STRINGSTRING
pdgfba pdgfba pik3cg pik3cg map3k7 map3k7 fgf1a fgf1a MAP3K13 MAP3K13 tnfb tnfb fgfr1a fgfr1a dkk1a dkk1a drd4-rs drd4-rs ern1 ern1 pdcd10b pdcd10b fzd5 fzd5 tenm1 tenm1 sash1a sash1a map2k7 map2k7 drd4b drd4b map2k5 map2k5 F1RCE2_DANRE F1RCE2_DANRE fgf24 fgf24 fzd8b fzd8b dusp19a dusp19a tgfb1a tgfb1a p2rx7 p2rx7 tpd52l1 tpd52l1 fgf1b fgf1b dkk1b dkk1b fzd8a fzd8a pdgfc pdgfc fgfr1b fgfr1b tgfa tgfa sash1b sash1b ntf3 ntf3 tnfsf11 tnfsf11 ccl19a.1 ccl19a.1 pdgfaa pdgfaa edn1 edn1 ptprc ptprc kita kita ajuba ajuba fgf18a fgf18a tnfrsf11a tnfrsf11a il34 il34 LOC100334396 LOC100334396 cd40 cd40 ccl19b ccl19b ern2 ern2 LOC569566 LOC569566 tgfb1b tgfb1b nek10 nek10 fgf2 fgf2 map3k4 map3k4 ENSDARP00000135075 ENSDARP00000135075 ccdc137 ccdc137 axin1 axin1 drd4a drd4a fzd4 fzd4 pdgfab pdgfab il1b il1b dusp19b dusp19b epgn epgn pdgfbb pdgfbb htr2b htr2b pik3r5 pik3r5 ENSDARP00000150942 ENSDARP00000150942 Nox4 Nox4 pdcd10a pdcd10a
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pdgfbaPlatelet-derived growth factor beta polypeptide a; Belongs to the PDGF/VEGF growth factor family. (463 aa)
pik3cgPhosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1098 aa)
map3k7Mitogen-activated protein kinase kinase kinase 7. (551 aa)
fgf1aPutative fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with i [...] (147 aa)
MAP3K13Mitogen-activated protein kinase kinase kinase. (982 aa)
tnfbTumor necrosis factor b (TNF superfamily, member 2). (242 aa)
fgfr1aFibroblast growth factor receptor 1-A; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2 triggers [...] (809 aa)
dkk1aDickkopf WNT-signaling pathway inhibitor 1a. (256 aa)
drd4-rsDopamine receptor D4-related sequence; Belongs to the G-protein coupled receptor 1 family. (418 aa)
ern1Endoplasmic reticulum to nucleus-signaling 1. (1031 aa)
pdcd10bProgrammed cell death protein 10-B; Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity). Required for normal cardiovascular development. (210 aa)
fzd5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (592 aa)
tenm1Teneurin transmembrane protein 1. (2736 aa)
sash1aSAM and SH3 domain-containing 1a. (1192 aa)
map2k7Mitogen-activated protein kinase kinase 7. (438 aa)
drd4bDopamine D4c receptor; Belongs to the G-protein coupled receptor 1 family. (382 aa)
map2k5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (450 aa)
F1RCE2_DANRESi:rp71-17i16.5; Belongs to the PI3/PI4-kinase family. (1072 aa)
fgf24Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
fzd8bFrizzled class receptor 8b; Belongs to the G-protein coupled receptor Fz/Smo family. (576 aa)
dusp19aDual-specificity phosphatase 19a. (213 aa)
tgfb1aTransforming growth factor beta; Belongs to the TGF-beta family. (377 aa)
p2rx7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (596 aa)
tpd52l1Zgc:110003 protein. (189 aa)
fgf1bMultifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (102 aa)
dkk1bDickkopf WNT-signaling pathway inhibitor 1b. (241 aa)
fzd8aFrizzled class receptor 8a; Belongs to the G-protein coupled receptor Fz/Smo family. (579 aa)
pdgfcPlatelet-derived growth factor c; Belongs to the PDGF/VEGF growth factor family. (343 aa)
fgfr1bFibroblast growth factor receptor. (766 aa)
tgfaTransforming growth factor, alpha. (191 aa)
sash1bSAM and SH3 domain-containing 1b. (1032 aa)
ntf3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (243 aa)
tnfsf11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (251 aa)
ccl19a.1C-C motif chemokine. (119 aa)
pdgfaaPlatelet-derived growth factor alpha polypeptide a; Belongs to the PDGF/VEGF growth factor family. (194 aa)
edn1Endothelin 1. (188 aa)
ptprcProtein tyrosine phosphatase receptor type C. (1130 aa)
kitaMast/stem cell growth factor receptor kita; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine kitlg/scf and plays a role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, and in mast cell development, migration and function. Required for the migration of cells in the melanocyte lineage and the survival of embryonic melanocytes. Required for the differentiation of some, but not all, melanocytes. Not essential for hematopoiesis or primordial germ cell development. (981 aa)
ajubaAjuba LIM protein. (688 aa)
fgf18aFibroblast growth factor 18a; Belongs to the heparin-binding growth factors family. (208 aa)
tnfrsf11aTumor necrosis factor receptor superfamily, member 11a, NFKB activator. (574 aa)
il34Si:ch211-239j19.3 protein. (213 aa)
LOC100334396Uncharacterized protein. (415 aa)
cd40CD40 molecule, TNF receptor superfamily member 5. (286 aa)
ccl19bChemokine (C-C motif) ligand 19b. (128 aa)
ern2Endoplasmic reticulum to nucleus-signaling 2. (927 aa)
LOC569566Fibroblast growth factor receptor 1b,-like. (509 aa)
tgfb1bTransforming growth factor beta; Belongs to the TGF-beta family. (379 aa)
nek10NIMA-related kinase 10. (935 aa)
fgf2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (154 aa)
map3k4Mitogen-activated protein kinase kinase kinase 4. (1540 aa)
ENSDARP00000135075Platelet-derived growth factor alpha polypeptide a. (194 aa)
ccdc137Coiled-coil domain-containing 137. (242 aa)
axin1Axin-1; Component of the beta-catenin destruction complex required for regulating ctnnb1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects: down- regulates ctnnb1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. (835 aa)
drd4aDopamine receptor D4a; Belongs to the G-protein coupled receptor 1 family. (380 aa)
fzd4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (523 aa)
pdgfabPlatelet-derived growth factor alpha polypeptide b; Belongs to the PDGF/VEGF growth factor family. (230 aa)
il1bInterleukin-1. (284 aa)
dusp19bDual-specificity phosphatase 19b. (205 aa)
epgnEpithelial mitogen homolog (mouse). (148 aa)
pdgfbbPlatelet-derived growth factor beta polypeptide b; Belongs to the PDGF/VEGF growth factor family. (483 aa)
htr2b5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled. (443 aa)
pik3r5Phosphoinositide-3-kinase, regulatory subunit 5. (874 aa)
ENSDARP00000150942Uncharacterized protein. (78 aa)
Nox4NADPH oxidase 4. (246 aa)
pdcd10aProgrammed cell death protein 10-A; Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity). Required for normal cardiovascular development. (210 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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