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| | pde6a | Phosphodiesterase. (858 aa) |
| | fkbp8 | Peptidylprolyl isomerase. (406 aa) |
| | sp3a | Sp3a transcription factor. (679 aa) |
| | traf3ip1 | TRAF3-interacting protein 1; Plays an inhibitory role on IL13 signaling by binding to IL13RA1 and recruits TRAF3 and DISC1 to the microtubules. Involved in the regulation of microtubule cytoskeleton organization. Is a negative regulator of microtubule stability, acting through the control of MAP4 levels. Involved in ciliogenesis (By similarity). (629 aa) |
| | rnf2 | E3 ubiquitin-protein ligase RING2; E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin he [...] (338 aa) |
| | prph2lb | Si:dkey-85n7.2 protein. (359 aa) |
| | fzr1a | Fizzy/cell division cycle 20 related 1 (Drosophila). (495 aa) |
| | gdf5 | Growth differentiation factor 5. (474 aa) |
| | epha4l | Eph receptor A4,-like. (988 aa) |
| | cdh2 | Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion (By similarity). Cadherins contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development. Required for normal neural tube morphogenesis. Required to allow mid- and hindbrain neurons to reach and maintain their appropriate positions within the neural tube by restricting neuronal motility within the embryonic mid- and hindbrain. (893 aa) |
| | med27 | Mediator of RNA polymerase II transcription subunit 27; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required [...] (311 aa) |
| | prkci | Protein kinase C iota type; Calcium- and diacylglycerol-independent serine/ threonine- protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway (By similarity). Is required for the formation and maintenance of the zonula adherens during early epithelial development and plays a critical role in organ morphogenesis and in regulating the orientation of cell division. (588 aa) |
| | phactr1 | Phosphatase and actin regulator. (542 aa) |
| | ints7 | Integrator complex subunit 7; Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'- box-dependent processing. May play a role in DNA damage response (DDR) signaling during the S phase (By similarity). Essential during embryogenesis for eye development. (964 aa) |
| | fkbp16 | Peptidylprolyl isomerase. (430 aa) |
| | myod1 | Myoblast determination protein 1 homolog; May act as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. (275 aa) |
| | efnb2a | Ephrin-B2a; Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with ephb4 may play a central role in heart morph [...] (332 aa) |
| | ptf1a | Pancreas transcription factor 1 subunit alpha; Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Required for exocrine pancreatic development. Plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates. (265 aa) |
| | prph2b | Peripherin 2b (retinal degeneration, slow). (342 aa) |
| | wnt11f2 | Protein Wnt-11; Ligand for members of the frizzled family of seven transmembrane receptors. May play a role in the formation of dermal structure, both limb and feather buds. Is likely to signal over only few cell diameters (By similarity); Belongs to the Wnt family. (353 aa) |
| | otx2a | Homeobox protein OTX1 A; Plays a role in very early embryogenesis, gastrulation, and the development and subdivision of the diencephalon and the midbrain. Establishes and positions the zona limitans intrathalamica (ZLI) in the diencephalon. May play a role in the organizer function. Probably acts redundantly with otx2 in early brain development. (338 aa) |
| | pax4 | Paired box 4. (344 aa) |
| | stk3 | Serine/threonine-protein kinase 3 20kDa subunit; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein stk3/mst2 and stk4/mst1, in complex with its regulatory protein sav1, phosphorylates and activates lats1/2 in complex with its regul [...] (492 aa) |
| | bsg | Basigin. (404 aa) |
| | fgf8a | Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration (By similarity). Required for Kupffer's vesicle ciliogenesis. (210 aa) |
| | znf503 | Zinc finger protein 503; Required for segmental gene expression during hindbrain development. May function as a transcriptional repressor. Belongs to the Elbow/Noc family. (563 aa) |
| | mab21l2 | Protein mab-21-like 2; Required for eye morphogenesis. May promote the survival of proliferating retinal progenitor cells; Belongs to the mab-21 family. (359 aa) |
