STRINGSTRING
fgf8a fgf8a bmp1a bmp1a ENSDARP00000147138 ENSDARP00000147138 mapk8a mapk8a twsg1b twsg1b ctnnb1 ctnnb1 mapk10 mapk10 vox vox grem2b grem2b grem2a grem2a fsta fsta wnt8-2 wnt8-2 wnt8a wnt8a max max bmp2b bmp2b zfr2 zfr2 LOC100332300 LOC100332300 ppp4cb ppp4cb ppp4ca ppp4ca ift46 ift46 ctnnb2 ctnnb2 fstb fstb gdf6a gdf6a zfr zfr gid8b gid8b tll1 tll1 smad5 smad5 chrd chrd grem1a grem1a gid8a gid8a aida aida bmp2a bmp2a mapk8b mapk8b gdf5 gdf5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
fgf8aFibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration (By similarity). Required for Kupffer's vesicle ciliogenesis. (210 aa)
bmp1aMetalloendopeptidase. (986 aa)
ENSDARP00000147138TGFb_propeptide domain-containing protein. (179 aa)
mapk8aMitogen-activated protein kinase. (427 aa)
twsg1bTwisted gastrulation protein homolog 1-B; Involved in dorsal-ventral patterning. Appears to function predominantly as a ventralizing factor, through its actions as a BMP signaling agonist, acting through both chd-dependent and chd- independent mechanisms. May also antagonize BMP signaling, probably via formation of ternary complexes with chd and BMPs, resulting in dorsalization; Belongs to the twisted gastrulation protein family. (155 aa)
ctnnb1Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] (789 aa)
mapk10Mitogen-activated protein kinase. (472 aa)
voxVentral homeobox. (242 aa)
grem2bGremlin. (166 aa)
grem2aGremlin 2, DAN family BMP antagonist a. (195 aa)
fstaFollistatin-A; Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (fsh) (By similarity). Inhibits bmp-signaling during later stages of development including late phases of dorsoventral patterning, to refine the early pattern set up by the interaction of chordino and bmp2/4. Not involved in organizer function or early phases of dorsoventral pattern formation. (324 aa)
wnt8-2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
wnt8aProtein Wnt-8a; Ligand for members of the frizzled family of seven transmembrane receptors. Plays a role in embryonic patterning. May be involved in the specification of the spatial patterns of expression of Gsc and other regulatory genes leading to the establishment of the embryonic axis; Belongs to the Wnt family. (387 aa)
maxProtein max; Transcription regulator. Forms a sequence-specific DNA- binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC-MAX complex is a transcriptional activator, whereas the MAD-MAX complex is a repressor (By similarity). (160 aa)
bmp2bBone morphogenetic protein 2b. (411 aa)
zfr2Zinc finger RNA-binding protein 2. (1011 aa)
LOC100332300Gremlin 1a, DAN family BMP antagonist. (177 aa)
ppp4cbSerine/threonine-protein phosphatase 4 catalytic subunit B; Protein phosphatase that regulates many processes such as microtubule organization at centrosomes; Belongs to the PPP phosphatase family. PP-4 (PP-X) subfamily. (307 aa)
ppp4caSerine/threonine-protein phosphatase 4 catalytic subunit A; Protein phosphatase that regulates many processes such as microtubule organization at centrosomes; Belongs to the PPP phosphatase family. PP-4 (PP-X) subfamily. (311 aa)
ift46Intraflagellar transport protein 46 homolog; Forms part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. Plays a role in early embryonic development; Belongs to the IFT46 family. (355 aa)
ctnnb2Catenin, beta 2. (778 aa)
fstbFollistatin 2. (344 aa)
gdf6aGrowth/differentiation factor 6-A; Growth factor that controls proliferation and cellular differentiation in the retina. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map. Functions maternally in dorsal/ventral patterning to induce the expression of the zygotic bmp2b and bmp4 genes and ventralize embryos. Zygotic expression does not appear to regulate axis specification, but instead functions to establish the integrity of the axial vessels during embryon [...] (404 aa)
zfrZinc finger RNA-binding protein; Involved in postimplantation and gastrulation stages of development. Binds to DNA and RNA (By similarity). (1074 aa)
gid8bGlucose-induced degradation protein 8-B homolog; Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Acts as a positive regulator of Wnt signaling pathway by promoting beta-catenin (CTNNB1) nuclear accumulation (By similarity). Required for normal Wnt signaling and normal dorsoventral patterning during embryogenesis. (229 aa)
tll1Dorsal-ventral patterning tolloid-like protein 1; Required for patterning ventral tissues of the tail. May increase bone morphogenetic protein (BMP) activity at the end of gastrulation by proteolytic cleavage of chordin and release of BMP from inactive complexes. (1022 aa)
smad5Mothers against decapentaplegic homolog 5; Involved in ventralization. May mediate Bmp2b signaling during early phases of embryonic dorsal-ventral pattern formation. Required for initiation of Smad1 expression during gastrulation. Belongs to the dwarfin/SMAD family. (464 aa)
chrdChordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes (By similarity); Belongs to the chordin family. (940 aa)
grem1aGremlin. (177 aa)
gid8aGlucose-induced degradation protein 8-A homolog; Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Acts as a positive regulator of Wnt signaling pathway by promoting beta-catenin (CTNNB1) nuclear accumulation (By similarity). Required for normal Wnt signaling and normal dorsoventral patterning during embryogenesis. Belongs to the GID8 family. (228 aa)
aidaAxin interactor, dorsalization-associated protein; Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin- independent dorsalization pathway activated by axin/JNK-signaling. (303 aa)
bmp2aBone morphogenetic protein 2a. (386 aa)
mapk8bMitogen-activated protein kinase 8; Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. May play a role in the regulation of the circadian clock. (384 aa)
gdf5Growth differentiation factor 5. (474 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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