(12 nodes) Maintenance of protein localization in endoplasmic reticulum network (Danio rerio)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	kdelr2a	ER lumen protein-retaining receptor 2; Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum (By similarity). Binding is pH dependent, and is optimal at pH 5-5.4 (By similarity). (212 aa)
	ENSDARP00000140144	ER lumen protein-retaining receptor. (203 aa)
	ankrd13c	Ankyrin repeat domain-containing protein 13C; Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER. (488 aa)
	hspa5	Immunoglobulin binding protein; Belongs to the heat shock protein 70 family. (650 aa)
	tapt1a	Transmembrane anterior posterior transformation 1a. (577 aa)
	unm_hu7912	Un-named hu7912. (1057 aa)
	tapt1b	Transmembrane anterior posterior transformation protein 1 homolog; Plays a role in primary cilia formation. Involved in cartilage and bone development. May play a role in the differentiation of cranial neural crest cells. May act as a downstream effector of hoxc8 during development (By similarity). (567 aa)
	kdelr3	ER lumen protein-retaining receptor 3; Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum. (215 aa)
	kdelr2b	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2, like. (212 aa)
	insig1	Insulin-induced gene 1 protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (251 aa)
	insig2	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (221 aa)
	rer1	Protein RER1; Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment. (196 aa)

Your Current Organism:

Danio rerio

NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
insig1	insig2	ENSDARP00000018378	ENSDARP00000153121	Insulin-induced gene 1 protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.	0.557
insig2	insig1	ENSDARP00000153121	ENSDARP00000018378	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.	Insulin-induced gene 1 protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.	0.557
kdelr2a	kdelr2b	ENSDARP00000011420	ENSDARP00000054366	ER lumen protein-retaining receptor 2; Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum (By similarity). Binding is pH dependent, and is optimal at pH 5-5.4 (By similarity).	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2, like.	0.411
kdelr2a	kdelr3	ENSDARP00000011420	ENSDARP00000059955	ER lumen protein-retaining receptor 2; Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum (By similarity). Binding is pH dependent, and is optimal at pH 5-5.4 (By similarity).	ER lumen protein-retaining receptor 3; Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum.	0.439
kdelr2a	rer1	ENSDARP00000011420	ENSDARP00000007832	ER lumen protein-retaining receptor 2; Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum (By similarity). Binding is pH dependent, and is optimal at pH 5-5.4 (By similarity).	Protein RER1; Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.	0.557
kdelr2b	kdelr2a	ENSDARP00000054366	ENSDARP00000011420	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2, like.	ER lumen protein-retaining receptor 2; Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum (By similarity). Binding is pH dependent, and is optimal at pH 5-5.4 (By similarity).	0.411
kdelr2b	kdelr3	ENSDARP00000054366	ENSDARP00000059955	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2, like.	ER lumen protein-retaining receptor 3; Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum.	0.442
kdelr2b	rer1	ENSDARP00000054366	ENSDARP00000007832	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2, like.	Protein RER1; Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.	0.410
kdelr3	kdelr2a	ENSDARP00000059955	ENSDARP00000011420	ER lumen protein-retaining receptor 3; Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum.	ER lumen protein-retaining receptor 2; Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum (By similarity). Binding is pH dependent, and is optimal at pH 5-5.4 (By similarity).	0.439
kdelr3	kdelr2b	ENSDARP00000059955	ENSDARP00000054366	ER lumen protein-retaining receptor 3; Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum.	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2, like.	0.442
rer1	kdelr2a	ENSDARP00000007832	ENSDARP00000011420	Protein RER1; Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.	ER lumen protein-retaining receptor 2; Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum (By similarity). Binding is pH dependent, and is optimal at pH 5-5.4 (By similarity).	0.557
rer1	kdelr2b	ENSDARP00000007832	ENSDARP00000054366	Protein RER1; Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2, like.	0.410

Server load: low (10%) [HD]

Permalink

Network

Cooccurrence

Databases

Coexpression

Textmining

Neighborhood

Experiments

Fusion

© STRING Consortium 2025

Credits

Access

Info

About