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| | wnt2bb | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (396 aa) |
| | upf2 | Uncharacterized protein. (470 aa) |
| | znrf3 | E3 ubiquitin-protein ligase znrf3; E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components. Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification (By similarity). Belongs to the ZNRF3 family. (866 aa) |
| | cenpa | Histone H3-like centromeric protein A; Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes. Replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. Required [...] (145 aa) |
| | apoa1b | Apolipoprotein A-Ib. (257 aa) |
| | ENSDARP00000151202 | Peptidase_M48_N domain-containing protein. (272 aa) |
| | msc | Musculin (activated B-cell factor-1). (160 aa) |
| | gpc1b | Glypican 1b; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (559 aa) |
| | zdhhc21 | Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (141 aa) |
| | msx1a | Muscle segment homeobox 1a. (233 aa) |
| | ENSDARP00000147138 | TGFb_propeptide domain-containing protein. (179 aa) |
| | Zmp:0000001167 | ANK_REP_REGION domain-containing protein. (136 aa) |
| | bmp16 | Bone morphogenetic protein 16. (416 aa) |
| | hnf1bb | Hepatocyte nuclear factor 1-beta-B; Transcription factor, probably binds to the inverted palindrome 5'-GTTAATNATTAAC-3' (By similarity). Acts downstream of hnf1ba but is not required for induction of rhombomere r5/r6 gene expression in the hindbrain. (532 aa) |
| | fgl1 | Fibrinogen-like 1. (307 aa) |
| | rargb | Retinoic acid receptor gamma-B; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Required for hindbrain development; Belongs to the nuclear hormone receptor family. NR1 subfamily. (392 aa) |
| | tbxta | T-box transcription factor T-A; Involved in the transcriptional regulation of genes required for mesoderm differentiation, including itself. Indispensable for the formation of the notochord and the tail structure. Functions together with tbx16/spadetail in development of trunk and tail mesoderm. Functions by itself early in development to repress medial floor plate and promote notochord fate but at later times, functions together with tbx16/spadetail to promote medial floor plate formation. Acts in a parallel pathway to, but cooperates with, non-canonical wnt-signaling during tail form [...] (423 aa) |
| | ENSDARP00000141388 | Uncharacterized protein. (316 aa) |
| | nrp1a | Neuropilin-1a; Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. Regulates angiogenesis through a VEGF-dependent pathway. (923 aa) |
| | fadd | Fas (tnfrsf6)-associated via death domain. (192 aa) |
| | cyp1c1 | Cytochrome P450, family 1, subfamily C, polypeptide 1; Belongs to the cytochrome P450 family. (523 aa) |
| | ctnnb1 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] (789 aa) |
| | srp54 | Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Belongs to the GTP-binding SRP family. SRP54 subfamily. (504 aa) |
| | apela | Apelin receptor early endogenous ligand; Endogenous ligand for the apelin receptor (aplnra and/or aplnrb). Hormone required for mesendodermal differentiation, blood vessels formation and heart morphogenesis during early development and for adult cardiovascular homeostasis. Acts as a motogen by promoting mesendodermal cell migration during gastrulation by binding and activating the apelin receptor. Acts as an early embryonic regulator of cellular movement with a role in migration and development of cardiac progenitor cells. May act as a chemoattractant for the activation of angioblast m [...] (58 aa) |
| | notch1a | Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] (2438 aa) |
| | dkk3a | Dickkopf WNT-signaling pathway inhibitor 3a. (293 aa) |
| | hhex | Hematopoietically-expressed homeobox protein hhex; Recognizes the DNA sequence 5'-ATTAA-3' (By similarity). Transcriptional repressor. Regulates the differentiation of both endothelial and blood cells. Plays a role in embryonic dorsoventral patterning by regulating bmp expression. May establish anterior identity. Functions in the embryo to regulate liver development. Functions extraembryonically to generate organ chirality. (177 aa) |
