STRINGSTRING
ENSDARP00000153246 ENSDARP00000153246 strc1 strc1 pacsin1a pacsin1a ENSDARP00000147138 ENSDARP00000147138 bloc1s5 bloc1s5 adgrg4a adgrg4a kcnq1.2 kcnq1.2 clrn1 clrn1 pdzd7a pdzd7a slitrk6 slitrk6 nbl1 nbl1 slc44a4 slc44a4 gas8 gas8 ttc39c ttc39c tprn tprn fgf3 fgf3 wdpcp wdpcp cep290 cep290 fsta fsta adgrg4b adgrg4b F1QB00_DANRE F1QB00_DANRE mdn1 mdn1 gata2b gata2b hnf1ba hnf1ba whrnb whrnb cthrc1b cthrc1b adgrg6 adgrg6 ptprq ptprq cthrc1a cthrc1a pax5 pax5 myo3a myo3a foxg1c foxg1c myo6a myo6a tmie tmie tbx3b tbx3b hmx2 hmx2 bmp2b bmp2b adgrg2a adgrg2a foxj1b foxj1b ush1c ush1c whrna whrna foxg1d foxg1d lrig1 lrig1 dlx4b dlx4b stm stm hmx3a hmx3a foxg1a foxg1a ptk7a ptk7a shrprbck1r shrprbck1r kcnq1.1 kcnq1.1 gata2a gata2a ttc25 ttc25 fstb fstb pax2a pax2a sox3 sox3 otx1 otx1 crbn crbn myo6b myo6b pacsin1b pacsin1b smad5 smad5 wnt8b wnt8b chrd chrd tmc2b tmc2b hpn hpn pax2b pax2b tbx1 tbx1 OTOP1 OTOP1 pax8 pax8 tbx2a tbx2a tcap tcap tbx3a tbx3a msx3 msx3 dlx3b dlx3b foxg1b foxg1b fgf8a fgf8a cobl cobl myo3b myo3b gata3 gata3 ttc36 ttc36 msx1b msx1b bmp2a bmp2a jag1b jag1b gbx2 gbx2 cldn7b cldn7b cdh2 cdh2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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ENSDARP00000153246Ig-like domain-containing protein. (160 aa)
strc1Stereocilin 1. (2032 aa)
pacsin1aProtein kinase C and casein kinase substrate in neurons 1a. (438 aa)
ENSDARP00000147138TGFb_propeptide domain-containing protein. (179 aa)
bloc1s5Biogenesis of lysosome-related organelles complex 1 subunit 5; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO). (155 aa)
adgrg4aAdhesion G protein-coupled receptor G4a; Belongs to the G-protein coupled receptor 2 family. (1201 aa)
kcnq1.2Potassium voltage-gated channel, KQT-like subfamily, member 1.2; Belongs to the potassium channel family. (531 aa)
clrn1Clrn1 protein. (232 aa)
pdzd7aPDZ domain-containing 7a. (954 aa)
slitrk6SLIT and NTRK-like family, member 6. (830 aa)
nbl1Neuroblastoma suppressor of tumorigenicity 1; May act as a tumor suppressor; Belongs to the DAN family. (86 aa)
slc44a4Choline transporter-like protein 4; Choline transporter that seems to play a role in the choline- acetylcholine system and is required to the efferent innervation of hair cells in the olivocochlear bundle for the maintenance of physiological function of outer hair cells and the protection of hair cells from acoustic injury; Belongs to the CTL (choline transporter-like) family. (703 aa)
gas8Dynein regulatory complex subunit 4; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays an important role in the assembly of the N-DRC linker (By similarity). Plays dual roles at both the primary (or non-motile) cilia to regulate hedgehog signaling and in motile cilia to coordinate cilia movement. Required for proper slow muscle development and positively regulates ciliary smoothened (SMO)-dependent Hedgehog ( [...] (475 aa)
ttc39cTetratricopeptide repeat protein 39C. (579 aa)
tprnTaperin. (758 aa)
fgf3Fibroblast growth factor 3; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Belongs to the heparin-binding growth factors family. (256 aa)
wdpcpWD repeat-containing planar cell polarity effector. (707 aa)
cep290Centrosomal protein of 290 kDa; Involved in early and late steps in cilia formation. May play a role in early ciliogenesis in the disappearance of centriolar satellites and in the transition of primary ciliar vesicles (PCVs) to capped ciliary vesicles (CCVs). In the ciliary transition zone is part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. Involved in regulation of the BBSome complex integrity and in ciliary targeting of selected BBSome cargos. Required for the correct localization of ciliary and photot [...] (2439 aa)
