(55 nodes) Fat cell differentiation network (Danio rerio)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	nr4a1	Nuclear receptor subfamily 4, group A, member 1. (574 aa)
	ptgs2b	Prostaglandin-endoperoxide synthase 2b. (606 aa)
	ctbp2a	C-terminal-binding protein 2a. (710 aa)
	ptgs2a	Prostaglandin-endoperoxide synthase 2a. (601 aa)
	mkks	McKusick-Kaufman syndrome. (563 aa)
	si:dkey-90m5.4	Si:dkey-90m5.4. (327 aa)
	tmem120a	Transmembrane protein 120A; May play a role in adipogenesis. Belongs to the TMEM120 family. (341 aa)
	fam120b	Family with sequence similarity 120B. (537 aa)
	socs1a	Suppressor of cytokine-signaling 1a. (201 aa)
	zgc:103681	Zgc:103681. (337 aa)
	cebpb	CCAAT/enhancer-binding protein. (280 aa)
	plac8.1	Placenta-associated 8, tandem duplicate 1. (106 aa)
	nr4a2b	Nuclear receptor subfamily 4, group A, member 2b. (586 aa)
	aldh6a1	Aldehyde dehydrogenase 6 family, member A1. (525 aa)
	nr4a3	Nuclear receptor subfamily 4, group A, member 3. (594 aa)
	hmga2	High mobility group AT-hook 2. (110 aa)
	bbs7	Bardet-Biedl syndrome 7 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. (715 aa)
	sirt1	Sirtuin 1. (710 aa)
	atf5a	Activating transcription factor 5a. (511 aa)
	znf516	Zinc finger protein 516. (1084 aa)
	retreg1	Reticulophagy regulator 1. (391 aa)
	nr4a2a	Nuclear receptor subfamily 4, group A, member 2a. (635 aa)
	LOC571502	G_PROTEIN_RECEP_F1_2 domain-containing protein. (311 aa)
	bbs1	Bardet-Biedl syndrome 1. (588 aa)
	bbs4	Bardet-Biedl syndrome 4. (528 aa)
	tmem120b	Transmembrane protein 120B; May play a role in adipogenesis. Belongs to the TMEM120 family. (337 aa)
	prdm16	Si:ch211-263k4.2. (927 aa)
	adrb3a	Adrenoceptor beta 3a; Belongs to the G-protein coupled receptor 1 family. (413 aa)
	ctbp1	C-terminal-binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (449 aa)
	adrb1	Adrenergic, beta-1-, receptor. (390 aa)
	cebpd	CCAAT/enhancer-binding protein. (280 aa)
	adrb2b	Adrenoceptor beta 2, surface b. (409 aa)
	steap4	STEAP family member 4. (472 aa)
	B8JHX5_DANRE	Si:ch211-263k4.2. (129 aa)
	plac8.2	Placenta-associated 8, tandem duplicate 2. (104 aa)
	dhrs7b	Dehydrogenase/reductase SDR family member 7B; Putative oxidoreductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (316 aa)
	F1QGA7_DANRE	Si:ch1073-15f12.3. (306 aa)
	bscl2	BSCL2 lipid droplet biogenesis-associated, seipin. (386 aa)
	E7FGN5_DANRE	Si:ch211-161c3.6. (111 aa)
	ep300b	E1A-binding protein p300 b. (2615 aa)
	X1WGW1_DANRE	Si:ch73-90p23.1. (278 aa)
	adrb2a	Adrenoceptor beta 2, surface a. (405 aa)
	CTBP1	Zgc:136929; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (440 aa)
	metrnla	Meteorin-like protein; Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance (By similarity); Belongs to the meteorin family. (286 aa)
	trim32	Tripartite motif-containing 32. (663 aa)
	prlh	Prolactin-releasing hormone. (81 aa)
	bscl2l	BSCL2 lipid droplet biogenesis-associated, seipin,-like. (392 aa)
	ep300a	E1A-binding protein p300 a. (2679 aa)
	ttc8	Tetratricopeptide repeat domain 8. (268 aa)
	adipoqb	Adiponectin, C1Q and collagen domain-containing, b. (299 aa)
	ENSDARP00000145842	Uncharacterized protein. (313 aa)
	cntn2	Contactin 2. (1040 aa)
	bbs9	Bardet-Biedl syndrome 9. (842 aa)
	bbs12	Bardet-Biedl syndrome 12. (763 aa)
	metrnlb	Meteorin-like, glial cell differentiation regulator b. (290 aa)

