STRINGSTRING
si:dkey-1k23.3 si:dkey-1k23.3 fkbp8 fkbp8 pwp1 pwp1 ppp1r8a ppp1r8a pip4k2aa pip4k2aa rtraf rtraf smcr8b smcr8b C13H9orf72 C13H9orf72 slc27a1a slc27a1a parp1 parp1 fkbp16 fkbp16 cdkn1ca cdkn1ca oclna oclna tnfb tnfb fgfr1op fgfr1op rabgef1l rabgef1l ATG14 ATG14 tsg101b tsg101b pibf1 pibf1 rabgef1 rabgef1 dkk1a dkk1a fam102bb fam102bb agt agt paqr3a paqr3a LOC101882206 LOC101882206 rb1 rb1 midn midn smad7 smad7 itgb1bp1 itgb1bp1 aida aida lats1 lats1 cbl cbl gadd45ba gadd45ba zgpat zgpat lrrk1 lrrk1 cblb cblb cav3 cav3 nf2b nf2b trib3 trib3 ppp1r8b ppp1r8b tspo tspo styxl1 styxl1 socs3a socs3a tsg101a tsg101a arpp19a arpp19a prdx3 prdx3 grem1a grem1a prkrip1 prkrip1 prkar2aa prkar2aa cdkn1ba cdkn1ba rd3 rd3 ppm1f ppm1f ptpn2b ptpn2b ppp1r11 ppp1r11 spry2 spry2 zgc:103586 zgc:103586 hexim1 hexim1 socs1a socs1a cdab cdab pmepa1 pmepa1 arpp19b arpp19b dusp19a dusp19a ppp1r35 ppp1r35 hspb1 hspb1 dnajc3a dnajc3a tgfb1a tgfb1a qars1 qars1 ptpn1 ptpn1 fam43a fam43a bag4 bag4 ppm1e ppm1e nck2b nck2b jun jun si:dkey-63b1.1 si:dkey-63b1.1 gdf11 gdf11 dkk1b dkk1b irak3 irak3 tigarb tigarb dusp10 dusp10 bmp4 bmp4 cdkn1bb cdkn1bb samsn1a samsn1a dtnbp1a dtnbp1a mastl mastl pdzd3b pdzd3b ntf3 ntf3 nprl2 nprl2 plpp3 plpp3 cox11 cox11 cmya5 cmya5 tesk2 tesk2 ctdspla ctdspla flcn flcn socs5b socs5b FAM72B FAM72B hmgcra hmgcra sema4d sema4d sirt1 sirt1 spry4 spry4 sh3bp5la sh3bp5la ctdsp1 ctdsp1 ppp1r15a ppp1r15a smad6b smad6b pard6a pard6a ppp1r1b ppp1r1b sfrp2 sfrp2 nck2a nck2a fam43b fam43b F1QYY8_DANRE F1QYY8_DANRE dtnbp1b dtnbp1b ctdsp2 ctdsp2 cdk5rap1 cdk5rap1 dusp6 dusp6 pdgfaa pdgfaa emilin1b emilin1b smyd3 smyd3 socs3b socs3b M9MMA2_DANRE M9MMA2_DANRE ptprc ptprc mgat5 mgat5 tgfb5 tgfb5 tigara tigara zgc:174906 zgc:174906 gba gba E7F9P7_DANRE E7F9P7_DANRE cblc cblc ajuba ajuba samsn1b samsn1b sema4e sema4e mfhas1 mfhas1 nck1a nck1a hspb15 hspb15 E7FDE8_DANRE E7FDE8_DANRE emilin1a emilin1a LOC100332300 LOC100332300 pkig pkig lrp5 lrp5 pard3ab pard3ab klhl31 klhl31 chp1 chp1 smad6a smad6a pip4k2ab pip4k2ab sh3bp5lb sh3bp5lb ldlrad4b ldlrad4b lats2 lats2 cdkn1a cdkn1a cdk5rap3 cdk5rap3 ptprq ptprq pik3ip1 pik3ip1 prkar2ab prkar2ab ldlrad4a ldlrad4a adar adar TESK1 TESK1 zfyve28 zfyve28 ankle2 ankle2 inpp5jb inpp5jb cdkn2c cdkn2c paqr3b paqr3b ptpa ptpa E9QHS4_DANRE E9QHS4_DANRE ptpn2a ptpn2a MYADM MYADM LOC569071 LOC569071 cep85 cep85 nf1b nf1b fam102ab fam102ab ppp4r4 ppp4r4 ptpn20 ptpn20 nf2a nf2a prkar1aa prkar1aa nck1b nck1b pip5kl1 pip5kl1 sh2b3 sh2b3 tmed2 tmed2 tgfb1b tgfb1b ptprh ptprh uri1 uri1 rock2a rock2a epm2a epm2a tnfaip3 tnfaip3 deptor deptor tgfb2 tgfb2 zc3h12a zc3h12a smpd1 smpd1 gckr gckr ptprja ptprja pdzd3a pdzd3a men1 men1 zgc:123278 zgc:123278 ensaa ensaa grem2a grem2a X1WCE8_DANRE X1WCE8_DANRE ptprjb.1 ptprjb.1 akt1s1 akt1s1 nf1a nf1a ptprjb.2 ptprjb.2 X1WFB5_DANRE X1WFB5_DANRE sorl1 sorl1 errfi1a errfi1a ENSDARP00000130602 ENSDARP00000130602 nupr1a nupr1a plek plek tmem130 tmem130 dusp7 dusp7 fbxo7 fbxo7 tsc2 tsc2 slc27a1b slc27a1b sh3bp5b sh3bp5b LOC100536607 LOC100536607 zgc:77748 zgc:77748 hmgcrb hmgcrb Wars1 Wars1 ptpro ptpro ptpro-2 ptpro-2 cdkn1d cdkn1d sirt6 sirt6 ENSDARP00000135075 ENSDARP00000135075 lrp6 lrp6 igfbp3 igfbp3 ccdc137 ccdc137 spry1 spry1 june june B8JJU9_DANRE B8JJU9_DANRE wars wars socs9 socs9 gadd45ab gadd45ab bod1l1 bod1l1 socs5a socs5a prkar1ab prkar1ab cib1 cib1 