STRINGSTRING
sp3a sp3a gata1a gata1a spo11 spo11 ptgs2b ptgs2b prdm1a prdm1a eaf2 eaf2 spint1b spint1b inhbaa inhbaa wnt7ba wnt7ba fosl1a fosl1a atm atm amh amh bmp7a bmp7a bsg bsg cyp7b1 cyp7b1 ptgs2a ptgs2a bmp6 bmp6 kif18a kif18a msh2 msh2 bcl2l1 bcl2l1 wt1a wt1a asb1 asb1 tppp2 tppp2 fancg fancg gas2 gas2 socs3a socs3a pkd1a pkd1a serpine2 serpine2 prdx3 prdx3 ercc1 ercc1 tbc1d20 tbc1d20 wnt2bb wnt2bb ptpn11b ptpn11b igf2b igf2b E9QFY7_DANRE E9QFY7_DANRE cx27.5 cx27.5 tcf21 tcf21 bmp15 bmp15 bmpr2a bmpr2a inhbb inhbb cebpb cebpb cx35.4 cx35.4 srd5a2a srd5a2a arid4a arid4a wnt7aa wnt7aa hsd17b2 hsd17b2 stk11 stk11 eif2s2 eif2s2 hectd1 hectd1 ube3a ube3a dmc1 dmc1 ghsra ghsra ghsrb ghsrb tmf1 tmf1 ptpn11a ptpn11a LOC568110 LOC568110 gata1b gata1b gata2a gata2a fem1b fem1b tnfaip6 tnfaip6 ar ar sirt1 sirt1 ptx3a ptx3a taf10 taf10 pla2g4aa pla2g4aa prdx4 prdx4 rec8b rec8b spint2 spint2 sfrp2 sfrp2 scaper scaper wnt2ba wnt2ba ttpal ttpal alkbh1 alkbh1 socs3b socs3b bcl2l11 bcl2l11 smad4a smad4a cdx4 cdx4 sgpl1 sgpl1 zmp:0000000846 zmp:0000000846 il10 il10 pcdh12 pcdh12 eif2b5 eif2b5 brca2 brca2 gb:cr929477 gb:cr929477 fbxw8 fbxw8 mertka mertka tex11 tex11 bptf bptf cited1 cited1 nr0b1 nr0b1 ash1l ash1l atrx atrx eif2b4 eif2b4 bmpr2b bmpr2b cyp1b1 cyp1b1 arid4b arid4b tfpt tfpt dmrt1 dmrt1 MDFI MDFI junba junba si:dkey-6b12.5 si:dkey-6b12.5 tcf23 tcf23 ppardb ppardb TCF24 TCF24 dhcr24 dhcr24 lepa lepa cyp19a1a cyp19a1a apoda.2 apoda.2 nrip1a nrip1a tnc tnc VASH1 VASH1 lef1 lef1 rusc1 rusc1 setd2 setd2 hyal3 hyal3 plekha1b plekha1b greb1 greb1 nkx3-1 nkx3-1 LOC108192159 LOC108192159 ttpa ttpa tppp3 tppp3 gdf7 gdf7 bmp7b bmp7b gata2b gata2b Q1L8R8_DANRE Q1L8R8_DANRE bcl2a bcl2a ghrl ghrl ptx3b ptx3b wt1b wt1b srd5a1 srd5a1 tmed2 tmed2 fosl1b fosl1b tlr5a tlr5a tlr5b tlr5b cx31.7 cx31.7 pparda pparda srd5a2b srd5a2b E7FFZ5_DANRE E7FFZ5_DANRE hsd17b3 hsd17b3 nrip1b nrip1b bcl2b bcl2b stox2a stox2a ndp ndp sp3b sp3b pkd1b pkd1b vash2 vash2 zfat zfat msh4 msh4 wnt7bb wnt7bb birc6 birc6 gfra1a gfra1a lhb lhb pla2g4ab pla2g4ab LOC100332902 LOC100332902 sf1 sf1 nupr1a nupr1a junbb junbb zgc:113363 zgc:113363 ENSDARP00000132312 ENSDARP00000132312 plekha1a plekha1a map3k4 map3k4 bmp5 bmp5 CCDC134 CCDC134 hsd17b4 hsd17b4 gfra1b gfra1b atrxl atrxl fanca fanca epor epor fzd4 fzd4 cyp1c1 cyp1c1 zgc:153993 zgc:153993 ptn ptn nsdhl nsdhl zgc:63863 zgc:63863 ENSDARP00000141388 ENSDARP00000141388 ENSDARP00000142835 ENSDARP00000142835 klhl10b.2 klhl10b.2 pdgfba pdgfba AXL AXL klhl10b.1 klhl10b.1 pdgfbb pdgfbb ptpn6 ptpn6 prdm1b prdm1b sfrp2l sfrp2l spint1a spint1a wdr19 wdr19 msc msc LOC110438398 LOC110438398 ENSDARP00000153869 ENSDARP00000153869 inhbab inhbab tfeb tfeb klhl10a klhl10a
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
sp3aSp3a transcription factor. (679 aa)
gata1aGATA-binding protein 1a. (418 aa)
spo11SPO11 initiator of meiotic double stranded breaks. (383 aa)
ptgs2bProstaglandin-endoperoxide synthase 2b. (606 aa)
prdm1aPR domain-containing 1a, with ZNF domain. (776 aa)
eaf2ELL-associated factor 2. (259 aa)
spint1bSerine peptidase inhibitor, Kunitz type 1 b. (499 aa)
inhbaaInhibin subunit beta Aa. (395 aa)
wnt7baProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
fosl1aFOS-like 1, AP-1 transcription factor subunit a. (346 aa)
atmNon-specific serine/threonine protein kinase. (3091 aa)
amhAnti-Mullerian hormone. (549 aa)
bmp7aBone morphogenetic protein 7a. (432 aa)
bsgBasigin. (404 aa)
cyp7b1Cytochrome P450, family 7, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (504 aa)