| | foxn4 | Forkhead box protein N4; Transcription factor essential for neural and some non-neural tissues development. Binds to an 11-bp consensus sequence containing the invariant tetranucleotide 5'-ACGC-3'. During development of the central nervous system, required to specify the amacrine and horizontal cell fates from multipotent retinal progenitors while suppressing the alternative photoreceptor cell fates. Drives commitment of p2 progenitors to the V2b interneuron fates during spinal cord neurogenesis. In development of non-neural tissues, plays an essential role in the specification of the [...] (550 aa) |
| | lhx1a | LIM/homeobox protein Lhx1; Seems to play a role in dorsal axis formation. (405 aa) |
| | dlx3b | Homeobox protein Dlx3b; Involved in the development of the inner ear; Belongs to the distal-less homeobox family. (269 aa) |
| | mpp5b | Membrane protein, palmitoylated 5b (MAGUK p55 subfamily member 5); Belongs to the MAGUK family. (639 aa) |
| | sox21b | Transcription factor Sox-21-B; Acts as a negative regulator of transcription. (245 aa) |
| | unc45b | Protein unc-45 homolog B; Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain (By similarity). Plays a role in sarcomere formation during muscle cell development. Required for myoseptal integrity, myofiber attachment, motility and craniofacial development. Is necessary for normal early lens development. (934 aa) |
| | ctns | Cystinosin, lysosomal cystine transporter. (384 aa) |
| | poc1b | POC1 centriolar protein homolog B; Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Belongs to the WD repeat POC1 family. (490 aa) |
| | neurod1 | Neurogenic differentiation factor 1; May act as a transcriptional activator. Differentiation factor required for neurogenesis. Acts as an upstream activator of isl1. (350 aa) |
| | meis1a | Myeloid ecotropic viral integration site 4.1a. (380 aa) |
| | dmbx1b | Diencephalon/mesencephalon homeobox protein 1-B. (369 aa) |
| | angptl7 | Angiopoietin-like 7. (338 aa) |
| | six1b | Homeobox protein six1b; Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Depending on context, functions as transcriptional repressor or activator. Transcriptional activation is enhanced by eya1 (in vitro). Plays an important role in the development of the inner ear, where it promotes hair cell proliferation and inhibits proliferation of neural progenitor cells. Required for normal myogenesis. Plays a role in the development of fast muscle fibers throughout the body, as well as the development of craniofacial muscles. R [...] (284 aa) |
| | igfn1.1 | Immunoglobulin-like and fibronectin type III domain-containing 1, tandem duplicate 1. (534 aa) |
| | six6a | Sine oculis-related homeobox 6a. (245 aa) |
| | tbx5a | T-box transcription factor TBX5-A; Required for pectoral fin formation. Together with tbx5b, involved in eye and heart development. Required for the looping stage of heart development. May bind to the core DNA motif of promoters. (492 aa) |
| | pax8 | Paired box 8. (448 aa) |
| | suv39h1a | Histone-lysine N-methyltransferase SUV39H1-A; Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric [...] (411 aa) |
| | nf2b | Neurofibromin 2b (merlin). (586 aa) |
| | aqp1a.1 | Aquaporin 1a (Colton blood group), tandem duplicate 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (260 aa) |
| | vax1 | Ventral anterior homeobox 1; Transcription factor that is required for closure of the choroid fissure and together with Vax2 is required for optic nerve differentiation and to limit retinal development to the optic cup. Belongs to the EMX homeobox family. (317 aa) |
| | tgfbr2b | TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (556 aa) |
| | rtn4ip1 | Reticulon-4-interacting protein 1 homolog, mitochondrial; Plays a role in the regulation of retinal ganglion cell (RGC) maturation, neurite outgrowth, and hence in the development of the inner retina and optic nerve. Appears to be a potent inhibitor of regeneration following spinal cord injury (By similarity). Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. (387 aa) |
| | tdrd7a | Tudor domain-containing protein 7A; Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Probably required during spermatogenesis (By similarity). Required for structural integrity of granules in primordial germ cells (PGCs). (1079 aa) |
| | celf1 | CUGBP Elav-like family member 1; RNA-binding protein implicated in the regulation of several post-transcriptional events. May be involved in mRNA translation activation and stability (By similarity). Involved in the regulation of muscle-specific splicing of alpha actinin pre-mRNAs via the binding to the UR-repeat element (URE) at the branch point of the non-muscle (NM) exon; Belongs to the CELF/BRUNOL family. (534 aa) |