pid1 pid1 fam102aa fam102aa ptpn13 ptpn13 tfap4 tfap4 zgc:153993 zgc:153993 CAMK2N1 CAMK2N1 sh3bp5a sh3bp5a snx25 snx25 zgc:158343 zgc:158343 pdgfab pdgfab cdkn1cb cdkn1cb prkar1b prkar1b inpp5ka inpp5ka adipoqb adipoqb rock1 rock1 prkn prkn dnajc3b dnajc3b ctdsplb ctdsplb dusp19b dusp19b si:rp71-46j2.7 si:rp71-46j2.7 dgkab dgkab LOC101885386 LOC101885386 ptprb ptprb ENSDARP00000143947 ENSDARP00000143947 ibtk ibtk bmp16 bmp16 cdkn2a/b cdkn2a/b pdgfba pdgfba pdgfbb pdgfbb LOC569568 LOC569568 bod1 bod1 sfrp2l sfrp2l LOC562648 LOC562648 cdkn2d cdkn2d impact impact ENSDARP00000153406 ENSDARP00000153406 PRKAR2B PRKAR2B PARD3 PARD3 inpp5kb inpp5kb cdaa cdaa
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
si:dkey-1k23.3Si:dkey-1k23.3; Belongs to the small heat shock protein (HSP20) family. (365 aa)
fkbp8Peptidylprolyl isomerase. (406 aa)
pwp1PWP1 homolog (S. cerevisiae). (490 aa)
ppp1r8aProtein phosphatase 1, regulatory subunit 8a. (351 aa)
pip4k2aaSimilar to type II phosphatidylinositolphosphate kinase-alpha. (404 aa)
rtrafRNA transcription, translation and transport factor protein; RNA-binding protein involved in modulation of mRNA transcription by Polymerase II. Component of the tRNA-splicing ligase complex. (242 aa)
smcr8bGuanine nucleotide exchange protein smcr8b; Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation. The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activity. (985 aa)
C13H9orf72Zgc:100846. (462 aa)
slc27a1aSolute carrier family 27 member 1a. (647 aa)
parp1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1013 aa)
fkbp16Peptidylprolyl isomerase. (430 aa)
cdkn1caCyclin-dependent kinase inhibitor 1C (P57, Kip2). (212 aa)
oclnaOccludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (491 aa)
tnfbTumor necrosis factor b (TNF superfamily, member 2). (242 aa)
fgfr1opChemokine (C-C motif) receptor 6a. (511 aa)
rabgef1lRAB guanine nucleotide exchange factor (GEF) 1,-like. (470 aa)
ATG14Zgc:113944. (517 aa)
tsg101bTumor susceptibility 101b. (393 aa)
pibf1Progesterone immunomodulatory-binding factor 1. (752 aa)
rabgef1RAB guanine nucleotide exchange factor (GEF) 1. (502 aa)
dkk1aDickkopf WNT-signaling pathway inhibitor 1a. (256 aa)
fam102bbFamily with sequence similarity 102, member B, b. (367 aa)
agtAngiotensinogen; Belongs to the serpin family. (454 aa)
paqr3aProgestin and adipoQ receptor family member IIIa. (312 aa)
LOC101882206MARVEL domain-containing protein. (288 aa)
rb1Retinoblastoma 1. (903 aa)
midnMidnolin; Facilitates ubiquitin-independent proteasomal degradation of polycomb protein CBX4. Plays a role in inhibiting the activity of glucokinase GCK and both glucose-induced and basal insulin secretion. (509 aa)
smad7Mothers against decapentaplegic homolog. (372 aa)
itgb1bp1Integrin beta-1-binding protein 1. (198 aa)
aidaAxin interactor, dorsalization-associated protein; Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin- independent dorsalization pathway activated by axin/JNK-signaling. (303 aa)
lats1LATS, large tumor suppressor, homolog 1 (Drosophila). (1068 aa)
cblCbl proto-oncogene, E3 ubiquitin protein ligase. (913 aa)
gadd45baGrowth arrest and DNA-damage-inducible, beta a. (159 aa)
zgpatZinc finger CCCH-type with G patch domain-containing protein; Transcription repressor that specifically binds the 5'- GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration (By similarity). (504 aa)
