STRINGSTRING
tnnt2b tnnt2b csrp1a csrp1a cnn1a cnn1a phactr1 phactr1 klhl41b klhl41b nkx2.5 nkx2.5 chrnd chrnd tmod2 tmod2 rhoab rhoab qki2 qki2 racgap1 racgap1 epb41l3b epb41l3b hsp90aa1.1 hsp90aa1.1 orai1b orai1b unc45b unc45b naca naca hsp90aa1.2 hsp90aa1.2 tcap tcap epb41b epb41b cdc42bpab cdc42bpab myh11a myh11a tnnt2c tnnt2c csrp1b csrp1b cdc42bpb cdc42bpb myoz2a myoz2a cnn2 cnn2 ENSDARP00000052802 ENSDARP00000052802 ache ache cul3a cul3a cnn3b cnn3b epb41l4a epb41l4a myoz1a myoz1a adprhl1 adprhl1 lmod2a lmod2a alkbh4 alkbh4 srfa srfa LOC101887017 LOC101887017 ldb3a ldb3a bves bves epb41l4b epb41l4b myo18ab myo18ab megf11 megf11 lmod3 lmod3 myh9b myh9b rock2b-2 rock2b-2 f11r.2 f11r.2 klhl41a klhl41a tnnt3a tnnt3a lrrc39 lrrc39 fam171a1 fam171a1 FRMD1 FRMD1 fam171a2a fam171a2a LOC797104 LOC797104 E7FEE9_DANRE E7FEE9_DANRE f11r.1 f11r.1 FRMD5 FRMD5 Dmpk Dmpk mylk3 mylk3 tmod1 tmod1 frmd5 frmd5 lmod1b lmod1b nrap nrap epb41l3a epb41l3a tmod4 tmod4 zyx zyx myh14 myh14 fhdc3 fhdc3 frmd3 frmd3 csrp2 csrp2 lmod2b lmod2b neb neb frmd6 frmd6 fhdc1 fhdc1 myo18aa myo18aa tnnt2d tnnt2d limch1a limch1a tnnt3b tnnt3b pdcd6ip pdcd6ip rock2a rock2a epb41l5 epb41l5 F1QHP3_DANRE F1QHP3_DANRE myoz2b myoz2b elnb elnb myh9a myh9a LOC101882071 LOC101882071 tnnt2a tnnt2a fam171b fam171b myh10 myh10 U3JAK2_DANRE U3JAK2_DANRE flii flii fhdc4 fhdc4 LOC108190739 LOC108190739 ENSDARP00000130960 ENSDARP00000130960 cnn3a cnn3a cul3b cul3b fhdc2 fhdc2 cdc42bpaa cdc42bpaa tpcn2 tpcn2 tnnt2e tnnt2e myh11b myh11b srfb srfb limch1b limch1b cnn1b cnn1b LOC100334697 LOC100334697 EPB41L2 EPB41L2 rock2b rock2b csrp3 csrp3 qkia qkia rock1 rock1 rock2bl rock2bl dusp27 dusp27 epb41a epb41a anln anln tnnt1 tnnt1 WDR1 WDR1 phactr4a-2 phactr4a-2 qkib qkib ENSDARP00000150236 ENSDARP00000150236 megf10 megf10 ENSDARP00000155954 ENSDARP00000155954
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
tnnt2bTroponin T type 2b (cardiac). (233 aa)
csrp1aCysteine and glycine-rich protein 1a. (192 aa)
cnn1aCalponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (287 aa)
phactr1Phosphatase and actin regulator. (542 aa)
klhl41bKelch-like protein 41b; Involved in skeletal muscle development and maintenance. (605 aa)
nkx2.5NK2 homeobox 5. (314 aa)
chrndCholinergic receptor, nicotinic, delta (muscle). (518 aa)
tmod2Tropomodulin 2. (344 aa)
rhoabRho-related GTP-binding protein RhoA-B; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. (193 aa)
qki2Protein quaking-B; RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs which promotes oligodendrocyte differentiation. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of some pre-mRNA. Acts as a translational repressor (By similarity). (319 aa)
racgap1Rac GTPase-activating protein 1. (654 aa)
epb41l3bErythrocyte membrane protein band 4.1-like 3b. (838 aa)
hsp90aa1.1Heat shock protein HSP 90-alpha 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a [...] (725 aa)
orai1bCalcium release-activated calcium channel protein 1; Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores; Belongs to the Orai family. (222 aa)
unc45bProtein unc-45 homolog B; Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain (By similarity). Plays a role in sarcomere formation during muscle cell development. Required for myoseptal integrity, myofiber attachment, motility and craniofacial development. Is necessary for normal early lens development. (934 aa)
nacaNascent polypeptide-associated complex subunit alpha; May promote appropriate targeting of ribosome-nascent polypeptide complexes. (215 aa)
hsp90aa1.2Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2. (734 aa)
tcapTitin-cap (telethonin). (179 aa)
epb41bErythrocyte membrane protein band 4.1 (Elliptocytosis 1, RH-linked). (1534 aa)
cdc42bpabNon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1716 aa)
