| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| cdc73 | ctr9 | ENSDARP00000129750 | ENSDARP00000016047 | Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae). | CTR9 homolog, Paf1/RNA polymerase II complex component. | 0.999 |
| cdc73 | rnf20 | ENSDARP00000129750 | ENSDARP00000107071 | Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae). | E3 ubiquitin protein ligase. | 0.823 |
| cdc73 | rnf40 | ENSDARP00000129750 | ENSDARP00000070816 | Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae). | E3 ubiquitin protein ligase. | 0.823 |
| cdc73 | waca | ENSDARP00000129750 | ENSDARP00000073355 | Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae). | WW domain-containing adapter protein with coiled-coil; Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1). Positive regulator of amino acid starvation-induced autophagy. Positively regulates MTOR activity. May negatively regulate the ubiquitin proteasome pathway. | 0.558 |
| ctr9 | cdc73 | ENSDARP00000016047 | ENSDARP00000129750 | CTR9 homolog, Paf1/RNA polymerase II complex component. | Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae). | 0.999 |
| ctr9 | rnf20 | ENSDARP00000016047 | ENSDARP00000107071 | CTR9 homolog, Paf1/RNA polymerase II complex component. | E3 ubiquitin protein ligase. | 0.791 |
| ctr9 | rnf40 | ENSDARP00000016047 | ENSDARP00000070816 | CTR9 homolog, Paf1/RNA polymerase II complex component. | E3 ubiquitin protein ligase. | 0.799 |
| ctr9 | waca | ENSDARP00000016047 | ENSDARP00000073355 | CTR9 homolog, Paf1/RNA polymerase II complex component. | WW domain-containing adapter protein with coiled-coil; Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1). Positive regulator of amino acid starvation-induced autophagy. Positively regulates MTOR activity. May negatively regulate the ubiquitin proteasome pathway. | 0.582 |
| rnf20 | cdc73 | ENSDARP00000107071 | ENSDARP00000129750 | E3 ubiquitin protein ligase. | Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae). | 0.823 |
| rnf20 | ctr9 | ENSDARP00000107071 | ENSDARP00000016047 | E3 ubiquitin protein ligase. | CTR9 homolog, Paf1/RNA polymerase II complex component. | 0.791 |
| rnf20 | rnf40 | ENSDARP00000107071 | ENSDARP00000070816 | E3 ubiquitin protein ligase. | E3 ubiquitin protein ligase. | 0.976 |
| rnf20 | rnf8 | ENSDARP00000107071 | ENSDARP00000125628 | E3 ubiquitin protein ligase. | E3 ubiquitin-protein ligase rnf8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated mdc1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of tp53 [...] | 0.429 |
| rnf20 | waca | ENSDARP00000107071 | ENSDARP00000073355 | E3 ubiquitin protein ligase. | WW domain-containing adapter protein with coiled-coil; Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1). Positive regulator of amino acid starvation-induced autophagy. Positively regulates MTOR activity. May negatively regulate the ubiquitin proteasome pathway. | 0.810 |
| rnf40 | cdc73 | ENSDARP00000070816 | ENSDARP00000129750 | E3 ubiquitin protein ligase. | Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae). | 0.823 |
| rnf40 | ctr9 | ENSDARP00000070816 | ENSDARP00000016047 | E3 ubiquitin protein ligase. | CTR9 homolog, Paf1/RNA polymerase II complex component. | 0.799 |
| rnf40 | rnf20 | ENSDARP00000070816 | ENSDARP00000107071 | E3 ubiquitin protein ligase. | E3 ubiquitin protein ligase. | 0.976 |
| rnf40 | rnf8 | ENSDARP00000070816 | ENSDARP00000125628 | E3 ubiquitin protein ligase. | E3 ubiquitin-protein ligase rnf8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated mdc1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of tp53 [...] | 0.496 |
| rnf40 | waca | ENSDARP00000070816 | ENSDARP00000073355 | E3 ubiquitin protein ligase. | WW domain-containing adapter protein with coiled-coil; Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1). Positive regulator of amino acid starvation-induced autophagy. Positively regulates MTOR activity. May negatively regulate the ubiquitin proteasome pathway. | 0.806 |
| rnf8 | rnf20 | ENSDARP00000125628 | ENSDARP00000107071 | E3 ubiquitin-protein ligase rnf8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated mdc1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of tp53 [...] | E3 ubiquitin protein ligase. | 0.429 |
| rnf8 | rnf40 | ENSDARP00000125628 | ENSDARP00000070816 | E3 ubiquitin-protein ligase rnf8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated mdc1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of tp53 [...] | E3 ubiquitin protein ligase. | 0.496 |