(110 nodes) Multicellular organism growth network (Danio rerio)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A8WHX8_DANRE	Si:rp71-45g20.11. (265 aa)
	F1R5U9_DANRE	Si:dkey-27d5.10. (277 aa)
	LOC100005157	Si:dkey-27d5.3. (235 aa)
	tmed2	Transmembrane p24-trafficking protein 2. (208 aa)
	tns2a	Tensin 2a. (1589 aa)
	wdr11	WD repeat-containing protein 11; Involved in the Hedgehog (Hh) signaling pathway, is essential for normal ciliogenesis. Regulates the proteolytic processing of gli3 and cooperates with the transcription factor emx1 in the induction of downstream Hh pathway gene expression and gonadotropin-releasing hormone production. WDR11 complex facilitates the tethering of Adaptor protein-1 complex (AP-1)-derived vesicles. (1239 aa)
	tal2	T-cell acute lymphocytic leukemia 2. (109 aa)
	apba2a	Amyloid beta (A4) precursor protein-binding, family A, member 2a. (907 aa)
	ep300b	E1A-binding protein p300 b. (2615 aa)
	stk40	Serine/threonine kinase 40. (436 aa)
	si:dkey-23f9.7	Si:dkey-23f9.7. (227 aa)
	ENSDARP00000131028	Si:dkey-23f9.6. (223 aa)
	ENSDARP00000132232	DWNN domain-containing protein. (174 aa)
	plekha1a	Pleckstrin homology domain-containing, family A (phosphoinositide-binding-specific) member 1a. (401 aa)
	smpd3	Sphingomyelin phosphodiesterase 3. (684 aa)
	LOC100004392	Uncharacterized protein. (278 aa)
	slc1a2b	Amino acid transporter. (564 aa)
	LOC110439267	Si:dkey-23f9.11. (174 aa)
	E7FD51_DANRE	DWNN domain-containing protein. (168 aa)
	si:dkey-23f9.8	Si:dkey-23f9.8. (174 aa)
	si:dkey-23f9.9	Si:dkey-23f9.9. (174 aa)
	atrxl	ATRX chromatin remodeler,-like. (1760 aa)
	ENSDARP00000137102	Si:dkey-23f9.12. (278 aa)
	LOC110440092	Si:ch211-156l18.4. (142 aa)
	slitrk6	SLIT and NTRK-like family, member 6. (830 aa)
	zgc:174354-3	Zgc:174354. (278 aa)
	ep300a	E1A-binding protein p300 a. (2679 aa)
	ttc8	Tetratricopeptide repeat domain 8. (268 aa)
	slc1a9	Amino acid transporter. (424 aa)
	zgc:174463	Zgc:77614 protein. (115 aa)
	LOC110438889	Si:dkey-27d5.14. (174 aa)
	LOC100007069	E3 ubiquitin-protein ligase RBBP6-like. (173 aa)
	apba1a	Amyloid beta (A4) precursor protein-binding, family A, member 1a. (968 aa)
	apba2b	Amyloid beta (A4) precursor protein-binding, family A, member 2b. (833 aa)
	slc1a2a	Amino acid transporter. (548 aa)
	LOC100536964	E3 ubiquitin-protein ligase RBBP6-like. (173 aa)
	LOC103911809	Zgc:174356 protein. (174 aa)
	LOC103908740	Uncharacterized protein. (277 aa)
	zgc:174355	Zgc:174355. (174 aa)
	zgc:174353-2	Zgc:174353. (278 aa)
	zgc:174355-2	Zgc:174355. (277 aa)
	LOC101882874	E3 ubiquitin-protein ligase RBBP6-like. (173 aa)
	zgc:77614	Zgc:77614. (173 aa)
	LOC103911535	E3 ubiquitin-protein ligase RBBP6-like. (173 aa)
	zgc:174355-3	Zgc:174353. (278 aa)
	LOC100536005	DWNN domain-containing protein. (173 aa)
	LOC100007007	E3 ubiquitin-protein ligase RBBP6-like. (115 aa)
	LOC101885891	E3 ubiquitin-protein ligase RBBP6-like. (173 aa)
	LOC100006401	E3 ubiquitin-protein ligase RBBP6-like. (173 aa)
	zgc:91850-3	Zgc:91850 protein. (174 aa)
	ENSDARP00000149948	Si:busm1-37i06.3. (173 aa)