| | arnt2 | Aryl hydrocarbon receptor nuclear translocator 2; Transcription factor that plays a role in the development of the hypothalamo-pituitary axis. Specifically recognizes the xenobiotic response element (XRE) (By similarity). Isoform 1 acts as a transcriptional activator. Isoform 3 acts as a transcriptional repressor. (737 aa) |
| | zgc:91849 | Zgc:91849. (986 aa) |
| | june | JunE proto-oncogene, AP-1 transcription factor subunit. (323 aa) |
| | LOC100005927 | Uncharacterized protein. (982 aa) |
| | ddx46 | Probable ATP-dependent RNA helicase DDX46; Plays an essential role in splicing, either prior to, or during A complex formation; Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily. (1018 aa) |
| | lrp6 | Low density lipoprotein receptor-related protein 6. (935 aa) |
| | uhrf1 | E3 ubiquitin-protein ligase UHRF1; Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits dnmt1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylate [...] (775 aa) |
| | pam | Peptidylglycine alpha-amidating monooxygenase. (1017 aa) |
| | kdrl | Vascular endothelial growth factor receptor kdr-like; Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels. Particularly involved in artery formation. Does not appear to be required for hematopoiesis. (1301 aa) |
| | srfb | Serum response factor b. (260 aa) |
| | vegfaa | Vascular endothelial growth factor A-A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis, and induces permeabilization of blood vessels. Acts both upstream of kdr and tie1 to stimulate endothelial cell differentiation, and upstream of gata1 to stimulate hematopoietic cell differentiation. (188 aa) |
| | fgf3 | Fibroblast growth factor 3; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Belongs to the heparin-binding growth factors family. (256 aa) |
| | mst1 | Macrophage stimulating 1 (Hepatocyte growth factor-like); Belongs to the peptidase S1 family. Plasminogen subfamily. (709 aa) |
| | cul3b | Cullin 3b; Belongs to the cullin family. (766 aa) |
| | med24 | Mediator of RNA polymerase II transcription subunit 24; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required [...] (989 aa) |
| | arf6a | ADP-ribosylation factor 6a. (175 aa) |
| | gpr22b | G protein-coupled receptor 22b. (440 aa) |
| | med12 | Mediator of RNA polymerase II transcription subunit 12; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Require [...] (2175 aa) |
| | gli1 | GLI family zinc finger 1. (1404 aa) |
| | nf1a | Neurofibromin 1a. (2759 aa) |
| | arhgap35a | Rho GTPase-activating protein 35a. (1536 aa) |
| | U3JAJ7_DANRE | Si:dkey-61p9.11. (2105 aa) |
| | pkd1b | Polycystic kidney disease 1b. (3827 aa) |
| | armc5 | Armadillo repeat-containing 5. (1218 aa) |
| | mki67 | Marker of proliferation Ki-67. (2057 aa) |
| | atp7b | ATPase copper-transporting beta. (1363 aa) |
| | sp3b | Sp3b transcription factor. (649 aa) |
| | shha | Sonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (418 aa) |
| | bcl2b | BCL2 apoptosis regulator b. (209 aa) |
| | E7FFZ5_DANRE | Mothers against decapentaplegic homolog. (568 aa) |
| | elf3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ). (417 aa) |
| | fgfr2 | Fibroblast growth factor receptor 2; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in kerati [...] (838 aa) |
| | aprt | Adenine phosphoribosyltransferase. (177 aa) |
| | ednrab | Endothelin receptor type Ab; Belongs to the G-protein coupled receptor 1 family. (408 aa) |
| | tgfb2 | Transforming growth factor, beta 2. (413 aa) |
| | sostdc1b | Sclerostin domain-containing 1b. (204 aa) |
| | mad1l1 | Mitotic arrest deficient-like protein 1. (717 aa) |
| | fgf7 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (180 aa) |
| | tgfb1b | Transforming growth factor beta; Belongs to the TGF-beta family. (379 aa) |
| | wt1b | WT1 transcription factor b. (412 aa) |
| | jag1a | Protein jagged-1a; Ligand for multiple Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions. (1253 aa) |
| | bcl2a | B-cell leukemia/lymphoma 2. (228 aa) |
| | Q1L8R8_DANRE | Mothers against decapentaplegic homolog. (571 aa) |
| | gata2b | GATA-binding protein 2b. (428 aa) |
| | nf1b | Neurofibromin 1b. (2759 aa) |
| | arf6b | ADP-ribosylation factor 6a; Belongs to the small GTPase superfamily. Arf family. (175 aa) |
