STRINGSTRING
baiap2b baiap2b l1cama l1cama spint1b spint1b faimb faimb tnfb tnfb smo smo plxnb3 plxnb3 gata3 gata3 mdkb mdkb XRCC2 XRCC2 foxg1b foxg1b plxna4 plxna4 faima faima dbnla dbnla dbnlb dbnlb spast spast nkx6.1 nkx6.1 rufy3 rufy3 caprin2 caprin2 chodl chodl serpine2 serpine2 plxnb2b plxnb2b plxna3 plxna3 wnt2bb wnt2bb layna layna eef2k eef2k mdka mdka acy3.1 acy3.1 bmpr2a bmpr2a shtn1 shtn1 tgfb1a tgfb1a gsx2 gsx2 nptnb nptnb ngfb ngfb stk11 stk11 islr2 islr2 ist1 ist1 aspa aspa srfa srfa lig4 lig4 kdm1a kdm1a adnpa adnpa baiap2a baiap2a wnt3a wnt3a caprin1b caprin1b dbn1 dbn1 atoh7 atoh7 vegfc vegfc numb numb wnt2ba wnt2ba fn1b fn1b foxg1a foxg1a neurod6a neurod6a map6b map6b spen spen si:dkey-28e7.3 si:dkey-28e7.3 Q5RHX7_DANRE Q5RHX7_DANRE Wu:fb69f10 Wu:fb69f10 foxg1d foxg1d map6a map6a amigo3 amigo3 fbxw8 fbxw8 tiam1a tiam1a adnpb adnpb tnfrsf1b tnfrsf1b wnt3 wnt3 mtor mtor caprin1a caprin1a bmpr2b bmpr2b il34 il34 acy3.2 acy3.2 mecp2 mecp2 sema7a sema7a ankrd27 ankrd27 cdkl5 cdkl5 plxnd1 plxnd1 fn1a fn1a rnd2 rnd2 Q5RH90_DANRE Q5RH90_DANRE foxg1c foxg1c zfyve27 zfyve27 il1rapl2 il1rapl2 plxnc1 plxnc1 trak1a trak1a nsmfa nsmfa plxnb2a-2 plxnb2a-2 cux2b cux2b l1camb l1camb tgfb1b tgfb1b F8W238_DANRE F8W238_DANRE disc1 disc1 nin nin laynb laynb ptprz1a ptprz1a X1WGX6_DANRE X1WGX6_DANRE tiam2b tiam2b plxnb2a plxnb2a xrcc5 xrcc5 numbl numbl plxnb1b plxnb1b fgf3 fgf3 tiam1b tiam1b il6st il6st srfb srfb ENSDARP00000134495 ENSDARP00000134495 nsmfb nsmfb ngfa ngfa trim32 trim32 nptna nptna snw1 snw1 plxnb1a plxnb1a anapc2 anapc2 dhx36 dhx36 nkx6.2 nkx6.2 il1b il1b ENSDARP00000142109 ENSDARP00000142109 plxna1a plxna1a znf16l znf16l ptprz1b ptprz1b tiam2a tiam2a tenm4 tenm4 ENSDARP00000145392 ENSDARP00000145392 Reln Reln spint1a spint1a ENSDARP00000149939 ENSDARP00000149939 ZNF335 ZNF335 plxna2 plxna2 golga4 golga4
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
baiap2bBAR/IMD domain-containing adaptor protein 2b. (401 aa)
l1camaNeural cell adhesion molecule L1.2; Cell adhesion molecule with an important role in the development of the nervous system. Involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. Binds to axonin on neurons (By similarity); Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family. (1271 aa)
spint1bSerine peptidase inhibitor, Kunitz type 1 b. (499 aa)
faimbFas apoptotic inhibitory molecule b. (180 aa)
tnfbTumor necrosis factor b (TNF superfamily, member 2). (242 aa)
smoSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (822 aa)
plxnb3Plexin B3. (1886 aa)
gata3Transcription factor GATA-3. (438 aa)
mdkbMidkine-related growth factor Mdk2. (147 aa)
XRCC2X-ray repair cross complementing 2. (314 aa)
foxg1bForkhead box G1b. (341 aa)
plxna4Plexin-A4; Involved in the development of primary sensory neurons especially in branching of the peripheral axons. Interacts with the SLIT2 signaling specifically to promote axonal branching of Rohon-Beard neurons and the trigeminal sensory ganglion neurons. (1903 aa)
faimaFas apoptotic inhibitory molecule a. (179 aa)
dbnlaDrebrin-like a. (496 aa)
dbnlbDrebrin-like b. (476 aa)
spastSpastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Go [...] (570 aa)
nkx6.1NK6 homeobox 1. (312 aa)
rufy3RUN and FYVE domain-containing 3. (470 aa)
caprin2Caprin-2; Promotes phosphorylation of the Wnt coreceptor LRP6, leading to increased activity of the canonical Wnt signaling pathway. Facilitates constitutive LRP6 phosphorylation by CDK14/CCNY during G2/M stage of the cell cycle, which may potentiate cells for Wnt signaling. May regulate the transport and translation of mRNAs, modulating for instance the expression of proteins involved in synaptic plasticity in neurons. Involved in regulation of growth as erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation. May be involved in apoptosis. (914 aa)
chodlChondrolectin; Plays a role in the development of the nervous system such as in neurite outgrowth and elongation. Involved in motor axon growth and guidance. Required for correct interactions of motor axons with the horizontal myoseptum. (296 aa)