| | cryba2a | Crystallin, beta A2a; Belongs to the beta/gamma-crystallin family. (197 aa) |
| | crygn2 | Gamma-crystallin N-B; Crystallins are the dominant structural components of the vertebrate eye lens. (206 aa) |
| | pax2b | Paired box 2b. (386 aa) |
| | phactr4b | Phosphatase and actin regulator 4B; Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to repression of the integrin signaling through the rho/rock pathway (By similarity). (754 aa) |
| | tbc1d20 | TBC1 domain family, member 20. (397 aa) |
| | crygs3 | Crystallin, gamma S3; Belongs to the beta/gamma-crystallin family. (183 aa) |
| | tspan12 | Tetraspanin. (301 aa) |
| | naglu | N-acetylglucosaminidase, alpha. (757 aa) |
| | cryba1a | Crystallin, beta A1a; Belongs to the beta/gamma-crystallin family. (196 aa) |
| | wnt8b | Protein Wnt-8b; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. May play a role in the establishment of polarity in the nervous system. (358 aa) |
| | pfdn5 | Pfdn5 protein. (153 aa) |
| | rd3 | Retinal degeneration 3, GUCY2D regulator. (215 aa) |
| | znf703 | Zinc finger protein 703; Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Required for segmental gene expression during hindbrain development. May regulate cell adhesion, migration and proliferation. (589 aa) |
| | marcksl1b | MARCKS-related protein 1-B; Involved in the control of cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. (207 aa) |
| | pitx2 | Pituitary homeobox 2; Isoform a and isoform c differentially regulate mesendoderm formation and asymmetric organ development. Both isoforms regulate left-right development, but isoform a has a stronger effect on heart laterality; Belongs to the paired homeobox family. Bicoid subfamily. (314 aa) |
| | egr1 | Early growth response protein 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Mediates responses to ischemia and hypoxia; regulates the express [...] (511 aa) |
| | bhlhe23 | Basic helix-loop-helix family, member e23. (227 aa) |
| | trappc11 | Trafficking protein particle complex subunit 11; Involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage. (1132 aa) |
| | prph2a | Peripherin 2a (retinal degeneration, slow). (345 aa) |
| | th2 | Tyrosine hydroxylase 2. (471 aa) |
| | skila | SKI-like proto-oncogene a. (623 aa) |
| | bmpr2a | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1003 aa) |
| | marcksl1a | MARCKS-related protein 1-A; Involved in the control of cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. (213 aa) |
| | vstm4a | V-set and transmembrane domain-containing 4a. (329 aa) |
| | bbs5 | Bardet-Biedl syndrome 5 protein homolog; Required for ciliogenesis; Belongs to the BBS5 family. (342 aa) |
| | rbm42 | RNA-binding protein 42; May bind RNA; Belongs to the RRM RBM42 family. (402 aa) |
| | gpm6aa | Glycoprotein M6Aa. (278 aa) |
| | rx2 | Retinal homeobox protein Rx2; Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation; Belongs to the paired homeobox family. Bicoid subfamily. (327 aa) |
| | tgfb1a | Transforming growth factor beta; Belongs to the TGF-beta family. (377 aa) |
| | ift172 | Intraflagellar transport protein 172 homolog; Required for the maintenance and formation of cilia. (1745 aa) |
| | cryaba | Crystallin, alpha B, a; Belongs to the small heat shock protein (HSP20) family. (168 aa) |
| | jun | Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (308 aa) |
| | otx1 | Homeobox protein OTX1 B; May play a role in very early embryogenesis, gastrulation, and the development and subdivision of the diencephalon and the midbrain; Belongs to the paired homeobox family. Bicoid subfamily. (323 aa) |
| | gnrh2 | Gonadoliberin; Stimulates the secretion of gonadotropins. Belongs to the GnRH family. (86 aa) |
| | rx3 | Retinal homeobox protein Rx3; Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation. (292 aa) |
| | prss56 | Serine protease 56; Belongs to the peptidase S1 family. (299 aa) |
| | vstm4b | V-set and transmembrane domain-containing 4b. (357 aa) |
| | gdf6a | Growth/differentiation factor 6-A; Growth factor that controls proliferation and cellular differentiation in the retina. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map. Functions maternally in dorsal/ventral patterning to induce the expression of the zygotic bmp2b and bmp4 genes and ventralize embryos. Zygotic expression does not appear to regulate axis specification, but instead functions to establish the integrity of the axial vessels during embryon [...] (404 aa) |
