STRINGSTRING
phox2a phox2a bmp2a bmp2a mafba mafba fgf8a fgf8a mpp5b mpp5b pax8 pax8 pax2b pax2b Q1LWT0_DANRE Q1LWT0_DANRE cdk5r1a cdk5r1a cdk5r1b cdk5r1b pax2a pax2a cdk5r2b cdk5r2b ENSDARP00000147138 ENSDARP00000147138 rest rest srrm4 srrm4 fgf3 fgf3 phox2bb phox2bb hoxb1a hoxb1a cdk5r2a cdk5r2a bmp2b bmp2b phox2ba phox2ba pax5 pax5 mpp5a mpp5a prkci prkci
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
phox2aPaired-like homeobox 2A. (280 aa)
bmp2aBone morphogenetic protein 2a. (386 aa)
mafbaTranscription factor MafB; May act as a transcriptional activator or repressor. Involved in neurogenesis. Involved in the development of rhombomeres (r) 5 and 6 segments from their common precursor 'proto-segment' in the hindbrain. Belongs to the bZIP family. Maf subfamily. (397 aa)
fgf8aFibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration (By similarity). Required for Kupffer's vesicle ciliogenesis. (210 aa)
mpp5bMembrane protein, palmitoylated 5b (MAGUK p55 subfamily member 5); Belongs to the MAGUK family. (639 aa)
pax8Paired box 8. (448 aa)
pax2bPaired box 2b. (386 aa)
Q1LWT0_DANRECyclin-dependent kinase 5 activator. (317 aa)
cdk5r1aCyclin-dependent kinase 5 activator. (306 aa)
cdk5r1bCyclin-dependent kinase 5 activator. (304 aa)
pax2aPaired box protein Pax-2a; Probable transcription factor involved in the development of the midbrain/hindbrain boundary (MHB) organizer and specification of neuronal cell fates. Required for establishment of eng2 and eng3 gene expression in the midbrain and MHB primordium during late gastrulation. (391 aa)
cdk5r2bCyclin-dependent kinase 5 activator. (302 aa)
ENSDARP00000147138TGFb_propeptide domain-containing protein. (179 aa)
restRE1-silencing transcription factor; Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. (854 aa)
srrm4Serine/arginine repetitive matrix protein 4; Splicing factor specifically required for neural cell differentiation. Acts in conjunction with nPTB/PTBP2 by binding directly to its regulated target transcripts and promotes neural-specific exon inclusion in many genes that function in neural cell differentiation. Required to promote the inclusion of neural- specific exon 10 in nPTB/PTBP2, leading to increased expression of neural-specific nPTB/PTBP2 (By similarity). (574 aa)
fgf3Fibroblast growth factor 3; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Belongs to the heparin-binding growth factors family. (256 aa)
phox2bbPaired-like homeobox 2Bb. (284 aa)
hoxb1aHomeobox protein Hox-B1a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (316 aa)
cdk5r2aCyclin-dependent kinase 5 activator. (308 aa)
bmp2bBone morphogenetic protein 2b. (411 aa)
phox2baPaired-like homeobox 2Ba. (155 aa)
pax5Paired box 5. (396 aa)
mpp5aMAGUK p55 subfamily member 5-A; Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells (By similarity). Also involved in adherens junction biogenesis (By similarity). Functions in cellular patterning of the retina. (703 aa)
prkciProtein kinase C iota type; Calcium- and diacylglycerol-independent serine/ threonine- protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway (By similarity). Is required for the formation and maintenance of the zonula adherens during early epithelial development and plays a critical role in organ morphogenesis and in regulating the orientation of cell division. (588 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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