STRINGSTRING
Szt2 Szt2 castor2 castor2 gsk3ab gsk3ab atm atm kptn kptn itfg2 itfg2 gsk3ba gsk3ba tsc1a tsc1a nprl3 nprl3 tbc1d7 tbc1d7 tmem127 tmem127 sesn1 sesn1 stk11 stk11 gsk3bb gsk3bb nprl2 nprl2 prkaa1 prkaa1 prkaa2 prkaa2 sesn3 sesn3 bmt2 bmt2 flcn flcn sirt1 sirt1 sh3bp4 sh3bp4 sesn2 sesn2 ENSDARP00000153406 ENSDARP00000153406 F1QYY8_DANRE F1QYY8_DANRE sh3bp4a sh3bp4a ubr2 ubr2 rnf152 rnf152 ppp1r3ab ppp1r3ab gsk3aa gsk3aa mapkapk5 mapkapk5 depdc5 depdc5 C4H12orf66 C4H12orf66 tsc1b tsc1b tnfaip8l1 tnfaip8l1 deptor deptor ubr1-2 ubr1-2 ddit4 ddit4 akt1s1 akt1s1 E7F0F7_DANRE E7F0F7_DANRE tsc2 tsc2 ubr1 ubr1 MINAR1 MINAR1 ENSDARP00000139625 ENSDARP00000139625 fnip1 fnip1 castor1 castor1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Szt2Uncharacterized protein. (111 aa)
castor2Cytosolic arginine sensor for mTORC1 subunit 2. (329 aa)
gsk3abGlycogen synthase kinase 3 alpha b; Belongs to the protein kinase superfamily. (440 aa)
atmNon-specific serine/threonine protein kinase. (3091 aa)
kptnKaptin (actin-binding protein). (436 aa)
itfg2Integrin alpha FG-GAP repeat-containing 2. (436 aa)
gsk3baGlycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily. (421 aa)
tsc1aTSC complex subunit 1a. (1128 aa)
nprl3NPR3-like, GATOR1 complex subunit. (581 aa)
tbc1d7TBC1 domain family member 7; Component of the TSC-TBC complex, that contains tbc1d7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protein (GAP) activity toward rheb in response to alterations in specific cellular growth conditions. The small GTPase rheb is a direct activator of the protein kinase activity of mTORC1 and the TSC-TBC complex acts as a negative regulator of mTORC1 signaling cascade by acting as a GAP for RHEB (By similarity). (294 aa)
tmem127Transmembrane protein 127; Controls cell proliferation acting as a negative regulator of TOR signaling pathway mediated by mTORC1; Belongs to the TMEM127 family. (237 aa)
sesn1Sestrin 1. (488 aa)
stk11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (438 aa)
gsk3bbGlycogen synthase kinase 3 beta, genome duplicate b; Belongs to the protein kinase superfamily. (419 aa)
nprl2NPR2-like, GATOR1 complex subunit. (379 aa)
prkaa1Non-specific serine/threonine protein kinase. (573 aa)
prkaa2Non-specific serine/threonine protein kinase. (553 aa)
sesn3Sestrin 3. (466 aa)
bmt2S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] (393 aa)
flcnFolliculin. (558 aa)
sirt1Sirtuin 1. (710 aa)
sh3bp4SH3-domain-binding protein 4. (960 aa)
sesn2Sestrin 2. (444 aa)
ENSDARP00000153406DUF3384 domain-containing protein. (162 aa)
F1QYY8_DANRESi:dkeyp-97e7.9. (393 aa)
sh3bp4aSH3 domain-binding protein 4-A; Possible role in regulating endocytosis of the transferrin receptor at the plasma membrane. Alternatively, may function as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy (By similarity). (965 aa)
ubr2E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1759 aa)
rnf152E3 ubiquitin-protein ligase rnf152; E3 ubiquitin-protein ligase mediating 'Lys-63'-linked polyubiquitination of RRAGA in response to amino acid starvation. Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability. Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation; Belongs to the RNF152 family. (197 aa)
ppp1r3abProtein phosphatase 1, regulatory subunit 3Ab. (1207 aa)
gsk3aaGlycogen synthase kinase 3 alpha a; Belongs to the protein kinase superfamily. (462 aa)
mapkapk5Mitogen-activated protein kinase-activated protein kinase 5. (471 aa)
depdc5DEP domain-containing 5, GATOR1 subcomplex subunit. (1568 aa)
C4H12orf66KICSTOR complex protein C12orf66 homolog; As part of the KICSTOR complex may function in the amino acid-sensing branch of the TORC1 signaling pathway. Belongs to the UPF0536 family. (449 aa)
tsc1bTSC complex subunit 1b. (1228 aa)
tnfaip8l1Tumor necrosis factor alpha-induced protein 8-like protein 1. (186 aa)
deptorDEP domain-containing MTOR-interacting protein. (407 aa)
ubr1-2E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (414 aa)
ddit4DNA damage-inducible transcript 4 protein; Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves ddit4/redd1, akt1, the tsc1-tsc2 complex and the GTPase rheb. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage, via its effect on mTORC1 activity. Plays a role in neuronal differentiation, neuron migration during embryonic brain development and in neuronal cell death (B [...] (220 aa)
akt1s1AKT1 substrate 1 (proline-rich). (354 aa)
E7F0F7_DANRESi:zfos-80g12.1. (444 aa)
tsc2TSC complex subunit 2. (1674 aa)
ubr1E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1058 aa)
MINAR1Major intrinsically disordered Notch2-binding receptor 1; Intrinsically disordered protein which may negatively regulate mTOR signaling pathway by stabilizing the mTOR complex component DEPTOR. Negatively regulates angiogenesis. Negatively regulates cell growth (By similarity). May play a role in neuronal development ; Belongs to the MINAR family. (840 aa)
ENSDARP00000139625Si:dkey-88e18.8. (775 aa)
fnip1Folliculin-interacting protein 1. (1077 aa)
castor1Cytosolic arginine sensor for mTORC1 subunit 1. (37 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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