STRINGSTRING
epha4l epha4l dip2cb dip2cb zp3 zp3 l1cama l1cama sash3 sash3 tnr tnr gsk3ab gsk3ab ruvbl1 ruvbl1 syt5b syt5b smo smo sema3b sema3b nkx2.5 nkx2.5 E7FF92_DANRE E7FF92_DANRE igf2a igf2a smn1 smn1 igfbp2b igfbp2b colq colq dip2ba dip2ba chrna1 chrna1 stat5a stat5a mkks mkks sav1 sav1 dbnla dbnla stat6 stat6 tbx20 tbx20 meis1a meis1a lats1 lats1 gsk3ba gsk3ba dbnlb dbnlb mycbp2 mycbp2 spast spast rtn4r rtn4r sema3ga sema3ga rufy3 rufy3 mapk14a mapk14a plxna3 plxna3 dip2bb dip2bb wnt2bb wnt2bb sema3fa sema3fa sema3bl sema3bl sema3aa sema3aa sema3e sema3e ifrd2 ifrd2 bmpr2a bmpr2a shtn1 shtn1 zfpm2a zfpm2a kmt5b kmt5b myoz1a myoz1a sema3ab sema3ab sema3h sema3h plaa plaa plac8.1 plac8.1 ngfb ngfb gdf11 gdf11 LOC101883528 LOC101883528 islr2 islr2 ist1 ist1 gsk3bb gsk3bb dusp10 dusp10 igfbp2a igfbp2a ppib ppib srfa srfa ruvbl2 ruvbl2 ghsra ghsra cdk5 cdk5 ryk ryk ghsrb ghsrb zmpste24 zmpste24 mbd5 mbd5 mul1b mul1b syt17 syt17 slc6a4b slc6a4b slc6a4a slc6a4a sema6bb sema6bb adnpa adnpa sema4ab sema4ab ulk1a ulk1a sema4d sema4d ar ar wnt3a wnt3a csf1b csf1b sema6dl sema6dl yap1 yap1 ifrd1 ifrd1 sparta sparta dbn1 dbn1 sema3d sema3d syt1b syt1b larp7 larp7 wnt2ba wnt2ba fn1b fn1b wnt4 wnt4 edn1 edn1 M9MMA2_DANRE M9MMA2_DANRE bcl2l11 bcl2l11 sgpl1 sgpl1 sema4c sema4c wu:fc38h03 wu:fc38h03 becn1 becn1 sema4e sema4e sema4ga sema4ga sema4bb sema4bb csf1a csf1a adnpb adnpb bbs4 bbs4 wnt3 wnt3 mapta mapta sema3gb sema3gb zgc:171778 zgc:171778 bmpr2b bmpr2b fto fto adrb3a adrb3a adrb1 adrb1 ncaldb ncaldb sema7a sema7a ppardb ppardb lepa lepa sema4gb sema4gb cdkl5 cdkl5 sema3c sema3c stat5b stat5b fn1a fn1a adrb2b adrb2b map2 map2 rnd2 rnd2 gsk3aa gsk3aa F1Q5G8_DANRE F1Q5G8_DANRE apoda.2 apoda.2 zfyve27 zfyve27 ulk1b ulk1b lats2 lats2 rusc1 rusc1 socs2 socs2 fxn fxn hlx1 hlx1 sema4ba sema4ba nsmfa nsmfa tomm70a tomm70a parp2 parp2 E9QHS4_DANRE E9QHS4_DANRE dip2ca dip2ca bcl2a bcl2a syt2a syt2a sema6d sema6d l1camb l1camb plac8.2 plac8.2 prlh2 prlh2 ctdp1 ctdp1 nol12 nol12 epha4a epha4a pparda pparda F8W238_DANRE F8W238_DANRE LOC798168 LOC798168 disc1 disc1 bcl2b bcl2b shha shha RNF157 RNF157 gpam gpam maptb maptb ostn ostn ulk2 ulk2 mbd6 mbd6 adrb2a adrb2a appa appa vgll4a vgll4a sema6a sema6a agrn agrn srfb srfb ENSDARP00000134495 ENSDARP00000134495 nsmfb nsmfb ngfa ngfa prlh prlh sema6e sema6e hhex hhex sema5a sema5a zfpm2b zfpm2b sema5bb sema5bb anapc2 anapc2 musk musk spartb spartb prkn prkn syt1a syt1a SEMA4F SEMA4F ENSDARP00000142109 ENSDARP00000142109 vgll4b vgll4b plxna1a plxna1a si:ch73-40a2.1 si:ch73-40a2.1 sema6ba sema6ba ENSDARP00000145392 ENSDARP00000145392 sema3fb sema3fb lgmn lgmn ENSDARP00000149939 ENSDARP00000149939 ENSDARP00000151202 ENSDARP00000151202 ENSDARP00000151788 ENSDARP00000151788 akap6 akap6 zp3.2 zp3.2 sema5ba sema5ba dip2a dip2a golga4 golga4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
epha4lEph receptor A4,-like. (988 aa)
dip2cbDisco-interacting protein 2 homolog Cb. (1575 aa)
zp3Zona pellucida glycoprotein 3, tandem duplicate 2. (431 aa)
l1camaNeural cell adhesion molecule L1.2; Cell adhesion molecule with an important role in the development of the nervous system. Involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. Binds to axonin on neurons (By similarity); Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family. (1271 aa)
sash3SAM and SH3 domain-containing 3. (386 aa)
tnrTenascin R (Restrictin, janusin). (1350 aa)
gsk3abGlycogen synthase kinase 3 alpha b; Belongs to the protein kinase superfamily. (440 aa)
ruvbl1RuvB-like 1; Has single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity suggesting a role in nuclear processes such as recombination and transcription (By similarity). Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP- dependent nucleosome sliding (By similarity). May act as a negative regulator of embryonic heart growth. Belongs to the RuvB family. (456 aa)
syt5bSynaptotagmin Vb. (446 aa)
smoSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (822 aa)
