STRINGSTRING
ednrbb ednrbb thraa thraa ednraa ednraa cdh2 cdh2 rcc2 rcc2 gbx2 gbx2 sox9a sox9a phactr1 phactr1 pdcd6 pdcd6 wnt7ba wnt7ba dla dla smo smo nusap1 nusap1 sema3b sema3b colec11 colec11 coro1ca coro1ca pef1 pef1 tbx1 tbx1 phactr4b phactr4b dicer1 dicer1 sema3fa sema3fa sema3bl sema3bl sema3aa sema3aa sema3e sema3e nrp2b nrp2b cep41 cep41 sema3ab sema3ab sox9b sox9b wnt7aa wnt7aa rx3 rx3 ret ret leo1 leo1 foxc1b foxc1b flt3 flt3 LOC568110 LOC568110 tapt1b tapt1b sema6bb sema6bb sema4ab sema4ab sema4d sema4d sema6dl sema6dl sema3d sema3d nolc1 nolc1 pdgfra pdgfra fn1b fn1b kbtbd8 kbtbd8 edn1 edn1 anxa6 anxa6 M9MMA2_DANRE M9MMA2_DANRE ptprc ptprc sema4c sema4c sox10 sox10 sema4e sema4e sema4ga sema4ga sema4bb sema4bb tapt1a tapt1a dlx2a dlx2a foxc1a foxc1a sema7a sema7a ednrba ednrba sema4gb sema4gb sema3c sema3c nrarpa nrarpa fn1a fn1a F1Q5G8_DANRE F1Q5G8_DANRE phox2ba phox2ba setd2 setd2 sema4ba sema4ba foxq2 foxq2 sema6d sema6d wdr11 wdr11 alx1 alx1 ednrab ednrab F8W238_DANRE F8W238_DANRE gdnfa gdnfa med13b med13b sh3pxd2aa sh3pxd2aa sh3pxd2ab sh3pxd2ab wnt7bb wnt7bb phox2bb phox2bb med12 med12 klhl12 klhl12 fgf3 fgf3 wtip wtip sema6a sema6a ENSDARP00000134495 ENSDARP00000134495 radil radil fgf19 fgf19 phactr4a phactr4a sema6e sema6e sema5a sema5a COLEC10 COLEC10 sema5bb sema5bb nrp1a nrp1a SEMA4F SEMA4F nrtn nrtn sema6ba sema6ba LOC101884662 LOC101884662 coro1cb coro1cb phactr4a-2 phactr4a-2 ENSDARP00000146009 ENSDARP00000146009 sema3fb sema3fb LOC103910147 LOC103910147 htr2b htr2b ENSDARP00000151788 ENSDARP00000151788 pdgfrb pdgfrb med13a med13a sema5ba sema5ba
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ednrbbEndothelin receptor type Bb; Belongs to the G-protein coupled receptor 1 family. (365 aa)
thraaThyroid hormone receptor alpha-A; High affinity receptor for triiodothyronine (By similarity). In the absence of thyroid hormone during late blastula stage development, acts as a transcriptional repressor. Whereas in the presence of thyroid hormone, can act as an activator of transcription. In addition, represses retinoic acid (RA)-signaling during blastula and gastrula stages of development; Belongs to the nuclear hormone receptor family. NR1 subfamily. (427 aa)
ednraaEndothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family. (422 aa)
cdh2Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion (By similarity). Cadherins contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development. Required for normal neural tube morphogenesis. Required to allow mid- and hindbrain neurons to reach and maintain their appropriate positions within the neural tube by restricting neuronal motility within the embryonic mid- and hindbrain. (893 aa)
rcc2Protein RCC2 homolog; Multifunctional protein that may effect its functions by regulating the activity of small GTPases, such as RAC1 and RALA. Required for normal progress through the cell cycle, both during interphase and during mitosis. Required for normal attachment of kinetochores to mitotic spindles. Required for normal organization of the microtubule cytoskeleton in interphase cells. Interferes with the activation of RAC1 by guanine nucleotide exchange factors. Prevents accumulation of active, GTP-bound RAC1, and suppresses RAC1-mediated reorganization of the actin cytoskeleton [...] (495 aa)
gbx2Gastrulation brain homeo box 2. (342 aa)
sox9aHMG box transcription factor Sox9a. (462 aa)
phactr1Phosphatase and actin regulator. (542 aa)
pdcd6Programmed cell death 6. (185 aa)
wnt7baProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
dlaDelta-like protein A; Acts as a ligand for Notch receptors and is involved in primary neurogenesis. Can activate Notch receptors, thereby playing a key role in lateral inhibition, a process that prevents the immediate neighbors of each nascent neural cell from simultaneously embarking on neural differentiation. Required for boundary formation during segmentation of the hindbrain. Required for midline cell fate specification prior to germ layer formation; regulates specification of floorplate, notochord and hypochord. In inner ear, it prevents adjacent cells from adopting the same cell [...] (772 aa)
smoSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (822 aa)