| | cryaa | Crystallin, alpha A; Belongs to the small heat shock protein (HSP20) family. (173 aa) |
| | crybb2 | Crystallin, beta B2; Belongs to the beta/gamma-crystallin family. (208 aa) |
| | crygmxl2 | Crystallin, gamma MX,-like 2; Belongs to the beta/gamma-crystallin family. (176 aa) |
| | srfa | Serum response factor a. (539 aa) |
| | pax2a | Paired box protein Pax-2a; Probable transcription factor involved in the development of the midbrain/hindbrain boundary (MHB) organizer and specification of neuronal cell fates. Required for establishment of eng2 and eng3 gene expression in the midbrain and MHB primordium during late gastrulation. (391 aa) |
| | six3b | Sine oculis homeobox homolog 3b. (293 aa) |
| | ptch2 | Protein patched homolog 1; Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal (By similarity). Belongs to the patched family. (1442 aa) |
| | zhx2a | Zinc fingers and homeoboxes 2a. (805 aa) |
| | ret | Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1106 aa) |
| | foxc1b | Forkhead box C1-B; DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin development. Acts either as a transcriptional activator or repressor. Binds to the consensus binding site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes. Upon DNA-binding, promotes DNA bending. Required for cell viability and resistance to oxidative stress in the eye. Promotes cell growth inhibition by stopping the cell cycle in the G1 phase through TGFB1- mediated signals. Involved in epithelia [...] (433 aa) |
| | foxh1 | Forkhead box protein H1; Transcriptional activator. Activates an activin response element (ARE). Recognizes and binds to the DNA sequence 5'- TGT[GT][GT]ATT-3'. Modulator of nodal signaling required for organizer formation. Also required for the development of dorsal axial structures and left-right symmetry. (472 aa) |
| | suv39h1b | Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (421 aa) |
| | dixdc1a | Dixin-A; Functions as a positive effector of the Wnt signaling pathway regulating antero-posterior neural patterning. (443 aa) |
| | six3a | Sine oculis homeobox homolog 3a. (294 aa) |
| | bves | Blood vessel epicardial substance; Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in skeletal muscle and heart development as well as in the maintenance of heart function. May play a role in vamp3-mediated vesicular transport and recycling of receptor molecules. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells. May induce primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)- independent manner. May be involved in epithelial movement during [...] (352 aa) |
| | vax2 | Ventral anterior homeobox 2; Transcription factor that may function in dorsoventral specification of the forebrain. Required for closure of the choroid fissure and together with vax1 is required for optic nerve differentiation and to limit retinal development to the optic cup. Belongs to the EMX homeobox family. (307 aa) |
| | tgfbr2a | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (645 aa) |
| | cactin | Cactin; May be involved in the regulation of innate immune response (By similarity). Plays a role during early embryonic development. Involved in the formation of the anteroposterior axis with important roles also in neural development; Belongs to the CACTIN family. (835 aa) |
| | crb2a | Crumbs cell polarity complex component 2a. (1466 aa) |
| | nectin1b | Nectin cell adhesion molecule 1b. (539 aa) |
| | efnb2b | Ephrin-B2b; Belongs to the ephrin family. (334 aa) |
| | ranbp9 | Ran-binding protein 9; May act as scaffolding protein, and as adapter protein to couple membrane receptors to intracellular signaling pathways. Acts as a mediator of cell spreading and actin cytoskeleton rearrangement. Core component of the CTLH E3 ubiquitin-protein ligase complex that mediates ubiquitination and subsequent proteasomal degradation of target proteins. (597 aa) |
| | igf2bp1 | Insulin-like growth factor 2 mRNA-binding protein 1; RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Plays a direct role in the transport and translation of transcripts required for axonal regeneration in adult sensory neurons (By similarity). Regulates localized beta- actin/AC [...] (598 aa) |