sema3bSema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B; Belongs to the semaphorin family. (775 aa)
nkx2.5NK2 homeobox 5. (314 aa)
E7FF92_DANREC2 domain-containing protein. (258 aa)
igf2aInsulin-like growth factor 2a. (197 aa)
smn1Survival motor neuron protein 1; The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. It may also play a role in the metabolism of snoRNPs. Required in motor neurons and proprioceptive neurons to ensure correct U12 intron splicing and proper levels of tmem41b mRNA. Required for the maturation of motor neuron axonal branches and dendrites. (281 aa)
igfbp2bInsulin-like growth factor-binding protein 2-B; IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. (265 aa)
colqCollagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase. (455 aa)
dip2baDisco-interacting protein 2 homolog B-A; Belongs to the DIP2 family. (1577 aa)
chrna1Acetylcholine receptor subunit alpha; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. (456 aa)
stat5aSignal transducer and activator of transcription. (785 aa)
mkksMcKusick-Kaufman syndrome. (563 aa)
sav1Salvador family WW domain-containing protein 1. (397 aa)
dbnlaDrebrin-like a. (496 aa)
stat6Signal transducer and activator of transcription. (758 aa)
tbx20T-box transcription factor TBX20; Transcriptional regulator that may play a very early role in the differentiation of the cardiac precursors. (446 aa)
meis1aMyeloid ecotropic viral integration site 4.1a. (380 aa)
lats1LATS, large tumor suppressor, homolog 1 (Drosophila). (1068 aa)
gsk3baGlycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily. (421 aa)
dbnlbDrebrin-like b. (476 aa)
mycbp2E3 ubiquitin-protein ligase MYCBP2; Atypical E3 ubiquitin-protein ligase which specifically mediates ubiquitination of threonine and serine residues on target proteins, instead of ubiquitinating lysine residues (By similarity). Shows esterification activity towards both threonine and serine, with a preference for threonine, and acts via two essential catalytic cysteine residues that relay ubiquitin to its substrate via thioester intermediates (By similarity). Interacts with the E2 enzymes UBE2D1, UBE2D3, UBE2E1 and UBE2L3 (By similarity). Plays a key role in neural development, probabl [...] (4574 aa)
spastSpastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Go [...] (570 aa)
rtn4rReticulon 4 receptor. (479 aa)
sema3gaSema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Ga; Belongs to the semaphorin family. (749 aa)
rufy3RUN and FYVE domain-containing 3. (470 aa)
mapk14aMitogen-activated protein kinase 14A; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Mapk14a is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are [...] (361 aa)
plxna3Plexin A3; Coreceptor for class 3 semaphorins. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. (1892 aa)
dip2bbDisco-interacting protein 2 homolog B-A. (1603 aa)
wnt2bbProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (396 aa)
sema3faSema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Fa; Belongs to the semaphorin family. (801 aa)
sema3blSema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3bl; Belongs to the semaphorin family. (771 aa)
sema3aaSemaphorin-3aa; May influence outgrowth by a variety of growth cones including those of the posterior lateral line ganglion. (860 aa)
sema3eSema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E; Belongs to the semaphorin family. (768 aa)
ifrd2Interferon-related developmental regulator 2. (435 aa)
bmpr2aReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1003 aa)
shtn1Shootin-1; Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Belongs to the shootin family. (544 aa)
zfpm2aZinc finger protein, FOG family member 2a. (1142 aa)
kmt5bHistone-lysine N-methyltransferase KMT5B; Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity. In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (By similarity). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromat [...] (808 aa)
myoz1aZgc:77785 protein. (319 aa)
