STRINGSTRING
bnip4 bnip4 sirt2 sirt2 ptgs2b ptgs2b hif1ab hif1ab egln1b egln1b fndc1 fndc1 pink1 pink1 epas1a epas1a ptgs2a ptgs2a rbpja rbpja tsc1a tsc1a bnip3la bnip3la aqp1a.1 aqp1a.1 zgc:73226 zgc:73226 hif1an hif1an hif1aa hif1aa eef2k eef2k egln1a egln1a nfe2l2a nfe2l2a adoa adoa tbl2 tbl2 badb badb cpeb4a cpeb4a epas1b epas1b cpeb2 cpeb2 rbpjb rbpjb fam167aa fam167aa sirt1 sirt1 cpeb1b cpeb1b hyou1 hyou1 dnmt3aa dnmt3aa vhl vhl cpeb1a cpeb1a pick1 pick1 vhll vhll stox1 stox1 mtor mtor nfe2l2b nfe2l2b dnmt3ba dnmt3ba mpl mpl aqp1a.2 aqp1a.2 ppardb ppardb bada bada ENSDARP00000112868 ENSDARP00000112868 nkx3-1 nkx3-1 tp53 tp53 rgcc rgcc dnmt3bb.3 dnmt3bb.3 adob adob tsc1b tsc1b aifm1 aifm1 bcl2a bcl2a fam162a fam162a pparda pparda bcl2b bcl2b egln3 egln3 egln2 egln2 hif1al hif1al stox2b stox2b bnip3 bnip3 LOC100535961 LOC100535961 nop53 nop53 ndnf ndnf ak4 ak4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
bnip4BCL2-interacting protein 4. (177 aa)
sirt2NAD-dependent protein deacetylase sirtuin-2; NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and alpha-tubulin as well as many other proteins such as key transcription factors (By similarity). Participates in the modulation of multiple and diverse biological processes such as cell cycle control, genomic integrity, microtubule dynamics, cell differentiation, metabolic networks, and autophagy. Plays a major role in the control of cell cycle progression and genomic stability. Deacetylates histone H4 at 'Lys-16' (H4K16ac) at the VEGFA promoter. Thereby con [...] (379 aa)
ptgs2bProstaglandin-endoperoxide synthase 2b. (606 aa)
hif1abHypoxia-inducible factor 1 subunit alpha b. (777 aa)
egln1bEgl-9 family hypoxia-inducible factor 1b. (358 aa)
fndc1Fibronectin type III domain-containing 1. (1645 aa)
pink1PTEN-induced kinase 1. (574 aa)
epas1aEndothelial PAS domain protein 1a. (842 aa)
ptgs2aProstaglandin-endoperoxide synthase 2a. (601 aa)
rbpjaRecombination signal-binding protein for immunoglobulin kappa J region a. (496 aa)
tsc1aTSC complex subunit 1a. (1128 aa)
bnip3laBCL2/adenovirus E1B interacting protein 3-like, 2. (233 aa)
aqp1a.1Aquaporin 1a (Colton blood group), tandem duplicate 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (260 aa)
zgc:73226Zgc:73226. (187 aa)
hif1anHypoxia-inducible factor 1-alpha inhibitor; Hydroxylates a specific Asn residue in the C-terminal transactivation domain (CAD) of HIF-1 alpha. The hydroxylation prevents interaction of HIF-1 with transcriptional coactivators. Also hydroxylates specific Asn, Asp and His residues within ankyrin repeat domain-containing proteins. (344 aa)
hif1aaHypoxia-inducible factor 1 subunit alpha a. (717 aa)
eef2kEukaryotic elongation factor 2 kinase. (706 aa)
egln1aEgl-9 family hypoxia-inducible factor 1a. (328 aa)
nfe2l2aNuclear factor (Erythroid-derived 2)-like 2. (586 aa)
adoa2-aminoethanethiol (cysteamine) dioxygenase a. (248 aa)
tbl2Transducin beta-like 2. (439 aa)
badbBCL2-associated agonist of cell death b. (147 aa)
cpeb4aCytoplasmic polyadenylation element-binding protein 4; Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism; Belongs to the RRM CPEB family. (703 aa)
epas1bEndothelial PAS domain protein 1b. (834 aa)
cpeb2Cytoplasmic polyadenylation element-binding protein 2. (407 aa)
rbpjbRecombination signal-binding protein for immunoglobulin kappa J region b. (491 aa)
fam167aaFamily with sequence similarity 167 member Aa. (182 aa)
sirt1Sirtuin 1. (710 aa)
cpeb1bCytoplasmic polyadenylation element-binding protein 1; Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation and early development. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR (By similarity). (559 aa)
hyou1Hypoxia up-regulated protein 1; Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding; Belongs to the heat shock protein 70 family. (980 aa)
dnmt3aaDNA (cytosine-5-)-methyltransferase 3 alpha a; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (852 aa)
vhlVon Hippel-Lindau tumor suppressor. (175 aa)
cpeb1aCytoplasmic polyadenylation element-binding protein 1a. (522 aa)
pick1Protein-interacting with prkca 1. (406 aa)
vhllVon Hippel-Lindau tumor suppressor-like. (158 aa)
stox1Zgc:174575 protein. (967 aa)
mtorSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2563 aa)
nfe2l2bNuclear factor, erythroid 2-like 2b. (507 aa)
dnmt3baDNA (cytosine-5-)-methyltransferase 3 beta, duplicate a; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1500 aa)
mplMPL proto-oncogene, thrombopoietin receptor. (614 aa)
aqp1a.2Aquaporin 1a (Colton blood group), tandem duplicate 2; Belongs to the MIP/aquaporin (TC 1.A.8) family. (269 aa)
ppardbPeroxisome proliferator-activated receptor delta b. (517 aa)
badaBCL2-associated agonist of cell death a. (145 aa)
ENSDARP00000112868Egl-9 family hypoxia-inducible factor 1b. (232 aa)
nkx3-1NK3 homeobox 1. (214 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression. (369 aa)
rgccRegulator of cell cycle. (128 aa)
dnmt3bb.3DNA (cytosine-5-)-methyltransferase beta, duplicate b.3; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1296 aa)
adob2-aminoethanethiol (cysteamine) dioxygenase b. (254 aa)
tsc1bTSC complex subunit 1b. (1228 aa)
aifm1Apoptosis-inducing factor mitochondrion-associated 1. (750 aa)
bcl2aB-cell leukemia/lymphoma 2. (228 aa)
fam162aProtein FAM162B. (156 aa)
ppardaPeroxisome proliferator-activated receptor delta a. (496 aa)
bcl2bBCL2 apoptosis regulator b. (209 aa)
egln3Egl-9 family hypoxia-inducible factor 3. (243 aa)
egln2Egl-9 family hypoxia-inducible factor 2. (464 aa)
hif1alHypoxia-inducible factor 1 subunit alpha,-like. (626 aa)
stox2bStorkhead box 2b. (856 aa)
bnip3BCL2-interacting protein 3. (183 aa)
LOC100535961Uncharacterized protein. (182 aa)
nop53Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (473 aa)
ndnfNeuron-derived neurotrophic factor. (585 aa)
ak4Adenylate kinase 4, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity. (226 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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