lrrk1Leucine-rich repeat kinase 1. (1377 aa)
cblbCbl proto-oncogene B, E3 ubiquitin protein ligase. (939 aa)
cav3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (150 aa)
nf2bNeurofibromin 2b (merlin). (586 aa)
trib3Tribbles pseudokinase 3. (348 aa)
ppp1r8bProtein phosphatase 1, regulatory subunit 8b. (349 aa)
tspoTranslocator protein. (162 aa)
styxl1Serine/threonine/tyrosine-interacting-like 1. (295 aa)
socs3aSuppressor of cytokine-signaling 3a. (207 aa)
tsg101aTumor susceptibility 101a. (390 aa)
arpp19acAMP-regulated phosphoprotein 19a; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. Belongs to the endosulfine family. (111 aa)
prdx3Peroxiredoxin 3. (281 aa)
grem1aGremlin. (177 aa)
prkrip1PRKR-interacting protein 1 homolog; Required for pre-mRNA splicing as component of the spliceosome (By similarity). Binds double-stranded RNA (By similarity). (182 aa)
prkar2aaProtein kinase, cAMP-dependent, regulatory, type II, alpha A. (397 aa)
cdkn1baCyclin-dependent kinase inhibitor 1Ba. (187 aa)
rd3Retinal degeneration 3, GUCY2D regulator. (215 aa)
ppm1fProtein phosphatase, Mg2+/Mn2+-dependent, 1F. (424 aa)
ptpn2bTyrosine-protein phosphatase non-receptor type. (393 aa)
ppp1r11E3 ubiquitin-protein ligase PPP1R11; Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Inhibitor of protein phosphatase 1. (122 aa)
spry2Sprouty RTK-signaling antagonist 2. (301 aa)
zgc:103586Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (133 aa)
hexim1Protein HEXIM; Probable transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor; Belongs to the HEXIM family. (319 aa)
socs1aSuppressor of cytokine-signaling 1a. (201 aa)
cdabCytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (159 aa)
pmepa1Prostate transmembrane protein, androgen-induced 1. (193 aa)
arpp19bcAMP-regulated phosphoprotein 19b; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. Belongs to the endosulfine family. (111 aa)
dusp19aDual-specificity phosphatase 19a. (213 aa)
ppp1r35Protein phosphatase 1 regulatory subunit 35; May inhibit PPP1CA phosphatase activity. (251 aa)
hspb1Heat shock protein, alpha-crystallin-related, 1; Belongs to the small heat shock protein (HSP20) family. (199 aa)
dnajc3aDnaJ (Hsp40) homolog, subfamily C, member 3a. (504 aa)
tgfb1aTransforming growth factor beta; Belongs to the TGF-beta family. (377 aa)
qars1Glutaminyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (774 aa)
ptpn1Protein tyrosine phosphatase non-receptor type 1. (350 aa)
fam43aFamily with sequence similarity 43 member A. (348 aa)
bag4BCL2-associated athanogene 4. (399 aa)
ppm1eProtein phosphatase, Mg2+/Mn2+-dependent, 1E. (633 aa)
nck2bCytoplasmic protein. (380 aa)
junJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (308 aa)
si:dkey-63b1.1Si:dkey-63b1.1; Belongs to the G-protein coupled receptor 1 family. (365 aa)
gdf11Growth differentiation factor 11. (390 aa)
dkk1bDickkopf WNT-signaling pathway inhibitor 1b. (241 aa)
irak3Interleukin-1 receptor-associated kinase 3. (630 aa)
tigarbFructose-2,6-bisphosphatase TIGAR B; Fructose-bisphosphatase hydrolyzing fructose-2,6-bisphosphate as well as fructose-1,6-bisphosphate. Acts as a negative regulator of glycolysis by lowering intracellular levels of fructose-2,6- bisphosphate in a p53/TP53-dependent manner, resulting in the pentose phosphate pathway (PPP) activation and NADPH production. Contributes to the generation of reduced glutathione to cause a decrease in intracellular reactive oxygen species (ROS) content, correlating with its ability to protect cells from oxidative or metabolic stress-induced cell death. May p [...] (257 aa)