sema3abSemaphorin-3ab; Might normally influence the midsegmental pathway choice of the ventrally extending motor axons by contributing to a repulsive domain in the posterior somite. (778 aa)
sema3hSema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3H; Belongs to the semaphorin family. (749 aa)
plaaPhospholipase A2-activating protein. (798 aa)
plac8.1Placenta-associated 8, tandem duplicate 1. (106 aa)
ngfbNerve growth factor; Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. It stimulates division and differentiation of sympathetic and embryonic sensory neurons (By similarity). (194 aa)
gdf11Growth differentiation factor 11. (390 aa)
LOC101883528SCP domain-containing protein; Belongs to the CRISP family. (155 aa)
islr2Immunoglobulin superfamily-containing leucine-rich repeat 2. (712 aa)
ist1IST1 factor-associated with ESCRT-III. (354 aa)
gsk3bbGlycogen synthase kinase 3 beta, genome duplicate b; Belongs to the protein kinase superfamily. (419 aa)
dusp10Dual-specificity phosphatase 10. (459 aa)
igfbp2aInsulin-like growth factor-binding protein 2-A; IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. (276 aa)
ppibPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (208 aa)
srfaSerum response factor a. (539 aa)
ruvbl2RuvB-like 2; Has double-stranded DNA-stimulated ATPase activity. Has ATP-dependent DNA helicase (5' to 3') activity suggesting a role in nuclear processes such as recombination and transcription (By similarity). Represses gene activation mediated by beta-catenin. Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome- activated ATPase activity and catalyzes ATP-dependent nucleosome sliding (By similarity). Involved in the endoplasmic reticulum (ER)- associated degradation (ERAD) pathway where it negatively regulates expression of ER stress [...] (463 aa)
ghsraGrowth hormone secretagogue receptor a; Belongs to the G-protein coupled receptor 1 family. (360 aa)
cdk5Cyclin-dependent protein kinase 5; Belongs to the protein kinase superfamily. (292 aa)
rykReceptor-like tyrosine kinase. (604 aa)
ghsrbGrowth hormone secretagogue receptor b; Belongs to the G-protein coupled receptor 1 family. (365 aa)
zmpste24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (468 aa)
mbd5Methyl-CpG-binding domain protein 5. (792 aa)
mul1bMitochondrial E3 ubiquitin protein ligase 1b. (352 aa)
syt17Synaptotagmin XVII. (474 aa)
slc6a4bTransporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (591 aa)
slc6a4aTransporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (646 aa)
sema6bbSema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6Bb. (639 aa)
adnpaActivity-dependent neuroprotector homeobox a. (969 aa)
sema4abSemaphorin-4A isoform X1; Belongs to the semaphorin family. (831 aa)
ulk1aUnc-51-like autophagy-activating kinase 1a. (927 aa)
sema4dUncharacterized protein; Belongs to the semaphorin family. (856 aa)
arAndrogen receptor. (868 aa)
wnt3aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
csf1bColony-stimulating factor 1b (macrophage). (284 aa)
sema6dlSema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D,-like. (1018 aa)
yap1Transcriptional coactivator YAP1; Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (By similarity). Required for expansion of the neural plate and neural plate border zone progenitor pools. Acts as a direct regulator of pax3 expression via interaction with tead1. Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin netwo [...] (442 aa)
ifrd1Interferon-related developmental regulator 1. (427 aa)
spartaZgc:172059 protein. (567 aa)
dbn1Drebrin 1. (553 aa)
sema3dSemaphorin-3D; May play a role in the guidance of several axon pathways. (764 aa)
syt1bNovel protein similar to vertebrate synaptotagmin I (SYT1). (388 aa)
larp7La-related protein 7; Negative transcriptional regulator of polymerase II genes, acting by means of the 7SK RNP system. Within the 7SK RNP complex, the positive transcription elongation factor b (P-TEFb) is sequestered in an inactive form, preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. (555 aa)