| | ift46 | Intraflagellar transport protein 46 homolog; Forms part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. Plays a role in early embryonic development; Belongs to the IFT46 family. (355 aa) |
| | rorb | RAR-related orphan receptor B. (466 aa) |
| | B0UYP0_DANRE | Si:dkey-57a22.15; Belongs to the beta/gamma-crystallin family. (174 aa) |
| | zmp:0000000711 | Tubby-like protein; Belongs to the TUB family. (478 aa) |
| | yap1 | Transcriptional coactivator YAP1; Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (By similarity). Required for expansion of the neural plate and neural plate border zone progenitor pools. Acts as a direct regulator of pax3 expression via interaction with tead1. Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin netwo [...] (442 aa) |
| | tcf7l1a | Transcription factor 7-like 1-A; Participates in the Wnt signaling pathway. Probably binds to DNA and acts as a repressor in the absence of ctnnb1, and possibly as an activator in its presence. Required early in development for dorsal specific gene activation and during gastrulation for repression of dorsal-specific genes in the marginal zone. Required for head formation and forebrain specification. Regulates anterior-posterior patterning in the neuroectoderm by repressing posterior neural fates. Belongs to the TCF/LEF family. (560 aa) |
| | atp6v0d1 | V-type proton ATPase subunit d 1; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) p [...] (350 aa) |
| | alcamb | Activated leukocyte cell adhesion molecule b. (562 aa) |
| | atoh7 | Protein atonal homolog 7; Transcription factor involved in the differentiation of retinal ganglion cells. (134 aa) |
| | crygmxl1 | Crystallin, gamma MX,-like 1; Belongs to the beta/gamma-crystallin family. (173 aa) |
| | pitx3 | Pituitary homeobox 3; Transcriptional regulator which may play a role in the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons (By similarity). Required for lens and retinal development and for pituitary pre-placode formation and cell specification; Belongs to the paired homeobox family. Bicoid subfamily. (293 aa) |
| | six7 | Sine oculis homeobox homolog 7. (256 aa) |
| | scaper | S-phase cyclin A-associated protein in the ER. (1318 aa) |
| | abhd12 | Lysophosphatidylserine lipase ABHD12; Lysophosphatidylserine (LPS) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes (By similarity). Represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous system (By similarity). Also able to hydrolyze oxidized phosphatidylserine; oxidized phosphatidylserine is produced in response to severe inflammatory stress and constitutes a proapoptotic 'eat me' signal. Also has monoacylglycerol (MAG) lipase act [...] (382 aa) |
| | crygmx | Crystallin, gamma MX; Belongs to the beta/gamma-crystallin family. (175 aa) |
| | dlx4b | Homeobox protein Dlx4b; During larvae development, may be important for neurocranium morphogenesis. (254 aa) |
| | rx1 | Retinal homeobox protein Rx1; Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation; Belongs to the paired homeobox family. Bicoid subfamily. (330 aa) |
| | opn8b | Opsin 8, group member b; Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. (357 aa) |
| | tulp1a | TUB-like protein 1a; Belongs to the TUB family. (506 aa) |
| | hps1 | HPS1 biogenesis of lysosomal organelles complex 3 subunit 1. (668 aa) |
| | get1 | Tail-anchored protein insertion receptor WRB; Receptor for ASNA1/TRC40-mediated insertion of tail-anchored (TA) proteins into the ER membrane. (170 aa) |
| | sdk1a | Sidekick cell adhesion molecule 1a. (2159 aa) |
| | tdrd7b | Tudor domain-containing protein 7B; Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Probably required during spermatogenesis (By similarity). (1085 aa) |
| | nectin1a | Nectin cell adhesion molecule 1a. (475 aa) |
| | BFSP1 | Beaded filament structural protein 1. (422 aa) |
| | nhsa | Nance-Horan syndrome a (congenital cataracts and dental anomalies). (1259 aa) |
| | opn8a | Opsin 8, group member a. (335 aa) |
| | bbs4 | Bardet-Biedl syndrome 4. (528 aa) |
| | ush1c | Usher syndrome 1C (Autosomal recessive, severe). (548 aa) |
| | foxc1a | Forkhead box C1-A; DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin development. Acts either as a transcriptional activator or repressor. Binds to the consensus binding site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes. Upon DNA-binding, promotes DNA bending. Required for cell viability and resistance to oxidative stress in the eye. Promotes cell growth inhibition by stopping the cell cycle in the G1 phase through TGFB1- mediated signals. Involved in epithelia [...] (476 aa) |
