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| | si:dkey-1k23.3 | Si:dkey-1k23.3; Belongs to the small heat shock protein (HSP20) family. (365 aa) |
| | adgrg4a | Adhesion G protein-coupled receptor G4a; Belongs to the G-protein coupled receptor 2 family. (1201 aa) |
| | ENSDARP00000144302 | Si:ch73-380n15.2. (509 aa) |
| | adgrb1a | Adhesion G protein-coupled receptor B1a; Belongs to the G-protein coupled receptor 2 family. (1610 aa) |
| | cemip | Cell migration-inducing hyaluronidase 1. (1163 aa) |
| | aggf1 | Angiogenic factor with G patch and FHA domains 1. (775 aa) |
| | tie1 | Tyrosine-protein kinase receptor Tie-1; Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis. (1150 aa) |
| | thbs2a | Thrombospondin 2a. (1177 aa) |
| | ENSDARP00000148508 | ecTbetaR2 domain-containing protein. (382 aa) |
| | sfrp2l | Secreted frizzled-related protein 2-like. (333 aa) |
| | itgb8 | Integrin beta; Belongs to the integrin beta chain family. (668 aa) |
| | thbs1a | Thrombospondin 1a. (795 aa) |
| | rock1 | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1359 aa) |
| | f3b | Coagulation factor IIIb. (288 aa) |
| | sirt2 | NAD-dependent protein deacetylase sirtuin-2; NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and alpha-tubulin as well as many other proteins such as key transcription factors (By similarity). Participates in the modulation of multiple and diverse biological processes such as cell cycle control, genomic integrity, microtubule dynamics, cell differentiation, metabolic networks, and autophagy. Plays a major role in the control of cell cycle progression and genomic stability. Deacetylates histone H4 at 'Lys-16' (H4K16ac) at the VEGFA promoter. Thereby con [...] (379 aa) |
| | fgf1a | Putative fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with i [...] (147 aa) |
| | tnfb | Tumor necrosis factor b (TNF superfamily, member 2). (242 aa) |
| | epha2a | Eph receptor A2 a. (984 aa) |
| | efna1b | Ephrin A-L1; Belongs to the ephrin family. (229 aa) |
| | efna3a | Ephrin-A3a; Belongs to the ephrin family. (220 aa) |
| | sars1 | Serine--tRNA ligase, cytoplasmic; Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). In the nucleus, binds to the vegfa core promoter and prevents myc binding and transcriptional activation by myc. Thereby inhibits the production of vegfa and sprouting angiogenesis mediated by vegfa. Belongs t [...] (515 aa) |
| | mtdhb | Metadherin b. (525 aa) |
| | mdkb | Midkine-related growth factor Mdk2. (147 aa) |
| | ism1 | Isthmin-1; May specifically influence certain angiogenesis process. (461 aa) |
| | jupa | Junction plakoglobin a. (729 aa) |
| | btg1 | B-cell translocation gene 1, anti-proliferative. (182 aa) |
| | aqp1a.1 | Aquaporin 1a (Colton blood group), tandem duplicate 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (260 aa) |
| | htatip2 | HIV-1 Tat interactive protein 2. (236 aa) |
| | tgfbr2b | TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (556 aa) |
| | si:dkey-90m5.4 | Si:dkey-90m5.4. (327 aa) |
| | epha2b | Eph receptor A2 b. (979 aa) |
| | sash1a | SAM and SH3 domain-containing 1a. (1192 aa) |
| | tspan12 | Tetraspanin. (301 aa) |
| | kdr | Vascular endothelial growth factor receptor 2; Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels. Particularly involved in artery formation. Does not appear to be required for hematopoiesis. (1357 aa) |
| | efna1a | Ephrin-A1a; Belongs to the ephrin family. (222 aa) |
| | mdka | Midkine-related growth factor Mdk1. (146 aa) |
| | fgf24 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa) |
| | ramp2 | Receptor (G protein-coupled) activity-modifying protein 2. (206 aa) |
| | tek | Tyrosine-protein kinase receptor Tie-2; Tyrosine-protein kinase that acts as cell-surface receptor for angiopoietins and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Can activate or inhibit angiogenesis, depending on the context. Angiopoietin signaling triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors (By similarity). (1116 aa) |