serpine2Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2; Belongs to the serpin family. (395 aa)
plxnb2bPlexin b2b. (1846 aa)
plxna3Plexin A3; Coreceptor for class 3 semaphorins. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. (1892 aa)
wnt2bbProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (396 aa)
laynaLayilin a. (345 aa)
eef2kEukaryotic elongation factor 2 kinase. (706 aa)
mdkaMidkine-related growth factor Mdk1. (146 aa)
acy3.1N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) A; Plays an important role in deacetylating mercapturic acids in kidney proximal tubules; Belongs to the AspA/AstE family. Aspartoacylase subfamily. (328 aa)
bmpr2aReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1003 aa)
shtn1Shootin-1; Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Belongs to the shootin family. (544 aa)
tgfb1aTransforming growth factor beta; Belongs to the TGF-beta family. (377 aa)
gsx2GS homeobox 2. (242 aa)
nptnbNeuroplastin b. (403 aa)
ngfbNerve growth factor; Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. It stimulates division and differentiation of sympathetic and embryonic sensory neurons (By similarity). (194 aa)
stk11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (438 aa)
islr2Immunoglobulin superfamily-containing leucine-rich repeat 2. (712 aa)
ist1IST1 factor-associated with ESCRT-III. (354 aa)
aspaAspartoacylase; Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate; Belongs to the AspA/AstE family. Aspartoacylase subfamily. (315 aa)
srfaSerum response factor a. (539 aa)
lig4DNA ligase. (909 aa)
kdm1aLysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (833 aa)
adnpaActivity-dependent neuroprotector homeobox a. (969 aa)
baiap2aBAR/IMD domain-containing adaptor protein 2a. (514 aa)
wnt3aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
caprin1bCell cycle-associated protein 1b. (695 aa)
dbn1Drebrin 1. (553 aa)
atoh7Protein atonal homolog 7; Transcription factor involved in the differentiation of retinal ganglion cells. (134 aa)
vegfcVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (396 aa)
numbNUMB endocytic adaptor protein. (680 aa)
wnt2baProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (387 aa)
fn1bFibronectin 1b. (2500 aa)
foxg1aForkhead box G1a. (420 aa)
neurod6aNeurogenic differentiation factor 6-A; Differentiation factor required for neurogenesis. Acts as an upstream activator of isl1. (327 aa)
map6bMicrotubule-associated protein 6b. (381 aa)
spenSpen family transcriptional repressor. (3476 aa)
si:dkey-28e7.3Si:dkey-28e7.3. (733 aa)
Q5RHX7_DANRESi:ch211-127b11.1 protein. (477 aa)
Wu:fb69f10Si:ch1073-335m2.2. (3139 aa)
foxg1dForkhead box G1d. (316 aa)
map6aMicrotubule-associated protein 6a. (452 aa)
amigo3Adhesion molecule with Ig-like domain 3. (486 aa)
fbxw8F-box and WD repeat domain-containing 8. (627 aa)
tiam1aTIAM Rac1-associated GEF 1a. (1621 aa)
adnpbActivity-dependent neuroprotector homeobox b. (1003 aa)
tnfrsf1bTumor necrosis factor receptor superfamily, member 1B. (425 aa)
wnt3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
mtorSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2563 aa)
caprin1aCell cycle-associated protein 1a. (670 aa)
bmpr2bReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1071 aa)
il34Si:ch211-239j19.3 protein. (213 aa)
acy3.2N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) B; Plays an important role in deacetylating mercapturic acids in kidney proximal tubules; Belongs to the AspA/AstE family. Aspartoacylase subfamily. (314 aa)
mecp2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (524 aa)
sema7aSemaphorin 7A; Belongs to the semaphorin family. (640 aa)
ankrd27Ankyrin repeat domain 27 (VPS9 domain). (862 aa)
cdkl5Cyclin dependent kinase like 5 long. (1080 aa)
plxnd1Plexin D1. (398 aa)
fn1aFibronectin 1a. (2480 aa)
rnd2Rho family GTPase 2. (234 aa)
Q5RH90_DANRESi:dkey-183c2.4. (568 aa)
foxg1cForkhead box G1c. (379 aa)
zfyve27Zinc finger, FYVE domain-containing 27. (409 aa)
il1rapl2Interleukin 1 receptor accessory protein-like 2. (681 aa)
