STRINGSTRING
cdh5 cdh5 vcla vcla krit1 krit1 il1b il1b rock1 rock1 ENSDARP00000142696 ENSDARP00000142696 cldn5b cldn5b zdhhc21 zdhhc21 npas4l npas4l proca-2 proca-2 rock2a rock2a apol1 apol1 hhex hhex proca proca tnfb tnfb tnfrsf1a tnfrsf1a btg1 btg1 id1 id1 cldn5a cldn5a tal1 tal1 f11r.2 f11r.2 f11r.1 f11r.1 vclb vclb
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cdh5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (767 aa)
vclaVinculin a. (1131 aa)
krit1Krev interaction trapped protein 1; Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Plays a role in integrin signaling. Plays an important role in the maintenance of the intracellular reactive oxygen species (ROS) homeostasis to prevent oxidative cellular damage. Facilitates the down-regulation of cyclin-D1 (CCND1) levels required for cell transition from pr [...] (741 aa)
il1bInterleukin-1. (284 aa)
rock1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1359 aa)
ENSDARP00000142696Si:cabz01007807.1. (472 aa)
cldn5bClaudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa)
zdhhc21Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (141 aa)
npas4lNeuronal PAS domain-containing protein 4-like; Transcription factor specifically expressed in endothelial and hematopoietic precursor cells that acts as a key regulator of the endothelial differentiation cascade. Acts as an early-response transcription factor that regulates the expression of early regulators of endothelial and haematopoietic differentiation, such as etv2 and tal1. (658 aa)
proca-2Protein C (inactivator of coagulation factors Va and VIIIa), a. (434 aa)
rock2aRho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1375 aa)
apol1Apolipoprotein L, 1. (326 aa)
hhexHematopoietically-expressed homeobox protein hhex; Recognizes the DNA sequence 5'-ATTAA-3' (By similarity). Transcriptional repressor. Regulates the differentiation of both endothelial and blood cells. Plays a role in embryonic dorsoventral patterning by regulating bmp expression. May establish anterior identity. Functions in the embryo to regulate liver development. Functions extraembryonically to generate organ chirality. (177 aa)
procaProtein C (inactivator of coagulation factors Va and VIIIa), a. (434 aa)
tnfbTumor necrosis factor b (TNF superfamily, member 2). (242 aa)
tnfrsf1aTumor necrosis factor receptor superfamily, member 1a. (389 aa)
btg1B-cell translocation gene 1, anti-proliferative. (182 aa)
id1Inhibitor of DNA-binding 1, HLH protein. (128 aa)
cldn5aClaudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (215 aa)
tal1T-cell acute lymphocytic leukemia protein 1 homolog; Transcription factor that plays a pivotal role in hemopoietic and endothelial development, acting synergistically with lmo2 and downstream of clo. Specifies mesodermal precursors to a hemangioblast cell fate. Hemangioblasts are bipotential precursors of blood and endothelium, and in the absence of hemopoietic induction cues such as gata1, tal1/scl-lmo2-induced hemangioblasts differentiate into endothelial cells. Isoform alpha and isoform beta are redundant for the initiation of primitive hemopoiesis but have distinct roles in the reg [...] (324 aa)
f11r.2F11 receptor, tandem duplicate 2. (294 aa)
f11r.1F11 receptor, tandem duplicate 1. (292 aa)
vclbVinculin b. (987 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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