ptgs2aProstaglandin-endoperoxide synthase 2a. (601 aa)
bmp6Bone morphogenetic protein 6. (417 aa)
kif18aKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (895 aa)
msh2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (936 aa)
bcl2l1Bcl-XL-like protein 1. (238 aa)
wt1aWT1 transcription factor a. (419 aa)
asb1Ankyrin repeat and SOCS box-containing 1. (335 aa)
tppp2Tubulin polymerization-promoting protein family member 2. (181 aa)
fancgFA complementation group G. (617 aa)
gas2Growth arrest-specific 2a. (362 aa)
socs3aSuppressor of cytokine-signaling 3a. (207 aa)
pkd1aPolycystic kidney disease 1a. (4346 aa)
serpine2Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2; Belongs to the serpin family. (395 aa)
prdx3Peroxiredoxin 3. (281 aa)
ercc1Excision repair cross-complementing rodent repair deficiency, complementation group 1. (342 aa)
tbc1d20TBC1 domain family, member 20. (397 aa)
wnt2bbProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (396 aa)
ptpn11bTyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (592 aa)
igf2bInsulin-like growth factor 2b. (212 aa)
E9QFY7_DANRESi:dkey-167k11.5. (227 aa)
cx27.5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (254 aa)
tcf21Transcription factor 21; Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. (176 aa)
bmp15Bone morphogenetic protein 15. (384 aa)
bmpr2aReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1003 aa)
inhbbInhibin subunit beta B. (393 aa)
cebpbCCAAT/enhancer-binding protein. (280 aa)
cx35.4Connexin 35.4; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Belongs to the connexin family. (304 aa)
srd5a2a3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (252 aa)
arid4aAT-rich interactive domain 4A (RBP1-like). (1196 aa)
wnt7aaProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
hsd17b2Hydroxysteroid (17-beta) dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (358 aa)
stk11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (438 aa)
eif2s2Eukaryotic translation initiation factor 2, subunit 2 beta. (327 aa)
hectd1Novel protein with HECT-domain (Ubiquitin-transferase). (2576 aa)
ube3aUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (857 aa)
dmc1Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (342 aa)
ghsraGrowth hormone secretagogue receptor a; Belongs to the G-protein coupled receptor 1 family. (360 aa)
ghsrbGrowth hormone secretagogue receptor b; Belongs to the G-protein coupled receptor 1 family. (365 aa)
tmf1TATA element modulatory factor 1. (1135 aa)
ptpn11aTyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
LOC568110Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
gata1bGATA-binding protein 1b. (361 aa)
gata2aGATA-binding protein 2a. (456 aa)
fem1bFem-1 homolog b. (638 aa)
tnfaip6Tumor necrosis factor, alpha-induced protein 6. (271 aa)
arAndrogen receptor. (868 aa)
sirt1Sirtuin 1. (710 aa)
ptx3aPentraxin 3, long a. (447 aa)
taf10Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (181 aa)
pla2g4aaCytosolic phospholipase A2; Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response. (741 aa)
prdx4Peroxiredoxin 4. (260 aa)
rec8bREC8 meiotic recombination protein b. (564 aa)
spint2Serine peptidase inhibitor, Kunitz type, 2. (431 aa)
sfrp2Secreted frizzled-related protein 2. (294 aa)
scaperS-phase cyclin A-associated protein in the ER. (1318 aa)
wnt2baProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (387 aa)
ttpalTocopherol (alpha) transfer protein-like. (341 aa)