myh11aMyosin, heavy polypeptide 11, smooth muscle; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1974 aa)
tnnt2cTroponin T1, skeletal, slow. (290 aa)
csrp1bCysteine and glycine-rich protein 1b. (192 aa)
cdc42bpbCDC42-binding protein kinase beta (DMPK-like); Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1708 aa)
myoz2aMyozenin 2a. (264 aa)
cnn2Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (307 aa)
ENSDARP00000052802Si:dkey-30c15.10. (966 aa)
acheAcetylcholinesterase; Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. (634 aa)
cul3aCullin 3a; Belongs to the cullin family. (774 aa)
cnn3bCalponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (331 aa)
epb41l4aBand 4.1-like protein 4; Not known, binds calmodulin. (671 aa)
myoz1aZgc:77785 protein. (319 aa)
adprhl1[Protein ADP-ribosylarginine] hydrolase-like protein 1; Belongs to the ADP-ribosylglycohydrolase family. (350 aa)
lmod2aLeiomodin 2 (cardiac) a. (324 aa)
alkbh4AlkB homolog 4, lysine demthylase. (284 aa)
srfaSerum response factor a. (539 aa)
LOC101887017Leiomodin 1a (smooth muscle). (645 aa)
ldb3aCypher/ZASP splice variant 1 gamma. (596 aa)
bvesBlood vessel epicardial substance; Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in skeletal muscle and heart development as well as in the maintenance of heart function. May play a role in vamp3-mediated vesicular transport and recycling of receptor molecules. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells. May induce primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)- independent manner. May be involved in epithelial movement during [...] (352 aa)
epb41l4bErythrocyte membrane protein band 4.1-like 4B. (475 aa)
myo18abMyosin XVIIIAb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2557 aa)
megf11Multiple EGF-like-domains 11. (1114 aa)
lmod3Leiomodin-3; Essential for the organization of sarcomeric thin filaments in skeletal muscle; Belongs to the tropomodulin family. (670 aa)
myh9bMyosin, heavy chain 9b, non-muscle; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1749 aa)
rock2b-2Rho-associated, coiled-coil-containing protein kinase 2b. (383 aa)
f11r.2F11 receptor, tandem duplicate 2. (294 aa)
klhl41aKelch-like protein 41a; Involved in skeletal muscle development and differentiation. (599 aa)
tnnt3aTroponin T type 3a (skeletal, fast). (230 aa)
lrrc39Leucine-rich repeat-containing protein 39; Component of the sarcomeric M-band which plays a role in myocyte response to biomechanical stress (By similarity). May regulate expression of other M-band proteins via an SRF-dependent pathway (By similarity). Important for normal contractile function in heart. (343 aa)
fam171a1Family with sequence similarity 171 member A1. (822 aa)
FRMD1Zgc:172136 protein. (552 aa)
fam171a2aFamily with sequence similarity 171 member A2a. (828 aa)
LOC797104Family with sequence similarity 171 member A2b. (849 aa)
E7FEE9_DANRESi:dkey-178k16.1. (881 aa)
f11r.1F11 receptor, tandem duplicate 1. (292 aa)
FRMD5Si:ch211-69m14.1. (576 aa)
DmpkUncharacterized protein; Belongs to the protein kinase superfamily. (419 aa)
mylk3Myosin light chain kinase 3; Kinase that phosphorylates MYL2 in vitro (By similarity). Increases cardiomyocyte contractility (By similarity). Required for sarcomere formation in the developing heart. (716 aa)
tmod1Tropomodulin 1. (356 aa)
frmd5FERM domain-containing 5. (571 aa)
lmod1bLeiomodin 1b (smooth muscle). (671 aa)
nrapNebulin-related-anchoring protein. (1861 aa)
epb41l3aErythrocyte membrane protein band 4.1-like 3a. (826 aa)
tmod4Tropomodulin 4 (Muscle). (343 aa)
zyxZyxin. (608 aa)
myh14Myosin, heavy chain 14, non-muscle; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2020 aa)
fhdc3FH2 domain-containing 3. (826 aa)
frmd3FERM domain-containing 3. (380 aa)
csrp2Cysteine and glycine-rich protein 2. (193 aa)
lmod2bLeiomodin 2 (cardiac) b. (604 aa)