	en1b	Homeobox protein engrailed-like. (274 aa)
	LOC100535555	E3 ubiquitin-protein ligase RBBP6-like. (173 aa)
	LOC100006815	E3 ubiquitin-protein ligase RBBP6-like. (141 aa)
	zgc:174354-4	Zgc:174354. (174 aa)
	LOC100002202	E3 ubiquitin-protein ligase RBBP6-like. (173 aa)
	ENSDARP00000151202	Peptidase_M48_N domain-containing protein. (272 aa)
	LOC573060	E3 ubiquitin-protein ligase RBBP6-like. (173 aa)
	LOC108191592	DWNN domain-containing protein. (174 aa)
	zgc:174354	Zgc:174354. (278 aa)
	LOC110440030	E3 ubiquitin-protein ligase RBBP6-like. (173 aa)
	LOC108179082	DWNN domain-containing protein. (174 aa)
	LOC100535522	E3 ubiquitin-protein ligase RBBP6-like. (173 aa)
	LOC100006889	E3 ubiquitin-protein ligase RBBP6-like. (173 aa)
	fkbp8	Peptidylprolyl isomerase. (406 aa)
	fkbp16	Peptidylprolyl isomerase. (430 aa)
	smo	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (822 aa)
	atm	Non-specific serine/threonine protein kinase. (3091 aa)
	XRCC2	X-ray repair cross complementing 2. (314 aa)
	ercc1	Excision repair cross-complementing rodent repair deficiency, complementation group 1. (342 aa)
	pkdcca	Protein kinase domain-containing, cytoplasmic a. (516 aa)
	pkdccb	Protein kinase domain-containing, cytoplasmic b. (481 aa)
	zmpste24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (468 aa)
	kdm6al	Ubiquitously transcribed tetratricopeptide repeat, X chromosome like 1. (1311 aa)
	ccdc151	Coiled-coil domain-containing 151. (545 aa)
	rc3h2	Ring finger and CCCH-type domains 2. (1028 aa)
	ankrd12	Ankyrin repeat domain 12. (1987 aa)
	ar	Androgen receptor. (868 aa)
	atf5a	Activating transcription factor 5a. (511 aa)
	tns2b	Tensin 2b. (1339 aa)
	taf10	Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (181 aa)
	rbbp6	Retinoblastoma-binding protein 6. (1766 aa)
	zgc:91850	Zgc:91850. (223 aa)
	si:dkey-27d5.6	Si:dkey-27d5.6. (278 aa)
	zgc:173948	Si:ch211-198k9.6. (173 aa)
	sp2	Sp2 transcription factor. (610 aa)
	wdtc1	WD and tetratricopeptide repeats 1. (674 aa)
	A8WHX4_DANRE	Si:rp71-45g20.4. (265 aa)
	E7F162_DANRE	Si:ch211-156l18.6. (278 aa)
	LOC100329917	Zgc:174463. (173 aa)
	LOC110439268	Zgc:174353. (223 aa)
	mtor	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2563 aa)
	atrx	ATRX chromatin remodeler. (2013 aa)
	zgc:91850-2	Zgc:91850. (232 aa)
	zgc:174357	Zgc:174357. (228 aa)
	E7EXC5_DANRE	Si:ch211-209f22.3. (223 aa)
	zgc:174353	Si:dkey-23f9.13. (278 aa)
	A8WHX6_DANRE	Si:rp71-45g20.10. (265 aa)
	ercc2	Excision repair cross-complementation group 2. (760 aa)
	plekha1b	Pleckstrin homology domain-containing, family A (phosphoinositide-binding-specific) member 1b. (401 aa)
	si:dkey-27d5.5	Si:dkey-27d5.5. (174 aa)
	si:dkey-27d5.9	Si:dkey-27d5.9. (234 aa)
	kdm6a	Lysine (K)-specific demethylase 6A. (1390 aa)
	zgc:174354-2	Zgc:174354. (235 aa)
	si:dkey-27d5.4	Si:dkey-27d5.4. (174 aa)
	ercc6	Excision repair cross-complementation group 6. (1389 aa)
	apba1b	Amyloid beta (A4) precursor protein-binding, family A, member 1b. (960 aa)