nusap1Nucleolar and spindle-associated protein 1; Microtubule-associated protein with the capacity to bundle and stabilize microtubules. May associate with chromosomes and promote the organization of mitotic spindle microtubules around them (By similarity). (446 aa)
sema3bSema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B; Belongs to the semaphorin family. (775 aa)
colec11Collectin-11; Lectin that plays a role in innate immunity, apoptosis and embryogenesis. Calcium-dependent lectin that binds self and non-self glycoproteins presenting high mannose oligosaccharides with at least one terminal alpha-1,2-linked mannose epitope. Primarily recognizes the terminal disaccharide of the glycan. Also recognizes a subset of fucosylated glycans and lipopolysaccharides. Plays a role in innate immunity through its ability to bind non-self sugars presented by microorganisms and to activate the complement through the recruitment of MAPS1. Also plays a role in apoptosis [...] (271 aa)
coro1caCoronin-1C-A; Plays a role in directed cell migration by regulating the activation and subcellular location of RAC1 (Probable). Increases the presence of activated RAC1 at the leading edge of migrating cells. Required for normal organization of the cytoskeleton, including the actin cytoskeleton, microtubules and the vimentin intermediate filaments. Plays a role in endoplasmic reticulum-associated endosome fission: endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane. [...] (474 aa)
pef1Peflin; Calcium-binding protein that acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protein complexes in response to calcium. Acts as a negative regulator of ER-Golgi transport (By similarity). (270 aa)
tbx1T-box transcription factor TBX1; May act as a transcriptional factor. Acts cell autonomously in the pharyngeal mesendoderm and influences the development of neural crest-derived cartilages secondarily. (460 aa)
phactr4bPhosphatase and actin regulator 4B; Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to repression of the integrin signaling through the rho/rock pathway (By similarity). (754 aa)
dicer1Endoribonuclease Dicer; Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, al [...] (1865 aa)
sema3faSema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Fa; Belongs to the semaphorin family. (801 aa)
sema3blSema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3bl; Belongs to the semaphorin family. (771 aa)
sema3aaSemaphorin-3aa; May influence outgrowth by a variety of growth cones including those of the posterior lateral line ganglion. (860 aa)
sema3eSema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E; Belongs to the semaphorin family. (768 aa)
nrp2bNeuropilin; Belongs to the neuropilin family. (920 aa)
cep41Centrosomal protein of 41 kDa; Required during ciliogenesis for tubulin glutamylation in cilium. Probably acts by participating in the transport of tubulin polyglutamylases between the basal body and the cilium. Belongs to the CEP41 family. (374 aa)
sema3abSemaphorin-3ab; Might normally influence the midsegmental pathway choice of the ventrally extending motor axons by contributing to a repulsive domain in the posterior somite. (778 aa)
sox9bHMG box transcription factor Sox9b. (407 aa)
wnt7aaProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
rx3Retinal homeobox protein Rx3; Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation. (292 aa)
retProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1106 aa)
leo1RNA polymerase-associated protein LEO1; Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II. PAF1C associates with RNA polymerase II, is involved in transcriptional elongation and in histone modifications including methylation on histone H3 'Lys-4' (H3K4me3) (By similarity). PAF1C seems to be required for multiple steps in cardiac formation. Involved in heart development and required for differentiation of the atrioventricular boundary. Required for neural crest cell development. (696 aa)
foxc1bForkhead box C1-B; DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin development. Acts either as a transcriptional activator or repressor. Binds to the consensus binding site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes. Upon DNA-binding, promotes DNA bending. Required for cell viability and resistance to oxidative stress in the eye. Promotes cell growth inhibition by stopping the cell cycle in the G1 phase through TGFB1- mediated signals. Involved in epithelia [...] (433 aa)