Your Current Organism:

Danio rerio

NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B8JHX5_DANRE	cebpb	ENSDARP00000119466	ENSDARP00000062701	Si:ch211-263k4.2.	CCAAT/enhancer-binding protein.	0.619
B8JHX5_DANRE	prdm16	ENSDARP00000119466	ENSDARP00000107731	Si:ch211-263k4.2.	Si:ch211-263k4.2.	0.916
B8JHX5_DANRE	znf516	ENSDARP00000119466	ENSDARP00000095054	Si:ch211-263k4.2.	Zinc finger protein 516.	0.596
CTBP1	ctbp1	ENSDARP00000130473	ENSDARP00000107990	Zgc:136929; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	C-terminal-binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.901
CTBP1	prdm16	ENSDARP00000130473	ENSDARP00000107731	Zgc:136929; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Si:ch211-263k4.2.	0.493
CTBP1	trim32	ENSDARP00000130473	ENSDARP00000136136	Zgc:136929; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Tripartite motif-containing 32.	0.451
CTBP1	znf516	ENSDARP00000130473	ENSDARP00000095054	Zgc:136929; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Zinc finger protein 516.	0.684
ENSDARP00000145842	F1QGA7_DANRE	ENSDARP00000145842	ENSDARP00000123078	Uncharacterized protein.	Si:ch1073-15f12.3.	0.632
F1QGA7_DANRE	ENSDARP00000145842	ENSDARP00000123078	ENSDARP00000145842	Si:ch1073-15f12.3.	Uncharacterized protein.	0.632
LOC571502	X1WGW1_DANRE	ENSDARP00000100306	ENSDARP00000129470	G_PROTEIN_RECEP_F1_2 domain-containing protein.	Si:ch73-90p23.1.	0.406
X1WGW1_DANRE	LOC571502	ENSDARP00000129470	ENSDARP00000100306	Si:ch73-90p23.1.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.406
adipoqb	adrb3a	ENSDARP00000141357	ENSDARP00000107786	Adiponectin, C1Q and collagen domain-containing, b.	Adrenoceptor beta 3a; Belongs to the G-protein coupled receptor 1 family.	0.464
adipoqb	cebpb	ENSDARP00000141357	ENSDARP00000062701	Adiponectin, C1Q and collagen domain-containing, b.	CCAAT/enhancer-binding protein.	0.410
adipoqb	sirt1	ENSDARP00000141357	ENSDARP00000088981	Adiponectin, C1Q and collagen domain-containing, b.	Sirtuin 1.	0.563
adrb1	adrb2a	ENSDARP00000109357	ENSDARP00000130127	Adrenergic, beta-1-, receptor.	Adrenoceptor beta 2, surface a.	0.814
adrb1	adrb3a	ENSDARP00000109357	ENSDARP00000107786	Adrenergic, beta-1-, receptor.	Adrenoceptor beta 3a; Belongs to the G-protein coupled receptor 1 family.	0.828
adrb2a	adrb1	ENSDARP00000130127	ENSDARP00000109357	Adrenoceptor beta 2, surface a.	Adrenergic, beta-1-, receptor.	0.814
adrb2a	adrb2b	ENSDARP00000130127	ENSDARP00000112597	Adrenoceptor beta 2, surface a.	Adrenoceptor beta 2, surface b.	0.906
adrb2a	adrb3a	ENSDARP00000130127	ENSDARP00000107786	Adrenoceptor beta 2, surface a.	Adrenoceptor beta 3a; Belongs to the G-protein coupled receptor 1 family.	0.837
adrb2b	adrb2a	ENSDARP00000112597	ENSDARP00000130127	Adrenoceptor beta 2, surface b.	Adrenoceptor beta 2, surface a.	0.906

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