nebNebulin. (6177 aa)
frmd6FERM domain-containing 6. (616 aa)
fhdc1FH2 domain-containing 1. (1165 aa)
myo18aaMyosin XVIIIAa; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2454 aa)
tnnt2dTroponin T2d, cardiac. (241 aa)
limch1aLIM and calponin homology domains 1a. (1019 aa)
tnnt3bTroponin T type 3b (skeletal, fast). (284 aa)
pdcd6ipProgrammed cell death 6-interacting protein. (866 aa)
rock2aRho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1375 aa)
epb41l5Erythrocyte membrane protein band 4.1-like 5. (461 aa)
F1QHP3_DANRECarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (543 aa)
myoz2bMyozenin 2b. (226 aa)
elnbElastin b. (2041 aa)
myh9aMyosin, heavy chain 9a, non-muscle; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1964 aa)
LOC101882071FH2 domain-containing 5. (390 aa)
tnnt2aTroponin T type 2a (cardiac). (282 aa)
fam171bMembrane-associated ring finger (C3HC4) 7. (771 aa)
myh10Myosin, heavy chain 10, non-muscle; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1992 aa)
U3JAK2_DANRESi:ch73-205h11.1. (410 aa)
fliiFLII actin-remodeling protein. (1259 aa)
fhdc4FH2 domain-containing 4. (752 aa)
LOC108190739Myozenin-2-like. (122 aa)
ENSDARP00000130960Si:dkey-65b13.9. (181 aa)
cnn3aCalponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (329 aa)
cul3bCullin 3b; Belongs to the cullin family. (766 aa)
fhdc2FH2 domain-containing 2. (916 aa)
cdc42bpaaNon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1697 aa)
tpcn2Two pore calcium channel protein 2; Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal membrane. May be involved in smooth muscle contraction (By similarity). (774 aa)
tnnt2eNovel slow skeletal troponin T family protein. (285 aa)
myh11bMyosin, heavy chain 11b, smooth muscle; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1972 aa)
srfbSerum response factor b. (260 aa)
limch1bLIM and calponin homology domains 1b. (1020 aa)
cnn1bCalponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (296 aa)
LOC100334697Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (576 aa)
EPB41L2Si:ch73-18b11.1. (930 aa)
rock2bRho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1401 aa)
csrp3Cysteine and glycine-rich protein 3 (cardiac LIM protein). (193 aa)
qkiaProtein quaking-A; RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs which promotes oligodendrocyte differentiation. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of some pre-mRNA. Acts as a translational repressor (By similarity). (383 aa)
rock1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1359 aa)
rock2blRho-associated, coiled-coil-containing protein kinase 2b,-like. (181 aa)
dusp27Inactive dual specificity phosphatase 27; Required for myofiber maturation. (1100 aa)
epb41aErythrocyte membrane protein band 4.1a. (914 aa)
anlnAnillin, actin-binding protein. (1171 aa)
tnnt1Troponin T type 1 (skeletal, slow). (342 aa)
WDR1WD repeat domain 1. (606 aa)
phactr4a-2Phosphatase and actin regulator 4A; Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to repression of the integrin signaling through the rho/rock pathway (By similarity). (118 aa)
qkibProtein quaking-B. (347 aa)
ENSDARP00000150236Si:ch1073-416j23.1. (671 aa)
megf10Multiple epidermal growth factor-like domains protein 10; Membrane receptor involved in phagocytosis by macrophages and astrocytes of apoptotic cells (By similarity). Essential factor in the regulation of muscle development including myogenesis (Ref.4). Likely plays a key role in muscle cell proliferation, adhesion and motility. May control the balance between skeletal muscle satellite cells proliferation and differentiation through regulation of the notch signaling pathway. (1142 aa)
ENSDARP00000155954Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (194 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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