| | hnf1ba | Hepatocyte nuclear factor 1-beta-A; Transcription factor, probably binds to the inverted palindrome 5'-GTTAATNATTAAC-3' (By similarity). Required for induction of rhombomere r5/r6 gene expression in the hindbrain. (555 aa) |
| | gdf7 | Growth differentiation factor 7. (396 aa) |
| | ppp1r12a | Protein phosphatase 1 regulatory subunit 12A; Regulates myosin phosphatase activity. (1117 aa) |
| | pygo2 | Pygopus homolog 2 (Drosophila). (571 aa) |
| | e2f7 | Transcription factor E2F7; Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as e2f1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC- 3' and mediating repression of G1/S-regulated genes (By similarity). Acts as a promoter of spro [...] (723 aa) |
| | LOC569566 | Fibroblast growth factor receptor 1b,-like. (509 aa) |
| | acadm | Acyl-CoA dehydrogenase medium chain. (426 aa) |
| | usf2 | Upstream transcription factor 2, c-fos-interacting. (328 aa) |
| | hlx1 | H2.0-like homeo box 1 (Drosophila). (356 aa) |
| | nkx3-1 | NK3 homeobox 1. (214 aa) |
| | socs2 | Suppressor of cytokine signaling 2. (197 aa) |
| | cdk5rap3 | CDK5 regulatory subunit-associated protein 3. (507 aa) |
| | pax5 | Paired box 5. (396 aa) |
| | lef1 | Lymphocyte enhancer binding factor 1 Lef1. (365 aa) |
| | tnc | Tenascin C. (1811 aa) |
| | prl2 | Prolactin 2. (237 aa) |
| | F1Q5G8_DANRE | Si:dkey-49n23.1; Belongs to the semaphorin family. (758 aa) |
| | prop1 | PROP paired-like homeobox 1. (242 aa) |
| | fasn | Coiled-coil domain containing 57. (2511 aa) |
| | stat5b | Signal transducer and activator of transcription. (786 aa) |
| | sema3c | Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C. (713 aa) |
| | ripk3 | Receptor-interacting serine-threonine kinase 3. (361 aa) |
| | six6b | Sine oculis-related homeobox 6b. (245 aa) |
| | tbx3b | T-box transcription factor 3b. (594 aa) |
| | lrp5 | Low density lipoprotein receptor-related protein 5. (1615 aa) |
| | cita | Citron rho-interacting serine/threonine kinase a; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (2344 aa) |
| | aplnrb | Apelin receptor B; Receptor for apelin receptor early endogenous ligand (apela) and apelin (apln) hormones coupled to G proteins that inhibit adenylate cyclase activity. Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a receptor for apela hormone, promoting endoderm and mesendoderm cell migration and regulating the migration of cells fated to become myocardial progenitors, respectively. Positively regulates angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during [...] (359 aa) |
| | tbx2b | T-box transcription factor TBX2b; Involved in the transcriptional regulation of genes required for mesoderm differentiation. Plays a role in the specification of late notochordal precursor cells and formation of the differentiated notochord. Required for cardiac atrioventricular canal formation. (687 aa) |
| | gpr22a | G-protein coupled receptor 22; Orphan G-protein coupled receptor that regulates cilia length and structure in the Kupffer's vesicle leading to the left-right asymmetry development by establishing a directional fluid flow. (460 aa) |
| | bmp2b | Bone morphogenetic protein 2b. (411 aa) |
| | rpgrip1l | RPGRIP1-like. (1256 aa) |
| | tnfrsf11a | Tumor necrosis factor receptor superfamily, member 11a, NFKB activator. (574 aa) |
| | cyp1b1 | Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (526 aa) |
| | fa2h | Fatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...] (377 aa) |
| | xbp1 | Transcription factor Treb5. (263 aa) |
| | nrg3b | Neuregulin 3b. (764 aa) |
| | gpc1a | Secreted glypican-1; Cell surface proteoglycan that bears heparan sulfate; Belongs to the glypican family. (563 aa) |
| | e2f8 | Transcription factor E2F8; Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as e2f1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC- 3' and mediating repression of G1/S-regulated genes (By similarity). Acts as a promoter of spro [...] (917 aa) |
| | LOC100333880 | Citron rho-interacting serine/threonine kinase b. (1582 aa) |
| | ash1l | Ash1 (absent, small, or homeotic)-like (Drosophila). (2962 aa) |
| | nr0b1 | Nuclear receptor subfamily 0, group B, member 1. (302 aa) |
