STRINGSTRING
yod1 yod1 atf6 atf6 creb3l1 creb3l1 parp16 parp16 ern1 ern1 crybg1b crybg1b creb3l3l creb3l3l eif2s1a eif2s1a atf3 atf3 pkz pkz derl1 derl1 herpud2 herpud2 derl3 derl3 atf4b atf4b derl2 derl2 nfe2l2a nfe2l2a tbl2 tbl2 eif2s1b eif2s1b ddit3 ddit3 selenos selenos wfs1a wfs1a ppp1r15a ppp1r15a SERP1 SERP1 bhlha15 bhlha15 dnajc10 dnajc10 erlec1 erlec1 nfe2l2b nfe2l2b xbp1 xbp1 tmtc4 tmtc4 LOC100334396 LOC100334396 creb3l3b creb3l3b serp2 serp2 creb3l3a creb3l3a rhbdd2 rhbdd2 cdk5rap3 cdk5rap3 ern2 ern2 zgc:85858 zgc:85858 os9 os9 eif2ak3 eif2ak3 tmed2 tmed2 wfs1b wfs1b herpud1 herpud1 ep300b ep300b creb3l2 creb3l2 hspa5 hspa5 eif2ak2 eif2ak2 si:dkey-26m3.1 si:dkey-26m3.1 serp1 serp1 ep300a ep300a F1QA69_DANRE F1QA69_DANRE atf4a atf4a ENSDARP00000151512 ENSDARP00000151512 ENSDARP00000157534 ENSDARP00000157534
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
yod1Ubiquitin thioesterase OTU1; Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. A [...] (301 aa)
atf6Activating transcription factor 6. (653 aa)
creb3l1cAMP-responsive element-binding protein 3-like 1. (526 aa)
parp16Poly [ADP-ribose] polymerase. (328 aa)
ern1Endoplasmic reticulum to nucleus-signaling 1. (1031 aa)
crybg1bCrystallin beta-gamma domain-containing 1b; Belongs to the beta/gamma-crystallin family. (3043 aa)
creb3l3lcAMP-responsive element-binding protein 3-like 3 like. (503 aa)
eif2s1aEukaryotic translation initiation factor 2, subunit 1 alpha, like. (315 aa)
atf3Activating transcription factor 3. (202 aa)
pkzProtein kinase-containing Z-DNA-binding domains. (511 aa)
derl1Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (261 aa)
herpud2Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein; Could be involved in the unfolded protein response (UPR) pathway. (397 aa)
derl3Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (247 aa)
atf4bActivating transcription factor 4b. (425 aa)
derl2Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (239 aa)
nfe2l2aNuclear factor (Erythroid-derived 2)-like 2. (586 aa)
tbl2Transducin beta-like 2. (439 aa)
eif2s1bEukaryotic translation initiation factor 2, subunit 1 alpha b. (315 aa)
ddit3DNA-damage-inducible transcript 3. (242 aa)
selenosSelenoprotein S; Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner (By similarity). (190 aa)
wfs1aWolfram syndrome 1a (wolframin). (814 aa)
ppp1r15aProtein phosphatase 1, regulatory subunit 15A. (319 aa)
SERP1Stress-associated endoplasmic reticulum protein; May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation. Belongs to the RAMP4 family. (65 aa)
bhlha15Basic helix-loop-helix family, member a15. (184 aa)
dnajc10DnaJ (Hsp40) homolog, subfamily C, member 10. (791 aa)
erlec1Endoplasmic reticulum lectin 1. (425 aa)
nfe2l2bNuclear factor, erythroid 2-like 2b. (507 aa)
xbp1Transcription factor Treb5. (263 aa)
tmtc4Transmembrane O-mannosyltransferase targeting cadherins 4. (739 aa)
LOC100334396Uncharacterized protein. (415 aa)
creb3l3bCyclic AMP-responsive element-binding protein 3-like protein 3-B. (388 aa)
serp2Stress-associated endoplasmic reticulum protein; May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation. Belongs to the RAMP4 family. (65 aa)
creb3l3aProcessed cyclic AMP-responsive element-binding protein 3-like protein 3-B; Transcriptional activator. Binds the cAMP response element (CRE). Activates transcription through box-B element and CRE. Seems to function synergistically with atf6 (By similarity). (460 aa)
rhbdd2Rhomboid domain-containing 2. (380 aa)
cdk5rap3CDK5 regulatory subunit-associated protein 3. (507 aa)
ern2Endoplasmic reticulum to nucleus-signaling 2. (927 aa)
zgc:85858Stress-associated endoplasmic reticulum protein; May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation. Belongs to the RAMP4 family. (66 aa)
os9OS9 endoplasmic reticulum lectin. (703 aa)
eif2ak3Eukaryotic translation initiation factor 2-alpha kinase 3. (1099 aa)
tmed2Transmembrane p24-trafficking protein 2. (208 aa)
wfs1bWolfram syndrome 1b (wolframin). (895 aa)
herpud1Homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1. (402 aa)
ep300bE1A-binding protein p300 b. (2615 aa)
creb3l2Processed cyclic AMP-responsive element-binding protein 3-like protein 2; Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/mbtps1 and S2P/mbtps2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific [...] (519 aa)
hspa5Immunoglobulin binding protein; Belongs to the heat shock protein 70 family. (650 aa)
eif2ak2Eukaryotic translation initiation factor 2-alpha kinase 2. (682 aa)
si:dkey-26m3.1Si:dkey-26m3.1. (268 aa)
serp1Stress-associated endoplasmic reticulum protein; May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation. Belongs to the RAMP4 family. (66 aa)
ep300aE1A-binding protein p300 a. (2679 aa)
F1QA69_DANREBZIP domain-containing protein. (559 aa)
atf4aCyclic AMP-dependent transcription factor ATF-4; Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. May play a role in the regulation of the circadian clock (By similarity). (339 aa)
ENSDARP00000151512Peptidase_M28 domain-containing protein. (272 aa)
ENSDARP00000157534Uncharacterized protein. (264 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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