) |
| | shhb | Tiggy-winkle hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Involved in dorso-ventral patterning of the brain and in early patterning of the developing eyes. (416 aa) |
| | dmrta2 | Doublesex- and mab-3-related transcription factor A2; May be involved in sexual development; Belongs to the DMRT family. (440 aa) |
| | emx2 | Empty spiracles homeobox 2. (247 aa) |
| | gli3 | GLI family zinc finger 3. (1553 aa) |
| | F1QSV1_DANRE | Si:ch73-352p4.8. (492 aa) |
| | hsd3b1 | Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1; Belongs to the 3-beta-HSD family. (374 aa) |
| | fgf16 | Fibroblast growth factor 16; Plays a crucial role in pectoral fin bud outgrowth. Belongs to the heparin-binding growth factors family. (203 aa) |
| | gsx2 | GS homeobox 2. (242 aa) |
| | disp1 | Protein dispatched homolog 1; Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal. Synergizes with SCUBE2 to cause an increase in SHH secretion (By similarity); Belongs to the dispatched family. (1464 aa) |
| | wnt7aa | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa) |
| | cdk5r1b | Cyclin-dependent kinase 5 activator. (304 aa) |
| | dkk1b | Dickkopf WNT-signaling pathway inhibitor 1b. (241 aa) |
| | rx3 | Retinal homeobox protein Rx3; Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation. (292 aa) |
| | bmp4 | Bone morphogenetic protein 4. (400 aa) |
| | srfa | Serum response factor a. (539 aa) |
| | six3b | Sine oculis homeobox homolog 3b. (293 aa) |
| | badb | BCL2-associated agonist of cell death b. (147 aa) |
| | foxh1 | Forkhead box protein H1; Transcriptional activator. Activates an activin response element (ARE). Recognizes and binds to the DNA sequence 5'- TGT[GT][GT]ATT-3'. Modulator of nodal signaling required for organizer formation. Also required for the development of dorsal axial structures and left-right symmetry. (472 aa) |
| | crk | V-crk sarcoma virus CT10 oncogene homolog (Avian). (311 aa) |
| | npas4a | Neuronal PAS domain-containing protein 4A; Transcription factor expressed in neurons of the brain that regulates the excitatory-inhibitory balance within neural circuits and is required for contextual memory in the hyppocampus. Plays a key role in the structural and functional plasticity of neurons. Acts as an early-response transcription factor in both excitatory and inhibitory neurons, where it induces distinct but overlapping sets of late- response genes in these two types of neurons, allowing the synapses that form on inhibitory and excitatory neurons to be modified by neuronal act [...] (933 aa) |
| | zswim5 | Zinc finger, SWIM-type-containing 5. (1151 aa) |
| | neurog1 | Neurogenin-1; Transcriptional regulator. Activates transcription by binding to the E box-containing promoter (By similarity). Mediates neuronal differentiation. Required for the development of Rohon-Beard spinal sensory neurons and dorsal root ganglion neurons, but not for primary motoneurons or autonomic neurons. Required for development of all cranial ganglia but not associated glial cells. Regulates epiphysial neurogenesis, acting partially redundantly with ascl1a and downstream of flh. Required for the development of basal forebrain dopaminergic neurons; involved in the specificati [...] (208 aa) |
| | dixdc1a | Dixin-A; Functions as a positive effector of the Wnt signaling pathway regulating antero-posterior neural patterning. (443 aa) |
| | cdk5 | Cyclin-dependent protein kinase 5; Belongs to the protein kinase superfamily. (292 aa) |
| | ryk | Receptor-like tyrosine kinase. (604 aa) |
| | lhx5 | LIM/homeobox protein Lhx5; Probably involved in the patterning of the nervous system, in particular in the early specification of the diencephalon. (399 aa) |
| | six3a | Sine oculis homeobox homolog 3a. (294 aa) |