plxnc1Plexin C1. (1056 aa)
trak1aTrafficking protein, kinesin-binding 1a. (860 aa)
nsmfaNMDA receptor synaptonuclear-signaling and neuronal migration factor a. (600 aa)
plxnb2a-2Plexin b2a. (544 aa)
cux2bHomeobox protein cut-like. (1356 aa)
l1cambNeural cell adhesion molecule L1.1; Cell adhesion molecule with an important role in the development of the nervous system. Involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. Binds to axonin on neurons (By similarity); Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family. (1332 aa)
tgfb1bTransforming growth factor beta; Belongs to the TGF-beta family. (379 aa)
F8W238_DANRESi:ch211-113g11.6; Belongs to the semaphorin family. (474 aa)
disc1DISC1 scaffold protein. (994 aa)
ninNinein (GSK3B-interacting protein). (1954 aa)
laynbLayilin b. (358 aa)
ptprz1aProtein tyrosine phosphatase receptor type Z1a. (1837 aa)
X1WGX6_DANRESi:ch73-330k17.3. (221 aa)
tiam2bTIAM Rac1-associated GEF 2b. (461 aa)
plxnb2aPlexin b2a. (1864 aa)
xrcc5X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (727 aa)
numblNUMB-like endocytic adaptor protein. (618 aa)
plxnb1bPlexin b1b. (2220 aa)
fgf3Fibroblast growth factor 3; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Belongs to the heparin-binding growth factors family. (256 aa)
tiam1bTIAM Rac1-associated GEF 1b. (1580 aa)
il6stInterleukin 6 signal transducer. (866 aa)
srfbSerum response factor b. (260 aa)
ENSDARP00000134495Uncharacterized protein; Belongs to the semaphorin family. (482 aa)
nsmfbNMDA receptor synaptonuclear signaling and neuronal migration factor; Stimulates outgrowth of olfactory axons and migration of hypophysiotropic gonadotropin-releasing hormone 3 (GnRH3) neurons. May couple NMDA-sensitive glutamate receptor signaling to the nucleus and trigger long-lasting changes in the cytoarchitecture of dendrites and spine synapse processes. (570 aa)
ngfaNeurotrophin-7; Recombinant ZNT-7 was able to bind to the human p75 neurotrophin receptor/NGFR and to induce tyrosine phosphorylation of the rat NTRK1/TRKA receptor tyrosine kinase, albeit less efficiently than rat NGF. ZNT-7 did not interact with rat NTRK2/TRKB or NTRK3/TRKC, indicating a similar receptor specificity as NGF; Belongs to the NGF-beta family. (233 aa)
trim32Tripartite motif-containing 32. (663 aa)
nptnaZgc:162565 protein. (277 aa)
snw1SNW domain-containing 1. (536 aa)
plxnb1aPlexin b1a. (1945 aa)
anapc2Anaphase-promoting complex subunit 2; Belongs to the cullin family. (802 aa)
dhx36DEAH (Asp-Glu-Ala-His) box polypeptide 36. (1037 aa)
nkx6.2NK6 homeobox 2. (278 aa)
il1bInterleukin-1. (284 aa)
ENSDARP00000142109Si:dkey-280e21.3. (652 aa)
plxna1aPlexin A1a. (1891 aa)
znf16lZinc finger protein 16-like; Probable transcription factor (Probable). Important for development and migration of oligodendrocyte precursor cells, and normal myelination of axons in the central nervous system (CNS). Functions autonomously in oligodendrocytes to promote CNS myelination. Seems to act in parallel with notch3 during oligodendrocyte development. Belongs to the krueppel C2H2-type zinc-finger protein family. (528 aa)
ptprz1bProtein tyrosine phosphatase receptor type Z1b. (1303 aa)
tiam2aTIAM Rac1-associated GEF 2a. (1671 aa)
tenm4Teneurin-4; Involved in neural development, regulating the establishment of proper connectivity within the nervous system. May play a role in the establishment of the anterior-posterior axis during gastrulation. Regulates the differentiation of oligodendrocytes and myelination of axons. May function as a cellular signal transducer (By similarity). Belongs to the tenascin family. Teneurin subfamily. (2865 aa)
ENSDARP00000145392Sema domain-containing protein. (1885 aa)
RelnReelin domain-containing protein. (259 aa)
spint1aSerine peptidase inhibitor, Kunitz type 1 a. (523 aa)
ENSDARP00000149939Si:dkey-40c11.2. (771 aa)
ZNF335Si:ch211-269m15.3. (1534 aa)
plxna2Plexin A2. (1902 aa)
golga4Golgin A4. (2171 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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