fstaFollistatin-A; Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (fsh) (By similarity). Inhibits bmp-signaling during later stages of development including late phases of dorsoventral patterning, to refine the early pattern set up by the interaction of chordino and bmp2/4. Not involved in organizer function or early phases of dorsoventral pattern formation. (324 aa)
adgrg4bAdhesion G protein-coupled receptor G4b; Belongs to the G-protein coupled receptor 2 family. (522 aa)
F1QB00_DANRESi:dkey-259j3.5; Belongs to the G-protein coupled receptor 2 family. (720 aa)
mdn1Midasin; Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits; Belongs to the midasin family. (5523 aa)
gata2bGATA-binding protein 2b. (428 aa)
hnf1baHepatocyte nuclear factor 1-beta-A; Transcription factor, probably binds to the inverted palindrome 5'-GTTAATNATTAAC-3' (By similarity). Required for induction of rhombomere r5/r6 gene expression in the hindbrain. (555 aa)
whrnbWhirlin b. (946 aa)
cthrc1bCollagen triple helix repeat-containing 1b. (233 aa)
adgrg6Adhesion G-protein coupled receptor G6; G-protein coupled receptor which is activated by type IV collagen, a major constituent of the basement membrane. Couples to G(i)-proteins as well as G(s)-proteins. Essential for normal differentiation of promyelinating Schwann cells and for normal myelination of axons. Plays also a role in inner ear development. (1240 aa)
ptprqProtein tyrosine phosphatase receptor type Q. (2301 aa)
cthrc1aCollagen triple helix repeat-containing 1a. (232 aa)
pax5Paired box 5. (396 aa)
myo3aMyosin IIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1775 aa)
foxg1cForkhead box G1c. (379 aa)
myo6aMyosin VIa; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1288 aa)
tmieTransmembrane inner ear. (231 aa)
tbx3bT-box transcription factor 3b. (594 aa)
hmx2H6 family homeobox 2. (269 aa)
bmp2bBone morphogenetic protein 2b. (411 aa)
adgrg2aAdhesion G protein-coupled receptor G2a; Belongs to the G-protein coupled receptor 2 family. (1037 aa)
foxj1bForkhead box protein J1-B; Key transcription factor required for motile ciliogenesis. Activates genes essential for motile cilia formation and function. Belongs to the FOXJ1 family. (442 aa)
ush1cUsher syndrome 1C (Autosomal recessive, severe). (548 aa)
whrnaWhirlin a. (939 aa)
foxg1dForkhead box G1d. (316 aa)
lrig1Leucine-rich repeats and immunoglobulin-like domains 1. (1022 aa)
dlx4bHomeobox protein Dlx4b; During larvae development, may be important for neurocranium morphogenesis. (254 aa)
stmProtein starmaker; Essential for the formation of otoliths in the inner ear of developing larvae and for the perception of gravity and acceleration. May be one of the organic components of the ortholiths. (613 aa)
hmx3aHomeobox protein HMX3; Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. Binds to the 5'-CAAGTG-3' core sequence (By similarity). Belongs to the HMX homeobox family. (297 aa)
foxg1aForkhead box G1a. (420 aa)
ptk7aProtein tyrosine kinase 7a; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1061 aa)
shrprbck1rRanBP-type and C3HC4-type zinc finger-containing protein 1; Component of the LUBAC complex which conjugates linear ('M- 1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. (714 aa)
kcnq1.1Potassium voltage-gated channel, KQT-like subfamily, member 1.1; Belongs to the potassium channel family. (655 aa)
gata2aGATA-binding protein 2a. (456 aa)
ttc25Tetratricopeptide repeat protein 25; Required for the docking of the outer dynein arm to cilia, hence plays an essential role in cilia motility. (486 aa)
fstbFollistatin 2. (344 aa)
pax2aPaired box protein Pax-2a; Probable transcription factor involved in the development of the midbrain/hindbrain boundary (MHB) organizer and specification of neuronal cell fates. Required for establishment of eng2 and eng3 gene expression in the midbrain and MHB primordium during late gastrulation. (391 aa)
sox3Transcription factor Sox-3; Transcriptional activator. (300 aa)
otx1Homeobox protein OTX1 B; May play a role in very early embryogenesis, gastrulation, and the development and subdivision of the diencephalon and the midbrain; Belongs to the paired homeobox family. Bicoid subfamily. (323 aa)