| | arxa | Aristaless-related homeobox protein; Appears to be indispensable for the central nervous system development. May have a role in the neuronal differentiation of the ganglionic eminence and ventral thalamus. May also be involved in axonal guidance in the floor plate; Belongs to the paired homeobox family. Bicoid subfamily. (453 aa) |
| | vax2 | Ventral anterior homeobox 2; Transcription factor that may function in dorsoventral specification of the forebrain. Required for closure of the choroid fissure and together with vax1 is required for optic nerve differentiation and to limit retinal development to the optic cup. Belongs to the EMX homeobox family. (307 aa) |
| | akirin2 | Akirin 2. (180 aa) |
| | LOC568110 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa) |
| | arnt | Aryl hydrocarbon receptor nuclear translocator. (728 aa) |
| | dpcd | Protein DPCD; Belongs to the DPCD family. (200 aa) |
| | kdm1a | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (833 aa) |
| | kif14 | Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1506 aa) |
| | tacc1 | Transforming, acidic coiled-coil-containing protein 1. (757 aa) |
| | atf5a | Activating transcription factor 5a. (511 aa) |
| | tcf7l1a | Transcription factor 7-like 1-A; Participates in the Wnt signaling pathway. Probably binds to DNA and acts as a repressor in the absence of ctnnb1, and possibly as an activator in its presence. Required early in development for dorsal specific gene activation and during gastrulation for repression of dorsal-specific genes in the marginal zone. Required for head formation and forebrain specification. Regulates anterior-posterior patterning in the neuroectoderm by repressing posterior neural fates. Belongs to the TCF/LEF family. (560 aa) |
| | bsx | Brain-specific homeobox protein homolog; DNA binding protein that function as transcriptional activator. May play a role in the determination and function of cell types in the brain; Belongs to the distal-less homeobox family. (227 aa) |
| | arl13b | ADP-ribosylation factor-like protein 13B; Cilium-specific protein required to control the microtubule- based, ciliary axoneme structure. May act by maintaining the association between IFT subcomplexes A and B. Binds GTP but is not able to hydrolyze it; the GTPase activity remains unclear. Required to pattern the neural tube. Involved in cerebral cortex development: required for the initial formation of a polarized radial glial scaffold, the first step in the construction of the cerebral cortex, by regulating ciliary signaling. Regulates the migration and placement of postmitotic intern [...] (407 aa) |
| | pitx3 | Pituitary homeobox 3; Transcriptional regulator which may play a role in the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons (By similarity). Required for lens and retinal development and for pituitary pre-placode formation and cell specification; Belongs to the paired homeobox family. Bicoid subfamily. (293 aa) |
| | six7 | Sine oculis homeobox homolog 7. (256 aa) |
| | mettl14 | N6-adenosine-methyltransferase non-catalytic subunit; The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with mettl3, mettl14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing. (455 aa) |
| | numb | NUMB endocytic adaptor protein. (680 aa) |
| | fezf2 | Fez family zinc finger protein 2; Transcription repressor. Component of the regulatory cascade that controls the development of dopaminergic (DA) and serotonergic (5HT) neurons. (438 aa) |
| | foxg1a | Forkhead box G1a. (420 aa) |
| | vsx1 | Visual system homeobox 1; May be involved in maintenance as well as cellular differentiation of retinal interneurons, such as bipolar cells. May play a role in establishing interneuronal cell classes in nonsensory as well as sensory systems; Belongs to the paired homeobox family. (340 aa) |
