STRINGSTRING
X1WG91_DANRE X1WG91_DANRE si:dkey-3h3.3 si:dkey-3h3.3 rnf8 rnf8 rnf20 rnf20 waca waca rnf40 rnf40 ctr9 ctr9 zgc:66440 zgc:66440 X1WFS5_DANRE X1WFS5_DANRE E7FBV5_DANRE E7FBV5_DANRE ENSDARP00000135458 ENSDARP00000135458 cdc73 cdc73
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
X1WG91_DANRESi:dkey-40c23.2. (967 aa)
si:dkey-3h3.3Si:dkey-3h3.3. (441 aa)
rnf8E3 ubiquitin-protein ligase rnf8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated mdc1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of tp53 [...] (531 aa)
rnf20E3 ubiquitin protein ligase. (1013 aa)
wacaWW domain-containing adapter protein with coiled-coil; Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1). Positive regulator of amino acid starvation-induced autophagy. Positively regulates MTOR activity. May negatively regulate the ubiquitin proteasome pathway. (558 aa)
rnf40E3 ubiquitin protein ligase. (1010 aa)
ctr9CTR9 homolog, Paf1/RNA polymerase II complex component. (1160 aa)
zgc:66440Zgc:66440. (384 aa)
X1WFS5_DANRESi:dkey-40c23.1. (542 aa)
E7FBV5_DANRESi:ch73-78o10.1. (178 aa)
ENSDARP00000135458Si:dkey-40c23.2. (770 aa)
cdc73Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae). (530 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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