dusp10Dual-specificity phosphatase 10. (459 aa)
bmp4Bone morphogenetic protein 4. (400 aa)
cdkn1bbCyclin-dependent kinase inhibitor 1b (P27, kip1). (179 aa)
samsn1aSAM domain, SH3 domain and nuclear localisation signals 1a. (621 aa)
dtnbp1aDysbindin-A; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. Plays a role in intracellular vesicle trafficking. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. May be required for normal dopamine homeostasis in the cerebral cortex, hippocampus, and hypothalamus. Plays a role in the regulation of cell surface exposure of DRD2. Contributes to the regulation of dopamine signaling. May play a role in actin cytoskeleton reorganization and neu [...] (362 aa)
mastlSerine/threonine-protein kinase greatwall; Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of arpp19 and ensa at 'Ser- 62' and 'Ser-74', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the ppp2r2d (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity hi [...] (860 aa)
pdzd3bPDZ domain-containing 3b. (524 aa)
ntf3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (243 aa)
nprl2NPR2-like, GATOR1 complex subunit. (379 aa)
plpp3Phospholipid phosphatase 3. (312 aa)
cox11Cytochrome c oxidase assembly homolog 11 (yeast). (259 aa)
cmya5Cardiomyopathy associated 5 like. (1759 aa)
tesk2Testis-associated actin remodelling kinase 2. (634 aa)
ctdsplaCTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like a. (265 aa)
flcnFolliculin. (558 aa)
socs5bSuppressor of cytokine signaling 5-like. (557 aa)
FAM72BZgc:101564. (147 aa)
hmgcra3-hydroxy-3-methylglutaryl coenzyme A reductase. (884 aa)
sema4dUncharacterized protein; Belongs to the semaphorin family. (856 aa)
sirt1Sirtuin 1. (710 aa)
spry4Sprouty homolog 4 (Drosophila). (310 aa)
sh3bp5laSH3-binding domain protein 5-like, a. (425 aa)
ctdsp1CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1. (265 aa)
ppp1r15aProtein phosphatase 1, regulatory subunit 15A. (319 aa)
smad6bMothers against decapentaplegic homolog. (486 aa)
pard6aPar-6 family cell polarity regulator alpha. (385 aa)
ppp1r1bProtein phosphatase 1, regulatory (inhibitor) subunit 1B. (189 aa)
sfrp2Secreted frizzled-related protein 2. (294 aa)
nck2aCytoplasmic protein. (403 aa)
fam43bFamily with sequence similarity 43 member B. (305 aa)
F1QYY8_DANRESi:dkeyp-97e7.9. (393 aa)
dtnbp1bDystrobrevin-binding protein 1b. (216 aa)
ctdsp2CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2. (258 aa)
cdk5rap1CDK5 regulatory subunit-associated protein 1. (577 aa)
dusp6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (382 aa)
pdgfaaPlatelet-derived growth factor alpha polypeptide a; Belongs to the PDGF/VEGF growth factor family. (194 aa)
emilin1bElastin microfibril interfacer 1b. (1059 aa)
smyd3SET and MYND domain-containing 3. (429 aa)
socs3bSuppressor of cytokine-signaling 3b. (210 aa)
M9MMA2_DANRESi:ch211-129c21.1; Belongs to the semaphorin family. (775 aa)
ptprcProtein tyrosine phosphatase receptor type C. (1130 aa)
mgat5Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase. (742 aa)
tgfb5Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