| | sox2 | Transcription factor Sox-2; Transcriptional activator. May function as a switch in neuronal development (By similarity). Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). (315 aa) |
| | sox14 | Transcription factor Sox-14; Acts as a negative regulator of transcription. May function as a switch in neuronal development (By similarity). (238 aa) |
| | ccdc85ca | Coiled-coil domain-containing protein 85C-A; May play a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family (By similarity). May play an important role in cortical development, especially in the maintenance of radial glia (By similarity); Belongs to the CCDC85 family. (391 aa) |
| | wnt4 | Protein Wnt-4a; Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Plays an important role in embryonic development. (352 aa) |
| | zgc:152977 | Zgc:152977. (574 aa) |
| | zdhhc15b | Palmitoyltransferase ZDHHC15B; Catalyzes palmitoylation of Cys residues on target proteins. (332 aa) |
| | ccdc85cb | Coiled-coil domain-containing protein 85C-B; May play a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family (By similarity). May play an important role in cortical development, especially in the maintenance of radial glia (By similarity); Belongs to the CCDC85 family. (400 aa) |
| | cdk5r2b | Cyclin-dependent kinase 5 activator. (302 aa) |
| | foxg1d | Forkhead box G1d. (316 aa) |
| | sall1a | Spalt-like transcription factor 1a. (1313 aa) |
| | sall3a | Spalt-like transcription factor 3a. (1322 aa) |
| | bbs1 | Bardet-Biedl syndrome 1. (588 aa) |
| | cdk5r2a | Cyclin-dependent kinase 5 activator. (308 aa) |
| | tctn1 | Tectonic family member 1. (534 aa) |
| | bbs4 | Bardet-Biedl syndrome 4. (528 aa) |
| | dzip1 | Zinc finger protein Dzip1; Acts as a permissive factor that is required for the proper regulation of Hedgehog (Hh) target genes in response to Hh signals. Acts downstream of the Smoothened protein to modulate Gli activity in the somites of the developing embryo. Required for establishment of left-right asymmetry during embryogenesis. Has a role in primary cilium formation. (897 aa) |
| | atrx | ATRX chromatin remodeler. (2013 aa) |
| | nrg3b | Neuregulin 3b. (764 aa) |
| | rbfox1 | RNA binding protein fox-1 homolog 1; RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Regulates alternative splicing of tissue-specific exons (By similarity). (373 aa) |
| | rpgrip1l | RPGRIP1-like. (1256 aa) |
| | si:dkey-1m11.5 | Si:dkey-1m11.5. (619 aa) |
| | BMERB1 | Zgc:114175. (184 aa) |
| | tbx2b | T-box transcription factor TBX2b; Involved in the transcriptional regulation of genes required for mesoderm differentiation. Plays a role in the specification of late notochordal precursor cells and formation of the differentiated notochord. Required for cardiac atrioventricular canal formation. (687 aa) |
| | fez1 | Fasciculation and Elongation protein zeta 1 (Zygin I). (394 aa) |
| | btbd3b | BTB (POZ) domain-containing 3b. (535 aa) |
| | sema7a | Semaphorin 7A; Belongs to the semaphorin family. (640 aa) |
| | aqp1a.2 | Aquaporin 1a (Colton blood group), tandem duplicate 2; Belongs to the MIP/aquaporin (TC 1.A.8) family. (269 aa) |
| | tmem108 | Transmembrane protein 108. (524 aa) |
| | six6b | Sine oculis-related homeobox 6b. (245 aa) |
| | sun1 | Sad1 and UNC84 domain-containing 1. (997 aa) |
| | cep120 | Centrosomal protein 120. (929 aa) |
| | prop1 | PROP paired-like homeobox 1. (242 aa) |
| | foxg1c | Forkhead box G1c. (379 aa) |
| | lef1 | Lymphocyte enhancer binding factor 1 Lef1. (365 aa) |
| | setd2 | SET domain-containing 2, histone lysine methyltransferase. (2737 aa) |
| | jakmip2 | Janus kinase and microtubule-interacting protein 2. (841 aa) |
| | ptchd4 | Patched domain-containing protein 1. (897 aa) |