| | skilb | SKI-like proto-oncogene b. (624 aa) |
| | emc3 | ER membrane protein complex subunit 3. (261 aa) |
| | bmpr2b | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1071 aa) |
| | dmbx1a | Diencephalon/mesencephalon homeobox protein 1-A; Required for eye and tectum development. May act as a transcriptional repressor. (383 aa) |
| | cyp1b1 | Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (526 aa) |
| | rpgrip1l | RPGRIP1-like. (1256 aa) |
| | tbx2b | T-box transcription factor TBX2b; Involved in the transcriptional regulation of genes required for mesoderm differentiation. Plays a role in the specification of late notochordal precursor cells and formation of the differentiated notochord. Required for cardiac atrioventricular canal formation. (687 aa) |
| | reep6 | Receptor expression-enhancing protein 6; Required correct function and survival of retinal photoreceptors. Required for retinal development (By similarity). In rod photoreceptors, facilitates stability and/or trafficking of guanylate cyclases and is required to maintain endoplasmic reticulum and mitochondrial homeostasis (By similarity). May play a role in clathrin-coated intracellular vesicle trafficking of proteins from the endoplasmic reticulum to the retinal rod plasma membrane (By similarity). (208 aa) |
| | insm1a | Insulinoma-associated protein 1a; May act as a transcriptional regulator. May play a role in neurogenesis and neuroendocrine cell differentiation during embryonic development (By similarity). (383 aa) |
| | ran | GTP-binding nuclear protein Ran; GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP- bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment [...] (215 aa) |
| | lrp5 | Low density lipoprotein receptor-related protein 5. (1615 aa) |
| | myf5 | Myogenic factor. (237 aa) |
| | gnl3 | Guanine nucleotide-binding protein-like 3; May play a role in regulating cellular proliferation. (561 aa) |
| | aqp1a.2 | Aquaporin 1a (Colton blood group), tandem duplicate 2; Belongs to the MIP/aquaporin (TC 1.A.8) family. (269 aa) |
| | six6b | Sine oculis-related homeobox 6b. (245 aa) |
| | mfrp | Membrane frizzled-related protein. (572 aa) |
| | nr2e3 | Nuclear receptor subfamily 2, group E, member 3. (426 aa) |
| | otx2b | Homeobox protein OTX2; May play a role in very early embryogenesis, gastrulation, and the development and subdivision of the diencephalon and the midbrain. (289 aa) |
| | cryba2b | Crystallin, beta A2b; Belongs to the beta/gamma-crystallin family. (197 aa) |
| | ift140 | Intraflagellar transport 140 homolog (Chlamydomonas). (1445 aa) |
| | nes | Nestin; Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). Required for brain and eye development. (1265 aa) |
| | pax5 | Paired box 5. (396 aa) |
| | rp1 | RP1 axonemal microtubule-associated. (259 aa) |
| | crygs1 | Crystallin, gamma S1; Belongs to the beta/gamma-crystallin family. (178 aa) |
| | F1Q847_DANRE | Si:dkey-76d14.2. (114 aa) |
| | pomgnt2 | Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2; O-linked mannose beta-1,4-N-acetylglucosaminyltransferase that transfers UDP-N-acetyl-D-glucosamine to the 4-position of the mannose to generate N-acetyl-D-glucosamine-beta-1,4-O-D- mannosylprotein. Involved in the biosynthesis of the phosphorylated O- mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N- acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affini [...] (585 aa) |
| | lmo2 | Rhombotin-2; Transcription factor that acts synergistically with tal1/scl in primitive and definitive hematopoiesis, and in endothelial development. Specifies mesodermal precursors to a hemangioblast cell fate. Hemangioblasts are bipotential precursors of blood and endothelium, and in the absence of hematopoietic induction cues such as gata1, tal1/scl-lmo2-induced haemangioblasts differentiate into endothelial cells. (159 aa) |
| | sdk1b | Sidekick cell adhesion molecule 1b. (2095 aa) |
| | nrf1 | Nuclear respiratory factor 1; Probable transcription factor that is required for normal development of the outer retina. (504 aa) |
| | pygo2 | Pygopus homolog 2 (Drosophila). (571 aa) |
| | sdk2b | Sidekick cell adhesion molecule 2b. (2237 aa) |
| | usp45 | Ubiquitin carboxyl-terminal hydrolase 45; May be involved in the maintenance of photoreceptor function. Belongs to the peptidase C19 family. (803 aa) |
| | rpgrip1 | RPGR-interacting protein 1. (1342 aa) |