crbnProtein cereblon; Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Normal degradation of key regulatory proteins is required for limb outgrowth and expression of the fibroblast growth factor FGF8. May also play a role in the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning. (446 aa)
myo6bMyosin VIb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1267 aa)
pacsin1bProtein kinase C and casein kinase substrate in neurons protein 1; Binds to membranes via its F-BAR domain and mediates membrane tubulation. Plays a role in cellular transport processes by recruiting dynamins to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with cobl, and by recruiting cobl to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neur [...] (445 aa)
smad5Mothers against decapentaplegic homolog 5; Involved in ventralization. May mediate Bmp2b signaling during early phases of embryonic dorsal-ventral pattern formation. Required for initiation of Smad1 expression during gastrulation. Belongs to the dwarfin/SMAD family. (464 aa)
wnt8bProtein Wnt-8b; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. May play a role in the establishment of polarity in the nervous system. (358 aa)
chrdChordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes (By similarity); Belongs to the chordin family. (940 aa)
tmc2bTransmembrane channel-like protein 2-B; Belongs to the TMC family. (892 aa)
hpnNovel protein similar to H.sapiens HPN, hepsin (Transmembrane protease, serine 1) (HPN); Belongs to the peptidase S1 family. (425 aa)
pax2bPaired box 2b. (386 aa)
tbx1T-box transcription factor TBX1; May act as a transcriptional factor. Acts cell autonomously in the pharyngeal mesendoderm and influences the development of neural crest-derived cartilages secondarily. (460 aa)
OTOP1Otopetrin 1. (587 aa)
pax8Paired box 8. (448 aa)
tbx2aT-box transcription factor 2a. (686 aa)
tcapTitin-cap (telethonin). (179 aa)
tbx3aT-box transcription factor 3a. (689 aa)
msx3Homeobox protein MSH-C; Involved in the development of the inner ear; Belongs to the Msh homeobox family. (273 aa)
dlx3bHomeobox protein Dlx3b; Involved in the development of the inner ear; Belongs to the distal-less homeobox family. (269 aa)
foxg1bForkhead box G1b. (341 aa)
fgf8aFibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration (By similarity). Required for Kupffer's vesicle ciliogenesis. (210 aa)
coblProtein cordon-bleu; Plays an important role in the reorganization of the actin cytoskeleton. Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. Regulates neuron morphogenesis and increases branching of axons and dendrites (By similarity). Required for normal embryonic development, including normal develop [...] (1327 aa)
myo3bMyosin IIIB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1272 aa)
gata3Transcription factor GATA-3. (438 aa)
ttc36Tetratricopeptide repeat protein 36; Belongs to the TTC36 family. (187 aa)
msx1bHomeobox protein MSH-B; Probable morphogenetic role; Belongs to the Msh homeobox family. (257 aa)
bmp2aBone morphogenetic protein 2a. (386 aa)
jag1bProtein jagged-1b; Ligand for Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions. (1213 aa)
gbx2Gastrulation brain homeo box 2. (342 aa)
cldn7bClaudin-7-B; Plays a major role in tight junction-specific obliteration of the intercellular space; Belongs to the claudin family. (215 aa)
cdh2Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion (By similarity). Cadherins contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development. Required for normal neural tube morphogenesis. Required to allow mid- and hindbrain neurons to reach and maintain their appropriate positions within the neural tube by restricting neuronal motility within the embryonic mid- and hindbrain. (893 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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