| | htr6 | 5-hydroxytryptamine (serotonin) receptor 6; Belongs to the G-protein coupled receptor 1 family. (472 aa) |
| | E7F184_DANRE | Si:dkey-92f12.2. (577 aa) |
| | dclk1a | Doublecortin-like kinase 1a. (770 aa) |
| | gdf7 | Growth differentiation factor 7. (396 aa) |
| | zdhhc16a | Palmitoyltransferase ZDHHC16A; Palmitoyl acyltransferase that mediates palmitoylation of proteins and is required during embryonic heart development. Involved in the proliferation of neural stem cells by regulating the FGF/ERK pathway (By similarity). Involved in the proliferation of neural stem cells by regulating the FGF/ERK pathway. (387 aa) |
| | tsc1b | TSC complex subunit 1b. (1228 aa) |
| | nf1b | Neurofibromin 1b. (2759 aa) |
| | nf2a | Similar to neurofibromin 2. (593 aa) |
| | LOC799481 | LIM homeobox 8b. (238 aa) |
| | nars1 | Asparaginyl-tRNA synthetase. (556 aa) |
| | akna | AT-hook transcription factor. (1452 aa) |
| | zdhhc20b | Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (385 aa) |
| | otpa | Orthopedia homeobox a. (332 aa) |
| | pgap1 | GPI inositol-deacylase; Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI- anchored proteins from the endoplasmic reticulum to the Golgi. (952 aa) |
| | otpb | Homeobox protein orthopedia B; Involved in the specification of isotocin cells. Required for the specification of dopaminergic neurons in the developing hypothalamus and posterior tuberculum; Belongs to the paired homeobox family. Bicoid subfamily. (328 aa) |
| | lhx2b | LIM homeobox 2b. (427 aa) |
| | mpp5a | MAGUK p55 subfamily member 5-A; Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells (By similarity). Also involved in adherens junction biogenesis (By similarity). Functions in cellular patterning of the retina. (703 aa) |
| | epha4a | Ephrin type-A receptor 4a; Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI- anchored ephrin-A and transmembrane ephrin-B ligands including efna1 and efnb3. [...] (995 aa) |
| | sall1b | Spalt-like transcription factor 1b. (1203 aa) |
| | F8W238_DANRE | Si:ch211-113g11.6; Belongs to the semaphorin family. (474 aa) |
| | disc1 | DISC1 scaffold protein. (994 aa) |
| | shha | Sonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (418 aa) |
| | mcph1 | Microcephalin 1. (463 aa) |
| | nin | Ninein (GSK3B-interacting protein). (1954 aa) |
| | nf1a | Neurofibromin 1a. (2759 aa) |
| | si:dkey-1m11.6 | Si:dkey-1m11.6. (1647 aa) |
| | wnt7bb | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa) |
| | gli1 | GLI family zinc finger 1. (1404 aa) |
| | med12 | Mediator of RNA polymerase II transcription subunit 12; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Require [...] (2175 aa) |
| | TRAPPC9 | Si:dkey-218f9.10. (995 aa) |
| | appa | Amyloid beta (A4) precursor protein a. (194 aa) |
| | numbl | NUMB-like endocytic adaptor protein. (618 aa) |
| | draxin | Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord; Belongs to the draxin family. (360 aa) |
| | zdhhc15a | Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (328 aa) |
| | dclk1b | Doublecortin-like kinase 1b. (746 aa) |
| | agtpbp1 | Cytosolic carboxypeptidase 1; Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate. (1153 aa) |
| | fgf3 | Fibroblast growth factor 3; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Belongs to the heparin-binding growth factors family. (256 aa) |
| | mib1 | E3 ubiquitin-protein ligase mib1; E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. It thereby participates in many processes regulated by the Notch signaling pathway, such as midline cell fate specification prior to germ layer formation, patterning of sensory cell differentiation in the ear, neurogenesis of the hindbrain and commitment to a secretory fate in the intesti [...] (1041 aa) |
| | zswim6 | Zinc finger, SWIM-type-containing 6. (998 aa) |