wnt2baProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (387 aa)
fn1bFibronectin 1b. (2500 aa)
wnt4Protein Wnt-4a; Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Plays an important role in embryonic development. (352 aa)
edn1Endothelin 1. (188 aa)
M9MMA2_DANRESi:ch211-129c21.1; Belongs to the semaphorin family. (775 aa)
bcl2l11BCL2-like 11. (176 aa)
sgpl1Sphingosine-1-phosphate lyase 1. (572 aa)
sema4cSemaphorin-4C precursor; Belongs to the semaphorin family. (863 aa)
wu:fc38h03Wu:fc38h03. (411 aa)
becn1Beclin-1; Plays a central role in autophagy. Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3- phosphate and are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 P [...] (447 aa)
sema4eSemaphorin-4E. (766 aa)
sema4gaSemaphorin-4G; Belongs to the semaphorin family. (883 aa)
sema4bbSemaphorin-4B; Belongs to the semaphorin family. (849 aa)
csf1aColony-stimulating factor 1a (macrophage). (526 aa)
adnpbActivity-dependent neuroprotector homeobox b. (1003 aa)
bbs4Bardet-Biedl syndrome 4. (528 aa)
wnt3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
maptaMicrotubule-associated protein. (406 aa)
sema3gbSema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Gb; Belongs to the semaphorin family. (745 aa)
zgc:171778Zona pellucida glycoprotein 3, tandem duplicate 2. (432 aa)
bmpr2bReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1071 aa)
ftoFTO alpha-ketoglutarate-dependent dioxygenase. (567 aa)
adrb3aAdrenoceptor beta 3a; Belongs to the G-protein coupled receptor 1 family. (413 aa)
adrb1Adrenergic, beta-1-, receptor. (390 aa)
ncaldbNeurocalcin-delta B; May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions (By similarity). (192 aa)
sema7aSemaphorin 7A; Belongs to the semaphorin family. (640 aa)
ppardbPeroxisome proliferator-activated receptor delta b. (517 aa)
lepaPutative leptin. (166 aa)
sema4gbSemaphorin-4G. (752 aa)
cdkl5Cyclin dependent kinase like 5 long. (1080 aa)
sema3cSema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C. (713 aa)
stat5bSignal transducer and activator of transcription. (786 aa)
fn1aFibronectin 1a. (2480 aa)
adrb2bAdrenoceptor beta 2, surface b. (409 aa)
map2Microtubule-associated protein 2. (248 aa)
rnd2Rho family GTPase 2. (234 aa)
gsk3aaGlycogen synthase kinase 3 alpha a; Belongs to the protein kinase superfamily. (462 aa)
F1Q5G8_DANRESi:dkey-49n23.1; Belongs to the semaphorin family. (758 aa)
apoda.2Apolipoprotein Da, duplicate 2; Belongs to the calycin superfamily. Lipocalin family. (189 aa)
zfyve27Zinc finger, FYVE domain-containing 27. (409 aa)
ulk1bUnc-51-like autophagy-activating kinase 1. (1011 aa)
lats2Large tumor suppressor kinase 2. (1140 aa)
rusc1RUN and SH3 domain-containing 1. (610 aa)
socs2Suppressor of cytokine signaling 2. (197 aa)
fxnFrataxin. (200 aa)
hlx1H2.0-like homeo box 1 (Drosophila). (356 aa)
sema4baSemaphorin 4; Belongs to the semaphorin family. (830 aa)
nsmfaNMDA receptor synaptonuclear-signaling and neuronal migration factor a. (600 aa)
tomm70aTranslocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae). (579 aa)
parp2Poly [ADP-ribose] polymerase. (649 aa)
E9QHS4_DANRESi:dkey-175m17.7. (892 aa)
dip2caDisco-interacting protein 2 homolog Ca. (1547 aa)
bcl2aB-cell leukemia/lymphoma 2. (228 aa)
syt2aSynaptotagmin IIa. (430 aa)
sema6dSema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D; Belongs to the semaphorin family. (898 aa)
l1cambNeural cell adhesion molecule L1.1; Cell adhesion molecule with an important role in the development of the nervous system. Involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. Binds to axonin on neurons (By similarity); Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family. (1332 aa)
plac8.2Placenta-associated 8, tandem duplicate 2. (104 aa)
prlh2Prolactin-releasing hormone 2. (117 aa)
ctdp1RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. (947 aa)
nol12Nucleolar protein 12; May bind to rRNA; Belongs to the RRP17 family. (228 aa)