| | dzip1 | Zinc finger protein Dzip1; Acts as a permissive factor that is required for the proper regulation of Hedgehog (Hh) target genes in response to Hh signals. Acts downstream of the Smoothened protein to modulate Gli activity in the somites of the developing embryo. Required for establishment of left-right asymmetry during embryogenesis. Has a role in primary cilium formation. (897 aa) |
| | foxc1a | Forkhead box C1-A; DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin development. Acts either as a transcriptional activator or repressor. Binds to the consensus binding site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes. Upon DNA-binding, promotes DNA bending. Required for cell viability and resistance to oxidative stress in the eye. Promotes cell growth inhibition by stopping the cell cycle in the G1 phase through TGFB1- mediated signals. Involved in epithelia [...] (476 aa) |
| | wnt3 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa) |
| | sec31a | Protein transport protein Sec31A; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). (1250 aa) |
| | pcsk9 | Proprotein convertase subtilisin/kexin type 9; Belongs to the peptidase S8 family. (667 aa) |
| | igsf3 | Immunoglobulin superfamily, member 3. (1042 aa) |
| | csf1a | Colony-stimulating factor 1a (macrophage). (526 aa) |
| | LOC100334116 | Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (685 aa) |
| | abcd1 | ATP-binding cassette sub-family D member 1; Plays a role in the transport of free very-long-chain fatty acids (VLCFAs) as well as their CoA-esters across the peroxisomal membrane by acting as an ATP-specific binding subunit releasing ADP after ATP hydrolysis (By similarity). Involved in oligodendrocyte patterning and myelination. (766 aa) |
| | LOC100002406 | Solute carrier family 46 member 2. (406 aa) |
| | gb:cr929477 | SMAD family member 4. (332 aa) |
| | zgc:174895 | Zgc:174895. (200 aa) |
| | supv3l1 | ATP-dependent RNA helicase SUPV3L1, mitochondrial; Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation o [...] (763 aa) |
| | rhbdd3 | Rhomboid domain-containing 3. (348 aa) |
| | zmp:0000000846 | Zmp:0000000846. (1532 aa) |
| | elk1 | ETS transcription factor ELK1. (521 aa) |
| | smad4a | Mothers against decapentaplegic homolog. (547 aa) |
| | rb1cc1 | RB1-inducible coiled-coil 1. (1622 aa) |
| | bcl2l11 | BCL2-like 11. (176 aa) |
| | tgfb5 | Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa) |
| | edn1 | Endothelin 1. (188 aa) |
| | sox2 | Transcription factor Sox-2; Transcriptional activator. May function as a switch in neuronal development (By similarity). Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). (315 aa) |
| | samm50 | Sorting and assembly machinery component 50 homolog A; May play a role in the maintenance of the structure of mitochondrial cristae; Belongs to the SAM50/omp85 family. (469 aa) |
| | dkk3b | Dickkopf WNT-signaling pathway inhibitor 3b. (283 aa) |
| | wnt2ba | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (387 aa) |
| | hoxc8a | Homeobox protein Hox-C8a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (250 aa) |
| | eda | Ectodysplasin A; Belongs to the tumor necrosis factor family. (359 aa) |
| | six7 | Sine oculis homeobox homolog 7. (256 aa) |
| | pitx3 | Pituitary homeobox 3; Transcriptional regulator which may play a role in the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons (By similarity). Required for lens and retinal development and for pituitary pre-placode formation and cell specification; Belongs to the paired homeobox family. Bicoid subfamily. (293 aa) |
| | gfer | Sulfhydryl oxidase. (191 aa) |
| | sema3d | Semaphorin-3D; May play a role in the guidance of several axon pathways. (764 aa) |
| | hgfa | Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (699 aa) |
| | acot16 | Acyl-CoA thioesterase 16. (470 aa) |
| | bsx | Brain-specific homeobox protein homolog; DNA binding protein that function as transcriptional activator. May play a role in the determination and function of cell types in the brain; Belongs to the distal-less homeobox family. (227 aa) |
| | sostdc1a | Sclerostin domain-containing 1a. (196 aa) |
| | taf10 | Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (181 aa) |