alkbh1AlkB homolog 1, histone H2A dioxygenase. (331 aa)
socs3bSuppressor of cytokine-signaling 3b. (210 aa)
bcl2l11BCL2-like 11. (176 aa)
smad4aMothers against decapentaplegic homolog. (547 aa)
cdx4Caudal type homeo box transcription factor 4. (270 aa)
sgpl1Sphingosine-1-phosphate lyase 1. (572 aa)
zmp:0000000846Zmp:0000000846. (1532 aa)
il10Interleukin-10. (180 aa)
pcdh12Protocadherin 12. (1174 aa)
eif2b5Eukaryotic translation initiation factor 2B, subunit 5 epsilon. (607 aa)
brca2BRCA2 DNA repair-associated. (2874 aa)
gb:cr929477SMAD family member 4. (332 aa)
fbxw8F-box and WD repeat domain-containing 8. (627 aa)
mertkaC-mer proto-oncogene tyrosine kinase a. (952 aa)
tex11Testis-expressed 11. (913 aa)
bptfBromodomain PHD finger transcription factor. (2899 aa)
cited1Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1. (152 aa)
nr0b1Nuclear receptor subfamily 0, group B, member 1. (302 aa)
ash1lAsh1 (absent, small, or homeotic)-like (Drosophila). (2962 aa)
atrxATRX chromatin remodeler. (2013 aa)
eif2b4Eukaryotic translation initiation factor 2B, subunit 4 delta; Belongs to the eIF-2B alpha/beta/delta subunits family. (540 aa)
bmpr2bReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1071 aa)
cyp1b1Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (526 aa)
arid4bTranslocase of outer mitochondrial membrane 20. (1239 aa)
tfptTCF3 (E2A) fusion partner. (186 aa)
dmrt1Doublesex- and mab-3-related transcription factor 1; Transcription factor that plays a key role in sex determination and differentiation by controlling gonad development and germ cell proliferation. Acts both as a transcription repressor and activator (By similarity); Belongs to the DMRT family. (268 aa)
MDFISi:dkey-91m3.1. (252 aa)
junbaJunB proto-oncogene, AP-1 transcription factor subunit a. (325 aa)
si:dkey-6b12.5Si:dkey-6b12.5. (619 aa)
tcf23Transcription factor 23. (172 aa)
ppardbPeroxisome proliferator-activated receptor delta b. (517 aa)
TCF24Transcription factor 24. (176 aa)
dhcr2424-dehydrocholesterol reductase. (516 aa)
lepaPutative leptin. (166 aa)
cyp19a1aAromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. (517 aa)
apoda.2Apolipoprotein Da, duplicate 2; Belongs to the calycin superfamily. Lipocalin family. (189 aa)
nrip1aNuclear receptor-interacting protein 1a. (1080 aa)
tncTenascin C. (1811 aa)
VASH1Vasohibin 1. (370 aa)
lef1Lymphocyte enhancer binding factor 1 Lef1. (365 aa)
rusc1RUN and SH3 domain-containing 1. (610 aa)
setd2SET domain-containing 2, histone lysine methyltransferase. (2737 aa)
hyal3Hyaluronidase. (428 aa)
plekha1bPleckstrin homology domain-containing, family A (phosphoinositide-binding-specific) member 1b. (401 aa)
greb1Growth-regulating estrogen receptor-binding 1. (1840 aa)
nkx3-1NK3 homeobox 1. (214 aa)
LOC108192159REC8 meiotic recombination protein a. (460 aa)
ttpaTocopherol (alpha) transfer protein. (285 aa)
tppp3Tubulin polymerization-promoting protein family member 3. (177 aa)
gdf7Growth differentiation factor 7. (396 aa)
bmp7bBone morphogenetic protein 7b. (427 aa)
gata2bGATA-binding protein 2b. (428 aa)
Q1L8R8_DANREMothers against decapentaplegic homolog. (571 aa)
bcl2aB-cell leukemia/lymphoma 2. (228 aa)
ghrlGhrelin/obestatin prepropeptide. (104 aa)
ptx3bPentraxin 3, long b. (387 aa)
wt1bWT1 transcription factor b. (412 aa)
srd5a13-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (265 aa)
tmed2Transmembrane p24-trafficking protein 2. (208 aa)
fosl1bFOS-like 1, AP-1 transcription factor subunit b. (200 aa)