	selenom	Selenoprotein M; May function as a thiol-disulfide oxidoreductase that participates in disulfide bond formation; Belongs to the selenoprotein M/F family. (151 aa)
	LOC100535429	E3 ubiquitin-protein ligase RBBP6-like. (173 aa)
	LOC100329825	E3 ubiquitin-protein ligase RBBP6. (173 aa)

Your Current Organism:

Danio rerio

NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
XRCC2	atm	ENSDARP00000019152	ENSDARP00000015167	X-ray repair cross complementing 2.	Non-specific serine/threonine protein kinase.	0.696
XRCC2	ercc1	ENSDARP00000019152	ENSDARP00000041750	X-ray repair cross complementing 2.	Excision repair cross-complementing rodent repair deficiency, complementation group 1.	0.477
ar	ep300a	ENSDARP00000088795	ENSDARP00000140048	Androgen receptor.	E1A-binding protein p300 a.	0.647
ar	ep300b	ENSDARP00000088795	ENSDARP00000129212	Androgen receptor.	E1A-binding protein p300 b.	0.647
atm	XRCC2	ENSDARP00000015167	ENSDARP00000019152	Non-specific serine/threonine protein kinase.	X-ray repair cross complementing 2.	0.696
atm	atrx	ENSDARP00000015167	ENSDARP00000105895	Non-specific serine/threonine protein kinase.	ATRX chromatin remodeler.	0.601
atm	atrxl	ENSDARP00000015167	ENSDARP00000137092	Non-specific serine/threonine protein kinase.	ATRX chromatin remodeler,-like.	0.469
atm	ep300a	ENSDARP00000015167	ENSDARP00000140048	Non-specific serine/threonine protein kinase.	E1A-binding protein p300 a.	0.432
atm	ep300b	ENSDARP00000015167	ENSDARP00000129212	Non-specific serine/threonine protein kinase.	E1A-binding protein p300 b.	0.432
atm	ercc1	ENSDARP00000015167	ENSDARP00000041750	Non-specific serine/threonine protein kinase.	Excision repair cross-complementing rodent repair deficiency, complementation group 1.	0.761
atm	ercc2	ENSDARP00000015167	ENSDARP00000114026	Non-specific serine/threonine protein kinase.	Excision repair cross-complementation group 2.	0.755
atrx	atm	ENSDARP00000105895	ENSDARP00000015167	ATRX chromatin remodeler.	Non-specific serine/threonine protein kinase.	0.601
atrx	kdm6a	ENSDARP00000105895	ENSDARP00000116325	ATRX chromatin remodeler.	Lysine (K)-specific demethylase 6A.	0.434
atrxl	atm	ENSDARP00000137092	ENSDARP00000015167	ATRX chromatin remodeler,-like.	Non-specific serine/threonine protein kinase.	0.469
ep300a	ar	ENSDARP00000140048	ENSDARP00000088795	E1A-binding protein p300 a.	Androgen receptor.	0.647
ep300a	atm	ENSDARP00000140048	ENSDARP00000015167	E1A-binding protein p300 a.	Non-specific serine/threonine protein kinase.	0.432
ep300b	ar	ENSDARP00000129212	ENSDARP00000088795	E1A-binding protein p300 b.	Androgen receptor.	0.647
ep300b	atm	ENSDARP00000129212	ENSDARP00000015167	E1A-binding protein p300 b.	Non-specific serine/threonine protein kinase.	0.432
ep300b	ercc6	ENSDARP00000129212	ENSDARP00000119156	E1A-binding protein p300 b.	Excision repair cross-complementation group 6.	0.838
ercc1	XRCC2	ENSDARP00000041750	ENSDARP00000019152	Excision repair cross-complementing rodent repair deficiency, complementation group 1.	X-ray repair cross complementing 2.	0.477

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