tigaraProbable fructose-2,6-bisphosphatase TIGAR A; Fructose-bisphosphatase hydrolyzing fructose-2,6-bisphosphate as well as fructose-1,6-bisphosphate. Acts as a negative regulator of glycolysis by lowering intracellular levels of fructose-2,6- bisphosphate in a p53/TP53-dependent manner, resulting in the pentose phosphate pathway (PPP) activation and NADPH production. Contributes to the generation of reduced glutathione to cause a decrease in intracellular reactive oxygen species (ROS) content, correlating with its ability to protect cells from oxidative or metabolic stress-induced cell dea [...] (256 aa)
zgc:174906Zgc:174906. (224 aa)
gbaGlucosylceramidase. (518 aa)
E7F9P7_DANRESi:ch211-253b8.5. (198 aa)
cblcCbl proto-oncogene C, E3 ubiquitin protein ligase. (502 aa)
ajubaAjuba LIM protein. (688 aa)
samsn1bSAM domain, SH3 domain and nuclear localisation signals 1b. (354 aa)
sema4eSemaphorin-4E. (766 aa)
mfhas1Malignant fibrous histiocytoma-amplified sequence 1. (992 aa)
nck1aNCK adaptor protein 1a. (332 aa)
hspb15Heat shock protein, alpha-crystallin-related, b15; Belongs to the small heat shock protein (HSP20) family. (154 aa)
E7FDE8_DANRESi:ch1073-174d20.1. (166 aa)
emilin1aElastin microfibril interfacer 1a. (1014 aa)
LOC100332300Gremlin 1a, DAN family BMP antagonist. (177 aa)
pkigProtein kinase (cAMP-dependent, catalytic) inhibitor gamma. (77 aa)
lrp5Low density lipoprotein receptor-related protein 5. (1615 aa)
pard3abPar-3 family cell polarity regulator alpha, b. (1332 aa)
klhl31Kelch-like protein 31. (635 aa)
chp1Calcineurin-like EF-hand protein 1. (194 aa)
smad6aMothers against decapentaplegic homolog. (456 aa)
pip4k2abPhosphatidylinositol-5-phosphate 4-kinase, type II, alpha b. (413 aa)
sh3bp5lbGeneral transcription factor IIH, polypeptide 4. (465 aa)
ldlrad4bLow density lipoprotein receptor class A domain-containing 4b. (265 aa)
lats2Large tumor suppressor kinase 2. (1140 aa)
cdkn1aCyclin-dependent kinase inhibitor 1A. (154 aa)
cdk5rap3CDK5 regulatory subunit-associated protein 3. (507 aa)
ptprqProtein tyrosine phosphatase receptor type Q. (2301 aa)
pik3ip1Phosphoinositide-3-kinase-interacting protein 1; Negative regulator of hepatic phosphatidylinositol 3-kinase (PI3K) activity. (265 aa)
prkar2abProtein kinase, cAMP-dependent, regulatory, type II, alpha, B. (422 aa)
ldlrad4aLow density lipoprotein receptor class A domain-containing 4a. (305 aa)
adarAdenosine deaminase RNA-specific. (1381 aa)
TESK1Si:ch211-113e8.3. (657 aa)
zfyve28Lateral signaling target protein 2 homolog; Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated (By similarity); Belongs to the lst-2 family. (975 aa)
ankle2Ankyrin repeat and LEM domain-containing 2. (961 aa)
inpp5jbInositol polyphosphate-5-phosphatase Jb. (566 aa)
cdkn2cCyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4). (170 aa)
paqr3bProgestin and adipoQ receptor family member IIIb. (307 aa)
ptpaSerine/threonine-protein phosphatase 2A activator; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. (324 aa)
E9QHS4_DANRESi:dkey-175m17.7. (892 aa)
ptpn2aTyrosine-protein phosphatase non-receptor type. (392 aa)
MYADMSi:dkeyp-67a8.2. (294 aa)
LOC569071Protein tyrosine phosphatase receptor type H. (770 aa)
cep85Centrosomal protein 85. (763 aa)
nf1bNeurofibromin 1b. (2759 aa)
fam102abFamily with sequence similarity 102 member Ab. (398 aa)
ppp4r4Protein phosphatase 4, regulatory subunit 4. (875 aa)