| | srfb | Serum response factor b. (260 aa) |
| | ENSDARP00000134495 | Uncharacterized protein; Belongs to the semaphorin family. (482 aa) |
| | slc1a2b | Amino acid transporter. (564 aa) |
| | rtn4rl1b | Reticulon 4 receptor-like 1b. (474 aa) |
| | axin1 | Axin-1; Component of the beta-catenin destruction complex required for regulating ctnnb1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects: down- regulates ctnnb1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. (835 aa) |
| | pax6a | Paired box protein Pax-6; Transcription factor expressed in spatially restricted regions of the neural tube during embryonic development; Belongs to the paired homeobox family. (451 aa) |
| | agbl1 | ATP/GTP-binding protein-like 1. (1028 aa) |
| | pcm1 | Pericentriolar material 1. (2018 aa) |
| | arnt2 | Aryl hydrocarbon receptor nuclear translocator 2; Transcription factor that plays a role in the development of the hypothalamo-pituitary axis. Specifically recognizes the xenobiotic response element (XRE) (By similarity). Isoform 1 acts as a transcriptional activator. Isoform 3 acts as a transcriptional repressor. (737 aa) |
| | lgr4 | Leucine-rich repeat-containing G-protein coupled receptor 4; Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activat [...] (971 aa) |
| | atrxl | ATRX chromatin remodeler,-like. (1760 aa) |
| | arxb | Aristaless-related homeobox b. (385 aa) |
| | e2f1 | E2F transcription factor 1. (429 aa) |
| | notch1a | Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] (2438 aa) |
| | lrrc45 | Leucine-rich repeat-containing 45. (674 aa) |
| | ttc8 | Tetratricopeptide repeat domain 8. (268 aa) |
| | slc1a9 | Amino acid transporter. (424 aa) |
| | bcan | Brevican. (1295 aa) |
| | aplp1 | Amyloid beta (A4) precursor-like protein 1. (723 aa) |
| | Szt2 | Uncharacterized protein. (111 aa) |
| | eomesb | Eomesodermin homolog b. (534 aa) |
| | uchl5 | Ubiquitin carboxyl-terminal hydrolase. (329 aa) |
| | tbxta | T-box transcription factor T-A; Involved in the transcriptional regulation of genes required for mesoderm differentiation, including itself. Indispensable for the formation of the notochord and the tail structure. Functions together with tbx16/spadetail in development of trunk and tail mesoderm. Functions by itself early in development to repress medial floor plate and promote notochord fate but at later times, functions together with tbx16/spadetail to promote medial floor plate formation. Acts in a parallel pathway to, but cooperates with, non-canonical wnt-signaling during tail form [...] (423 aa) |
| | trappc9 | Trafficking protein particle complex 9. (133 aa) |
| | slc7a11 | Solute carrier family 7 member 11. (498 aa) |
| | si:ch73-40a2.1 | Si:ch73-40a2.1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (723 aa) |
| | slc1a2a | Amino acid transporter. (548 aa) |
| | bmp16 | Bone morphogenetic protein 16. (416 aa) |
| | Reln | Reelin domain-containing protein. (259 aa) |
| | ENSDARP00000146009 | CUB domain-containing protein. (101 aa) |
| | eomesa | T-box transcription factor eomesodermin. (661 aa) |
| | msx1a | Muscle segment homeobox 1a. (233 aa) |
| | dixdc1b | DIX domain-containing 1b. (685 aa) |
| | fat4 | FAT atypical cadherin 4. (4531 aa) |
| | cntn2 | Contactin 2. (1040 aa) |
| | ENSDARP00000151118 | HMG box domain-containing protein. (229 aa) |
| | jakmip1 | Janus kinase and microtubule-interacting protein 1. (824 aa) |
| | ZNF335 | Si:ch211-269m15.3. (1534 aa) |
| | ndnf | Neuron-derived neurotrophic factor. (585 aa) |
| | pax6b | Paired box 6b. (450 aa) |
| | rtn4rl1a | Reticulon 4 receptor-like 1a. (419 aa) |
| | rapgef2 | Rap guanine nucleotide exchange factor (GEF) 2. (1619 aa) |
| | ptchd1 | Patched domain-containing protein 1. (887 aa) |
| | rapgef6 | Rap guanine nucleotide exchange factor (GEF) 6. (1261 aa) |
