(14 nodes) Cholesterol efflux network (Danio rerio)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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Predicted Interactions

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Your Input:
	scarb1	Scavenger receptor class B, member 1; Belongs to the CD36 family. (496 aa)
	apoeb	Apolipoprotein Eb; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. Belongs to the apolipoprotein A1/A4/E family. (281 aa)
	spg11	SPG11 vesicle-trafficking-associated, spatacsin. (1612 aa)
	apoba	Apolipoprotein Ba. (4418 aa)
	npc2	NPC intracellular cholesterol transporter 2; Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. May bind and mobilize cholesterol that is associated with membranes. NPC2 binds cholesterol with a 1:1 stoichiometry. Can bind a variety of sterols, including lathosterol, desmosterol and the pl [...] (149 aa)
	apoa1a	Proapolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). (262 aa)
	zgc:193725	Zgc:193725. (149 aa)
	abcg5	ATP-binding cassette, sub-family G (WHITE), member 5. (652 aa)
	abcg1	ATP-binding cassette, sub-family G (WHITE), member 1. (673 aa)
	abcg4b	ATP-binding cassette, sub-family G (WHITE), member 4b. (644 aa)
	abcg8	ATP-binding cassette, sub-family G (WHITE), member 8. (332 aa)
	abcg4a	ATP-binding cassette, sub-family G (WHITE), member 4a. (641 aa)
	apom	Apolipoprotein M. (215 aa)
	apoea	Apolipoprotein Ea. (269 aa)

Your Current Organism:

Danio rerio

NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
abcg1	abcg5	ENSDARP00000087241	ENSDARP00000086278	ATP-binding cassette, sub-family G (WHITE), member 1.	ATP-binding cassette, sub-family G (WHITE), member 5.	0.690
abcg1	apoba	ENSDARP00000087241	ENSDARP00000062792	ATP-binding cassette, sub-family G (WHITE), member 1.	Apolipoprotein Ba.	0.452
abcg1	apoea	ENSDARP00000087241	ENSDARP00000133853	ATP-binding cassette, sub-family G (WHITE), member 1.	Apolipoprotein Ea.	0.655
abcg1	apoeb	ENSDARP00000087241	ENSDARP00000058964	ATP-binding cassette, sub-family G (WHITE), member 1.	Apolipoprotein Eb; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. Belongs to the apolipoprotein A1/A4/E family.	0.812
abcg4a	abcg4b	ENSDARP00000116517	ENSDARP00000102351	ATP-binding cassette, sub-family G (WHITE), member 4a.	ATP-binding cassette, sub-family G (WHITE), member 4b.	0.902
abcg4a	abcg5	ENSDARP00000116517	ENSDARP00000086278	ATP-binding cassette, sub-family G (WHITE), member 4a.	ATP-binding cassette, sub-family G (WHITE), member 5.	0.683
abcg4b	abcg4a	ENSDARP00000102351	ENSDARP00000116517	ATP-binding cassette, sub-family G (WHITE), member 4b.	ATP-binding cassette, sub-family G (WHITE), member 4a.	0.902
abcg4b	abcg5	ENSDARP00000102351	ENSDARP00000086278	ATP-binding cassette, sub-family G (WHITE), member 4b.	ATP-binding cassette, sub-family G (WHITE), member 5.	0.602
abcg5	abcg1	ENSDARP00000086278	ENSDARP00000087241	ATP-binding cassette, sub-family G (WHITE), member 5.	ATP-binding cassette, sub-family G (WHITE), member 1.	0.690
abcg5	abcg4a	ENSDARP00000086278	ENSDARP00000116517	ATP-binding cassette, sub-family G (WHITE), member 5.	ATP-binding cassette, sub-family G (WHITE), member 4a.	0.683
abcg5	abcg4b	ENSDARP00000086278	ENSDARP00000102351	ATP-binding cassette, sub-family G (WHITE), member 5.	ATP-binding cassette, sub-family G (WHITE), member 4b.	0.602
abcg5	abcg8	ENSDARP00000086278	ENSDARP00000102567	ATP-binding cassette, sub-family G (WHITE), member 5.	ATP-binding cassette, sub-family G (WHITE), member 8.	0.999
abcg5	apoba	ENSDARP00000086278	ENSDARP00000062792	ATP-binding cassette, sub-family G (WHITE), member 5.	Apolipoprotein Ba.	0.615
abcg5	apoeb	ENSDARP00000086278	ENSDARP00000058964	ATP-binding cassette, sub-family G (WHITE), member 5.	Apolipoprotein Eb; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. Belongs to the apolipoprotein A1/A4/E family.	0.531
abcg5	scarb1	ENSDARP00000086278	ENSDARP00000137986	ATP-binding cassette, sub-family G (WHITE), member 5.	Scavenger receptor class B, member 1; Belongs to the CD36 family.	0.449
abcg8	abcg5	ENSDARP00000102567	ENSDARP00000086278	ATP-binding cassette, sub-family G (WHITE), member 8.	ATP-binding cassette, sub-family G (WHITE), member 5.	0.999
abcg8	apoba	ENSDARP00000102567	ENSDARP00000062792	ATP-binding cassette, sub-family G (WHITE), member 8.	Apolipoprotein Ba.	0.621
abcg8	apoeb	ENSDARP00000102567	ENSDARP00000058964	ATP-binding cassette, sub-family G (WHITE), member 8.	Apolipoprotein Eb; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. Belongs to the apolipoprotein A1/A4/E family.	0.441
abcg8	scarb1	ENSDARP00000102567	ENSDARP00000137986	ATP-binding cassette, sub-family G (WHITE), member 8.	Scavenger receptor class B, member 1; Belongs to the CD36 family.	0.404
apoa1a	apoba	ENSDARP00000025613	ENSDARP00000062792	Proapolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT).	Apolipoprotein Ba.	0.977

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