| | impg2a | Interphotoreceptor matrix proteoglycan 2a. (270 aa) |
| | foxq2 | Forkhead box Q2. (263 aa) |
| | nf1b | Neurofibromin 1b. (2759 aa) |
| | rp2 | Protein XRP2; Acts as a GTPase-activating protein (GAP) involved in trafficking between the Golgi and the ciliary membrane (By similarity). Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization (By similarity). In the retina, required for maintenance of rod and cone photoreceptor cells. May have a role in normal retinal localization of the transducins GNB1 and GNAT1, and the rhodopsin kinase GRK1. (376 aa) |
| | nf2a | Similar to neurofibromin 2. (593 aa) |
| | prpf31 | U4/U6 small nuclear ribonucleoprotein Prp31; Involved in pre-mRNA splicing as component of the spliceosome. Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. (508 aa) |
| | tgfb1b | Transforming growth factor beta; Belongs to the TGF-beta family. (379 aa) |
| | crybb1 | Crystallin, beta B1; Belongs to the beta/gamma-crystallin family. (253 aa) |
| | opn5 | Teleost neuropsin; Belongs to the G-protein coupled receptor 1 family. (352 aa) |
| | pde6b | Phosphodiesterase. (854 aa) |
| | mpp5a | MAGUK p55 subfamily member 5-A; Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells (By similarity). Also involved in adherens junction biogenesis (By similarity). Functions in cellular patterning of the retina. (703 aa) |
| | epha4a | Ephrin type-A receptor 4a; Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI- anchored ephrin-A and transmembrane ephrin-B ligands including efna1 and efnb3. [...] (995 aa) |
| | ahi1 | Abelson helper integration site 1. (1193 aa) |
| | tulp1b | TUB-like protein 1b; Belongs to the TUB family. (504 aa) |
| | cln8 | CLN8 transmembrane ER and ERGIC protein. (289 aa) |
| | gpm6ab | Glycoprotein M6Ab. (292 aa) |
| | cep290 | Centrosomal protein of 290 kDa; Involved in early and late steps in cilia formation. May play a role in early ciliogenesis in the disappearance of centriolar satellites and in the transition of primary ciliar vesicles (PCVs) to capped ciliary vesicles (CCVs). In the ciliary transition zone is part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. Involved in regulation of the BBSome complex integrity and in ciliary targeting of selected BBSome cargos. Required for the correct localization of ciliary and photot [...] (2439 aa) |
| | shha | Sonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (418 aa) |
| | ndp | Norrin cystine knot growth factor NDP. (138 aa) |
| | sp3b | Sp3b transcription factor. (649 aa) |
| | rp1l1b | Rp1-like 1b. (3919 aa) |
| | znf513a | Zinc finger protein 513a. (548 aa) |
| | rp1l1a | Rp1-like 1a. (2394 aa) |
| | igfn1.2 | Immunoglobulin-like and fibronectin type III domain-containing 1, tandem duplicate 2. (1409 aa) |
| | MTERF4 | Si:dkeyp-94h10.5. (316 aa) |
| | fzr1b | Fizzy/cell division cycle 20-related 1b. (485 aa) |
| | nf1a | Neurofibromin 1a. (2759 aa) |
| | igfn1.4 | Immunoglobulin-like and fibronectin type III domain-containing 1, tandem duplicate 4. (1230 aa) |
| | wdpcp | WD repeat-containing planar cell polarity effector. (707 aa) |
| | igfn1.3 | Immunoglobulin-like and fibronectin type III domain-containing 1, tandem duplicate 3. (1355 aa) |
| | med24 | Mediator of RNA polymerase II transcription subunit 24; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required [...] (989 aa) |
| | crb2b | Crumbs cell polarity complex component 2b. (1010 aa) |
| | fgf3 | Fibroblast growth factor 3; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Belongs to the heparin-binding growth factors family. (256 aa) |
| | mib1 | E3 ubiquitin-protein ligase mib1; E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. It thereby participates in many processes regulated by the Notch signaling pathway, such as midline cell fate specification prior to germ layer formation, patterning of sensory cell differentiation in the ear, neurogenesis of the hindbrain and commitment to a secretory fate in the intesti [...] (1041 aa) |
| | fgf2 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (154 aa) |
| | impg2b | Interphotoreceptor matrix proteoglycan 2b. (353 aa) |
| | impg2b-2 | Interphotoreceptor matrix proteoglycan 2b. (428 aa) |
| | crygn1 | Gamma-crystallin N-A; Crystallins are the dominant structural components of the vertebrate eye lens. (183 aa) |
| | srfb | Serum response factor b. (260 aa) |