epha4aEphrin type-A receptor 4a; Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI- anchored ephrin-A and transmembrane ephrin-B ligands including efna1 and efnb3. [...] (995 aa)
ppardaPeroxisome proliferator-activated receptor delta a. (496 aa)
F8W238_DANRESi:ch211-113g11.6; Belongs to the semaphorin family. (474 aa)
LOC798168Semaphorin-4B-like; Belongs to the semaphorin family. (546 aa)
disc1DISC1 scaffold protein. (994 aa)
bcl2bBCL2 apoptosis regulator b. (209 aa)
shhaSonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (418 aa)
RNF157Si:dkey-49c17.3. (655 aa)
gpamGlycerol-3-phosphate acyltransferase 1, mitochondrial. (826 aa)
maptbMicrotubule-associated protein. (309 aa)
ostnOsteocrin. (134 aa)
ulk2Unc-51-like autophagy-activating kinase 2. (1034 aa)
mbd6Methyl-CpG-binding domain protein 6. (1320 aa)
adrb2aAdrenoceptor beta 2, surface a. (405 aa)
appaAmyloid beta (A4) precursor protein a. (194 aa)
vgll4aVestigial-like family member 4a. (265 aa)
sema6aSema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A. (604 aa)
agrnAgrin. (1926 aa)
srfbSerum response factor b. (260 aa)
ENSDARP00000134495Uncharacterized protein; Belongs to the semaphorin family. (482 aa)
nsmfbNMDA receptor synaptonuclear signaling and neuronal migration factor; Stimulates outgrowth of olfactory axons and migration of hypophysiotropic gonadotropin-releasing hormone 3 (GnRH3) neurons. May couple NMDA-sensitive glutamate receptor signaling to the nucleus and trigger long-lasting changes in the cytoarchitecture of dendrites and spine synapse processes. (570 aa)
ngfaNeurotrophin-7; Recombinant ZNT-7 was able to bind to the human p75 neurotrophin receptor/NGFR and to induce tyrosine phosphorylation of the rat NTRK1/TRKA receptor tyrosine kinase, albeit less efficiently than rat NGF. ZNT-7 did not interact with rat NTRK2/TRKB or NTRK3/TRKC, indicating a similar receptor specificity as NGF; Belongs to the NGF-beta family. (233 aa)
prlhProlactin-releasing hormone. (81 aa)
sema6eSema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6E; Belongs to the semaphorin family. (1064 aa)
hhexHematopoietically-expressed homeobox protein hhex; Recognizes the DNA sequence 5'-ATTAA-3' (By similarity). Transcriptional repressor. Regulates the differentiation of both endothelial and blood cells. Plays a role in embryonic dorsoventral patterning by regulating bmp expression. May establish anterior identity. Functions in the embryo to regulate liver development. Functions extraembryonically to generate organ chirality. (177 aa)
sema5aSemaphorin-5A. (1048 aa)
zfpm2bZinc finger protein, FOG family member 2b. (1093 aa)
sema5bbSemaphorin-5B. (1098 aa)
anapc2Anaphase-promoting complex subunit 2; Belongs to the cullin family. (802 aa)
muskMuscle, skeletal, receptor tyrosine kinase. (351 aa)
spartbSpartin b. (587 aa)
prknE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (458 aa)
syt1aSynaptotagmin Ia. (419 aa)
SEMA4FSsemaphorin 4F; Belongs to the semaphorin family. (766 aa)
ENSDARP00000142109Si:dkey-280e21.3. (652 aa)
vgll4bVestigial-like family member 4b. (194 aa)
plxna1aPlexin A1a. (1891 aa)
si:ch73-40a2.1Si:ch73-40a2.1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (723 aa)
sema6baSema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6Ba; Belongs to the semaphorin family. (895 aa)
ENSDARP00000145392Sema domain-containing protein. (1885 aa)
sema3fbSema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Fb; Belongs to the semaphorin family. (791 aa)
lgmnLegumain. (438 aa)
ENSDARP00000149939Si:dkey-40c11.2. (771 aa)
ENSDARP00000151202Peptidase_M48_N domain-containing protein. (272 aa)
ENSDARP00000151788Sema domain-containing protein; Belongs to the semaphorin family. (305 aa)
akap6A kinase (PRKA) anchor protein 6. (2174 aa)
zp3.2Zona pellucida glycoprotein 3, tandem duplicate 2. (427 aa)
sema5baannotation not available (1101 aa)
dip2aDisco-interacting protein 2 homolog A. (1610 aa)
golga4Golgin A4. (2171 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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