| | hspb1 | Heat shock protein, alpha-crystallin-related, 1; Belongs to the small heat shock protein (HSP20) family. (199 aa) |
| | ctsh | Cathepsin H; Belongs to the peptidase C1 family. (330 aa) |
| | s1pr1 | Sphingosine 1-phosphate receptor 1; G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. (362 aa) |
| | fgf1b | Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (102 aa) |
| | nfe2l2a | Nuclear factor (Erythroid-derived 2)-like 2. (586 aa) |
| | cldn5a | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (215 aa) |
| | il17a/f1 | Interleukin 17a/f1. (153 aa) |
| | adm2a | Adrenomedullin 2a. (154 aa) |
| | aplnra | Apelin receptor A; Receptor for apelin receptor early endogenous ligand (apela) and apelin (apln) hormones coupled to G proteins that inhibit adenylate cyclase activity. Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a receptor for apela hormone, promoting endoderm and mesendoderm cell migration and regulating the migration of cells fated to become myocardial progenitors, respectively. Positively regulates angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during [...] (362 aa) |
| | tnmd | Tenomodulin. (301 aa) |
| | tnn | Tenascin N. (932 aa) |
| | serpine1 | Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Belongs to the serpin family. (392 aa) |
| | hmga2 | High mobility group AT-hook 2. (110 aa) |
| | sash1b | SAM and SH3 domain-containing 1b. (1032 aa) |
| | jupb | Junction plakoglobin b. (726 aa) |
| | tgfbr2a | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (645 aa) |
| | yjefn3 | YjeF N-terminal domain-containing 3. (246 aa) |
| | c5 | Complement component 5. (1704 aa) |
| | sirt1 | Sirtuin 1. (710 aa) |
| | vegfc | Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (396 aa) |
| | sfrp2 | Secreted frizzled-related protein 2. (294 aa) |
| | emilin1b | Elastin microfibril interfacer 1b. (1059 aa) |
| | mydgf | Myeloid-derived growth factor. (164 aa) |
| | tgfb5 | Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa) |
| | il10 | Interleukin-10. (180 aa) |
| | rapgef3 | Rap guanine nucleotide exchange factor (GEF) 3. (867 aa) |
| | tbc1d31 | TBC1 domain family, member 31. (1070 aa) |
| | prok1 | Zgc:171925 protein. (105 aa) |
| | cdh5 | Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (767 aa) |
| | hspb15 | Heat shock protein, alpha-crystallin-related, b15; Belongs to the small heat shock protein (HSP20) family. (154 aa) |
| | emilin1a | Elastin microfibril interfacer 1a. (1014 aa) |
| | utp15 | U3 small nucleolar RNA-associated protein 15 homolog; Involved in nucleolar processing of pre-18S ribosomal RNA. (517 aa) |
| | nfe2l2b | Nuclear factor, erythroid 2-like 2b. (507 aa) |
| | xbp1 | Transcription factor Treb5. (263 aa) |
| | fgf18a | Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family. (208 aa) |
| | cyp1b1 | Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (526 aa) |
| | adgrg2a | Adhesion G protein-coupled receptor G2a; Belongs to the G-protein coupled receptor 2 family. (1037 aa) |
| | prok2 | Prokineticin 2. (107 aa) |
| | aplnrb | Apelin receptor B; Receptor for apelin receptor early endogenous ligand (apela) and apelin (apln) hormones coupled to G proteins that inhibit adenylate cyclase activity. Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a receptor for apela hormone, promoting endoderm and mesendoderm cell migration and regulating the migration of cells fated to become myocardial progenitors, respectively. Positively regulates angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during [...] (359 aa) |
| | vegfba | Vascular endothelial growth factor Ba; Belongs to the PDGF/VEGF growth factor family. (246 aa) |
| | mecp2 | Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (524 aa) |