| | uhrf1 | E3 ubiquitin-protein ligase UHRF1; Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits dnmt1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylate [...] (775 aa) |
| | lrp6 | Low density lipoprotein receptor-related protein 6. (935 aa) |
| | june | JunE proto-oncogene, AP-1 transcription factor subunit. (323 aa) |
| | pax6a | Paired box protein Pax-6; Transcription factor expressed in spatially restricted regions of the neural tube during embryonic development; Belongs to the paired homeobox family. (451 aa) |
| | crb1 | Crumbs cell polarity complex component 1. (1428 aa) |
| | phactr4a | Phosphatase and actin regulator 4A. (1011 aa) |
| | LOC568955 | Zinc finger protein 513b. (541 aa) |
| | mab21l1 | Putative nucleotidyltransferase MAB21L1; Putative nucleotidyltransferase required for several aspects of embryonic development including normal development of the eye (By similarity). It is unclear whether it displays nucleotidyltransferase activity in vivo. Binds single-stranded RNA (ssRNA) (By similarity). Belongs to the mab-21 family. (359 aa) |
| | pde6c | Phosphodiesterase. (852 aa) |
| | fzd4 | Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (523 aa) |
| | sdk2a | Sidekick cell adhesion molecule 2a. (2170 aa) |
| | cyp1c1 | Cytochrome P450, family 1, subfamily C, polypeptide 1; Belongs to the cytochrome P450 family. (523 aa) |
| | slitrk6 | SLIT and NTRK-like family, member 6. (830 aa) |
| | zgc:153993 | Zgc:153993 protein. (204 aa) |
| | tatdn1 | Putative deoxyribonuclease TATDN1; Putative deoxyribonuclease. (185 aa) |
| | ttc8 | Tetratricopeptide repeat domain 8. (268 aa) |
| | TULP1 | Tubby-related protein 1-like. (318 aa) |
| | ccnd1 | G1/S-specific cyclin-D1; May play a role in transcriptional regulation (By similarity). Essential for the control of the cell cycle at the G1/S (start) transition. (291 aa) |
| | zgc:63863 | Zgc:63863. (399 aa) |
| | LOC568600 | FAT atypical cadherin 3b. (4362 aa) |
| | bicdl1 | BICD family-like cargo adapter 1; Component of secretory vesicle machinery in developing neurons that acts as a regulator of neurite outgrowth. (569 aa) |
| | ttll5 | Tubulin tyrosine ligase-like family, member 5. (1190 aa) |
| | si:ch73-40a2.1 | Si:ch73-40a2.1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (723 aa) |
| | fen1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | eys-2 | Protein eyes shut homolog; Required to maintain the integrity of photoreceptor cells. Specifically required for normal morphology of the photoreceptor ciliary pocket, and might thus facilitate protein trafficking between the photoreceptor inner and outer segments via the transition zone. Belongs to the EYS family. (296 aa) |
| | phactr4a-2 | Phosphatase and actin regulator 4A; Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to repression of the integrin signaling through the rho/rock pathway (By similarity). (118 aa) |
| | atf4a | Cyclic AMP-dependent transcription factor ATF-4; Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. May play a role in the regulation of the circadian clock (By similarity). (339 aa) |
| | prph2la | Peripherin 2-like a. (364 aa) |
| | dixdc1b | DIX domain-containing 1b. (685 aa) |
| | ENSDARP00000148508 | ecTbetaR2 domain-containing protein. (382 aa) |
| | wdr19 | WD repeat domain 19. (1372 aa) |
| | fat3a | FAT atypical cadherin 3a. (4601 aa) |
| | pax6b | Paired box 6b. (450 aa) |
| | thrb | Thyroid hormone receptor beta; Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for the thyroid gland hormone triiodothyronine (T3). Transactivating activity is ligand-dependent, and is repressed in the absence of T3. (508 aa) |
| | alcama | CD166 antigen homolog A; Cell adhesion molecule that mediates both heterotypic cell- cell contacts via its interaction with CD6, as well as homotypic cell- cell contacts. Promotes T-cell activation and proliferation via its interactions with CD6 (By similarity). Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 (By similarity). Mediates homotypic interactions with cells that express ALCAM. Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction. Inhibits endothelial cell migration and promotes endothel [...] (564 aa) |
| | CABP4 | Si:cabz01076231.1. (218 aa) |
| | fjx1 | Four-jointed box kinase 1. (397 aa) |
| | nhsb | Nance-Horan syndrome b (congenital cataracts and dental anomalies). (1608 aa) |
| | cryba4 | Crystallin, beta A4; Belongs to the beta/gamma-crystallin family. (196 aa) |
| | tub | TUB bipartite transcription factor; Belongs to the TUB family. (509 aa) |