flt3Fms-related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (956 aa)
LOC568110Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
tapt1bTransmembrane anterior posterior transformation protein 1 homolog; Plays a role in primary cilia formation. Involved in cartilage and bone development. May play a role in the differentiation of cranial neural crest cells. May act as a downstream effector of hoxc8 during development (By similarity). (567 aa)
sema6bbSema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6Bb. (639 aa)
sema4abSemaphorin-4A isoform X1; Belongs to the semaphorin family. (831 aa)
sema4dUncharacterized protein; Belongs to the semaphorin family. (856 aa)
sema6dlSema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D,-like. (1018 aa)
sema3dSemaphorin-3D; May play a role in the guidance of several axon pathways. (764 aa)
nolc1Nucleolar and coiled-body phosphoprotein 1. (1001 aa)
pdgfraPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for pdgfa, pdgfb and pdgfc and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. Required for normal development of the gastrointestinal tract. Plays a role in cell migration and chemotaxis in wound [...] (1456 aa)
fn1bFibronectin 1b. (2500 aa)
kbtbd8Kelch repeat and BTB domain-containing protein 8; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification (By similarity). The BCR(KBTBD8) complex acts by mediating monoubiquitination of target proteins (By similarity). (601 aa)
edn1Endothelin 1. (188 aa)
anxa6Annexin. (577 aa)
M9MMA2_DANRESi:ch211-129c21.1; Belongs to the semaphorin family. (775 aa)
ptprcProtein tyrosine phosphatase receptor type C. (1130 aa)
sema4cSemaphorin-4C precursor; Belongs to the semaphorin family. (863 aa)
sox10HMG-box transcription factor Sox10. (485 aa)
sema4eSemaphorin-4E. (766 aa)
sema4gaSemaphorin-4G; Belongs to the semaphorin family. (883 aa)
sema4bbSemaphorin-4B; Belongs to the semaphorin family. (849 aa)
tapt1aTransmembrane anterior posterior transformation 1a. (577 aa)
dlx2aHomeobox protein Dlx2a; Involved in the development of the inner ear; Belongs to the distal-less homeobox family. (274 aa)
foxc1aForkhead box C1-A; DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin development. Acts either as a transcriptional activator or repressor. Binds to the consensus binding site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes. Upon DNA-binding, promotes DNA bending. Required for cell viability and resistance to oxidative stress in the eye. Promotes cell growth inhibition by stopping the cell cycle in the G1 phase through TGFB1- mediated signals. Involved in epithelia [...] (476 aa)
sema7aSemaphorin 7A; Belongs to the semaphorin family. (640 aa)
ednrbaEndothelin receptor Ba; Belongs to the G-protein coupled receptor 1 family. (426 aa)
sema4gbSemaphorin-4G. (752 aa)
sema3cSema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C. (713 aa)
nrarpaNotch-regulated ankyrin repeat-containing protein A; Regulates independently canonical Wnt and Notch signaling by modulating LEF1 and Notch protein turnover. Stabilizes LEF1, a pivotal transcription factor in the Wnt signaling cascade, by blocking its ubiquitination. Involved in angiogenesis; involved in intersegmental vessel patterning during development; Belongs to the NRARP family. (112 aa)
fn1aFibronectin 1a. (2480 aa)
F1Q5G8_DANRESi:dkey-49n23.1; Belongs to the semaphorin family. (758 aa)
phox2baPaired-like homeobox 2Ba. (155 aa)
setd2SET domain-containing 2, histone lysine methyltransferase. (2737 aa)
sema4baSemaphorin 4; Belongs to the semaphorin family. (830 aa)
foxq2Forkhead box Q2. (263 aa)
sema6dSema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D; Belongs to the semaphorin family. (898 aa)
wdr11WD repeat-containing protein 11; Involved in the Hedgehog (Hh) signaling pathway, is essential for normal ciliogenesis. Regulates the proteolytic processing of gli3 and cooperates with the transcription factor emx1 in the induction of downstream Hh pathway gene expression and gonadotropin-releasing hormone production. WDR11 complex facilitates the tethering of Adaptor protein-1 complex (AP-1)-derived vesicles. (1239 aa)