ptpn20Protein tyrosine phosphatase non-receptor type 20. (372 aa)
nf2aSimilar to neurofibromin 2. (593 aa)
prkar1aaProtein kinase, cAMP-dependent, regulatory, type I, alpha (tissue-specific extinguisher 1) a. (379 aa)
nck1bCytoplasmic protein. (381 aa)
pip5kl1Phosphatidylinositol-4-phosphate 5-kinase-like 1. (457 aa)
sh2b3SH2B adaptor protein 3. (596 aa)
tmed2Transmembrane p24-trafficking protein 2. (208 aa)
tgfb1bTransforming growth factor beta; Belongs to the TGF-beta family. (379 aa)
ptprhProtein tyrosine phosphatase receptor type H. (779 aa)
uri1URI1 prefoldin-like chaperone. (512 aa)
rock2aRho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1375 aa)
epm2aEPM2A glucan phosphatase, laforin. (310 aa)
tnfaip3Tumor necrosis factor, alpha-induced protein 3. (756 aa)
deptorDEP domain-containing MTOR-interacting protein. (407 aa)
tgfb2Transforming growth factor, beta 2. (413 aa)
zc3h12aZinc finger CCCH-type-containing 12A. (367 aa)
smpd1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (675 aa)
gckrGlucokinase (hexokinase 4) regulator. (281 aa)
ptprjaProtein tyrosine phosphatase receptor type Ja. (1650 aa)
pdzd3aPDZ domain-containing 3a. (501 aa)
men1Multiple endocrine neoplasia I. (617 aa)
zgc:123278Zgc:123278. (185 aa)
ensaaAlpha-endosulfine; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with ppp2r2d (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity); Belongs to the endosulfine family. (113 aa)
grem2aGremlin 2, DAN family BMP antagonist a. (195 aa)
X1WCE8_DANRESi:dkeyp-66d1.7. (293 aa)
ptprjb.1Protein tyrosine phosphatase receptor type Jb, tandem duplicate 1. (311 aa)
akt1s1AKT1 substrate 1 (proline-rich). (354 aa)
nf1aNeurofibromin 1a. (2759 aa)
ptprjb.2Protein tyrosine phosphatase receptor type Jb, tandem duplicate 2. (320 aa)
X1WFB5_DANRESi:ch211-147k10.5. (341 aa)
sorl1Sortilin-related receptor, L(DLR class) A repeats-containing. (2213 aa)
errfi1aERBB receptor feedback inhibitor 1a. (447 aa)
ENSDARP00000130602Si:ch1073-398f15.1. (647 aa)
nupr1aNuclear protein 1a. (76 aa)
plekPleckstrin. (352 aa)
tmem130Transmembrane protein 130. (318 aa)
dusp7Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (374 aa)
fbxo7F-box protein 7. (485 aa)
tsc2TSC complex subunit 2. (1674 aa)
slc27a1bSolute carrier family 27 member 1b. (648 aa)
sh3bp5bSH3-domain-binding protein 5b (BTK-associated). (446 aa)
LOC100536607Uncharacterized protein. (287 aa)
zgc:77748Zgc:77748. (288 aa)
hmgcrb3-hydroxy-3-methylglutaryl coenzyme A reductase. (844 aa)
Wars1Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family. (170 aa)
ptproProtein tyrosine phosphatase receptor type O. (385 aa)
ptpro-2Protein tyrosine phosphatase receptor type O. (866 aa)
cdkn1dCyclin-dependent kinase inhibitor 1D. (169 aa)
sirt6Sirtuin (Silent mating type information regulation 2 homolog) 6 (S. cerevisiae). (354 aa)
ENSDARP00000135075Platelet-derived growth factor alpha polypeptide a. (194 aa)
lrp6Low density lipoprotein receptor-related protein 6. (935 aa)
igfbp3Insulin-like growth factor-binding protein 3. (292 aa)
ccdc137Coiled-coil domain-containing 137. (242 aa)
spry1Sprouty homolog 1, antagonist of FGF-signaling (Drosophila). (292 aa)
juneJunE proto-oncogene, AP-1 transcription factor subunit. (323 aa)
B8JJU9_DANRESi:dkey-206d17.12. (626 aa)
warsTryptophanyl-tRNA synthetase. (304 aa)
socs9Suppressor of cytokine-signaling 9. (497 aa)