tlr5aToll-like receptor 5a; Belongs to the Toll-like receptor family. (881 aa)
tlr5bToll-like receptor 5b; Belongs to the Toll-like receptor family. (881 aa)
cx31.7Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (275 aa)
ppardaPeroxisome proliferator-activated receptor delta a. (496 aa)
srd5a2b3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (231 aa)
E7FFZ5_DANREMothers against decapentaplegic homolog. (568 aa)
hsd17b3Hydroxysteroid (17-beta) dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (236 aa)
nrip1bNuclear receptor-interacting protein 1b. (729 aa)
bcl2bBCL2 apoptosis regulator b. (209 aa)
stox2aStorkhead box 2a. (1010 aa)
ndpNorrin cystine knot growth factor NDP. (138 aa)
sp3bSp3b transcription factor. (649 aa)
pkd1bPolycystic kidney disease 1b. (3827 aa)
vash2Vasohibin 2. (348 aa)
zfatZinc finger and AT hook domain-containing. (1176 aa)
msh4MutS homolog 4. (931 aa)
wnt7bbProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
birc6Baculoviral IAP repeat-containing 6. (4927 aa)
gfra1aGdnf family receptor alpha 1a. (97 aa)
lhbLuteinizing hormone, beta polypeptide. (140 aa)
pla2g4abPhospholipase A2. (720 aa)
LOC100332902TGF_BETA_2 domain-containing protein. (264 aa)
sf1Splicing factor 1. (663 aa)
nupr1aNuclear protein 1a. (76 aa)
junbbJunB proto-oncogene, AP-1 transcription factor subunit b. (310 aa)
zgc:113363Zgc:113363. (243 aa)
ENSDARP00000132312Si:ch211-51f19.1. (142 aa)
plekha1aPleckstrin homology domain-containing, family A (phosphoinositide-binding-specific) member 1a. (401 aa)
map3k4Mitogen-activated protein kinase kinase kinase 4. (1540 aa)
bmp5Bone morphogenetic protein 5. (446 aa)
CCDC134Coiled-coil domain containing 134. (226 aa)
hsd17b417-beta-hydroxysteroid dehydrogenase type 4. (725 aa)
gfra1bGDNF family receptor alpha-1; Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. Belongs to the GDNFR family. (481 aa)
atrxlATRX chromatin remodeler,-like. (1760 aa)
fancaFA complementation group A. (1324 aa)
eporErythropoietin receptor. (509 aa)
fzd4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (523 aa)
cyp1c1Cytochrome P450, family 1, subfamily C, polypeptide 1; Belongs to the cytochrome P450 family. (523 aa)
zgc:153993Zgc:153993 protein. (204 aa)
ptnPleiotrophin. (158 aa)
nsdhlNAD(P)-dependent steroid dehydrogenase-like; Belongs to the 3-beta-HSD family. (345 aa)
zgc:63863Zgc:63863. (399 aa)
ENSDARP00000141388Uncharacterized protein. (316 aa)
ENSDARP00000142835Si:dkey-23i12.7. (158 aa)
klhl10b.2Kelch-like family member 10b, tandem duplicate 2. (606 aa)
pdgfbaPlatelet-derived growth factor beta polypeptide a; Belongs to the PDGF/VEGF growth factor family. (463 aa)
AXLAXL receptor tyrosine kinase. (786 aa)
klhl10b.1Kelch-like family member 10b, tandem duplicate 1. (614 aa)
pdgfbbPlatelet-derived growth factor beta polypeptide b; Belongs to the PDGF/VEGF growth factor family. (483 aa)
ptpn6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (590 aa)
prdm1bPR domain-containing 1b, with ZNF domain. (471 aa)
sfrp2lSecreted frizzled-related protein 2-like. (333 aa)
spint1aSerine peptidase inhibitor, Kunitz type 1 a. (523 aa)
wdr19WD repeat domain 19. (1372 aa)
mscMusculin (activated B-cell factor-1). (160 aa)
LOC110438398Fanconi_A_N domain-containing protein. (1317 aa)
ENSDARP00000153869Uncharacterized protein. (84 aa)
inhbabInhibin subunit beta Ab. (405 aa)
tfebTranscription factor EB. (493 aa)
klhl10aKelch-like family member 10a. (592 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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