| | dld | Delta-like protein D; Acts as a ligand for Notch receptors and is involved in primary neurogenesis and somitogenesis. Can activate Notch receptors, thereby playing a key role in lateral inhibition, a process that prevents the immediate neighbors of each nascent neural cell from simultaneously embarking on neural differentiation. Required in somite segmentation to keep the oscillations of neighboring presomitic mesoderm cells synchronized. (717 aa) |
| | yap1 | Transcriptional coactivator YAP1; Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (By similarity). Required for expansion of the neural plate and neural plate border zone progenitor pools. Acts as a direct regulator of pax3 expression via interaction with tead1. Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin netwo [...] (442 aa) |
| | acot19 | Acyl-CoA thioesterase 19. (431 aa) |
| | csf1b | Colony-stimulating factor 1b (macrophage). (284 aa) |
| | wnt3a | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa) |
| | tnfsf11 | TNF superfamily member 11; Belongs to the tumor necrosis factor family. (251 aa) |
| | ar | Androgen receptor. (868 aa) |
| | srebf2 | Processed sterol regulatory element-binding protein 2; Transcriptional activator required for lipid homeostasis. May regulate transcription of the LDL receptor gene as well as the cholesterol and fatty acid synthesis pathways. Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes (By similarity). (1095 aa) |
| | fem1b | Fem-1 homolog b. (638 aa) |
| | arhgap5 | Rho GTPase-activating protein 5. (1502 aa) |
| | arhgap35b | Rho GTPase-activating protein 35b. (1517 aa) |
| | tal1 | T-cell acute lymphocytic leukemia protein 1 homolog; Transcription factor that plays a pivotal role in hemopoietic and endothelial development, acting synergistically with lmo2 and downstream of clo. Specifies mesodermal precursors to a hemangioblast cell fate. Hemangioblasts are bipotential precursors of blood and endothelium, and in the absence of hemopoietic induction cues such as gata1, tal1/scl-lmo2-induced hemangioblasts differentiate into endothelial cells. Isoform alpha and isoform beta are redundant for the initiation of primitive hemopoiesis but have distinct roles in the reg [...] (324 aa) |
| | gata2a | GATA-binding protein 2a. (456 aa) |
| | zmpste24 | CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (468 aa) |
| | arnt | Aryl hydrocarbon receptor nuclear translocator. (728 aa) |
| | ctnnb2 | Catenin, beta 2. (778 aa) |
| | six3a | Sine oculis homeobox homolog 3a. (294 aa) |
| | raraa | Retinoic acid receptor alpha-A; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Required for hindbrain patterning; Belongs to the nuclear hormone receptor family. NR1 subfamily. (444 aa) |
| | suv39h1b | Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (421 aa) |
| | ube3a | Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (857 aa) |
| | id2a | Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein, a. (137 aa) |
| | six3b | Sine oculis homeobox homolog 3b. (293 aa) |
| | pax2a | Paired box protein Pax-2a; Probable transcription factor involved in the development of the midbrain/hindbrain boundary (MHB) organizer and specification of neuronal cell fates. Required for establishment of eng2 and eng3 gene expression in the midbrain and MHB primordium during late gastrulation. (391 aa) |
| | tgfa | Transforming growth factor, alpha. (191 aa) |
| | srfa | Serum response factor a. (539 aa) |
| | apln | Apelin; Endogenous ligand for the apelin receptor (aplnra and/or aplnrb). Drives internalization of the apelin receptor (By similarity). Hormone involved in the regulation of cardiac precursor cell movements during gastrulation and heart morphogenesis. Plays a role in early coronary blood vessels formation. Mediates myocardial contractility in an ERK1/2-dependent manner. May also have a role in the central control of body fluid homeostasis (By similarity). (77 aa) |
| | fgfr1b | Fibroblast growth factor receptor. (766 aa) |
| | bmp4 | Bone morphogenetic protein 4. (400 aa) |
| | rx3 | Retinal homeobox protein Rx3; Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation. (292 aa) |