alx1ALX homeobox protein 1; Sequence-specific DNA-binding transcription factor that binds palindromic sequences within promoters and may activate or repress the transcription of a subset of genes. Most probably regulates the expression of genes involved in the development of mesenchyme-derived craniofacial structures (By similarity). Required for proper neural crest cell migration into the frontonasal primordia during development ; Belongs to the paired homeobox family. (320 aa)
ednrabEndothelin receptor type Ab; Belongs to the G-protein coupled receptor 1 family. (408 aa)
F8W238_DANRESi:ch211-113g11.6; Belongs to the semaphorin family. (474 aa)
gdnfaGlial cell line-derived neurotrophic factor; Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high- affinity dopamine uptake (By similarity). Essential for the development of the enteric nervous system, but appears dispensable for the development of the kidney and primary motor neuron; Belongs to the TGF-beta family. GDNF subfamily. (235 aa)
med13bMediator of RNA polymerase II transcription subunit 13-like; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). (2103 aa)
sh3pxd2aaSH3 and PX domain-containing protein 2A; Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation; Belongs to the SH3PXD2 family. (1085 aa)
sh3pxd2abSH3 and PX domains 2Ab. (873 aa)
wnt7bbProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
phox2bbPaired-like homeobox 2Bb. (284 aa)
med12Mediator of RNA polymerase II transcription subunit 12; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Require [...] (2175 aa)
klhl12Kelch-like protein 12; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division (By similarity). Negatively regulates the Wnt signaling pathway, possibly via the targeted ubiquitination and subsequent proteolysis of dvl2 and dvl3. Regulates convergent-extension movements during early [...] (314 aa)
fgf3Fibroblast growth factor 3; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Belongs to the heparin-binding growth factors family. (256 aa)
wtipWilms tumor protein 1-interacting protein homolog; May monitor slit diaphragm protein assembly, a specialized adherens junction characteristic of podocytes. In case of podocyte injury, it shuttles into the nucleus and acts as a transcription regulator. Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity). Acts as a transcriptional corepressor for snai1 and snai2/slug and plays a role in regulating neural crest development (By similarity); Belongs to the zyxin/ajuba family. (648 aa)
sema6aSema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A. (604 aa)
ENSDARP00000134495Uncharacterized protein; Belongs to the semaphorin family. (482 aa)
radilRas-associating and dilute domain-containing protein; Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development. (1124 aa)
fgf19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
phactr4aPhosphatase and actin regulator 4A. (1011 aa)
sema6eSema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6E; Belongs to the semaphorin family. (1064 aa)
sema5aSemaphorin-5A. (1048 aa)
COLEC10Si:ch211-93i7.4. (271 aa)
sema5bbSemaphorin-5B. (1098 aa)
nrp1aNeuropilin-1a; Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. Regulates angiogenesis through a VEGF-dependent pathway. (923 aa)
SEMA4FSsemaphorin 4F; Belongs to the semaphorin family. (766 aa)
nrtnNeurturin. (211 aa)
sema6baSema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6Ba; Belongs to the semaphorin family. (895 aa)
LOC101884662BTB domain-containing protein. (555 aa)
coro1cbCoronin; Belongs to the WD repeat coronin family. (474 aa)
phactr4a-2Phosphatase and actin regulator 4A; Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to repression of the integrin signaling through the rho/rock pathway (By similarity). (118 aa)
ENSDARP00000146009CUB domain-containing protein. (101 aa)
sema3fbSema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Fb; Belongs to the semaphorin family. (791 aa)
LOC103910147TGF_BETA_2 domain-containing protein. (231 aa)
htr2b5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled. (443 aa)
ENSDARP00000151788Sema domain-containing protein; Belongs to the semaphorin family. (305 aa)
pdgfrbPlatelet-derived growth factor receptor, beta polypeptide; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1072 aa)
med13aMediator of RNA polymerase II transcription subunit 13; Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (2197 aa)
sema5baannotation not available (1101 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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