STRINGSTRING
parp1 parp1 vcp vcp rpa3 rpa3 ufl1 ufl1 zgc:101810 zgc:101810 xrcc4 xrcc4 parp3 parp3 rad18 rad18 actr3b actr3b zgc:101664 zgc:101664 poll poll helb helb rad51 rad51 rnf169 rnf169 rbbp8 rbbp8 actr2a actr2a arpc3 arpc3 arpc4l arpc4l smarcad1a smarcad1a arpc2 arpc2 zgc:136908 zgc:136908 actr2b actr2b samhd1 samhd1 tonsl tonsl prpf19 prpf19 paxx paxx timeless timeless tp53bp1 tp53bp1 setmar setmar actr3 actr3 smarcad1b smarcad1b NABP2 NABP2 wrap53 wrap53 rec114 rec114 polh polh arpc4 arpc4 rif1 rif1 SHLD2 SHLD2 slf2 slf2 B8JLP5_DANRE B8JLP5_DANRE nhej1 nhej1 rad50 rad50 rnf8 rnf8 pnkp pnkp ddb1 ddb1 sirt6 sirt6 ENSDARP00000135005 ENSDARP00000135005 LOC793232 LOC793232 slf1 slf1 Zgc:165656 Zgc:165656 mre11a mre11a smchd1 smchd1 HUS1B HUS1B rnf168 rnf168 WDR70 WDR70 sirt7 sirt7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
parp1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1013 aa)
vcpTransitional endoplasmic reticulum ATPase; Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. Also involved in DNA damage response: recruited to double-strand [...] (806 aa)
rpa3Replication protein A3. (121 aa)
ufl1E3 UFM1-protein ligase 1; E3 UFM1-protein ligase that mediates ufmylation of target proteins; Belongs to the UFL1 family. (793 aa)
zgc:101810Zgc:101810; Belongs to the actin family. (394 aa)
xrcc4X-ray repair-complementing defective repair in Chinese hamster cells 4. (357 aa)
parp3Poly [ADP-ribose] polymerase. (531 aa)
rad18RAD18 E3 ubiquitin protein ligase. (426 aa)
actr3bActin-related protein 3B; Belongs to the actin family. (425 aa)
zgc:101664Zgc:101664. (205 aa)
pollPolymerase (DNA directed), lambda; Belongs to the DNA polymerase type-X family. (566 aa)
helbHelicase (DNA) B. (1176 aa)
rad51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (340 aa)
rnf169E3 ubiquitin-protein ligase RNF169; Probable E3 ubiquitin-protein ligase that acts as a negative regulator of double-strand breaks (DSBs) repair following DNA damage. (630 aa)
rbbp8DNA endonuclease RBBP8; Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway. Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA. (651 aa)
actr2aActin-related protein 2-A; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (By similarity). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (By similarity). Seems to contact the pointed end of the daughter actin filament (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and [...] (394 aa)
arpc3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
arpc4lActin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (168 aa)
smarcad1aDNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double- strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication (By similarity). (972 aa)
arpc2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (299 aa)
zgc:136908Zgc:136908; Belongs to the AAA ATPase family. (805 aa)
actr2bActin-related protein 2-B; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (By similarity). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (By similarity). Seems to contact the pointed end of the daughter actin filament (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and [...] (394 aa)
samhd1Deoxynucleoside triphosphate triphosphohydrolase SAMHD1; Protein that acts both as a host restriction factor involved in defense response to virus and as a regulator of DNA end resection at stalled replication forks. Has deoxynucleoside triphosphate (dNTPase) activity, which is required to restrict infection by viruses: dNTPase activity reduces cellular dNTP levels to levels too low for retroviral reverse transcription to occur, blocking early-stage virus replication in dendritic and other myeloid cells. Functions during S phase at stalled DNA replication forks to promote the resection [...] (622 aa)
tonslTonsoku-like protein; Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks; Belongs to the Tonsoku family. (1427 aa)
prpf19PRP19/PSO4 homolog (S. cerevisiae). (505 aa)
paxxPAXX non-homologous end joining factor. (197 aa)
timelessTimeless circadian clock. (1278 aa)
tp53bp1Tumor protein p53-binding protein, 1. (1709 aa)
setmarSET domain and mariner transposase fusion protein. (293 aa)
actr3Actin-related protein 3; Belongs to the actin family. (231 aa)
smarcad1bDNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double- strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication (By similarity). (954 aa)
NABP2Si:ch73-190f16.2. (196 aa)
wrap53WD repeat-containing, antisense to TP53. (534 aa)
rec114REC114 meiotic recombination protein. (182 aa)
polhPolymerase (DNA directed), eta. (749 aa)
arpc4Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (193 aa)
rif1Replication timing regulatory factor 1. (2392 aa)
SHLD2Si:ch211-134m17.9. (784 aa)
slf2SMC5-SMC6 complex localization factor 2. (1129 aa)
B8JLP5_DANRESi:ch1073-75f15.2. (140 aa)
nhej1Non-homologous end-joining factor 1; DNA repair protein involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. (309 aa)
rad50RAD50 homolog, double strand break repair protein. (1312 aa)
rnf8E3 ubiquitin-protein ligase rnf8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated mdc1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of tp53 [...] (531 aa)
pnkpPolynucleotide kinase 3'-phosphatase. (588 aa)
ddb1Damage-specific DNA-binding protein 1. (1142 aa)
sirt6Sirtuin (Silent mating type information regulation 2 homolog) 6 (S. cerevisiae). (354 aa)
ENSDARP00000135005Si:ch73-236c18.8. (538 aa)
LOC793232Si:ch73-236c18.9. (527 aa)
slf1SMC5-SMC6 complex localization factor 1. (897 aa)
Zgc:165656Zgc:165656. (161 aa)
mre11aDouble-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (700 aa)
smchd1Structural maintenance of chromosomes flexible hinge domain-containing 1. (1983 aa)
HUS1BCheckpoint protein; Belongs to the HUS1 family. (284 aa)
rnf168E3 ubiquitin-protein ligase rnf168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with ube2n/ubc13 to amplify the rnf8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the rnf8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (474 aa)
WDR70WD repeat domain 70. (604 aa)
sirt7Sirtuin 7. (405 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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