| | aqp1a.2 | Aquaporin 1a (Colton blood group), tandem duplicate 2; Belongs to the MIP/aquaporin (TC 1.A.8) family. (269 aa) |
| | sp1 | Sp1 transcription factor. (594 aa) |
| | mtdha | Metadherin a. (543 aa) |
| | adgrb1b | Adhesion G protein-coupled receptor B1b; Belongs to the G-protein coupled receptor 2 family. (1241 aa) |
| | VASH1 | Vasohibin 1. (370 aa) |
| | cd40 | CD40 molecule, TNF receptor superfamily member 5. (286 aa) |
| | vegfbb | Vascular endothelial growth factor Bb; Belongs to the PDGF/VEGF growth factor family. (91 aa) |
| | adgrg6 | Adhesion G-protein coupled receptor G6; G-protein coupled receptor which is activated by type IV collagen, a major constituent of the basement membrane. Couples to G(i)-proteins as well as G(s)-proteins. Essential for normal differentiation of promyelinating Schwann cells and for normal myelination of axons. Plays also a role in inner ear development. (1240 aa) |
| | cxcr3.1 | Chemokine (C-X-C motif) receptor 3, tandem duplicate 1; Belongs to the G-protein coupled receptor 1 family. (367 aa) |
| | cldn5b | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa) |
| | gab1 | GRB2-associated-binding protein 1. (740 aa) |
| | tp53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression. (369 aa) |
| | fkbpl | FKBP prolyl isomerase-like. (236 aa) |
| | adgrb2 | Adhesion G protein-coupled receptor B2; Belongs to the G-protein coupled receptor 2 family. (635 aa) |
| | angptl3 | Angiopoietin-like 3. (466 aa) |
| | rgcc | Regulator of cell cycle. (128 aa) |
| | cemip2 | Cell surface hyaluronidase; Cell surface hyaluronidase that mediates the initial cleavage of extracellular high-molecular-weight hyaluronan into intermediate- size hyaluronan. Acts as a regulator of angiogenesis in embryos by mediating degradation of extracellular hyaluronan, thereby promoting VEGF signaling. Acts as a regulator of heart development during myocardial and endocardial morphogenesis: involved in the looping stage of heart morphogenesis. Stimulates migration of endocardial cells and increases both myocardial and endocardial fusion. Involved in the restriction of endocardia [...] (1378 aa) |
| | nf1b | Neurofibromin 1b. (2759 aa) |
| | vegfab | Vascular endothelial growth factor Ab; Belongs to the PDGF/VEGF growth factor family. (251 aa) |
| | E9QG92_DANRE | Si:dkey-205h13.2. (384 aa) |
| | thbs1b | Thrombospondin 1b. (1171 aa) |
| | F1QB00_DANRE | Si:dkey-259j3.5; Belongs to the G-protein coupled receptor 2 family. (720 aa) |
| | Chrna11 | Si:ch211-39a7.1. (589 aa) |
| | hgs | Hepatocyte growth factor-regulated tyrosine kinase substrate. (757 aa) |
| | adgrb3 | Adhesion G protein-coupled receptor B3; Belongs to the G-protein coupled receptor 2 family. (1216 aa) |
| | vegfd | Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (272 aa) |
| | adgrg4b | Adhesion G protein-coupled receptor G4b; Belongs to the G-protein coupled receptor 2 family. (522 aa) |
| | rock2a | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1375 aa) |
| | tgfb2 | Transforming growth factor, beta 2. (413 aa) |
| | zc3h12a | Zinc finger CCCH-type-containing 12A. (367 aa) |
| | thbs2b | Thrombospondin 2b. (1181 aa) |
| | jcada | Junctional cadherin 5-associated a. (1465 aa) |
| | vash2 | Vasohibin 2. (348 aa) |
| | pgfb | Placental growth factor b; Belongs to the PDGF/VEGF growth factor family. (164 aa) |
| | nf1a | Neurofibromin 1a. (2759 aa) |
| | E7FGN5_DANRE | Si:ch211-161c3.6. (111 aa) |
| | tbxa2r | Thromboxane A2 receptor. (202 aa) |
| | fgf2 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (154 aa) |
| | bmper | BMP-binding endothelial regulator. (667 aa) |
| | Wars1 | Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family. (170 aa) |
| | vegfaa | Vascular endothelial growth factor A-A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis, and induces permeabilization of blood vessels. Acts both upstream of kdr and tie1 to stimulate endothelial cell differentiation, and upstream of gata1 to stimulate hematopoietic cell differentiation. (188 aa) |
