STRINGSTRING
map3k7 map3k7 ddx1 ddx1 tnfb tnfb tnfrsf1a tnfrsf1a pink1 pink1 mtdhb mtdhb mul1a mul1a tab2 tab2 myd88 myd88 prkcba prkcba tnfa tnfa prkcbb prkcbb abl2 abl2 rbck1 rbck1 tradd tradd gapdh gapdh lurap1 lurap1 cflara cflara LOC795766 LOC795766 ikbke ikbke s100b s100b dhx15 dhx15 F2R F2R mul1b mul1b shrprbck1r shrprbck1r trim8b trim8b trim62.1 trim62.1 inavab inavab tab3 tab3 ddx21 ddx21 card9 card9 tnfsf11 tnfsf11 ccl19a.1 ccl19a.1 eda eda casp8 casp8 ajuba ajuba brd4 brd4 tirap tirap inavaa inavaa F2R-3 F2R-3 LOC100334178 LOC100334178 F2R-5 F2R-5 trim8a trim8a mtdha mtdha trim62.2 trim62.2 cd40 cd40 ccl19b ccl19b cth cth ikbkb ikbkb B0S5K1_DANRE B0S5K1_DANRE cthl cthl s100a11 s100a11 gprc5bb gprc5bb cflarb cflarb prkcg prkcg nod2 nod2 abl1 abl1 map3k14a map3k14a X1WD23_DANRE X1WD23_DANRE sharpin sharpin gprc5ba gprc5ba traf3ip2l traf3ip2l card11 card11 nod1 nod1 edar edar tbk1 tbk1 JMJD8 JMJD8 ripk2 ripk2 irak4 irak4 trim32 trim32 faslg faslg prkcab prkcab dhx36 dhx36 fadd fadd lpar1 lpar1 adipoqb adipoqb prkn prkn adgrg1-2 adgrg1-2 ENSDARP00000142832 ENSDARP00000142832 terf2ip terf2ip tmem101 tmem101 LOC110437957 LOC110437957 Traf3ip2b Traf3ip2b htr2b htr2b casp10 casp10 ENSDARP00000151824 ENSDARP00000151824 LOC108179742 LOC108179742 prkcaa prkcaa
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
map3k7Mitogen-activated protein kinase kinase kinase 7. (551 aa)
ddx1DEAD (Asp-Glu-Ala-Asp) box helicase 1. (740 aa)
tnfbTumor necrosis factor b (TNF superfamily, member 2). (242 aa)
tnfrsf1aTumor necrosis factor receptor superfamily, member 1a. (389 aa)
pink1PTEN-induced kinase 1. (574 aa)
mtdhbMetadherin b. (525 aa)
mul1aMitochondrial ubiquitin ligase activator of nfkb 1-A; E3 ubiquitin-protein ligase that plays a role in the control of mitochondrial morphology. Promotes mitochondrial fragmentation and influences mitochondrial localization. Inhibits cell growth. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. (341 aa)
tab2TGF-beta-activated kinase 1 and MAP3K7-binding protein 2; May play a role in signaling pathway. Involved in heart development. (711 aa)
myd88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and Il-1 receptor signaling pathway in the innate immune response. (284 aa)
prkcbaProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (668 aa)
tnfaTumor necrosis factor a (TNF superfamily, member 2). (234 aa)
prkcbbProtein kinase C beta type; Calcium-activated and phospholipid-dependent serine/threonine-protein kinase involved in various processes such as regulation of the B-cell receptor (BCR) signalosome, apoptosis and transcription regulation. Plays a key role in B-cell activation and function by regulating BCR-induced NF-kappa-B activation and B-cell survival. Required for recruitment and activation of the IKK kinase to lipid rafts and mediates phosphorylation of card11/carma1, leading to activate the NF-kappa-B signaling. Involved in apoptosis following oxidative damage: in case of oxidative [...] (670 aa)
abl2Tyrosine-protein kinase. (1135 aa)
rbck1RanBP-type and C3HC4-type zinc finger-containing protein 1. (515 aa)
traddTumor necrosis factor receptor type 1-associated DEATH domain protein; Adapter molecule for tnfrsf1a that specifically associates with the cytoplasmic domain of activated tnfrsf1a mediating its interaction with fadd. (293 aa)
gapdhGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...] (333 aa)
lurap1Leucine-rich adaptor protein 1. (286 aa)
cflaraCASP8 and FADD-like apoptosis regulator a; Belongs to the peptidase C14A family. (461 aa)
LOC795766ADP-ribosylation factor 2b. (783 aa)
ikbkeInhibitor of nuclear factor kappa B kinase subunit epsilon. (721 aa)
s100bS100 calcium-binding protein, beta (neural); Belongs to the S-100 family. (95 aa)
dhx15DEAH (Asp-Glu-Ala-His) box helicase 15. (769 aa)
F2RSi:dkey-163m14.2. (462 aa)
mul1bMitochondrial E3 ubiquitin protein ligase 1b. (352 aa)
shrprbck1rRanBP-type and C3HC4-type zinc finger-containing protein 1; Component of the LUBAC complex which conjugates linear ('M- 1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. (714 aa)
trim8bSimilar to tripartite motif-containing 8. (564 aa)
trim62.1Tripartite motif-containing 62, tandem duplicate 1. (475 aa)
