STRINGSTRING
epha2a epha2a efna1b efna1b efna3a efna3a epha3 epha3 efnb1 efnb1 epha4b epha4b ENSDARP00000152912 ENSDARP00000152912 ENSDARP00000153487 ENSDARP00000153487 ENSDARP00000154833 ENSDARP00000154833 nck2b nck2b efnb3b efnb3b efna1a efna1a epha2b epha2b ephb2b ephb2b ephb3a ephb3a efna2a efna2a E7F153_DANRE E7F153_DANRE ek1 ek1 epha7 epha7 nck2a nck2a ephb4b ephb4b LOC100334911 LOC100334911 efnb2b efnb2b epha5 epha5 efna2b efna2b nck1a nck1a ephb1 ephb1 ephb2a ephb2a efna5a efna5a anks1b anks1b nck1b nck1b epha6 epha6 epha4a epha4a efna3b efna3b efna5b efna5b ENSDARP00000140419 ENSDARP00000140419 si:ch73-40a2.1 si:ch73-40a2.1 efnb3a efnb3a ephb4a ephb4a epha4l epha4l efnb2a efnb2a
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
epha2aEph receptor A2 a. (984 aa)
efna1bEphrin A-L1; Belongs to the ephrin family. (229 aa)
efna3aEphrin-A3a; Belongs to the ephrin family. (220 aa)
epha3Ephrin type-A receptor 3. (963 aa)
efnb1Ephrin-B1; Belongs to the ephrin family. (341 aa)
epha4bEph receptor A4b. (976 aa)
ENSDARP00000152912Si:dkey-246i14.3; Belongs to the ephrin family. (176 aa)
ENSDARP00000153487Eph LBD domain-containing protein. (256 aa)
ENSDARP00000154833Eph LBD domain-containing protein. (578 aa)
nck2bCytoplasmic protein. (380 aa)
efnb3bEfnb3 protein; Belongs to the ephrin family. (342 aa)
efna1aEphrin-A1a; Belongs to the ephrin family. (222 aa)
epha2bEph receptor A2 b. (979 aa)
ephb2bEph receptor B2b. (989 aa)
ephb3aEphrin type-B receptor 3; Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Generally has an overlapping and redundant function with EPHB2. Like EPHB2, functions in axon guidance during development. In addition to its role in axon guidance plays also an important re [...] (925 aa)
efna2aEphrin-A2; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. With the epha2 receptor may play a role in bone remodeling thro [...] (195 aa)
E7F153_DANREEph LBD domain-containing protein. (255 aa)
ek1Ephrin type-A receptor 3; Receptor tyrosine kinase which binds promiscuously membrane- bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially efna5. Upon activation by efna5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in ca [...] (981 aa)
epha7Eph receptor A7. (1016 aa)
nck2aCytoplasmic protein. (403 aa)
ephb4bEphrin type-B receptor 4b; Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 is involved in the regulation of cell adhesion and cell migration, and plays a central role in heart morphogenesis, angiogenesis and [...] (976 aa)
LOC100334911Ankyrin repeat and sterile alpha motif domain-containing 1Aa. (318 aa)
efnb2bEphrin-B2b; Belongs to the ephrin family. (334 aa)
epha5Uncharacterized protein. (983 aa)
efna2bEphrin-A2b; Belongs to the ephrin family. (159 aa)
nck1aNCK adaptor protein 1a. (332 aa)
ephb1EPH receptor B1. (694 aa)
ephb2aEph receptor B2a. (1015 aa)
efna5aEphrin-A5a; Belongs to the ephrin family. (237 aa)
anks1bAnkyrin repeat and sterile alpha motif domain-containing protein 1B. (1280 aa)
nck1bCytoplasmic protein. (381 aa)
epha6Eph receptor A6. (1001 aa)
epha4aEphrin type-A receptor 4a; Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI- anchored ephrin-A and transmembrane ephrin-B ligands including efna1 and efnb3. [...] (995 aa)
efna3bEphrin-A3b; Belongs to the ephrin family. (219 aa)
efna5bEphrin-A5b; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the epha3 receptor [...] (91 aa)
ENSDARP00000140419Uncharacterized protein. (501 aa)
si:ch73-40a2.1Si:ch73-40a2.1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (723 aa)
efnb3aEphrin-B3a; Belongs to the ephrin family. (337 aa)
ephb4aEphrin type-B receptor 4a; Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 is involved in the regulation of cell adhesion and cell migration, and plays a central role in heart morphogenesis, angiogenesis and [...] (987 aa)
epha4lEph receptor A4,-like. (988 aa)
efnb2aEphrin-B2a; Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with ephb4 may play a central role in heart morph [...] (332 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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