gadd45abGrowth arrest and DNA-damage-inducible, alpha, b. (156 aa)
bod1l1Biorientation of chromosomes in cell division 1-like 1. (1651 aa)
socs5aSuppressor of cytokine-signaling 5a. (528 aa)
prkar1abProtein kinase, cAMP-dependent, regulatory, type I, alpha (tissue-specific extinguisher 1) b. (379 aa)
cib1Calcium and integrin-binding 1 (calmyrin). (188 aa)
pid1Phosphotyrosine interaction domain-containing 1. (207 aa)
fam102aaFamily with sequence similarity 102 member Aa. (391 aa)
ptpn13Protein tyrosine phosphatase non-receptor type 13. (1302 aa)
tfap4Transcription factor AP-4 (activating enhancer-binding protein 4). (335 aa)
zgc:153993Zgc:153993 protein. (204 aa)
CAMK2N1Si:dkey-33m11.6. (76 aa)
sh3bp5aSH3-domain-binding protein 5a (BTK-associated). (444 aa)
snx25Sorting nexin 25. (961 aa)
zgc:158343Zgc:158343. (208 aa)
pdgfabPlatelet-derived growth factor alpha polypeptide b; Belongs to the PDGF/VEGF growth factor family. (230 aa)
cdkn1cbCyclin-dependent kinase inhibitor 1Cb. (172 aa)
prkar1bProtein kinase, cAMP-dependent, regulatory, type I, beta. (380 aa)
inpp5kaInositol polyphosphate-5-phosphatase Ka. (476 aa)
adipoqbAdiponectin, C1Q and collagen domain-containing, b. (299 aa)
rock1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1359 aa)
prknE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (458 aa)
dnajc3bDnaJ (Hsp40) homolog, subfamily C, member 3b. (502 aa)
ctdsplbCTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like b. (266 aa)
dusp19bDual-specificity phosphatase 19b. (205 aa)
si:rp71-46j2.7Si:rp71-46j2.7. (864 aa)
dgkabDiacylglycerol kinase. (727 aa)
LOC101885386Uncharacterized protein. (224 aa)
ptprbProtein tyrosine phosphatase receptor type b. (1892 aa)
ENSDARP00000143947KIND domain-containing protein. (225 aa)
ibtkInhibitor of Bruton agammaglobulinemia tyrosine kinase. (1332 aa)
bmp16Bone morphogenetic protein 16. (416 aa)
cdkn2a/bCyclin-dependent kinase inhibitor 2A/B (p15, inhibits CDK4). (129 aa)
pdgfbaPlatelet-derived growth factor beta polypeptide a; Belongs to the PDGF/VEGF growth factor family. (463 aa)
pdgfbbPlatelet-derived growth factor beta polypeptide b; Belongs to the PDGF/VEGF growth factor family. (483 aa)
LOC569568Inositol polyphosphate-5-phosphatase Ja. (586 aa)
bod1Biorientation of chromosomes in cell division 1. (157 aa)
sfrp2lSecreted frizzled-related protein 2-like. (333 aa)
LOC562648Poly [ADP-ribose] polymerase. (1797 aa)
cdkn2dCyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4). (168 aa)
impactProtein IMPACT; Translational regulator that ensures constant high levels of translation upon a variety of stress conditions, such as amino acid starvation, UV-C irradiation, proteasome inhibitor treatment and glucose deprivation. Plays a role as a negative regulator of the EIF2AK4/GCN2 kinase activity; impairs GCN1-mediated EIF2AK4/GCN2 activation, and hence EIF2AK4/GCN2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis. Plays a role in differentiation of neuronal cells by stimulating neurite outgrowth. (317 aa)
ENSDARP00000153406DUF3384 domain-containing protein. (162 aa)
PRKAR2BSi:ch211-272n13.7. (398 aa)
PARD3Par-3 family cell polarity regulator. (531 aa)
inpp5kbInositol polyphosphate-5-phosphatase Kb. (526 aa)
cdaaCytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (139 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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