| | aplnra | Apelin receptor A; Receptor for apelin receptor early endogenous ligand (apela) and apelin (apln) hormones coupled to G proteins that inhibit adenylate cyclase activity. Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a receptor for apela hormone, promoting endoderm and mesendoderm cell migration and regulating the migration of cells fated to become myocardial progenitors, respectively. Positively regulates angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during [...] (362 aa) |
| | rag2 | V(D)J recombination-activating protein 2; Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T- cell receptor genes in developing B and T lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. DNA cleavage by the RAG complex occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the pho [...] (530 aa) |
| | MYO1D | Unconventional myosin-Id; Unconventional myosin that functions as actin-based motor protein with ATPase activity (By similarity). Plays a role in the formation of Kupffer's vesicle, an organ that functions as left-right organizer during embryogenesis. Plays a role in vesicular trafficking events that are required for normal lumen expansion of Kupffer's vesicle. Required for normal orientation of cilia in Kupffer's vesicle, and thus for normal, unidirectional circular flow and normal angular flow velocity, which then mediates asymmetric gene expression and left-right asymmetric developm [...] (1004 aa) |
| | stk11 | Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (438 aa) |
| | gcm2 | Glial cells missing homolog 2 (Drosophila). (496 aa) |
| | id4 | Inhibitor of DNA-binding 4. (126 aa) |
| | vps33b | Vacuolar protein sorting-associated protein 33B; May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. Mediates phagolysosomal fusion in macrophages. Proposed to be involved in endosomal maturation implicating vipas39. In epithelial cells, the vps33b:vipas39 complex may play a role in the apical recycling pathway and in the maintenance of the apical- basolateral polarity (By similarity). Plays a role in bile duct development. ECO:0000250|UniProtKB:Q9H267, ; Belongs to the STXBP/unc-18/SEC1 [...] (617 aa) |
| | disp1 | Protein dispatched homolog 1; Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal. Synergizes with SCUBE2 to cause an increase in SHH secretion (By similarity); Belongs to the dispatched family. (1464 aa) |
| | C20H20H6orf58 | Protein leg1a; Important for early development of liver, exocrine pancreas and intestine, probably through cell cycle regulation. In liver, its function is partially redundant with leg1b function. (364 aa) |
| | jun | Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (308 aa) |
| | cebpb | CCAAT/enhancer-binding protein. (280 aa) |
| | tgfb1a | Transforming growth factor beta; Belongs to the TGF-beta family. (377 aa) |
| | wnt2 | Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). (350 aa) |
| | gli3 | GLI family zinc finger 3. (1553 aa) |
| | cldn1 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (210 aa) |
| | dmrta2 | Doublesex- and mab-3-related transcription factor A2; May be involved in sexual development; Belongs to the DMRT family. (440 aa) |
| | igfbp5a | Insulin-like growth factor-binding protein 5a. (268 aa) |
| | nkx2.3 | NK2 transcription factor related 3. (321 aa) |
| | cul3a | Cullin 3a; Belongs to the cullin family. (774 aa) |
| | ascl1a | Achaete-scute homolog 1a; Transcriptional regulator. May mediate transcription activation by binding to the E box-containing promoter (By similarity). Involved in neurogenesis. Required for the development of neurons in the epiphysis, acting partially redundantly with neurog1 and downstream of flh. Involved in maintaining rhombomere boundaries in the hindbrain, probably via up-regulation of delta expression. Also involved in pituitary development; required cell-autonomously in adenohypophyseal cells for endocrine differentiation and for survival of a subset of cells. (196 aa) |
| | isl2b | Insulin gene enhancer protein isl-2b; Binds to one of the cis-acting domain of the insulin gene enhancer. May be involved in the regional specification of the myotome and also in target recognition by the caudal primary neuron. (358 aa) |
| | atp7a | ATPase copper-transporting alpha. (1500 aa) |
| | trappc11 | Trafficking protein particle complex subunit 11; Involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage. (1132 aa) |