| | efna3b | Ephrin-A3b; Belongs to the ephrin family. (219 aa) |
| | glula | Glutamine synthetase. (371 aa) |
| | JMJD8 | Jumonji domain containing 8. (207 aa) |
| | ecm1b | Extracellular matrix protein 1b. (499 aa) |
| | reck | Reversion-inducing cysteine-rich protein with Kazal motifs; Functions together with adgra2 to enable brain endothelial cells to selectively respond to Wnt7 signals (wnt7a or wnt7b). Plays a key role in Wnt7-specific responses: required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation. Acts as a Wnt7-specific coactivator of canonical Wnt signaling by decoding Wnt ligands: acts by interacting specifically with the disordered linker region of Wnt7, thereby conferring ligand selectivity for Wnt7. Adgra2 is then required to deliver reck-bound Wnt7 to frizzled [...] (755 aa) |
| | sirt6 | Sirtuin (Silent mating type information regulation 2 homolog) 6 (S. cerevisiae). (354 aa) |
| | faslg | Fas ligand (TNF superfamily, member 6); Belongs to the tumor necrosis factor family. (268 aa) |
| | cnmd | Leukocyte cell-derived chemotaxin 1; Bifunctional growth regulator. May contribute to the rapid growth of cartilage and vascular invasion prior to the replacement of cartilage by bone during endochondral bone development. Plays a role as antiangiogenic factor in cardiac valves to suppress neovascularization (By similarity); Belongs to the chondromodulin-1 family. (287 aa) |
| | B8JJU9_DANRE | Si:dkey-206d17.12. (626 aa) |
| | wars | Tryptophanyl-tRNA synthetase. (304 aa) |
| | glulb | Glutamine synthetase. (372 aa) |
| | gadd45ab | Growth arrest and DNA-damage-inducible, alpha, b. (156 aa) |
| | ddah2 | Dimethylarginine dimethylaminohydrolase 2. (286 aa) |
| | ENSDARP00000138435 | Si:ch211-286o17.1. (288 aa) |
| | apela | Apelin receptor early endogenous ligand; Endogenous ligand for the apelin receptor (aplnra and/or aplnrb). Hormone required for mesendodermal differentiation, blood vessels formation and heart morphogenesis during early development and for adult cardiovascular homeostasis. Acts as a motogen by promoting mesendodermal cell migration during gastrulation by binding and activating the apelin receptor. Acts as an early embryonic regulator of cellular movement with a role in migration and development of cardiac progenitor cells. May act as a chemoattractant for the activation of angioblast m [...] (58 aa) |
| | f3a | Coagulation factor IIIa. (294 aa) |
| | krit1 | Krev interaction trapped protein 1; Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Plays a role in integrin signaling. Plays an important role in the maintenance of the intracellular reactive oxygen species (ROS) homeostasis to prevent oxidative cellular damage. Facilitates the down-regulation of cyclin-D1 (CCND1) levels required for cell transition from pr [...] (741 aa) |
| | cyp1c1 | Cytochrome P450, family 1, subfamily C, polypeptide 1; Belongs to the cytochrome P450 family. (523 aa) |
| | emilin2b | Elastin microfibril interfacer 2b. (805 aa) |
| | chrna7 | Cholinergic receptor, nicotinic, alpha 7 (neuronal). (510 aa) |
| | il1b | Interleukin-1. (284 aa) |
| | nrp1a | Neuropilin-1a; Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. Regulates angiogenesis through a VEGF-dependent pathway. (923 aa) |
| | LOC101882451 | Uncharacterized protein. (545 aa) |
| | twsg1b | Twisted gastrulation protein homolog 1-B; Involved in dorsal-ventral patterning. Appears to function predominantly as a ventralizing factor, through its actions as a BMP signaling agonist, acting through both chd-dependent and chd- independent mechanisms. May also antagonize BMP signaling, probably via formation of ternary complexes with chd and BMPs, resulting in dorsalization; Belongs to the twisted gastrulation protein family. (155 aa) |
