STRINGSTRING
pdcd4b pdcd4b ptgs2b ptgs2b zp3 zp3 tnfb tnfb tnfrsf1a tnfrsf1a nfkbiab nfkbiab mdkb mdkb ptgs2a ptgs2a vamp8 vamp8 snx4 snx4 caspa caspa mdka mdka setd4 setd4 pycard pycard F1R519_DANRE F1R519_DANRE cebpb cebpb caspb caspb GPR68 GPR68 ccn4a ccn4a serpine1 serpine1 il17ra1a il17ra1a A9JRC2_DANRE A9JRC2_DANRE c2cd4a c2cd4a ptger4b ptger4b tnfsf11 tnfsf11 ptger4a ptger4a il17ra2 il17ra2 lgals2a lgals2a ptger4c ptger4c ccn4b ccn4b LOC571502 LOC571502 Q1L955_DANRE Q1L955_DANRE LOC100332608 LOC100332608 zgc:171778 zgc:171778 tnfrsf11a tnfrsf11a nfkbiaa nfkbiaa napepld napepld caspbl caspbl lgals1l1 lgals1l1 ccr7 ccr7 gprc5bb gprc5bb lgals2b lgals2b nlrp1 nlrp1 gprc5ba gprc5ba gpr4 gpr4 X1WGW1_DANRE X1WGW1_DANRE il16 il16 nfkbiz nfkbiz appa appa pdcd4a pdcd4a ifi35 ifi35 LOC103910107 LOC103910107 ctsc ctsc kars1 kars1 LOC100005924 LOC100005924 CAMK2N1 CAMK2N1 tnip1 tnip1 il1b il1b il1rl1 il1rl1 ENSDARP00000146237 ENSDARP00000146237 ccdc142 ccdc142 ENSDARP00000154441 ENSDARP00000154441 zp3.2 zp3.2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pdcd4bProgrammed cell death 4b. (470 aa)
ptgs2bProstaglandin-endoperoxide synthase 2b. (606 aa)
zp3Zona pellucida glycoprotein 3, tandem duplicate 2. (431 aa)
tnfbTumor necrosis factor b (TNF superfamily, member 2). (242 aa)
tnfrsf1aTumor necrosis factor receptor superfamily, member 1a. (389 aa)
nfkbiabNuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b. (312 aa)
mdkbMidkine-related growth factor Mdk2. (147 aa)
ptgs2aProstaglandin-endoperoxide synthase 2a. (601 aa)
vamp8Vesicle-associated membrane protein 8 (Endobrevin). (124 aa)
snx4Sorting nexin 4. (434 aa)
caspaCaspase a subunit p10; Thiol protease which cleaves IL-1 beta (il1b), releasing the mature cytokine which is involved in a variety of inflammatory processes, and mediates apoptosis. Component of the NLRP1 inflammasome, which plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, recruited to the NLRP1 inflammasome in its precursor form. Its subsequent activation causes the cleavage of pro-il1b into the midformed il1b, which then evetually leads to il1b maturation and secretion in the extracellular milieu. Required for the [...] (383 aa)
mdkaMidkine-related growth factor Mdk1. (146 aa)
setd4SET domain-containing 4. (440 aa)
pycardApoptosis-associated speck-like protein containing a CARD; Functions as key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis. Induces proteolytic processing of caspa and caspa- dependent apoptosis. In innate immune response acts as an integral adapter in the assembly of NLRP1 inflammasomes which activate caspases caspa and caspb leading to processing and secretion of the proinflammatory cytokine il1b. The function as activating adapter in different types of inflammasomes is mediated by the pyrin and CARD domains and their homotypic interactions. Also involved [...] (203 aa)
F1R519_DANRESi:ch211-231m23.4; Belongs to the G-protein coupled receptor 1 family. (305 aa)
cebpbCCAAT/enhancer-binding protein. (280 aa)
caspbCaspase b subunit p10; Thiol protease which cleaves IL-1 beta (il1b), releasing the mature cytokine which is involved in a variety of inflammatory processes, and mediates apoptosis. Component of the NLRP1 inflammasome, which plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, recruited to the NLRP1 inflammasome in its precursor form following the recruitment of caspase caspa. Its subsequent activation causes the cleavage of the midformed pro-il1b and results in il1b maturation and secretion in the extracellular milieu. [...] (404 aa)
