STRINGSTRING
nkx3-1 nkx3-1 tnfb tnfb rps6kb1a rps6kb1a igf2a igf2a gas6 gas6 tgfb1a tgfb1a ilk ilk rps6kb1b rps6kb1b flcn flcn tnfsf11 tnfsf11 mertka mertka LOC100537455 LOC100537455 mkrn2 mkrn2 cd40 cd40 pear1 pear1 tgfb1b tgfb1b setx setx tsc2 tsc2 vegfaa vegfaa smpd3 smpd3 il1b il1b AXL AXL ENSDARP00000153406 ENSDARP00000153406
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
nkx3-1NK3 homeobox 1. (214 aa)
tnfbTumor necrosis factor b (TNF superfamily, member 2). (242 aa)
rps6kb1aRibosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (506 aa)
igf2aInsulin-like growth factor 2a. (197 aa)
gas6Growth arrest-specific 6. (648 aa)
tgfb1aTransforming growth factor beta; Belongs to the TGF-beta family. (377 aa)
ilkIntegrin-linked kinase. (452 aa)
rps6kb1bRibosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (502 aa)
flcnFolliculin. (558 aa)
tnfsf11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (251 aa)
mertkaC-mer proto-oncogene tyrosine kinase a. (952 aa)
LOC100537455Uncharacterized protein. (175 aa)
mkrn2Probable E3 ubiquitin-protein ligase makorin-2; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Inhibits neurogenesis and axis formation during embryonic development by modulating the phosphatidylinositol 3-kinase (PI3K) pathway. Acts downstream of PI3K and akt1 to up-regulate gsk3b mRNA expression. (414 aa)
cd40CD40 molecule, TNF receptor superfamily member 5. (286 aa)
pear1Platelet endothelial aggregation receptor 1. (1020 aa)
tgfb1bTransforming growth factor beta; Belongs to the TGF-beta family. (379 aa)
setxSenataxin. (2368 aa)
tsc2TSC complex subunit 2. (1674 aa)
vegfaaVascular endothelial growth factor A-A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis, and induces permeabilization of blood vessels. Acts both upstream of kdr and tie1 to stimulate endothelial cell differentiation, and upstream of gata1 to stimulate hematopoietic cell differentiation. (188 aa)
smpd3Sphingomyelin phosphodiesterase 3. (684 aa)
il1bInterleukin-1. (284 aa)
AXLAXL receptor tyrosine kinase. (786 aa)
ENSDARP00000153406DUF3384 domain-containing protein. (162 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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