STRINGSTRING
cdh2 cdh2 sp8a sp8a tbx4 tbx4 dkk1a dkk1a hand2 hand2 tbx3a tbx3a tbx2a tbx2a tbx5a tbx5a fbxw4 fbxw4 tll1 tll1 crbn crbn sall4 sall4 LOC405768 LOC405768 ift52 ift52 dkk1b dkk1b sp8b sp8b mks1 mks1 nipblb nipblb sfrp2 sfrp2 hoxc8a hoxc8a bcl2l11 bcl2l11 smad4a smad4a gb:cr929477 gb:cr929477 fgf9 fgf9 rpgrip1l rpgrip1l tbx3b tbx3b ift140 ift140 fibinb fibinb lef1 lef1 Q1L8R8_DANRE Q1L8R8_DANRE frem3 frem3 E7FFZ5_DANRE E7FFZ5_DANRE wdpcp wdpcp med12 med12 frem2b frem2b nipbla nipbla fgf4 fgf4 fbln1 fbln1 fras1 fras1 sp9 sp9 msx1a msx1a hoxc10a hoxc10a sfrp2l sfrp2l wdr19 wdr19 zak zak en1b en1b bmp1a bmp1a Alx3 Alx3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cdh2Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion (By similarity). Cadherins contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development. Required for normal neural tube morphogenesis. Required to allow mid- and hindbrain neurons to reach and maintain their appropriate positions within the neural tube by restricting neuronal motility within the embryonic mid- and hindbrain. (893 aa)
sp8aSp8 transcription factor a. (406 aa)
tbx4T-box transcription factor 4. (543 aa)
dkk1aDickkopf WNT-signaling pathway inhibitor 1a. (256 aa)
hand2Heart- and neural crest derivatives-expressed protein 2; Essential for myocardial and pectoral fin differentiation, patterning and morphogenesis. (205 aa)
tbx3aT-box transcription factor 3a. (689 aa)
tbx2aT-box transcription factor 2a. (686 aa)
tbx5aT-box transcription factor TBX5-A; Required for pectoral fin formation. Together with tbx5b, involved in eye and heart development. Required for the looping stage of heart development. May bind to the core DNA motif of promoters. (492 aa)
fbxw4F-box and WD repeat domain-containing 4. (392 aa)
tll1Dorsal-ventral patterning tolloid-like protein 1; Required for patterning ventral tissues of the tail. May increase bone morphogenetic protein (BMP) activity at the end of gastrulation by proteolytic cleavage of chordin and release of BMP from inactive complexes. (1022 aa)
crbnProtein cereblon; Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Normal degradation of key regulatory proteins is required for limb outgrowth and expression of the fibroblast growth factor FGF8. May also play a role in the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning. (446 aa)
sall4Spalt-like transcription factor 4. (1091 aa)
LOC405768Sterile alpha motif and leucine zipper-containing kinase AZK. (371 aa)
ift52Intraflagellar transport 52 homolog (Chlamydomonas). (435 aa)
dkk1bDickkopf WNT-signaling pathway inhibitor 1b. (241 aa)
sp8bTranscription factor Sp8; Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos. Belongs to the Sp1 C2H2-type zinc-finger protein family. (455 aa)
mks1MKS transition zone complex subunit 1. (559 aa)
nipblbNipped-B-like protein B; May play a structural role in chromatin. Involved in sister chromatid cohesion, possibly by facilitating the cohesin complex loading. Transcription factor, which may promote cortical neuron migration during brain development by regulating the transcription of crucial genes in this process (By similarity). (2882 aa)
sfrp2Secreted frizzled-related protein 2. (294 aa)
hoxc8aHomeobox protein Hox-C8a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (250 aa)
bcl2l11BCL2-like 11. (176 aa)
smad4aMothers against decapentaplegic homolog. (547 aa)
gb:cr929477SMAD family member 4. (332 aa)
fgf9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (142 aa)
rpgrip1lRPGRIP1-like. (1256 aa)
tbx3bT-box transcription factor 3b. (594 aa)
ift140Intraflagellar transport 140 homolog (Chlamydomonas). (1445 aa)
fibinbFin bud initiation factor; Essential for the initiation of pectoral fin bud formation. Potentially acts downstream of retinoic acid and Wnt signaling and is required for tbx5 expression in the lateral plate mesoderm of presumptive pectoral fin bud regions; Belongs to the FIBIN family. (210 aa)
lef1Lymphocyte enhancer binding factor 1 Lef1. (365 aa)
Q1L8R8_DANREMothers against decapentaplegic homolog. (571 aa)
frem3Fras1-related extracellular matrix 3. (3075 aa)
E7FFZ5_DANREMothers against decapentaplegic homolog. (568 aa)
wdpcpWD repeat-containing planar cell polarity effector. (707 aa)
med12Mediator of RNA polymerase II transcription subunit 12; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Require [...] (2175 aa)
frem2bFRAS1-related extracellular matrix 2b. (3116 aa)
nipblaNipped-B-like protein A; May play a structural role in chromatin. Involved in sister chromatid cohesion, possibly by facilitating the cohesin complex loading. Transcription factor, which may promote cortical neuron migration during brain development by regulating the transcription of crucial genes in this process (By similarity). Belongs to the SCC2/Nipped-B family. (2382 aa)
fgf4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (191 aa)
fbln1Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (679 aa)
fras1Fraser extracellular matrix complex subunit 1. (4003 aa)
sp9Transcription factor Sp9; Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos. (439 aa)
msx1aMuscle segment homeobox 1a. (233 aa)
hoxc10aHomeobox C10a. (337 aa)
sfrp2lSecreted frizzled-related protein 2-like. (333 aa)
wdr19WD repeat domain 19. (1372 aa)
zakSterile alpha motif and leucine zipper-containing kinase AZK. (789 aa)
en1bHomeobox protein engrailed-like. (274 aa)
bmp1aMetalloendopeptidase. (986 aa)
Alx3Uncharacterized protein. (146 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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