GPR68G protein-coupled receptor 68; Belongs to the G-protein coupled receptor 1 family. (353 aa)
ccn4aCellular communication network factor 4a. (360 aa)
serpine1Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Belongs to the serpin family. (392 aa)
il17ra1aInterleukin 17 receptor A1a. (782 aa)
A9JRC2_DANRELOC794123 protein; Belongs to the G-protein coupled receptor 1 family. (338 aa)
c2cd4aC2 calcium-dependent domain-containing 4A. (457 aa)
ptger4bProstaglandin E receptor 4 (subtype EP4) b; Belongs to the G-protein coupled receptor 1 family. (497 aa)
tnfsf11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (251 aa)
ptger4aProstaglandin E receptor 4 (subtype EP4) a; Belongs to the G-protein coupled receptor 1 family. (403 aa)
il17ra2Interleukin 17 receptor A2. (245 aa)
lgals2aGalectin. (134 aa)
ptger4cProstaglandin E receptor 4 (subtype EP4) c; Belongs to the G-protein coupled receptor 1 family. (435 aa)
ccn4bCellular communication network factor 4b. (356 aa)
LOC571502G_PROTEIN_RECEP_F1_2 domain-containing protein. (311 aa)
Q1L955_DANRESi:dkey-211g8.6; Belongs to the G-protein coupled receptor 1 family. (328 aa)
LOC100332608C2 domain-containing protein. (421 aa)
zgc:171778Zona pellucida glycoprotein 3, tandem duplicate 2. (432 aa)
tnfrsf11aTumor necrosis factor receptor superfamily, member 11a, NFKB activator. (574 aa)
nfkbiaaNuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a. (310 aa)
napepldN-acyl phosphatidylethanolamine phospholipase D. (416 aa)
caspblCaspase b,-like; Belongs to the peptidase C14A family. (409 aa)
lgals1l1Galectin. (134 aa)
ccr7Chemokine (C-C motif) receptor 7; Belongs to the G-protein coupled receptor 1 family. (385 aa)
gprc5bbG protein-coupled receptor, class C, group 5, member Bb. (406 aa)
lgals2bGalectin. (132 aa)
nlrp1NACHT, LRR and PYD domains-containing protein 1 homolog; As the sensor component of the NLRP1 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, which activates caspases caspa and caspb leading to processing and secretion of proinflammatory cytokines. Required for the sequential recruitment of pro-caspa and pro-caspb to the inflammasome, which promotes activation of the caspases and the caspa/b-catalyzed il1b maturation and secretion in the e [...] (1192 aa)
gprc5baG protein-coupled receptor, class C, group 5, member Ba. (397 aa)
gpr4G protein-coupled receptor 4; Belongs to the G-protein coupled receptor 1 family. (373 aa)
X1WGW1_DANRESi:ch73-90p23.1. (278 aa)
il16Interleukin 16. (1521 aa)
nfkbizNuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta. (507 aa)
appaAmyloid beta (A4) precursor protein a. (194 aa)
pdcd4aProgrammed cell death 4a. (467 aa)
ifi35Interferon-induced protein 35. (384 aa)
LOC103910107NACHT domain-containing protein. (847 aa)
ctscCathepsin C; Belongs to the peptidase C1 family. (455 aa)
kars1Lysine--tRNA ligase. (602 aa)
LOC100005924Interleukin 17 receptor A1b. (770 aa)
CAMK2N1Si:dkey-33m11.6. (76 aa)
tnip1TNFAIP3-interacting protein 1. (653 aa)
il1bInterleukin-1. (284 aa)
il1rl1Uncharacterized protein. (342 aa)
ENSDARP00000146237Si:dkey-165a24.9; Belongs to the G-protein coupled receptor 1 family. (357 aa)
ccdc142Coiled-coil domain-containing 142. (1024 aa)
ENSDARP00000154441SEFIR domain-containing protein. (768 aa)
zp3.2Zona pellucida glycoprotein 3, tandem duplicate 2. (427 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.