| | hdac3 | Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (By similarity). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). May play a role in the regulation of the circadian clock in a deacetylase activity-independent manner (By similarity). (428 aa) |
| | tcf21 | Transcription factor 21; Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. (176 aa) |
| | aldh8a1 | 2-aminomuconic semialdehyde dehydrogenase; Catalyzes the NAD-dependent oxidation of 2-aminomuconic semialdehyde of the kynurenine metabolic pathway in L-tryptophan degradation. (487 aa) |
| | cebpg | CCAAT/enhancer binding protein (C/EBP), gamma. (163 aa) |
| | mdka | Midkine-related growth factor Mdk1. (146 aa) |
| | gsx1 | Genetic screen homeobox 1 protein. (243 aa) |
| | notch1b | Notch receptor 1b. (2465 aa) |
| | rarga | Retinoic acid receptor gamma-A; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Required for hindbrain development and for the development of pharyngeal arches; Belongs to the nuclear hormone receptor family. NR1 subfamily. (499 aa) |
| | id2b | Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein, b. (130 aa) |
| | rarab | Retinoic acid receptor alpha-B; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Required for hindbrain development and, in lateral plate mesoderm, for specification of the pectoral fins; Belongs to the nuclear hormone receptor family. NR1 subfamily. (458 aa) |
| | pax2b | Paired box 2b. (386 aa) |
| | serpine2 | Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2; Belongs to the serpin family. (395 aa) |
| | celf1 | CUGBP Elav-like family member 1; RNA-binding protein implicated in the regulation of several post-transcriptional events. May be involved in mRNA translation activation and stability (By similarity). Involved in the regulation of muscle-specific splicing of alpha actinin pre-mRNAs via the binding to the UR-repeat element (URE) at the branch point of the non-muscle (NM) exon; Belongs to the CELF/BRUNOL family. (534 aa) |
| | tbx1 | T-box transcription factor TBX1; May act as a transcriptional factor. Acts cell autonomously in the pharyngeal mesendoderm and influences the development of neural crest-derived cartilages secondarily. (460 aa) |
| | pkd1a | Polycystic kidney disease 1a. (4346 aa) |
| | acot14 | Acyl-CoA thioesterase 14. (449 aa) |
| | suv39h1a | Histone-lysine N-methyltransferase SUV39H1-A; Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric [...] (411 aa) |
| | pax8 | Paired box 8. (448 aa) |
| | ppdpfa | Pancreatic progenitor cell differentiation and proliferation factor A; Probable regulator of exocrine pancreas development. (117 aa) |
| | six6a | Sine oculis-related homeobox 6a. (245 aa) |
| | wt1a | WT1 transcription factor a. (419 aa) |
| | six1b | Homeobox protein six1b; Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Depending on context, functions as transcriptional repressor or activator. Transcriptional activation is enhanced by eya1 (in vitro). Plays an important role in the development of the inner ear, where it promotes hair cell proliferation and inhibits proliferation of neural progenitor cells. Required for normal myogenesis. Plays a role in the development of fast muscle fibers throughout the body, as well as the development of craniofacial muscles. R [...] (284 aa) |
| | tbx2a | T-box transcription factor 2a. (686 aa) |
| | pes | Pescadillo; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (583 aa) |
| | jag2a | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1206 aa) |
| | stat6 | Signal transducer and activator of transcription. (758 aa) |
| | tbx3a | T-box transcription factor 3a. (689 aa) |
| | tgfb3 | Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa) |
| | hand2 | Heart- and neural crest derivatives-expressed protein 2; Essential for myocardial and pectoral fin differentiation, patterning and morphogenesis. (205 aa) |
| | stat5a | Signal transducer and activator of transcription. (785 aa) |
| | fads2 | Fatty acid desaturase 2; Fatty acid desaturase with both Delta(5) and Delta(6) activities. Component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n- 6) and alpha-linolenic acid (ALA) (18:3n-3). (444 aa) |