inavabInnate immunity activator b. (612 aa)
tab3Mitogen-activated protein kinase kinase kinase 7 interacting protein 3 like. (573 aa)
ddx21DEAD (Asp-Glu-Ala-Asp) box helicase 21. (791 aa)
card9Caspase recruitment domain family, member 9. (534 aa)
tnfsf11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (251 aa)
ccl19a.1C-C motif chemokine. (119 aa)
edaEctodysplasin A; Belongs to the tumor necrosis factor family. (359 aa)
casp8Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (476 aa)
ajubaAjuba LIM protein. (688 aa)
brd4Bromodomain-containing protein 4; Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation. Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure. During interphase, plays a key role in regulating the transcription of signal-inducible genes by associating with the P-TEFb complex and rec [...] (1444 aa)
tirapToll-interleukin 1 receptor (TIR) domain-containing adaptor protein. (203 aa)
inavaaInnate immunity activator a. (596 aa)
F2R-3Si:dkey-163m14.4. (438 aa)
LOC100334178Uncharacterized protein. (981 aa)
F2R-5Si:dkey-163m14.6. (411 aa)
trim8aTripartite motif-containing 8a. (567 aa)
mtdhaMetadherin a. (543 aa)
trim62.2Tripartite motif-containing 62, tandem duplicate 2. (341 aa)
cd40CD40 molecule, TNF receptor superfamily member 5. (286 aa)
ccl19bChemokine (C-C motif) ligand 19b. (128 aa)
cthCystathionase (cystathionine gamma-lyase). (404 aa)
ikbkbInhibitor of nuclear factor kappa B kinase subunit beta. (779 aa)
B0S5K1_DANRESi:dkey-181m9.8. (633 aa)
cthlCystathionase (cystathionine gamma-lyase),-like. (404 aa)
s100a11S100 calcium-binding protein A11. (85 aa)
gprc5bbG protein-coupled receptor, class C, group 5, member Bb. (406 aa)
cflarbCASP8 and FADD-like apoptosis regulator b. (178 aa)
prkcgProtein kinase C, gamma; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (654 aa)
nod2Nucleotide-binding oligomerization domain-containing 2. (980 aa)
abl1Tyrosine-protein kinase. (1081 aa)
map3k14aMitogen-activated protein kinase kinase kinase 14a. (825 aa)
X1WD23_DANRESi:ch211-108d22.2. (1739 aa)
sharpinSHANK-associated RH domain-interacting protein. (394 aa)
gprc5baG protein-coupled receptor, class C, group 5, member Ba. (397 aa)
traf3ip2lTRAF3-interacting protein 2-like. (436 aa)
card11Caspase recruitment domain family, member 11. (1110 aa)
nod1Nucleotide-binding oligomerization domain-containing 1. (903 aa)
edarEctodysplasin A receptor. (460 aa)
tbk1TANK-binding kinase 1. (727 aa)
JMJD8Jumonji domain containing 8. (207 aa)
ripk2Receptor-interacting serine-threonine kinase 2. (457 aa)
irak4Interleukin-1 receptor-associated kinase 4. (447 aa)
trim32Tripartite motif-containing 32. (663 aa)
faslgFas ligand (TNF superfamily, member 6); Belongs to the tumor necrosis factor family. (268 aa)
prkcabProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (635 aa)
dhx36DEAH (Asp-Glu-Ala-His) box polypeptide 36. (1037 aa)
faddFas (tnfrsf6)-associated via death domain. (192 aa)
lpar1Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (280 aa)
adipoqbAdiponectin, C1Q and collagen domain-containing, b. (299 aa)
prknE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (458 aa)
adgrg1-2Adhesion G protein-coupled receptor G1. (513 aa)
ENSDARP00000142832Si:ch211-15b10.6. (193 aa)
terf2ipTelomeric repeat-binding factor 2-interacting protein 1; Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). Does not bind DNA directly: recruited to telomeric double-stranded 5'- TTAGGG-3' repeats via its interaction with terf2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with terf2 or other factors, and regulates gene expression (By similar [...] (644 aa)
tmem101Transmembrane protein 101. (255 aa)
LOC110437957CARD domain-containing protein. (201 aa)
Traf3ip2bSEFIR domain-containing protein. (107 aa)
htr2b5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled. (443 aa)
casp10Caspase 10, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (548 aa)
ENSDARP00000151824AGC-kinase C-terminal domain-containing protein. (58 aa)
LOC108179742Uncharacterized protein. (261 aa)
prkcaaProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (670 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: low (8%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.