| | nav3 | Neuron navigator 3; May be involved in neuron regeneration; Belongs to the Nav/unc-53 family. (2269 aa) |
| | zbtb1 | Zinc finger and BTB domain-containing 1. (677 aa) |
| | dag1 | Dystroglycan 1. (866 aa) |
| | isl2a | Insulin gene enhancer protein isl-2a; Binds to one of the cis-acting domain of the insulin gene enhancer. May be involved in subtype specialization of primary motoneurons. (359 aa) |
| | ddx55 | ATP-dependent RNA helicase DDX55; Probable ATP-binding RNA helicase. Plays an essential role in early embryonic development; Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily. (593 aa) |
| | cyp7b1 | Cytochrome P450, family 7, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (504 aa) |
| | rnpc3 | RNA-binding region-containing protein 3; Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprise less than 1% of all non-coding sequences. (505 aa) |
| | tg | Thyroglobulin. (2741 aa) |
| | wdr55 | WD repeat-containing protein 55; Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis (By similarity). (386 aa) |
| | fgf8a | Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration (By similarity). Required for Kupffer's vesicle ciliogenesis. (210 aa) |
| | mdkb | Midkine-related growth factor Mdk2. (147 aa) |
| | pck1 | Phosphoenolpyruvate carboxykinase 1 (soluble). (630 aa) |
| | eif3i | Eukaryotic translation initiation factor 3 subunit I; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (325 aa) |
| | pdx1 | Pancreatic and duodenal homeobox 1. (246 aa) |
| | C20H6orf58 | Protein leg1b; Involved in early development of liver, exocrine pancreas and intestine, probably through cell cycle regulation. In liver, its function is partially redundant with leg1a function. (364 aa) |
| | nkx2.5 | NK2 homeobox 5. (314 aa) |
| | gli2b | GLI family zinc finger 2b. (1225 aa) |
| | atm | Non-specific serine/threonine protein kinase. (3091 aa) |
| | fgfr1a | Fibroblast growth factor receptor 1-A; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2 triggers [...] (809 aa) |
| | bmp2a | Bone morphogenetic protein 2a. (386 aa) |
| | smo | Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (822 aa) |
| | isl1 | Insulin gene enhancer protein isl-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. May be involved in subtype specialization of primary motoneurons. May bind to insulin gene enhancer sequences. Essential for heart development (By similarity). (349 aa) |
| | utp25 | Digestive organ expansion factor; Regulates the p53 pathway to control the expansion growth of digestive organs. Required for the expansion growth of intestine, liver and exocrine pancreas, but not endocrine pancreas. May not play a major role during the early stage of endodermal organogenesis. (753 aa) |
| | ptf1a | Pancreas transcription factor 1 subunit alpha; Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Required for exocrine pancreatic development. Plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates. (265 aa) |
| | jag2b | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1254 aa) |
| | tnfb | Tumor necrosis factor b (TNF superfamily, member 2). (242 aa) |
| | gli2a | GLI family zinc finger 2a. (1439 aa) |
| | jag1b | Protein jagged-1b; Ligand for Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions. (1213 aa) |
| | hnf1a | HNF1 homeobox a. (560 aa) |
| | znf330 | Zinc finger protein 330. (320 aa) |
| | sec63 | SEC63 homolog, protein translocation regulator. (751 aa) |
| | foxn1 | Forkhead box N1. (565 aa) |
| | eaf2 | ELL-associated factor 2. (259 aa) |
| | pck2 | Phosphoenolpyruvate carboxykinase 2 (mitochondrial). (636 aa) |
| | sart3 | Squamous cell carcinoma antigen recognized by T-cells 3; U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery. Promotes the initial reassembly of U4 and U6 snRNPs following their ejection from the spliceosome during its maturation. May also function as a substrate targeting factor for deubiquitinases and mediate the deubiquitination of components of the spliceosome and histones (By similarity). (951 aa) |
| | pcsk1 | Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family. (755 aa) |
| | ednraa | Endothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family. (422 aa) |
| | sp3a | Sp3a transcription factor. (679 aa) |
